| 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced damage of striatal dopaminergic fibers attenuates subsequent astrocyte response to MPTP. | |
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MedLine Citation:
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PMID: 1981254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute administration of the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the C57BL/6 mouse caused a rapid decrease in the amount of striatal tyrosine hydroxylase (TH), a marker of the nigrostriatal dopaminergic pathway, followed by a large increase in the astrocyte protein, glial fibrillary acidic protein (GFAP). The astrocyte (GFAP) response declined to baseline three weeks after administration of MPTP. Administration of a second dosage of MPTP at this time evoked a second GFAP response. The magnitude of the second response, however, was decreased in comparison to the response seen after only a single exposure to MPTP. Increasing the initial dosage of MPTP resulted in greater reductions of the second GFAP response. These data indicate that MPTP-induced damage or loss of striatal dopaminergic neurons reduces the signal available for initiating astrogliosis and thereby reduces the astrocyte response to a second exposure to MPTP. |
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Authors:
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J P O'Callaghan; D B Miller; J F Reinhard |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 117 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1991-04-01 Completed Date: 1991-04-01 Revised Date: 2011-12-06 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 228-33 Citation Subset: IM |
Affiliation:
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Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / drug effects, metabolism* Brain / drug effects, metabolism* Corpus Striatum / drug effects, metabolism*, pathology Dopamine / physiology* Female Glial Fibrillary Acidic Protein / metabolism MPTP Poisoning* Mice Mice, Inbred C57BL Nerve Fibers / drug effects, physiology* Neurons / drug effects, metabolism Reference Values Tyrosine 3-Monooxygenase / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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RA-ND-89-4/ND/ONDIEH CDC HHS |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
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