Document Detail


1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.
MedLine Citation:
PMID:  17900912     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system.
Authors:
Maria Luisa Gelmi; Francesco Caputo; Francesca Clerici; Sara Pellegrino; Gino Giannaccini; Laura Betti; Laura Fabbrini; Lara Schmid; Lionella Palego; Antonio Lucacchini
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-12
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  15     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2008-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  7581-9     Citation Subset:  IM    
Affiliation:
Istituto di Chimica Organica "A. Marchesini", Facoltà di Farmacia, Università di Milano, Via Venezian 21, I-20133 Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Cyclopentanes / chemistry*,  pharmacology*
Drug Evaluation, Preclinical
Humans
Molecular Structure
Rats
Receptors, Glutamate / drug effects,  metabolism*
Receptors, Serotonin / drug effects,  metabolism*
Serotonin Agonists / chemistry*,  metabolism,  pharmacology
Stereoisomerism*
Tricarboxylic Acids / chemistry*,  pharmacology*
Chemical
Reg. No./Substance:
0/1-aminocyclopentane-1,2,4-tricarboxylic acid; 0/Cyclopentanes; 0/Receptors, Glutamate; 0/Receptors, Serotonin; 0/Serotonin Agonists; 0/Tricarboxylic Acids

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