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Results 201 - 250 of 504
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Hausman Dorothy B - - 2011
Associations between body mass index (BMI) and dietary patterns and health conditions were explored in a population-based multiethnic sample of centenarians from northern Georgia. BMI ≤20 and ≥25 was prevalent in 30.9% and 25.3% of study participants, respectively. In a series of logistic regression analyses controlled for gender and place ...
Shilo Malka - - 2010
Pressure ulcers (PU) are localised damage to skin and underlying tissues, caused by sustained tissue deformations and ischaemia. PU typically appear in insensitive or immobile patients, e.g. those with spinal cord injury (SCI) or geriatric patients. As these patients often experience fluctuations in blood pressure, and are also exposed to ...
Perez-Barcena Jon - - 2010
OBJECTIVES:: To determine the evolution of cytokine patterns using microdialysis in patients with traumatic brain injury with diffuse lesions and to study the relationship between cytokines and intracranial pressure, brain tissue oxygenation and lesion type on the computed cranial tomography scan (patients with and without brain swelling). DESIGN:: Prospective and ...
Trojnarska Olga - - 2011
Patients after successful repair of coarctation of aorta (CoAo) are at risk of hypertension at rest and associated end-organ damage. The aim of the study was to assess arterial stiffness and function in adults after coarctation repair in relation to descending aorta (AoD) residual coarctation and patient's age at operation. ...
Goodwin C Rory - - 2011
Sacral neoplasm resection is managed via partial or total sacrectomy that is performed via the Kraske approach. The combination of the patients positioning and the relatively long operative time required for this procedure increase the risk of pressure ulcers. Facial pressure ulcers can cause tissue necrosis and/or ulceration in a ...
McCarty William J - - 2011
The hydraulic resistance R across osteochondral tissue, especially articular cartilage, decreases with degeneration and erosion. Clinically useful measures to quantify and diagnose the extent of cartilage degeneration and efficacy of repair strategies, especially with regard to pressure maintenance, are still developing. The hypothesis of this study was that hydraulic resistance ...
Sun Lu - - 2010
A linear relation between stiffness and aspiration pressure is the basis for biomembrane force probe (BFP), a widely used technique to measure minuscule forces. Here we perform finite element simulations and semi-analytical modeling of the BFP operation to show that, at low aspiration pressures, there exists a characteristic regime in ...
Wang Yuan-Yuan - - 2010
Despite normal indices of left ventricular (LV) chamber function, impaired diastolic and systolic function are thought to coexist in hypertensive patients. The aim of this study was to investigate the effects of short-term manidipine therapy on LV global function in Chinese patients with hypertension using the tissue Doppler imaging (TDI) ...
Finnoff Jonathan T - - 2010
Foot compartment syndrome is diagnosed with intracompartmental pressure measurements. The purpose of this study was to determine the ability of two techniques to accurately place a needle tip within the medial foot compartment and to compare the proximity of the needle tip to the medial foot compartment neurovascular structures between ...
Green James - - 2010
Excessive intramedullary pressure coincident to surgical procedures requiring entrance and surgical manipulation within the intramedullary canal is a problem that was recognized by Gerhard Küntscher, the godfather of intramedullary nailing. He expressed concern about this phenomenon in his early writings during the 1940's. Although he suggested certain technical methods to ...
Wu L - - 2010
To report the immediate changes of intraocular (IOP) pressure after an intravitreal injection of 2.5mg (0.1 ml) of bevacizumab. Prospective, non-controlled, interventional case series of 45 patients undergoing intravitreal injection of 2.5mg (0.1 mL) of bevacizumab for a variety of retinal disorders. IOP was measured with a Goldmann tonometer at ...
Chow Ava K - - 2010
Matrix metalloproteinases (MMPs) are known to degrade components of the extracellular matrix. More recently, in myocardial oxidative stress injury including ischemia-reperfusion, MMP-2 is activated and degrades troponin I and α-actinin. MMP activity is regulated at several levels. We recently showed that MMP-2 is localized in the caveolae of cardiomyocytes and ...
Goldfarb Jillian L - - 2010
Despite the relatively small atomic fraction of a given heteroatom in a binary mixture of polycyclic aromatic compounds (PAC), the inclusion of heteroatomic substituted compounds can significantly impact mixture vapor pressure behavior over a wide range of temperatures. The vapor pressures of several binary PAC mixtures containing various heteroatoms show ...
Alexander Matthew D - - 2010
Cerebral arteriovenous malformations (AVMs) have abnormally enlarged arteries and veins prone to spontaneous hemorrhage. Immediately following surgical excision of a cerebral AVM, even normal brain tissue surrounding the lesion is subject to hemorrhage, a phenomenon termed normal perfusion pressure breakthrough (NPPB) syndrome. According to this theory, arteries supplying cerebral AVMs ...
Gartner Gabriel E A - - 2010
The cardiovascular system of all animals is affected by gravitational pressure gradients, the intensity of which varies according to organismic features, behavior, and habitat occupied. A previous nonphylogenetic analysis of heart position in snakes-which often assume vertical postures-found the heart located 15%-25% of total body length from the head in ...
Steele Catriona M - - 2010
Tongue-pressure resistance training is known to increase tongue strength in seniors and individuals with stroke-related dysphagia. However, evidence of associated functional improvements in swallowing is equivocal. We investigated similarities in pressure waveform profiles between swallowing and several tongue-palate pressure tasks to identify tasks that may be best suited for inclusion ...
Ruderman Sarah - - 2010
Noninvasive optical techniques for tissue characterization, in particular, light scattering properties and blood supply quantification of mucosa, is useful in a wide variety of applications. However, fiber-optic probes that require contact with the tissue surface can present a challenging problem in the variability of in vivo measurements due the nature ...
Biolo Andr??ia - - 2009
Elevated filling pressures are associated with heart failure deterioration, but mechanisms underlying this association remain poorly understood. We sought to investigate whether or not elevated filling pressures are associated with increased collagen turnover, evaluated by procollagen type III aminoterminal peptide (PIIINP) levels, in stable systolic heart failure. Eighty patients with ...
Natanzon Alex - - 2009
Transudative pleural and pericardial effusions are not uncommon in patients with congestive heart failure. Pericardial effusion forms only with elevation of the right-sided filling pressure in the heart. In patients with biventricular failure, there is no evidence that elevated left-sided pressure, in the absence of elevated right-sided pressure, can cause ...
Warriner David - - 2009
Chronic heart failure and hypertension are major clinical problems. This article gives an overview of some of the talks from a recent BJHM conference supported by Takeda which brought together leading experts in the field to discuss current issues, latest developments and practical management of chronic heart failure and hypertension. ...
Huang Haixia H Department of Physiology and Pathophysiology, Capital Medical University, Beijing 100069, People's Republic of - - 2009
Transient stretching of the ventricle can trigger arrhythmias and evoke ventricular fibrillation, especially when the stimulation occurs in the vulnerable period. To explore the sensitivity of small hearts we used a commercial pressure servo to study the kinetic relationship of left ventricular pressure to excitability and arrhythmias in the rat ...
Stefánsson Einar - - 2009
A variety of treatment options are available for the treatment of diabetic macular edema. They include laser photocoagulation, anti-VEGF drugs, intravitreal steroids, and vitrectomy with or without release of vitreoretinal traction. A full understanding of the physiological mechanisms of these treatment modalities allows sensible combination of treatment options. Retinal photocoagulation ...
Stevenson Lynne Warner - - 2009
Heart failure decompensation is dominated by congestive symptoms from elevated pulmonary and systemic venous pressures. In dilated heart failure, forward flow is optimal at near-normal filling pressures, with minimized mitral regurgitation. Tailored therapy to reduce filling pressures improves symptoms acutely. However, monitored reduction of filling pressures during hospitalization did not ...
Wu Jiun-Yan - - 2008
The maximum distance between the heart and a model Taser stimulation dart, called the dart-to-heart distance, at which the Taser can directly cause ventricular fibrillation (VF), was measured in pigs. A 9-mm-long blunt probe was advanced snugly through the surrounding tissues toward the heart. Five animals [pig mass=61.2+/-6.23 standard deviation ...
Kreso Amir - - 2008
The study was designed with the main intent to assess and explain the differences between athlete's heart syndrome and the heart of healthy non-athletes, and to distinguish between physiological and pathological heart condition. Prolonged athletic training causes changes in heart that are termed "athlete's heart syndrome". Athlete's heart diagnosis and ...
Abu-Issa Radwan - - 2008
In human development, it is postulated based on histological sections, that the cardiogenic mesoderm rotates 180 degrees with the pericardial cavity. This is also thought to be the case in mouse development where gene expression data suggests that the progenitors of the right ventricle and outflow tract invert their position ...
Ventura-Clapier Renée - - 2008
Although the concept of energy starvation in the failing heart was proposed decades ago, still very little is known about the origin of energetic failure. Recent advances in molecular biology have started to elucidate the transcriptional events governing mitochondrial biogenesis. In particular, a great step was taken with the discovery ...
Kraetschmer S - - 2008
OBJECTIVE: To determine if Buchanan's vertebral heart scale can be applied to beagle dogs to establish reference values for this breed and to determine the possible influence of optimal lung inflation on the cardiac measurements. METHODS: The cardiac health of 19 beagle dogs was examined by echocardiography, electrocardiogram, non-invasive blood ...
Chen Jian-Fu - - 2008
Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA (miRNA) processing, leads to rapidly progressive DCM, ...
Rahko Peter S - - 2008
BACKGROUND: An electromuscular incapacitating device (EMD) delivers pulses of high-voltage electricity, causing strong muscle contraction. Data from a pig model suggest that an EMD dart tip placed within 17 mm of the epicardial surface can cause ventricular fibrillation. The current study estimates minimum skin-to-heart distance in the adult, to determine ...
Bruce Alexandra F - - 2008
AIMS: Remodelling of gap junctions, involving reduction of total gap junction quantity and down-regulation of connexin43 (Cx43), contributes to the arrhythmic substrate in congestive heart failure. However, little is known of the underlying mechanisms. Recent studies from in vitro systems suggest that the connexin-interacting protein zonula occludens-1 (ZO-1) is a ...
Schuller S - - 2007
A 7-year-old male intact Rottweiler was presented with a 1-week history of lethargy, anorexia, vomiting and multiple syncopal events. The results of the clinical examination and electrocardiography were consistent with a third degree atrioventricular block and an intermittent accelerated idioventricular rhythm. Haematology, serum biochemistry, serology for Borrelia burgdorferi, blood culture, ...
Wirkner Christian S - - 2008
Tanaidacea and Cumacea are crucial for understanding the phylogenetic relationships of "core group" peracarids. Here, the haemolymph vascular system in three tanaidacean and four cumacean species was studied on the basis of histological sections and 3D reconstruction. The circulatory organs in Tanaidacea include a tubular heart which extends through most ...
Killeen M J - - 2008
We explored the anti-arrhythmic efficacy of K(+) channel activation in the hypokalaemic murine heart using NS1643 and nicorandil, compounds which augment I(Kr) and I(KATP) respectively. Left ventricular epicardial and endocardial monophasic action potentials were compared in normokalaemic and hypokalaemic preparations in the absence and presence of NS1643 (30 microM) and ...
Nagayama Takahiro - - 2007
BACKGROUND: Cardiac myosin binding protein-C (cMyBP-C) is a thick-filament protein whose presence and phosphorylation by protein kinase A (PKA) regulates cross-bridge formation and kinetics in isolated myocardium. We tested the influence of cMyBP-C and its PKA-phosphorylation on contraction/relaxation kinetics in intact hearts and revealed its essential role in several classic ...
Pontieri Vera - - 2007
INTRODUCTION: Catuama, an herbal drug very popular in Brazil, was tested on the reversion and prevention of ventricular fibrillation (VF) in the isolated rabbit heart. MATERIALS AND METHODS: Catuama (a mixture of Trichilia catigua, Paullinia cupana, Ptychopetalum olacoides, and Zinziber officinalis) was perfused in the isolated perfused rabbit heart. Its ...
Sabir Ian N - - 2008
The experiments investigated the applicability of two established criteria for arrhythmogenicity in Scn5a+/Delta and Scn5a+/- murine hearts modelling the congenital long QT syndrome type 3 (LQT3) and the Brugada syndrome (BrS). Monophasic action potentials (APs) recorded during extrasystolic stimulation procedures from Langendorff-perfused control hearts and hearts treated with flecainide (1 ...
Filas Benjamen A - - 2007
Optical coherence tomography (OCT) was used to investigate morphogenesis of the embryonic chick heart during the first phase of looping (c-looping), as the heart bends and twists into a c-shaped tube. The present study focuses on the morphomechanical effects of the splanchnopleure (SPL), a membrane that has been shown to ...
Sabir Ian N - - 2008
Alternans and arrhythmogenicity were studied in hypokalaemic (3.0 mM K(+)) Langendorff-perfused murine hearts paced at high rates. Epicardial and endocardial monophasic action potentials were recorded and durations quantified at 90% repolarization. Alternans and arrhythmia occurred in hypokalaemic, but not normokalaemic (5.2 mM K(+)) hearts (P<0.01): this was prevented by treatment ...
Ago Tetsuro - - 2007
Excessive reactive oxygen species (ROS) play an important role in the development of cardiac hypertrophy. In contrast, antioxidants scavenge ROS, thereby maintaining the reduced environment of cells and inhibiting hypertrophy in the heart. Thioredoxin1 (Trx1) not only functions as a major antioxidant in the heart but also interacts with important ...
Ruiz-Capillas C - - 2007
Biogenic amine formation and microbiota evolution were assessed in Spanish dry-cured "chorizo" sausage treated with high-pressure (HP) and kept at 2°C. High-pressures did not affect (p<0.05) pH or water activity (a(w)). However, HP treatment did significantly reduce the level of lactic acid bacteria, by <1 logarithmic unit. Microorganism levels remained ...
Sato Yuichi - - 2007
Double chambered right ventricle (DCRV) is a rare form of congenital heart disease in which the right ventricle is divided into a high-pressure inlet site and a low-pressure outlet site by anomalous muscle bands. Whole heart magnetic resonance imaging (MRI) which depicts 3-dimensional anatomy of the heart and coronary arteries ...
Cobb Alexander R - - 2007
Freeze-thaw cycles pose a major physiological challenge for all temperate perennial plants, but monocotyledonous vines face a still greater risk because their few large vessels are especially susceptible to embolism and are not replaced by secondary growth. The genus Smilax is particularly remarkable because it is widespread in the tropics ...
Milberg Peter - - 2007
BACKGROUND: Numerous noncardiovascular drugs prolong repolarization and thereby increase the risk for patients to develop life-threatening tachyarrhythmias of the torsade de pointes (TdP) type. The development of TdP is an individual, patient-specific response to a repolarization-prolonging drug, depending on the repolarization reserve. The aim of the present study was to ...
Karsdorp Petra A - - 2007
The present study was aimed at clarifying whether preattentive processing of heart cues results in biased perception of heart sensations in patients with congenital heart disease (ConHD) who are also highly trait anxious. Twenty-six patients with ConHD and 22 healthy participants categorized heart-related (heart rate) or neutral sensations (constant vibration) ...
Wu Jiun-Yan - - 2007
Electromuscular incapacitating devices (EMDs), such as Tasers, deliver high current, short duration pulses that cause muscular contractions and temporarily incapacitate the human subject. Some reports suggest that EMDs can kill. To help answer the question, "Can the EMD directly cause ventricular fibrillation (VF)?", ten tests were conducted to measure the ...
Zhu Xiaocheng - - 2007
The major developments in pig-to-non-human primate heart xenotransplantation during the past 20 years are summarized, largely through the experience of one investigator. Genetic modifications to organ-source pigs have been important steps in increasing heart xenograft survival from a few minutes in 1986 to 2 to 6 months in 2005.
Supavititpatana Thawatchai - - 2007
Ostrich meat sausages (yor) were subjected to ultra-high pressures of 300, 500 and 700MPa for 40 and 60min at 40 and 60°C. Subsequently the physical properties of the products, colour, released and expressible water, gel strength and stress relaxation as well as their thermal characteristics (by differential scanning calorimeter, DSC) ...
Linask Kersti K - - 2007
Over the past 10 years, key genes involved in specification of left-right laterality pathways in the embryo have been defined. The read-out for misexpression of laterality genes is usually the direction of heart looping. The question of how dextral looping direction occurred mechanistically and how the heart tube bends remains ...
van Wijk Bram - - 2007
Bone morphogenetic proteins (BMP) are involved in the regulation of a plethora of processes underlying cardiovascular development. This review summarizes the effects of BMP and the signaling pathways that regulate the differentiation of cardiomyocytes from mesoderm in the heart-forming region and at the distal borders of the heart tube from ...
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