| 1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems. | |
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MedLine Citation:
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PMID: 17900912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system. |
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Authors:
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Maria Luisa Gelmi; Francesco Caputo; Francesca Clerici; Sara Pellegrino; Gino Giannaccini; Laura Betti; Laura Fabbrini; Lara Schmid; Lionella Palego; Antonio Lucacchini |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-12 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 15 ISSN: 1464-3391 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-10-22 Completed Date: 2008-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 7581-9 Citation Subset: IM |
Affiliation:
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Istituto di Chimica Organica "A. Marchesini", Facoltà di Farmacia, Università di Milano, Via Venezian 21, I-20133 Milano, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Cyclopentanes / chemistry*, pharmacology* Drug Evaluation, Preclinical Humans Molecular Structure Rats Receptors, Glutamate / drug effects, metabolism* Receptors, Serotonin / drug effects, metabolism* Serotonin Agonists / chemistry*, metabolism, pharmacology Stereoisomerism* Tricarboxylic Acids / chemistry*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/1-aminocyclopentane-1,2,4-tricarboxylic acid; 0/Cyclopentanes; 0/Receptors, Glutamate; 0/Receptors, Serotonin; 0/Serotonin Agonists; 0/Tricarboxylic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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