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Lam, Han - - 2010
Problem statement: Immunosuppression is a common approach for pathogens or cancer to escape from immune system of the infected host. Some of the antimicrobe or anticancer drugs may also weaken the body immune system. Among various types of immune cell, natural killer cells are the key component of the innate ...
Anastasia, Utoh-Nedosa - - 2010
Problem statement: Two cancer patients were treated with Vernonia amygdalina (V. amygdalina) leaf extract and leaf powder. The leaf extract of V amygdalina was administered orally for 9 months to the first patient in response to his reception of a medical diagnosis of having traces of prostate cancer. Approach: This ...
Akbari-Asbagh, Firozeh - - 2010
Problem statement: Oxidative Stress (OS) has been recognized as one of the most important cause of male infertility. We studied the relation of serum and Semen Malondialdehyde (MDA) and Total Antioxidant Capacity (TAC) with sperm parameters in infertile men with sperm count within the normal range. Approach: The prospective case-control ...
Borvak, Jozef - - 2010
Problem statement: Dendritic Cells (DCs) integrate responses of innate and adaptive immune system via transmitting pro-inflammatory and regulatory signals to naive cells within draining lymph nodes. DCs have high capacity for endocytosis, both Clathrin-Dependent (CDE) and Caveolin-Dependent (CvDE). Approach: We have recently shown that ATP-hydrolysis by the multifunctional transporter protein ...
Saeed, Bahjat - - 2010
Problem statement: Pyridones are known to have variety of biological activities like antitumor, antibacterial, anti-inflammatory and antimalarial activities. This study presents antiviral evaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison. Approach: The compounds evaluated for their in vitro antiviral activities against the viruses: HIV-1, Bovin viral ...
Schumann, J. - - 2010
Since their first description only some years ago Th17 cells have become of vital importance in immunological research. However, the role of TGF-[beta] in Th17 cell development is still a matter of controversial discussion. Predicted to have a key function in Th17 cell differentiation in the mouse TGF-[beta] was shown ...
Sujatha, M. - - 2010
Problem statement: Antibiotic susceptibility is still the best way for bacterial pathogen escape mechanism against immunity. Approach: In the present investigation, bacterial pathogens like Staphylococcus aureus, Escherichia coli, Aeromonas hydrophila, Klebsiella and Pseudomonas aeruginosa were used to screen antibiotic susceptibility and immunomodulatory potential. Results: All the test pathogens were sensitive ...
Saeed, Bahjat - - 2010
Problem statement: Pyridones are known to have variety of biological activities like antitumor, antibacterial, antiinflamatory and antimalarial activities. This study presented antitumor evaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison. Approach: The compounds evaluated for a preliminary estimation of the in vitro tumor inhibiting activity against ...
Maripandi, A. - - 2010
Problem statement: Salmonella infection is a serious medical and veterinary problem worldwide and causes great concern in the human health and food safety. Salmonella enteritidis outer membrane proteins and lipopolysaccharide play important role in the virulence and immunological properties of bacteria. Prophylaxis of enterobacterial infection has proven difficult to achieve. ...
Jahromi, Abdolreza - - 2009
Problem statement: The incidence of infectious diseases is increased in patients with chronic renal failure. Chronic renal failure severely influences the immune functions of the host. Approach: To evaluate the antitetanus immunity level in southern Iranian patients with end stage renal disease undergoing hemodialysis and to find its association with ...
Wang, Renxi - - 2009
Problem statement: More and more evidences have shown that human cancer cells can express Foxp3, the regulatory T cell-associated transcription factor. The role of Foxp3 in human cancer cells is still unclear. We detected Foxp3 expression in human pancreatic cancer cell line PANC-1. SiRNA assays showed that Foxp3 expression suppressed ...
Capitini, Christian - - 2009
Problem statement: The development of a potent vaccine that can help treat tumors resistant to conventional cytotoxic therapies remains elusive. While part of the problem may be that trials have focused on patients with bulky residual disease, the desire to maximize responses to the vaccine remains. Approach: The gamma ([gamma]) ...
Sakai, Tohru - - 2009
Problem statement: NC/Nga (NC) mice produced high levels of ovalbumin (OVA)specific IgG, IgG1 and IgG2a. We previously found deletion polymorphisms in the promoter region of fcgr2b in NC mice. To determine whether this mutation causes a hyper-humoral immune response, we generated congenic BALB/c mice carrying the NC-type fcgr2b allele (NC ...
Hanane, Negaoui - - 2009
Problem statement: Cow's Milk Allergy (CMA) is a common disease in childhood. Pathophysiological mechanisms involved in gastrointestinal symptoms are relatively poorly understood. Approach: Therefore, an experimental model of intestinal anaphylaxis was needed to approach the problem. The aim of this study was to examine the effect of the parenteral sensitization ...
Qicai, Liu - - 2009
Problem statement: More and more severe hepatitis cases reported in China are infected with HBV and the immune response of HBV will be reduced if mutations occur in the TCR, therefore it is very important to investigate the relation of T-cellular function and clinical effect by studying the function of ...
Barrett, John - - 2009
Problem statement: Chemotherapeutic drugs have been used to treat malignancy for over 50 years, but the potential of cytotoxic agents to suppress immunity and interfere with Immunosurveillance (IS) of cancer has been largely ignored. Assuming that the immune control of the cancer had a priori already failed, the effect was ...
Block, Matthew - - 2009
Problem statement: The interactions of a malignant tumor with the patient's immune system are dynamic, multiple and bi-directional. Approach: This article reviews the clinical evidence of the interaction of cancer with immunity with emphasis on recent developments highlighting some of the mechanisms of tumor-mediated regulation of immunity. Results: Most of ...
Yang, Zhi-Zhang - - 2009
Problem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of [CD4.sup.+][CD25.sup.+] regulatory T ([T.sub.reg]) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although [T.sub.reg] cells were originally identified ...
Porrata, Luis - - 2009
Problem statement: The infused alloreactive lymphocytes in allogeneic stem cell transplantation (Allo-SCT) lead to an unspecific immune response causing Graft-Versus-Tumor (GVT) effect and Graft-Versus-Host Disease (GVHD). The current dogma regarding the anti-tumor effect of GVT is only observed in the Allo-SCT and not in the autologous hematopoietic stem cell transplantation ...
Shi, Wenfang - - 2008
Since the first parvovirus serotype AAV2 was isolated from human and used as a vector for gene therapy application, there have been significant progresses in AAV vector development. AAV vectors have been extensively investigated in gene therapy for a broad application. AAV vectors have been considered as the first choice ...
Abuhamed, Mutasem - - 2008
Problem statement: Epilepsy is a common neurological disorder that afflicts 1-2% of the general population worldwide. It encompasses a variety of disorders with seizures. Approach: Idiopathic epilepsies were defined as a heterogeneous group of seizure disorders that show no underlying cause .Voltage-gated ion channels defect were recognized etiology of epilepsy ...
Golding, R.M. - - 2008
Following a twisting strain with immediate pain in the neck of a polymyositis patient we detail the analysis of a specific range of data gathered before and after the event. The results reinforce that in this case that the creatine kinase isoenzyme and cardiac Troponin T cannot be used as ...
Abdulamir, A.S. - - 2008
This study was carried out for evaluating the interplay of p53, p21 and Ki-67 proteins along the colorectal adenoma-carcinoma oncogenic transformation sequel. Therefore, Fifty colorectal cancer and 14 adenoma patients were involved. The histopathological expression of p53, p21 and Ki-67 proteins was evaluated by immunohistochemistry assay. The results revealed that ...
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