Document Detail

1-Alpha-hydroxycholecalciferol-induced changes in the renal heandling of phosphate and the serum parathyroid hormone level.
MedLine Citation:
PMID:  983805     Owner:  NLM     Status:  MEDLINE    
The effect of 1-alpha-hydroxycholecalciferol (1alpha-OH-D3) on the renal handling of phosphate and the immunoreactive parathyroid hormone in serum (i-PTH) has been studied in 10 patients with a wide range of glomerular filtration rate (GFR), maximal tubular reabsorption of phosphate (TmP) and i-PTH. The patients were treated with 2 mug 1alpha-OH-D3 per day for approximately 80 days. Before and after this period of treatment, the TmP, i-PTH, 51Cr EDTA clearance, extracellular volume, standard bicarbonate, and serum calcium were measured in each patient. The TmP/GFR ratio was used as an index of the renal handling of phosphate. The index increased significantly (mean 26.5%, p less than 0.01) during the treatment, while i-PTH decreased significantly (mean 37.0%. p less than 0.01). An inverse significant correlation was demonstrated between TmP/GFR index and i-PTH both before (r = -0.87, p less than 0.001) and after (r = -0.79, p less than 0.01) the administration o alpha-OH-D3, while none of the other factors investigated were correlated to the index. It is concluded that 1alpha-OH-D3 increases the TmP/GFR index and reduces i-PTH in a parallel manner and it is therefore suggested that the 1alpha-OH-D3-induced changes in the renal handling of phosphate may be explained as being mediated solely via the suppression of i-PTH.
S Madsen; K Olgaard; J Ladefoged
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  200     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1976  
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  351-4     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Glomerular Filtration Rate / drug effects
Hydroxycholecalciferols / administration & dosage,  pharmacology*
Kidney Tubules / metabolism*
Middle Aged
Parathyroid Hormone / blood*
Phosphates / metabolism*
Time Factors
Reg. No./Substance:
0/Hydroxycholecalciferols; 0/Parathyroid Hormone; 0/Phosphates

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