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Authier S - - 2011
INTRODUCTION: Similarities between pigs and humans support the relevance of Göttingen minipigs for regulatory safety pharmacology. The minipig is the species of choice for cardiovascular safety pharmacology when pivotal repeat toxicology studies are conducted in this species. METHODS: 4 male Göttingen minipigs with cardiovascular telemetry transmitters received intravenous saline, esmolol ...
Borgquist Ola - - 2011
Negative-pressure wound therapy promotes healing by drainage of excessive fluid and debris and by mechanical deformation of the wound. The most commonly used negative pressure, -125 mmHg, may cause pain and ischemia, and the pressure often needs to be reduced. The aim of the present study was to examine wound ...
Rocklin Delphine - - 2011
The development of fishing efficiency coupled with an increase of fishing effort led to the overexploitation of numerous natural marine resources. In addition to this commercial pressure, the impact of recreational activities on fish assemblages remains barely known. Here we examined the impact of spearfishing limitation on resources in a ...
Palazy Lucille - - 2011
Trophy hunting is one of the most controversial issues in the field of biodiversity conservation. In particular, proponents and opponents debate fiercely over whether it poses a threat to hunted populations. Here, we show that trophy hunting constitutes a greater menace to threatened species than previously realized. Because humans value ...
Ineson Alastair - - 2010
A diving rebreather currently nearing release incorporates an infra-red CO2 analyser at the end of the exhale hose and uses the expired gas CO2 measurement made at this position to detect hypercapnia. This configuration may allow exhaled anatomic and mouthpiece dead space gas to mix with alveolar gas in the ...
Rudzka-Nowak Alina - - 2010
Antibiotic resistance of bacteria is on the rise and thus, the discovery of alternative therapeutic agents is urgently needed. Honey possesses good therapeutic potential, including wound healing properties and antimicrobial activity. The authors report on the case of a 55-year-old woman with extensive phlegmonous and necrotic lesions of the abdominal ...
Gall Trent T - - 2010
To evaluate fluid pressures generated via common wound-flushing techniques. 24 combinations of bottles, needles, a syringe, and a bag. 12 medically trained individuals used the following devices to forcefully expel fluid as for wound flushing: full and half-full 1-L and 500-mL bottles with holes in the cap made with 16-, ...
Kubiak Brian D - - 2010
Sepsis and hemorrhage can result in injury to multiple organs and is associated with an extremely high rate of mortality. We hypothesized that peritoneal negative pressure therapy (NPT) would reduce systemic inflammation and organ damage. Pigs (n = 12) were anesthetized and surgically instrumented for hemodynamic monitoring. Through a laparotomy, ...
Brancaccio Gianluca - - 2010
We present a case of neonatal poststernotomy mediastinitis treated by a vacuum-assisted closure (VAC). A newborn with hypoplastic left heart syndrome underwent a Norwood first-stage procedure and developed infection on the fourteenth postoperative day. Repeated cultures detected Staphylococcus epidermidis in two samples and Staphylococcus aureus in one. A VAC was ...
Weller C - - 2010
To estimate the difference between mean interface sub-bandage pressures of two multilayer compression bandage systems in healthy volunteers when supine, standing, exercising and during recovery. Inelastic and elastic compression bandages were randomised to opposite limbs of each participant. Sub-bandage interface pressures for both bandages were compared within person. Participants and ...
Rubio A - - 2010
Compression of a chew toy during regular play activity can create a vacuum effect eventually causing entrapment of oral tissues. Two cases of tongue entrapment are described, which resulted in severe tissue swelling, oedema and vascular obstruction. In the first dog, the toy was removed by the veterinary surgeon under ...
Mosti Giovanni - - 2010
It is widely believed that the loss of compression pressure of inelastic bandages is associated with a loss of efficacy in contrast to elastic material, which maintains its pressure and performance. This study compared the effect exerted by inelastic bandages vs elastic compression stockings on the venous pumping function in ...
Malmsjö Malin - - 2010
Pressure transduction to the wound bed in negative pressure wound therapy (NPWT) is crucial in stimulating the biological effects ultimately resulting in wound healing. In clinical practice, either foam or gauze is used as wound filler. Furthermore, two different drainage techniques are frequently employed. One involves the connection of a ...
Schuren J - - 2010
The aim of this paper was to determine whether Pascal's law can be used to explain the dynamics of compression therapy. Sub-bandage pressures were recorded at three different levels to investigate the transmission of applied pressure on the legs of 12 healthy volunteers and 216 applications. The experimental model revealed ...
Gnanaraj J - - 2010
Poorly healing wounds are a bane to any surgical unit, but particularly in rural areas, and require a lot of effort to manage. One of the most effective recent methods that has been described is the application of topical negative pressure. We describe here a simple system made from the ...
Zortuk Mustafa - - 2010
To compare the finger pressure applied by dentists during cementation and to examine the effect of gender and time of day on finger pressure. Fifteen dentists (9 males, 6 females) formed a study group and 10 master dies in premolar shape and Turcom Cera all-ceramic crowns were prepared to measure ...
Al Khaburi J - - 2011
Sub-bandage interface pressure generated by medical compression bandages (MCB) and hosiery changes in mobile patients as they move due to the change in the limb size. However, the amount of variation in the interface pressure is dependent on the stiffness of the compression material. Researchers have proposed several indices to ...
Gegel Brian - - 2010
BACKGROUND: Hemorrhage is the second leading cause of death in civilian trauma and the leading cause of preventable death in military trauma. The purpose of this study was to examine the effectiveness of three hemostatic agents: BleedArrest, TraumaDex, and Celox. MATERIALS AND METHODS: This was a prospective, experimental study using male ...
Petzina Rainer - - 2010
OBJECTIVE: Negative pressure wound therapy is the first-line treatment modality for poststernotomy mediastinitis in many heart centers. The aim of this study was to analyze major complications and possible preventive methods during negative pressure wound therapy in patients with deep sternal wound infections. METHODS: We retrospectively analyzed 69 consecutive patients ...
Arnold-Long Mary - - 2010
Our clinical experience suggests that the effectiveness of negative pressure wound therapy is enhanced by adding collagen alginate to the dressing regimen, applying foam over areas that are undermined or tunneled, and approximating and securing wound edges prior to applying foam. The use of this combined technique is described in ...
Engrav L H - - 2010
Pressure garment therapy is standard of care for prevention and treatment of hypertrophic scarring after burn injury. Nevertheless there is little objective data that confirms effectiveness. The purpose of this study was to determine the effectiveness of pressure garment therapy with objective data obtained with a randomized within-wound comparison. We ...
Landsman Adam - - 2010
Negative pressure wound therapy (NPWT) has become a widely used modality for the treatment of complex wounds. However, patient compliance is frequently difficult due to the need to carry a bulky, noisy electronic device. In this issue of Journal of Diabetes Science and Technology, Lerman and colleagues describe a new ...
Assadian Ojan - - 2010
The physical capacity of negative pressure wound therapy (NPWT) dressing on the bacterial growth in an in vitro wound model was investigated. Standardised wounds were contaminated with a clinical Staphylococcus aureus strain and incubated at 35 degrees C for 6 hours. Four wounds were treated with continuous negative pressure (125 ...
Scimeca Christy L - - 2010
Negative-pressure wound therapy (NPWT) is frequently employed in the treatment of complex wounds. The authors present a description of real-time streaming therapy of a variety of wound chemotherapeutic agents through NPWT. Doxycycline, which acts as a competitive inhibitor of matrix metalloproteinases and tumor necrosis factor alpha and further decreases inflammation ...
Takase Maki - - 2010
We present a case of low-pressure injection injury of the left index finger caused by puncture of the nozzle of a spray can. It resulted in symptoms as severe as those from a high-pressure injection injury. Several debridements meant that the finger did not have to be amputated. The raw ...
Borgquist Ola - - 2010
Negative pressure wound therapy (NPWT) results in 2 types of tissue deformation, macrodeformation (ie, wound contraction) and microdeformation (ie, the interaction of tissue and dressing on a microscopic level). These effects have been delineated for one type of wound filler, foam, but not for gauze. The mechanical deformation initiates a ...
Collinge Cory - - 2010
OBJECTIVES: To compare three commonly used methods and devices developed for measurement of intracompartmental pressure in injured limbs. SETTING: Level II regional trauma center. PATIENTS/PARTICIPANTS: Consecutive patients treated for extremity trauma suspected to have compartment syndrome. INTERVENTION: Analysis of compartment pressure data collected using 1) a solid-state transducer intracompartmental catheter; ...
Oshino Satoru - - 2010
BACKGROUND: To examine the strength and tolerance of the fibrin glue sealant in a situation of extended transsphenoidal surgery. The withstand pressure of fibrin glue sealant was measured using a simple sellar reconstruction model. METHODS: A 15-mm diameter hole at the bottom of a 51-cm high cylinder was covered with ...
Ousey Karen - - 2010
Effective communication to ensure maintenance of a seamless quality service for patients being transferred to the community from the acute sector with negative pressure wound therapy (NPWT) is essential. This paper reports the findings of a focus group convened to explore the decision making process; controversy or conflict surrounding the ...
Wyffels Jennifer T - - 2010
The incidence rate of pressure ulcers in the USA ranges from 0.4% to 38% in acute care settings and from 2.2% to 23.9% in long-term care settings, and their treatment costs are in the billions of dollars yearly. The proteome of wound fluid may contain early indicators or biomarkers associated ...
Hsu Chih-Chin - - 2010
Negative-pressure wound therapy has recently gained popularity in chronic wound care. This study attempted to explore effects of different negative pressures on epithelial migration in the wound-healing process. The electric cell-substrate impedance sensing (ECIS) technique was used to create a 5 x 10(-4) cm(2) wound in the Madin-Darby canine kidney ...
Durai R - - 2010
Active drains, which work by negative pressure, require a closed space for retaining the vacuum. Here the authors describe their novel technique of combining a J-Vac drain and the sponge of a vacuum assisted closure dressing pack to drain a rectal wound. This modification may be useful for rectal wounds ...
Fong Kenton D - - 2010
Negative-pressure wound therapy is traditionally achieved by attaching an electrically powered pump to a sealed wound bed and applying subatmospheric pressure by means of gauze or foam. The Smart Negative Pressure (SNaP) System (Spiracur, Inc., Sunnyvale, Calif.) is a novel ultraportable negative-pressure wound therapy system that does not require an ...
Nakayama Mitsuyuki - - 2010
Negative pressure therapy was applied to 39 deep pressure ulcers covered by soft necrotic tissue. All of the wounds were so deep that there were bones or ligaments just beneath the soft necrotic tissue. They had already received several types of conservative therapy including a necrotomy for periods ranging from ...
Negosanti Luca - - 2010
We report the case of a newborn with acute myeloid leukaemia, who developed perineal necrotizing fasciitis due to Pseudomonas Aeruginosa, after twenty days of life. Following surgical debridement, she was effectively treated with topical negative pressure therapy (V.A.C.(R) device) with silver foam dressings, this achieved complete closure in thirteen days. ...
Gegel Brian T - - 2010
The purpose of this study was to compare the effectiveness of 2 hemostatic agents, chitosan-based Celox and the biopolymeric, microporous particles TraumaDEX, with a control group in a porcine model of hemorrhage. The animals were randomly assigned to 1 of 3 groups: Celox (n = 5), TraumaDEX (n = 5), ...
Shuler Michael S - - 2010
BACKGROUND: Near-infrared spectroscopy estimates soft-tissue oxygenation approximately 2 to 3 cm below the skin. The purpose of the present study was to evaluate muscle oxygenation in the setting of an acute compartment syndrome of the leg and to determine if near-infrared spectroscopy is capable of detecting perfusion deficits. METHODS: Fourteen ...
Borgquist Ola - - 2010
Negative pressure wound therapy (NPWT) alters wound edge microvascular blood flow. Some preclinical data suggest that cycling between low and high negative pressure may be more beneficial than continuous NPWT. The purpose of this in vivo study was to compare the effect of intermittent negative pressure (cycled either from 0 ...
Lohi J - - 2010
A vast range of dressings can be used on pressure ulcers, but despite this and the high expense often involved, there is no gold standard for the local treatment of these wounds. This literature review therefore set out to examine the evidence.
Tschan Christoph A - - 2010
OBJECT: Waterjet dissection has been shown to separate tissues of different resistance, with preservation of blood vessels. In cranioplasty, separation of subcutaneous tissue and dura mater is often difficult to achieve because the various tissue layers strongly adhere to each other after decompressive craniotomy. In the present study, the potential ...
Chaiken J - - 2010
We present instrumentation for probing of volar side fingertip capillary beds with free space coupled near infrared light while collecting Raman, Rayleigh, and Mie scattered light as well as fluorescence. Fingertip skin capillary beds are highly vascularized relative to other tissues and present a desirable target for noninvasive probing of ...
Engelke Wilfried - - 2011
Oral posture is considered to have a major influence on the development and reoccurrence of malocclusion. A biofunctional model was tested with the null hypotheses that (1) there are no significant differences between pressures during different oral functions and (2) between pressure measurements in different oral compartments in order to ...
Kolkman I - - 2010
This article describes a study of the behaviour of double muscled Belgian Blue (BB) cows during the peri partum period to assess the differences in pain perception in cows calving per vaginam vs cows delivering by caesarean section (CS). In one herd, a total of 30 multiparous cows, of which ...
Shuler Franklin D - - 2010
BACKGROUND: Serial physical examination is recommended for patients for whom there is a high index of suspicion for compartment syndrome. This examination is more difficult when performed on an obtunded patient and relies on the sensitivity of manual palpation to detect compartment firmness-a direct manifestation of increased intracompartmental pressure. This ...
Durai Rajaraman - - 2010
High- and low-pressure vacuum drains are commonly used after surgical procedures. High-pressure vacuum drains (ie, sealed, closed-circuit systems) are efficient and allow for easy monitoring and safe disposal of the drainage. Low-pressure vacuum drains use gentle pressure to evacuate excess fluid and air, and are easy for patients to manage ...
Hon Janice - - 2010
Monitoring wound progress is essential for evaluating and documenting treatment outcomes. The Pressure Ulcer Scale for Healing (PUSH) was developed to track pressure ulcer (PU) progress but information about its utility for other types of chronic wounds is limited. A 10-month, descriptive, multicenter study was conducted to examine the responsiveness ...
Bitsch Rudi G - - 2011
Cementing irregularities have been associated with femoral failures of resurfacing arthroplasties in retrieval studies. We used an in vitro model to measure pressure, temperatures, and cement penetration as a function of 6 different cementing techniques. Filling the component with cement can lead to overpenetration or increase the resistance to component ...
Milic Dragan J - - 2010
Venous leg ulcers (VLU) have a huge social and economic impact. An estimated 1.5% of European adults will suffer a venous ulcer at some point in their lives. Despite the widespread use of bandaging with high pressure in the treatment of this condition, recurrence rates range between 25% to 70%. ...
Cohenca Nestor - - 2010
OBJECTIVE: The aim of this study was to compare in vivo the efficacy of 2 root canal disinfection techniques (apical negative pressure irrigation versus apical positive pressure irrigation plus triantibiotic intracanal dressing) in immature dog teeth with apical periodontitis. STUDY DESIGN: Two groups of root canals with pulp necrosis and ...
Moghimi Sahar - - 2010
Abstract-This article focuses on the development of a method to quantitatively assess the healing process of artificially induced pressure sores using high-frequency (20 MHz) ultrasound images. We induced sores in guinea pigs and monitored predefined regions on days 3, 7, 14, and 21 after sore generation. We extracted relevant parameters ...
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