| 1-Alpha-hydroxycholecalciferol-induced changes in the renal heandling of phosphate and the serum parathyroid hormone level. | |
| | |
MedLine Citation:
|
PMID: 983805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of 1-alpha-hydroxycholecalciferol (1alpha-OH-D3) on the renal handling of phosphate and the immunoreactive parathyroid hormone in serum (i-PTH) has been studied in 10 patients with a wide range of glomerular filtration rate (GFR), maximal tubular reabsorption of phosphate (TmP) and i-PTH. The patients were treated with 2 mug 1alpha-OH-D3 per day for approximately 80 days. Before and after this period of treatment, the TmP, i-PTH, 51Cr EDTA clearance, extracellular volume, standard bicarbonate, and serum calcium were measured in each patient. The TmP/GFR ratio was used as an index of the renal handling of phosphate. The index increased significantly (mean 26.5%, p less than 0.01) during the treatment, while i-PTH decreased significantly (mean 37.0%. p less than 0.01). An inverse significant correlation was demonstrated between TmP/GFR index and i-PTH both before (r = -0.87, p less than 0.001) and after (r = -0.79, p less than 0.01) the administration o alpha-OH-D3, while none of the other factors investigated were correlated to the index. It is concluded that 1alpha-OH-D3 increases the TmP/GFR index and reduces i-PTH in a parallel manner and it is therefore suggested that the 1alpha-OH-D3-induced changes in the renal handling of phosphate may be explained as being mediated solely via the suppression of i-PTH. |
| | |
Authors:
|
S Madsen; K Olgaard; J Ladefoged |
Related Documents
:
|
17213855 - Vitamin d, insulin resistance, and renal disease. 15153145 - Microencapsulation of parathyroid tissue with photosensitive poly(l-lysine) and short c... 3085235 - Hypercalcemia and reversible renal failure in heavy-chain disease. 9735655 - Surgical anatomy of the parathyroid glands in secondary hyperparathyroidism. 6346595 - Medical research council trial of antilymphocyte globulin in renal transplantation. a m... 8739725 - Arthroscopic osteochondral autograft transplantation in anterior cruciate ligament reco... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta medica Scandinavica Volume: 200 ISSN: 0001-6101 ISO Abbreviation: Acta Med Scand Publication Date: 1976 |
Date Detail:
|
Created Date: 1976-12-30 Completed Date: 1976-12-30 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370330 Medline TA: Acta Med Scand Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 351-4 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Adult Female Glomerular Filtration Rate / drug effects Humans Hydroxycholecalciferols / administration & dosage, pharmacology* Kidney Tubules / metabolism* Male Middle Aged Parathyroid Hormone / blood* Phosphates / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Hydroxycholecalciferols; 0/Parathyroid Hormone; 0/Phosphates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Observations on the different calcium metabolic patterns in sarcoidosis. A metabolic and kinetic stu...
Next Document: Clinical and laboratory findings in subjects with hypercalcaemia. A study including cases with prima...