Document Detail

1-Hydroxypyrene levels in coal-handling workers at a coke oven.
MedLine Citation:
PMID:  8941904     Owner:  NLM     Status:  MEDLINE    
An environmental and medical survey was conducted at the coal-handling area of a coke oven, where workers came in contact with coal-tar sludge. The purpose of the study was to determine if skin contact with coal-tar sludge was an important route of exposure to pyrene because workers were observed to have substantial contact with the sludge. Environmental monitoring revealed minimal airborne exposure to pyrene, a byproduct of the coke distillation process; only one personal breathing zone sample detected pyrene, and at least of 0.001 mg/m3. However, the mean preshift urinary 1-hydroxypyrene concentration was 1.00 mumol/mol creatinine (range, 0.16 to 2.96 mumol/mol creatinine) and the mean postshift level was 1.7 mumol/mol creatinine (range, 0.24 to 4.85 mumol/mol creatinine) (P < 0.01). These levels probably reflect absorption as a result of skin exposure.
R Malkin; M Kiefer; W Tolos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  38     ISSN:  1076-2752     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-05-15     Completed Date:  1997-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1141-4     Citation Subset:  IM    
Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA.
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MeSH Terms
Air Pollution / analysis
Biological Markers
Coal Tar / adverse effects*
Keratolytic Agents / adverse effects*
Occupational Exposure / analysis*
Pyrenes / metabolism*
Respiratory Protective Devices
Skin Absorption*
Reg. No./Substance:
0/Biological Markers; 0/Coke; 0/Keratolytic Agents; 0/Pyrenes; 5315-79-7/1-hydroxypyrene; 8007-45-2/Coal Tar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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