| 1-Desamino-8-D-arginine vasopressin (DDAVP) in patients with congenital nephrogenic diabetes insipidus. | |
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MedLine Citation:
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PMID: 8232694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In healthy subjects, intravenous infusion of the selective V2-vasopressin receptor agonist 1-desamino-8-D-arginine vasopressin (DDAVP, 400 ng/kg in 10 min) causes a marked increase in heart rate with a slight decrease in diastolic blood pressure. These haemodynamic responses are associated with increments in the plasma levels of renin, noradrenaline (NA), clotting factor VIII (FVIII:C), von Willebrand factor (vWF:ag), and tissue-type plasminogen activator (t-PA), and a fall in the plasma level of plasminogen activator inhibitor (PAI). None of these changes was observed in 3 patients with congenital nephrogenic diabetes insipidus (NDI), who had a genetic defect of the V2-receptor. Plasma AVP levels in these patients were normal or slightly elevated, which makes it unlikely that the lack of DDAVP responsiveness was caused by down-regulation of vasopressin V1-receptors. In one NDI patient, arginine vasopressin (AVP) was given in incremental doses (62.5-4000 pg/kg/min). The heart rate and blood pressure responses to AVP were normal, indicating the absence of a V1-receptor defect. The responses of vWF:ag and t-PA to venous occlusion in the patients with NDI were similar to those in 5 healthy volunteers, which indicates that in NDI the endothelial release of both vWF:ag and t-PA is normal. We conclude that DDAVP causes its effects on heart rate and blood pressure, and on the plasma levels of renin, noradrenaline, FVIII:C, vWF:ag, and t-PA through V2-receptor stimulation. |
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Authors:
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H S Brink; F H Derkx; F Boomsma; E J Brommer; M A Schalekamp |
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Publication Detail:
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Type: Case Reports; Clinical Trial; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 43 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-12-06 Completed Date: 1993-12-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 5-12 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, Erasmus University, Rotterdam, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Coagulation / drug effects* Deamino Arginine Vasopressin / pharmacology* Diabetes Insipidus / blood, congenital*, drug therapy*, physiopathology Factor VIII / analysis Fibrinolysis / drug effects* Hemodynamics / drug effects* Humans Infusions, Intravenous Male Norepinephrine / blood Plasminogen Inactivators / blood Receptors, Vasopressin / drug effects, genetics Renin / blood Tissue Plasminogen Activator / blood von Willebrand Factor / analysis |
| Chemical | |
Reg. No./Substance:
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0/Plasminogen Inactivators; 0/Receptors, Vasopressin; 0/von Willebrand Factor; 16679-58-6/Deamino Arginine Vasopressin; 51-41-2/Norepinephrine; 9001-27-8/Factor VIII; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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