| ENPP1/PC-1 K121Q and other predictors of posttransplant diabetes. | |
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MedLine Citation:
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PMID: 20958205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetes mellitus is a major cause of morbidity and mortality among transplanted patients. This study evaluated the role of the ENPP1 K121Q polymorphism and other variables known to affect diabetes risk in 115 nondiabetic and unrelated patients who underwent kidney transplant at our institution and had consented for use of genetic material (30% whites, 48% blacks, and 22% Hispanics). Thirty-six of these patients (30%) developed posttransplant diabetes mellitus (PTDM) within 1 year of observation from transplant. Black race, ENPP1 K121Q polymorphism, age, body mass index (BMI), and immunosuppressive medications were found to have the strongest associations with PTDM in the logistic regression and receiver operator characteristic (ROC) analysis. However, because ENPP1 K121Q is more common in Hispanics and in blacks, who also have higher PTDM prevalence, the studied genetic polymorphism did not exert independent predictive effect, whereas ethnicity, specifically black versus non-black, was the most robust predictor of PTDM. The model with the largest ROC area under the curve (AUC) of 0.80 was comprised of black/non-black, age, BMI, and tacrolimus treatment as significant predictors. A reduced model containing only ethnicity (black/non-black) and age as predictors yielded similar results (ROC AUC 0.78). We conclude that black race and age are major and not modifiable risk factors for PTDM. The specific role of ENPP1 K121Q on ethnic susceptibility to PTDM deserves further investigation in larger cohorts of transplanted patients. |
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Authors:
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Magdalene Szuszkiewicz; Jason Bell; Miguel Vazquez; Beverley Adams-Huet; Scott M Grundy; Manisha Chandalia; Nicola Abate |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-19 |
Journal Detail:
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Title: Metabolic syndrome and related disorders Volume: 9 ISSN: 1557-8518 ISO Abbreviation: Metab Syndr Relat Disord Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: 2011-05-04 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 101150318 Medline TA: Metab Syndr Relat Disord Country: United States |
Other Details:
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Languages: eng Pagination: 25-9 Citation Subset: IM |
Affiliation:
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The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Amino Acid Substitution Biological Markers / analysis, metabolism Continental Population Groups / genetics Diabetes Mellitus / diagnosis, ethnology, etiology*, genetics* Female Genetic Predisposition to Disease / ethnology Glutamic Acid / genetics Humans Lysine / genetics Male Middle Aged Phosphoric Diester Hydrolases / genetics*, physiology Polymorphism, Single Nucleotide* / physiology Prognosis Pyrophosphatases / genetics*, physiology Transplantation / adverse effects*, ethnology |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK072158/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 56-86-0/Glutamic Acid; 56-87-1/Lysine; EC 3.1.4.-/Phosphoric Diester Hydrolases; EC 3.1.4.1/ectonucleotide pyrophosphatase phosphodiesterase 1; EC 3.6.1.-/Pyrophosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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