Document Detail

0043 Benign pleural abnormalities and mesothelioma among asbestosis workers in Hong Kong.
MedLine Citation:
PMID:  25018430     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: To evaluate whether the presence of pleural abnormalities was a reasonable marker to predict mesothelioma among workers with asbestosis in Hong Kong.
METHOD: This is a historical cohort study comprised of 99 male asbestosis workers registered in the Pneumoconiosis Clinic under Hospital Authority of the Hong Kong Government during 1981-2008 who had records of chest radiograph at the time of diagnosis of asbestosis. All asbestosis workers were followed up till 31/12/2008 and the rate of follow-up was 97%. We calculated the sensitivity and specificity of the presence of benign pleural abnormalities (i.e., the presence of benign plaques and/or thickenings at the initial chest radiograph)" using mesothelioma deaths as the "good standard"; meanwhile, the positive predictive value (PPV) and negative predictive value (NPV) were also calculated.
RESULTS: Benign pleural abnormalities appeared in the initial radiograph for 54 asbestosis workers. We observed 15 mesothelioma deaths and 4 of them had benign pleural abnormalities at the initial chest radiographs. The sensitivity, specificity, PPV, and NPV for using the baseline benign pleural abnormalities to predict mesothelioma deaths was 0.27 (95% CI: 0.078-0.55), 0.63 (95% CI: 0.52-0.73), 0.11 (95% CI: 0.032-0.27), and 0.83 (95% CI: 0.71-0.91). These results remained unchanged when workers with co-presenting cancer at the baseline were excluded from the analyses.
CONCLUSIONS: This study suggests a relatively limited value for using benign pleural abnormalities as markers to predict mesothelioma deaths in workers with asbestosis. [Acknowledgement: CUHK Direct Grant (Project code.: 2041587), Hong Kong].
Lap Ah Shelly Tse; Ronald Kf Au; Minghui Chen; Feng Wang; Ignatius Ts Yu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  71 Suppl 1     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-07-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  A63-4     Citation Subset:  IM    
Copyright Information:
© 2014, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to
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