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Results 301 - 350 of 855
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Thayer Patrick - - 2011
Aortic valve interstitial cells (VIC) can exhibit phenotypic characteristics of fibroblasts, myofibroblasts, and smooth muscle cells. Others have proposed that valve cells become activated and exhibit myofibroblast or fibroblast characteristics during disease initiation and progression; however, the cues that modulate this phenotypic change remain unclear. We hypothesize that the mechanical ...
Appavou Marie-Sousai - - 2011
Pressure is a ubiquitous physical parameter in life and is commonly used in the life sciences to study new protein folding pathways or association-dissociation phenomena. In this paper, an investigation of the influence of pressure on hemoglobin, a multimeric protein, at the picosecond time scale is presented using time-of-flight neutron ...
Gao Yulong - - 2011
The elimination of spores from low-acid foods presents food-processing and food-safety challenges to high-pressure processing (HPP) developers as bacterial spores are extremely resistant to pressure. Therefore, the effects of pressure (400-800 MPa), temperature (35-95°C), and nisin (0-496 IU/mL) on the inactivation of Clostridium perfringens AS 64701 spores at various pressure-holding times ...
Sawada Yukihiro - - 2011
This study examines cardiovascular recovery from mental stress. Investigating the absence or presence of carryover effect, the effect of the final reactivity observed at the end of stressful task on the successive recovery, was the major objective. A recently advocated recovery measure related to the area under the curve, mean ...
Gebhardt Ronald - - 2011
Caseins form heterogeneous micelles composed of three types of disordered protein chains (α, β, κ), which include protein-bound calcium phosphate particles. We probe the stability limits of the micelle by applying hydrostatic pressure. The resulting changes of the size distribution and the average molecular weight are recorded in situ with ...
Erba A - - 2011
We have performed fully periodic ab initio post-Hartree-Fock calculations on three low-temperature molecular phases of solid nitrogen, namely α, γ, and ε. The aim is to characterize the pressure-induced transitions among these phases, which are prototypical molecular crystals, through a periodic local-MP2 method, implemented in the CRYSCOR program. Cohesive energies ...
Aftabuzzaman M - - 2011
We have performed ab initio calculations for a new high pressure phase of Ca-VI between 158 and 180 GPa. The study includes elastic parameters of monocrystalline and polycrystalline aggregates, electronic band structure, lattice dynamics and superconductivity. The calculations show that the orthorhombic Pnma structure is mechanically and dynamically stable in the ...
Liang Yunfeng - - 2011
Melanophlogite, a low-pressure silica polymorph, has been extensively studied at different temperatures and pressures by molecular dynamics simulations. While the high-temperature form is confirmed as cubic, the low-temperature phase is found to be slightly distorted, in agreement with experiments. With increasing pressure, the crystalline character is gradually lost. At 8 ...
Brunetti Natale Daniele - - 2011
The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in regulating blood pressure, volume, and electrolytes. The final product of RAAS cascade is angiotensin II, which exerts diverse biological activities via binding to one of three known receptor types, with different binding consequences. Despite the success with conventional strategies to limit ...
Cheng Xuehang - - 2011
Little information is available regarding the effectiveness of water disinfection by CO(2) at low pressure. The aim of this study was to evaluate the use of high levels of dissolved CO(2) at 0.3-0.6 MPa for the inactivation of microorganisms. Bacteriophage T4 was chosen as the model virus and Escherichia coli was ...
Alametsä Jarmo - - 2011
Short and long-term alterations of ballistocardiographic parameters (BCG) were studied in a sitting position using Electromechanical Film (EMFi) sensors. Several physiological parameters were recorded from 48 men of middle age in consecutive recordings and after a 2-week interval. The duration and amplitudes of the signal components were studied. The repeatability ...
Berger Terry A - - 2011
Pressure fluctuations and resulting refractive index changes, induced by the back pressure regulator (BPR) can be a significant source of UV detector noise in supercritical fluid chromatography (SFC). The refractive index (RI) of pure carbon dioxide (CO(2)) changes ≈0.2%/bar at the most commonly used conditions in supercritical fluid chromatography (SFC) ...
Navar L Gabriel LG Department of Physiology and the Hypertension and Renal Center of Excellence, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, USA. - - 2011
The increased activity of intrarenal renin-angiotensin system (RAS) in a setting of elevated arterial pressure elicits renal vasoconstriction, increased sodium reabsorption, proliferation, fibrosis and renal injury. Increases in intrarenal and interstitial angiotensin (Ang) II levels are due to increased AT(1) receptor mediated Ang II uptake and stimulation of renal angiotensinogen ...
Ceppatelli Matteo - - 2011
l,l-Lactide, a dimer of l-lactic acid, is the typical monomer used for the catalytic synthesis of poly(l-lactic acid) (PLLA). We studied its phase diagram and reactivity at high pressure and high temperature by means of a diamond anvil cell. FTIR and Raman spectroscopy were employed to probe the changes occurring ...
Enkhbaatar Perenlei P Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA. - - 2011
Although the beneficial effects of inducible nitric oxide synthase (iNOS) inhibition in acute lung injury secondary to cutaneous burn and smoke inhalation were previously demonstrated, the mechanistic aspects are not completely understood. The objective of the present study is to describe the mechanism(s) underlying these favourable effects. We hypothesised that ...
Matoušek Petr - - 2011
This paper presents two cases of using erroneous concentrations of epinephrine during endonasal surgery. The two patients discussed were part of a larger study aimed at monitoring the absorption of epinephrine upon injection into the nasal mucosa. During this study, we observed major cardiovascular reactions in two consecutive patients-ventricular tachycardia ...
Agarwal Rajiv - - 2011
Hypervolemia is an important and modifiable cause of hypertension. Hypertension improves with probing dry weight, but its effect on echocardiographic measures of volume is unknown. Shortly after dialysis, echocardiograms were obtained at baseline and longitudinally every 4 weeks on two occasions. Among 100 patients in the additional ultrafiltration group, 198 ...
Vaidya Anand A Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, USA. - - 2011
Concentrations of 1,25-hydroxyvitamin D have been positively associated with dietary sodium and salt sensitivity (SS) of blood pressure (BP), and inversely with plasma renin activity (PRA). We investigated the association between PRA and 25-hydroxyvitamin D (25OHD), the most clinically relevant vitamin D metabolite, and whether 25OHD associates with SS of ...
Oishi Yoshifumi - - 2011
BACKGROUND: Various measures of aortic stiffness have been proposed as cardiovascular risk markers, but interest has now shifted to more direct and easier evaluation of aortic function. The present study was conducted to determine the feasibility of measuring aortic stiffness (β) with two-dimensional (2D) strain echocardiography and the impact of ...
Davis Shyrin Cat - - 2011
OBJECTIVE: Pressure wave reflections are age-dependent and generally assumed to increase with increasing peripheral resistance. We sought to determine the effect of standing on wave reflection in healthy older and younger individuals and the influence of increased peripheral resistance. METHODS: During supine rest and active standing, continuous finger arterial blood ...
Yosten Gina L C - - 2011
Neuronostatin is a recently described neuropeptide that is derived from the somatostatin preprohormone. We have shown previously that neuronostatin led to a biphasic, dose-related increase in mean arterial pressure when injected into the lateral cerebroventricle of adult, male rats. Because neuronostatin depolarized both magnocellular and parvocellular, paraventricular nucleus neurons in ...
Kurnik Daniel D Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, - - 2011
α(2A)-Adrenoceptors (α(2A)-ARs) have important roles in sympathetic cardiovascular regulation. Variants of ADRA2A affect gene transcription and expression and are associated with insulin release and risk for type 2 diabetes. We examined whether ADRA2A variants are also associated with cardiovascular responses to the selective α(2)-AR-agonist dexmedetomidine. Seventy-three healthy subjects participated in ...
Inscho Edward W EW Department of Physiology, Georgia Health Sciences University, 1120 15th St, Augusta, GA 30912-3000, USA. - - 2011
Experiments tested the hypothesis that P2 receptor reactivity is impaired in angiotensin (Ang) II hypertensive rats fed an 8%NaCl diet (Ang II+HS). Juxtamedullary afferent arteriolar autoregulatory behavior was determined over a pressure range of 65 to 200 mm Hg. Arteriolar responsiveness to P2X1 (β,γ-methylene ATP) or P2Y2 receptor (uridine triphosphate) ...
Varghese Jeena - - 2011
A 54-year-old man presented with hypertensive crisis. He was found to have bilateral pheochromocytomas and left paraaortic sympathetic paraganglioma. Although he had no family history of paragangliomas or pheochromocytomas, he had been diagnosed with bilateral head and neck paragangliomas 10 years prior. The patient had symptoms of catecholamine excess exacerbated by ...
Nemati Farkhondeh - - 2011
The effects of clinically relevant concentrations of anti-hypertensive agents on lipopolysaccharide (LPS)-induced interleukin-1beta (IL-1β) secretion by polymorphonuclear leukocytes (PMNs) were investigated in vitro. Lipopolysaccharide-induced secretion of IL-1β by PMNs from 15 hypertensive and 15 normotensive subjects after incubation with losartan, captopril, amlodipine, atenolol, and hydrochlorothiazide were assessed. IL-1β secretion by ...
Remme Espen W - - 2011
We investigated the determinants of ventricular early diastolic lengthening and mechanics of suction using a mathematical model of the left ventricle (LV). The model was based on a force balance between the force represented by LV pressure (LVP) and active and passive myocardial forces. The predicted lengthening velocity, e', from ...
Picher Matthieu - - 2011
Single-walled carbon nanotubes are grown by catalytic chemical vapor deposition in various conditions of temperature and carbon precursor pressure. Systematic analyses of the Raman radial breathing modes at two laser wavelengths are used to monitor the evolution of the diameter distribution. Two distinct domains with opposite influences of the temperature ...
De Pergola Giovanni - - 2011
Background: Obesity has been recognized as an independent risk factor for arterial hypertension. Design: This study was addressed to identify parameters predictive of 24-h mean systolic and/or diastolic blood pressure levels in obesity. Methods: A cohort of 180 euthyroid overweight and obese patients, 79 women and 101 men, aged 20-63 ...
Lieb Wolfgang W Framingham Heart Study, Framingham, MA, - - 2011
Salt sensitivity, a trait characterized by a pressor blood pressure response to increased dietary salt intake, has been associated with higher rates of cardiovascular target organ damage and cardiovascular disease events. Recent experimental studies have highlighted the potential role of the natriuretic peptides and aldosterone in mediating salt sensitivity. Prospective ...
Kadziela Jacek - - 2011
Abstract Background. Clinical benefit from renal artery revascularization remains controversial, probably because of inaccurate stenosis severity assessment. Objective. The aim of the study was to evaluate resting translesional pressures ratio and renal fractional flow reserve (rFFR) in relation to angiography and Doppler duplex ultrasonography in patients with at least moderate ...
Lacchini R - - 2011
Matrix metalloproteinases (MMPs) are involved in cardiac remodelling. We examined whether MMP-2 genetic polymorphisms are associated with hypertension and left ventricular (LV) remodelling in hypertensive patients. We studied 160 hypertensive patients and 123 healthy controls. Echocardiography was performed in all patients and the C(-1306)T (rs243865) and C(-735)T (rs 2285053) MMP-2 ...
Noble Peter B - - 2011
In healthy individuals, deep inspiration produces bronchodilation and reduced airway responsiveness, which may be a response of the airway wall to mechanical stretch. The aim of this study was to examine the in vitro response of isolated human airways to the dynamic mechanical stretch associated with normal breathing. Human bronchial ...
Nawaz Syed Kashif - - 2011
PURPOSE: To investigate the role of ACE ID and ACE G2350A polymorphism in increasing the blood pressure of persons exposed to different sound levels. METHOD: Persons exposed to normal sound level (≤80 dBA) and noise (>80 dBA) were divided in two categories on the basis of blood pressure. Category A ...
Silva Pamela S - - 2011
PURPOSE: The antihypertensive effects of angiotensin-converting enzyme inhibitors (ACEi) are explained, at least in part, by enhanced bradykinin-dependent nitric oxide (NO) formation and decreased angiotensin II-induced oxidative stress and vasoconstriction. We examined for the first time whether treatment with enalapril increases the plasma levels of markers of NO formation and ...
Gyawali C P CP Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO 63110, USA. - - 2011
High-resolution manometry (HRM) can identify obstructive motor features at the esophagogastric junction and abnormalities in esophageal bolus transit. We sought to determine if HRM patterns can differentiate functional from organic mechanical lower esophageal sphincter (LES) obstruction. Segmental characteristics of peristalsis were examined using HRM in symptomatic subjects with elevated postdeglutitive ...
Li Xiao C XC Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, 39216-4505, - - 2011
The present study tested the hypothesis that intrarenal adenoviral transfer of an intracellular cyan fluorescent fusion of angiotensin II (ECFP/ANG II) selectively in proximal tubules of the kidney increases blood pressure by activating AT(1) (AT(1a)) receptors. Intrarenal transfer of ECFP/ANG II was induced in the superficial cortex of rat and ...
Lin Liangwu - - 2011
Large-scale centimetres-long single-crystal β-SiC nanowires have been prepared using CH(4) as the carbon source and SiO or the mixture of Si and SiO(2) as the silicon source by a simple catalyst-free CVD route under superatmospheric pressure conditions. The nanowries grown on ceramic boat or corundum substrates, with lengths of several ...
Cuspidi Cesare - - 2011
Abstract Background and aim. The ratio of deceleration time to early mitral wave velocity (mitral deceleration index, MDI) has been recently shown to predict cardiovascular events more precisely than deceleration time alone in human hypertension. Data, however, about the relationship of this parameter with cardiac structure are scant. In the ...
Zhang Wei - - 2011
BACKGROUND: Patients treated with propranolol, a nonselective β-adrenoceptor antagonist, have increased incidence and severity of anaphylaxis. We determined whether β1- or β2-adrenoceptor antagonist modulated pulmonary vasoconstriction and bronchoconstriction in rat anaphylactic hypotension. METHODS:: Anesthetized ovalbumin-sensitized male Sprague-Dawley rats were randomly allocated to the following pretreatment groups (n = 7/group): (1) ...
Furtado Filipe - - 2011
Pulsed field gradient NMR is applied for monitoring the diffusion properties of guest molecules in hierarchical pore systems after pressure variation in the external atmosphere. Following previous studies with purely mesoporous solids, also in the material containing both micro- and mesopores (activated carbon MA2), the diffusivity of the guest molecules ...
de Leeuw Peter W - - 2011
Nycthemeral changes in renal function have been known for a long time, but our knowledge about the underlying mechanisms is still far from complete. From a theoretical point of view, many physiological systems could be involved in turning the kidney from a sodium-excretory organ during daytime into a sodium-conserving organ ...
Hart Emma C - - 2011
Sympathetic neural function is essential to human blood pressure regulation, and overactivity of sympathetic nerves may have an important role in the development of hypertension and related cardiovascular disorders. Importantly, there is extensive interindividual variability in sympathetic vasoconstrictor nerve activity, even among healthy, young, normotensive people. Therefore, the relevance of ...
Sánchez David - - 2011
Essential hypertension is considered a serious health problem and diet can play an important role in its prevention and treatment. The aim of this study was to evaluate the effect of the long-term intake of a product based on milk casein hydrolysate on the development of hypertension in spontaneously hypertensive ...
Hill K M - - 2011
Models for dense sheared granular materials indicate that their rheological properties depend on particle size, but the representative size for mixtures is not obvious. Here, we computationally study pressure on a boundary due to sheared granular mixtures to determine its dependence on particle size distribution. We find that the pressure ...
Bogaard Harm J - - 2011
RATIONALE: Inhibitors of histone deacetylases (HDACs) reduce pressure-overload induced left ventricular hypertrophy and dysfunction, but their effects on right ventricular (RV) adaptation to pressure overload are unknown. OBJECTIVE: Determine the effect of the broad-spectrum HDAC inhibitors trichostatin A (TSA) and valproic acid (VPA) on RV function and remodeling after pulmonary ...
Lindemer Brian J BJ Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, - - 2011
The quinones duroquinone (DQ) and coenzyme Q(1) (CoQ(1)) and quinone reductase inhibitors have been used to identify reductases involved in quinone reduction on passage through the pulmonary circulation. In perfused rat lung, NAD(P)H:quinone oxidoreductase 1 (NQO1) was identified as the predominant DQ reductase and NQO1 and mitochondrial complex I as ...
Dunn Michael E - - 2011
BACKGROUND: Glycolytic flux in the mouse heart during the progression of left ventricular hypertrophy (LVH) and mechanical dysfunction has not been described. METHODS: The main objectives of this study were to characterize the effects of thoracic aortic banding, of 3- and 6-week duration, on: (1) left ventricular (LV) systolic and ...
Xu J-Z - - 2011
To investigate the relationship between left atrial (LA) size, endothelial dysfunction and different markers of target organ damage (TOD), we measured left atrial diameter (LAD) and endothelial function in hypertensive patients with or without TOD. In this study, 197 patients with hypertension were divided into four groups as follows: no ...
Hoorn Ewout J EJ Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, - - 2011
For vendor-derived mice, an acclimation period of 1 week is usually recommended before blood pressure measurements are started. However, we observed hypertension in wild-type vendor-derived mice 1 week after shipping. The index group (n = 12, BALB/c, age 3 months, weight 26-28 g) was shipped overnight (by truck, duration 13 ...
Kara Selin - - 2011
Benzoylformate decarboxylase (BFD, EC 4.1.1.7) is a homotetrameric thiamine diphosphate (ThDP)-dependent enzyme which catalyzes the synthesis of chiral 2-hydroxyketones accepting a broad range of aldehydes as substrates. In this study the synthesis of 2-hydroxypropiophenone (2-HPP) frombenzaldehyde and acetaldehyde was catalyzed by three BFD variants namely BFD F464I, BFD A460I and ...
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