Document Detail

1-Methyl-4-phenylpyridinium (MPP+) inhibits mitochondrial oxygen consumption mediated by succinate as well as malate in rat pheochromocytoma PC12 cells.
MedLine Citation:
PMID:  7663396     Owner:  NLM     Status:  MEDLINE    
When rat pheochromocytoma PC12 cells are cultured with 1 mM 1-methyl-4-phenylpyridinium (MPP+), the number of viable cells decreases to one third in 4 days while the number increases ten-fold without MPP+. Oxygen consumption by mitochondria in the presence of malate is inhibited about 80% by the treatment of the cells with MPP+ for 4 days. Unexpectedly, succinate-dependent oxygen consumption is also inhibited to essentially the same extent as malate-dependent one. These results suggest that the impairment of the respiration mediated by succinate as well as malate is important as a mechanism of MPP(+)-induced cell death.
E Hasegawa; H Asagami; D Kang; S Minakami; K Takeshige
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biochemistry and molecular biology international     Volume:  35     ISSN:  1039-9712     ISO Abbreviation:  Biochem. Mol. Biol. Int.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-10-12     Completed Date:  1995-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306673     Medline TA:  Biochem Mol Biol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  409-13     Citation Subset:  IM    
Department of Biochemistry, Kyushu University School of Medicine, Fukuoka, Japan.
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MeSH Terms
1-Methyl-4-phenylpyridinium / pharmacology*
Adrenal Gland Neoplasms
Cell Survival / drug effects
Dose-Response Relationship, Drug
Malates / metabolism*
Mitochondria / drug effects,  metabolism*
Oxygen Consumption / drug effects*
PC12 Cells
Succinates / metabolism*
Time Factors
Reg. No./Substance:
0/Malates; 0/Succinates; 48134-75-4/1-Methyl-4-phenylpyridinium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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