| 1-Hydroxypyrene in milk and urine as a bioindicator of polycyclic aromatic hydrocarbon exposure of ruminants. | |
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MedLine Citation:
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PMID: 18271539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urinary 1-hydroxypyrene (1-OH-pyrene) is now largely considered to be a valuable biomarker of exposure of man and animals to pyrene and other polycyclic aromatic hydrocarbons (PAHs). However, from a practical and agronomic standpoint, the question remains whether such biomarking capability still holds when 1-OH-pyrene is analyzed in milk produced by ruminants. To assess this hypothesis, four goats were daily submitted to three different amounts of pyrene oral ingestion, together with phenanthrene and benzo(a)pyrene (1, 7, and 49 mg/day during 1 week each). An HPLC-fluorometric analysis of 1-OH-pyrene in milk revealed a perfect correlation between pyrene doses and 1-OH-pyrene detected in milk, thus fully confirming the biomarking capability of 1-OH-pyrene and providing information on its transfer coefficient toward milk. Transfer equations such as the ones found in the present study could be used as a valuable and practical risk assessment tool in (i) the accurate monitoring of exposure of ruminants to pyrene and (ii) the evaluation of occupational and environmental exposure of ruminants to PAH mixtures. |
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Authors:
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Abir Chahin; Yann P Guiavarc'h; Marie-Antoinette Dziurla; Hervé Toussaint; Cyril Feidt; Guido Rychen |
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Publication Detail:
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Type: Journal Article Date: 2008-02-14 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 56 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-06 Completed Date: 2008-04-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1780-6 Citation Subset: IM |
Affiliation:
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Research Unit on Animal and Functionality of Animal Products (UR AFPA), Nancy University--Institut National de la Recherche Agronomique, ENSAIA, 54505 Vandoeuvre-lès-Nancy, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / analysis, urine Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Environmental Exposure* Environmental Monitoring / methods Female Goats / metabolism*, urine Milk / chemistry* Mutagens / administration & dosage, analysis*, metabolism Polycyclic Hydrocarbons, Aromatic / metabolism* Pyrenes / administration & dosage, analysis*, metabolism Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Mutagens; 0/Polycyclic Hydrocarbons, Aromatic; 0/Pyrenes; 5315-79-7/1-hydroxypyrene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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