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Harman, Ece - - 2011
Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced responsiveness of target tissues to thyroid hormone. It is usually first suspected due to findings of high serum free thyroxine (T4) and free triiodothyronine (T3) concentrations and normal or slightly high serum thyroid-stimulating hormone (TSH) concentrations. Herein, we ...
Gonulalan, Gulsum - - 2011
Graves' disease usually affects both lobes of the gland, thus, unilateral Graves' hyperthyroidism has been reported very rarely. Here, we report a case of Graves' disease presenting with unilateral involvement of the thyroid gland. Thyroid function tests revealed thyrotoxicosis and scintigraphy with technetium-99m showed increased diffuse unilateral radioisotope uptake in ...
Ipekci, Suleyman - - 2011
Subacute thyroiditis generally presents with pain in the thyroid region, fever, thyrotoxicosis and elevated markers of acute inflammation. On the other hand, Hashimoto's thyroiditis is most frequently diagnosed in the hypothyroid phase with positive antithyroid autoantibodies. Here, we describe the case of a patient who presented with clinical features of ...
Oyekcin, Demet - - 2011
Objectives: Epidemiologic data suggests an association between obesity and depression. However, a limited number of studies have investigated the prevalence of psychiatric symptoms among obese patients without a psychiatric diagnosis. The objective of this study was to determine psychiatric diagnosis in patients with obesity who applied to the endocrinology department ...
Yener, Serkan - - 2011
Objectives: The relation between non-functioning adrenal adenoma and unfavorable metabolic status has been a debate so far. We aimed to demonstrate the prevalence of non-alcoholic fatty liver disease (NAFLD) in subjects with silent adrenal adenomas.
Mahmoud, Moushira - - 2011
Background: Type 1 diabetes mellitus (T1D) is a polygenic autoimmune disease. Vitamin D is a potent modulator of the immune system and has been implicated in T1D pathogenesis and prevention. Vitamin D-binding protein (VDBP) is the main systemic transporter of vitamin D and is essential for its cellular endocytosis. Two ...
Erdogan, Mehmet - - 2011
Background: Diabetic foot ulcers and lower extremity amputations are leading causes of mortality and morbidity in diabetic patients. Diabetic neuropathy and peripheral vascular diseases are major reasons for the development of diabetic foot ulcer. Most of the studies showed that hyperhomocysteinemia is related with microvascular and macrovascular complications in diabetic ...
Ilkova, Hasan - - 2011
Background: The level of glycemic control is considered to be too low among patients with type 2 diabetes mellitus (DM) in Turkey. Despite availability of several anti-diabetic treatment alternatives, substantial amount of diabetic patients are at increased risk of diabetes-related macrovascular as well as microvascular complications.
Wiwanitkil, Viroj - - 2011
Ipekci, Suleyman - - 2011
Silent thyroiditis constitutes approximately 1% all of thyroiditis. Rarely, silent thyroiditis can present with recurrent attacks. Here, we present the case of a patient who had four episodes of painless (silent) thyroiditis.
Ipekci, Suleyman - - 2011
Pituitary apoplexy is a rare and sometimes underdiagnosed complication of pituitary adenomas. We present here the case of a patient who was referred to our endocrinology outpatient clinic for his acromegalic appearance. Endocrinological evaluation revealed low basal growth hormone and normal insulin-like growth factor 1 levels, secondary hypothyroidism and adrenal ...
Ozturk, Mine - - 2011
Bisphosphonates are strong inhibitors of bone resorption and are used in the treatment of osteoporosis. Bisphosphonates are known to be effective in prevention of fractures, improvement of bone mineral density as well as in relieving bone pain in osteogenesis imperfecta (OI) patients. Recent studies have shown that especially intravenous pamidronate ...
Tarcin, Ozlem - - 2011
Paraoxonase is an esterase bound to high-density lipoproteins which by metabolizing lipid peroxides, prevents their accumulation on low-density lipoproteins. It also hydrolyzes various organophosphorus compounds. Considering the role of PON1 in hydrolyzing phospholipid and cholesteryl-ester hydroperoxides and thus protecting lipoproteins against oxidative modification, it can be concluded that PON1 may ...
Cakir, Mehtap - - 2011
Transsphenoidal pituitary surgery is frequently complicated with mild to severe water and electrolyte disturbances in the postoperative period. These disorders are: transient diabetes insipidus, early or delayed hyponatremia, diabetes insipidus followed by hyponatremia (biphasic pattern), diabetes insipidus-hyponatremia-diabetes insipidus (triphasic pattern), permanent diabetes insipidus, and cerebral salt-wasting syndrome. Close monitoring of ...
Canan, Fatih - - 2011
Objective: Our aim was to assess the prevalence of binge eating disorder (BED) in individuals with type 2 diabetes and to investigate whether a comorbidity with BED would affect glycemic control in these patients.
Karaca, Halit - - 2011
Distant metastasis is uncommon in differentiated thyroid cancer (DTC) and 7% to 23% of DTC patients develop distant metastasis. The remarkably good prognosis and long-term survival in DTC are significantly reduced in patients with distant metastasis as those at the pelvic site. We report the rare case of a patient ...
Ozuguz, Ufuk - - 2011
Papillary thyroid microcarcinomas are slow-growing tumours; distant metastases causing mortality is very rare. Case presentation We report the case of a 35-year-old woman with lung and bone metastases of a multifocal papillary thyroid microcarcinoma (PTMC). She had undergone a subtotal thyroidectomy due to euthyroide multinodular goitre without fine needlle aspiration ...
Gorar, Suheyla - - 2011
Primary hyperparathyroidism (PHP), more common in women, is a disease associated with high calcium levels. Pregnancy within PHP is a condition of life in terms of both maternal and fetal facts. We've reported our patients who came to us with urinary symptoms with hypercalcemia, she was diagnosed as PHP. Surgery ...
Unluturk, Ugur - - 2011
Either recurrence or regional metastasis of differentiated thyroid carcinomas is often observed in cervical lymph nodes. Consequently, cytologic evaluation accompanied by fine-needle aspiration biopsy is applied to most of the suspected lymph nodes. Considering insufficient cellularity, poor sampling or the lack of competence of the cytologist, 20-50% of samples remain ...
Salman, Serpil - - 2011
Type 1A diabetes results from the destruction of the insulin-secreting islet [beta]-cells by an immune-mediated process. In the majority of patients, the clinical course is typical and there is no doubt about the diagnosis. However, the measurement of autoimmune diabetes markers is very useful in some situations such as differential ...
Mammadov, Vusal - - 2011
Background: The aim of our study was to determine the coronary angiographic distribution and frequency of atherosclerotic lesions in the coronary arteries in patients with stable angina and metabolic syndrome (MS) as well as to assess the association of these lesions with TIMI frame count and combinations of MS criteria.
Baskal, Nilgun - - 2010
Elbuken, Gulsah - - 2010
The diagnosis of Cushing's syndrome (CS) is still one of the most challenging problems in endocrinology. In ACTH-dependent CS, bilateral inferior petrosal sinus sampling (BIPSS) is a useful method for distinguishing between pituitary and ectopic sources of ACTH secretion. BIPSS is an interventional radiology method, in which ACTH levels obtained ...
Onder, Elif - - 2010
Objective: Recent studies have shown that subclinical hypothyroidism (SCH) has similar cardiovascular risks with clinical hypothyroidism (CH). We evaluated carotis intima media thickness (CIMT)-indicator of early changes in atherosclerotic process- in female patients, who have either CH or SCH, with similar age and demographic features.
Yazici, Dilek - - 2010
Objective: C-reactive protein (CRP) is considered to be a cardiovascular risk marker and changes in its level have been attributed to genetic factors. The aim of the study was to determine CRP 1059G/C gene polymorphism frequency and its relationship with CRP levels and carotid artery intima-media thickness (CIMT) in type ...
Cander, Soner - - 2010
Objective: Current goals of treatment of diabetes are to achieve near-normal glycemia, minimize the risk of severe hypoglycemia, limit excessive weight gain, and to improve quality of life. Insulin pump or continuous subcutaneous insulin infusion (CSII) therapy provides a treatment option to aid in achieving all of these goals. CSII ...
Qari, Faiza - - 2010
Adrenomyeloneuropathy is a rare X-linked inherited disorder of peroxisomes characterized by accumulation of very-long-chain fatty acids (VLCFA) in the central and peripheral nervous system, adrenal glands and testes, leading to dysfunction of these organs and systems (1). Here, we report a case of adrenomyeloneuropathy presenting initially as acute adrenal crisis, ...
Celik, Ozlem - - 2010
Primary hyperaldosteronism is an endocrine disorder characterized by an increased aldosterone excretion from the adrenal glands, which causes hypertension, hypokalemia, and suppressed plasma renin activity. It can be difficult to diagnose until hypokalemic manifestations, such as rhabdomyolysis, occur, and also these subjects may be treated as essential hypertensive patients. Here, ...
Simsir, Ilgin - - 2010
Selenium, which is toxic in high concentrations, is essential for the body. This trace element known for its antioxidant function is the cofactor of many enzymes. Selenium plays a role in many metabolic processes involving the enzymes glutathion peroxidases, deiodinases, thioredoxin reductases, and selenoprotein P that protect the organism from ...
Ozsan, Muge - - 2010
We present two cases of 17-alpha hydroxylase deficiency (17OHD), a rare cause of congenital adrenal hyperplasia (1%); our patients are first cousins (their fathers are brothers). Genetically female patients with congenital adrenal hyperplasia due to 17OHD represent with sexual infantilism, hypertension, while genetically male patients represent with male pseudohermaphroditisim and, ...
Satman, Ilhan - - 2010
Objective: To evaluate the impact of physicians' adherence to the guidelines developed by the Diabetes Study Group of The Society of Endocrinology and Metabolism of Turkey (SEMT) on glycemic control in diabetes mellitus.
Aydin, Hasan - - 2010
Objective: Since only a small proportion of diabetics achieve optimal glycemic targets, intensification of treatment with insulin is needed in most of the cases. Application of insulin lispro premix 50/50 TID provides better glycemic control compared to human insulin premix 70/30 and comparable results reported with basal-bolus insulin regimen.
Buyuktuncer, Zehra - - 2010
Objective: Metabolic syndrome is a highly prevalent complex disorder characterized by abdominal obesity, insulin resistance, dyslipidemia and hypertension. It occurs as a result of the interaction between genetic susceptibility and environmental factors, in particular, diet. The pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma (PPAR[gamma]), which generates a genetic diversity has ...
Boyanov, Mihail - - 2010
Objective: Previous studies in patients with Graves' disease (GD) and Graves' ophtalmopathy (GO) have focused mainly on the levels of TSH-receptor antibodies (TRAb). Our aim was to investigate the levels of TRAb, thyroid peroxidase (TPOAb) and thyroglobulin antibodies (TGAb) in patients with GD with and without GO.
Laway, Bashir - - 2010
Lactation failure is the first and the commonest manifestation of Sheehan's syndrome. We report the long-term follow-up of a patient with Sheehan's syndrome who presented with hyperprolactinemia rather than prolactin deficiency. A young woman developed Sheehan's syndrome after her 5th delivery, which was associated with severe postpartum hemorrhage. She presented ...
Ahmed, Shahid - - 2010
A 54-year-old man, banker by profession, presented with a three-year-history of generalized weakness, weight loss, fatigue, lethargy, irritability, decreased appetite, gastrointestinal symptoms, and sexual dysfunction. The symptoms had gradually and slowly worsened in the previous three years. He had suffered severe head injury due to road traffic accident 22 years ...
Arasil, Tansu - - 2010
Objective: To evaluate vitamin D status and its implications on bone metabolism in Ankara, Turkey.
Gorar, Suheyla - - 2010
Objective: Visfatin is a adipocytokine suggested to play a role in glucose homeostasis. The aim of this study is to investigate the relationship of simple anthropometric measures of obesity and metabolic syndrome with visfatin.
Kanat, Mustafa - - 2010
Objective: Statin therapy is well known to reduce inflammatory markers such as tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP). However, whether this relationship is maintained in the setting of targeting very low levels of LDL (<70 mg dl) in patients with type 2 diabetes has not ...
Uboh, Friday - - 2010
Objective: Effect of vitamin C (VC) on gasoline vapor (GV)-induced reproductive toxicity was assessed in female rats using the serum levels of estradiol, progesterone, follicle stimulating hormone (FSH), and luteinizing hormone (LH) as well as the histopathology of the ovarian tissues.
Eren, Mehmet - - 2010
Objective: Growth hormone (GH) stimulation tests are used in the diagnosis of GH deficiency, therefore, various pharmacological agents are applied for this aim. Since there is no gold standard, usually two tests are performed. We aimed to investigate clinical utilities of four stimulation tests (insulin tolerance test (ITT), clonidine, L-dopa ...
Ganie, Mohd - - 2010
Pregnancy in patients with panhypopituitarism is rare and considered high risk. Since the availability of ovulation induction with gonadotrophins, women with established hypopituitarism can expect near normal fecundity and the pregnancy outcome is better with support of the replacement of deficient hormones. We present a case of non-functioning pituitary macroadenoma, ...
Barbaros, Umut - - 2010
We report a case of adrenal schwannoma, which is an extremely rare neoplasm. The patient was a 49-year-old woman, with abdominal discomfort for three months, who had been referred to our unit after detection of a right adrenal mass on abdominal magnetic resonance imaging. Although the mass was embedded in ...
Uzum, Ayse - - 2010
Down's syndrome is the most common genetic disorder. It is well established that there is an increased risk of autoimmune endocrine diseases in Down's syndrome. Defect of a gene located on chromosome 21q22.3 causes autoimmune polyglandular syndrome type 1 and this might be related with susceptibility to autoimmune diseases in ...
Ceberut, Kadri - - 2010
Primary Pulmonary Paraganglioma (PPP) is an uncommon neuroendocrine tumor of the lung. We present the case of an asymptomatic 36-year-old female with a solid, round, mass 4.0 cm in diameter in the lower lobe of right lung. Encapsulated mass was excised and pathologic examination revealed paraganglioma. The diagnosis and treatment ...
Emre, Ufuk - - 2010
Objective: In this study, we aimed to assess the presence of minor complications in patients with type 2 diabetes mellitus (DM) referred to electroneurography (ENG) laboratory for evaluation of neuropathy. In addition, the relationship between duration of disease, electrophysiologic findings, neurological examination findings, plasma glycated hemoglobin A1C levels, glucose levels ...
Cinar, Fatma - - 2010
Objective: The purpose of this study was to investigate the effect of nurse telephone calls on glycemic parameters and adherence to diabetes control recommendations.
Anaforoglu, Inan - - 2009
Thyrotoxicosis and primary hyperaldosteronism both cause hypokalemic periodic paralysis. Here we report a 51-year-old woman presenting with severe hypokalemia due to both thyrotoxicosis and primary hyperaldosteronism. At first presentation, she had a potassium level of 1.5 mEq/L and thyrotoxicosis due to a hot nodule, and was diagnosed as having thyrotoxic ...
Guresci, Servet - - 2009
A 53-year-old female patient with long-standing hypertension was evaluated for left flank pain. Abdominal CT scan revealed a 2,8 cm left adrenal mass. Metanephrine, normetanephrine and vanylmandelic acid levels in a 24-hour urine sample were increased. The levels of serum cortisol, renin, aldosteron, calcitonin, parathormone, calcium and phosphate were normal. ...
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