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Donazzan Luca L Klinik für Innere Medizin III (Kardiologie, Angiologie und Internistische Intensivmedizin), Universitätsklinikum des Saarlandes, Kirrberger Str. 1, Geb. 40, 66421, Homburg, Saar, - - 2014
Hypertension has wide (30-45 %) prevalence in the general population and is related to important increases in overall cardiovascular morbidity and mortality. Despite lifestyle modifications and optimal medical therapy (three drugs, one being diuretic), about 5-20 % of hypertensives are affected by resistant hypertension. Chronic high blood pressure has adverse effects on ...
Wang Wang W Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, T6G 2S2, - - 2014
Angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II into Ang 1-7 thereby negatively regulating the renin-angiotensin system. However, heart disease in humans and in animal models is associated with only a partial loss of ACE2. ACE2 is an X-linked gene; and as such, we tested the clinical relevance of a partial ...
Tomkiewicz-Pajak Lidia - - 2014
Objectives: Increased arterial stiffness is a risk factor of atherosclerosis and cardio-vascular complications. The aim of the study was to determine whether peripheral vascular function might be an early marker of impaired health status in patients with a single ventricle after Fontan procedure.Methods and results: Twenty five consecutive adults (11 ...
Ulanovsky I I Departments of Neonatology, Rambam Health Care Campus, Technion-Israel Institute of Technology, Haifa, - - 2014
Objective:Apnea of prematurity is a common complication in premature newborns and caffeine is a widespread medication used to treat this complication. Caffeine may have adverse effects on the cardiovascular and central nervous system, yet its effects on the autonomic nervous system modulation of heart rate have not been studied in ...
Gorter Thomas M TM Department of Pediatric Cardiology, Center for Congenital Heart Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, - - 2014
In patients with severe pulmonary valve regurgitation or stenosis, pulmonary valve replacement (PVR) has a favourable effect on right ventricular (RV) volume and pressure unloading. PVR thereby decreases the progression of RV dilatation and/or hypertrophy. This study investigates RV remodelling patterns after PVR in patients with either pressure, volume or ...
López-Candales Angel A Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, - - 2014
Even though systolic eccentricity index has been traditionally categorized based on right ventricular (RV) pressure overload, which hemodynamic component is particularly responsible for modulating leftward ventricular septal bowing (LVSB) in chronic pulmonary arterial hypertension (PAH) is less well-known. Therefore, currently used echocardiographic variables, as suggested by the American Society of ...
Berge Hm H Oslo Sports Trauma Research Center, Oslo, - - 2014
High blood pressure (BP) is a leading cause of illness, and bilateral measurement of BP is recommended in IOC's preparticipation health examination. Still there is limited data on BP in elite athletes. To describe blood pressure, prevalence of hypertension and subclinical organ damage (left ventricular hypertrophy) in elite athletes. Systematic ...
Díez Javier J Department of Cardiovascular Sciences, Centre of Applied Medical Research, Pamplona, Spain; Department of Cardiology and Cardiac Surgery, University Clinic, Pamplona, Spain; University of Navarra, Pamplona, Spain. Electronic address: - - 2014
Hypertensive heart disease (HHD) has been considered the adaptive hypertrophy of the left ventricle wall to increased blood pressure. Recent findings in hypertensive animals and patients now challenge this paradigm by showing that HHD also results from pathologic structural remodeling of the myocardium in response to hemodynamic and nonhemodynamic factors ...
Jhund Pardeep S PS Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, - - 2014
The first in class angiotensin receptor neprilysin inhibitor, LCZ696 has been shown to reduce levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), reduce left atrial size and improve New York Heart Association (NYHA) class in patients with heart failure with preserved ejection fraction (HFpEF). We examined whether the effects of LCZ696 ...
Ruhparwar Arjang A Department of Cardiac Surgery, University Hospital of Heidelberg, Heidelberg, - - 2014
Research into the development of artificial heart muscle has been limited to assembly of stem cell-derived cardiomyocytes seeded around a matrix, while nonbiological approaches to tissue engineering have rarely been explored. The aim of the study was to apply electrically contractile polymer-based actuators as cardiomyoplasty for positive inotropic support of ...
Tadic Marijana M aUniversity Clinical Hospital Center 'Dr Dragisa Misovic' bClinical Centre of Serbia, Clinic of Cardiology cUniversity Clinical Hospital Center 'Zemun' dFaculty of Medicine, University of Belgrade, Belgrade, Serbia eClinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, - - 2014
The aim of this study was to examine the relationship between increasing blood pressure (BP) and right ventricular (RV) and right atrial (RA) mechanics using two-dimensional echocardiography (2DE) strain analysis and three-dimensional echocardiography (3DE). This cross-sectional study included 58 individuals with optimal BP, 57 individuals with high-normal BP, and 59 ...
Bassareo Pier Paolo PP Unit of Cardiology and Angiology, Department of Medical Sciences ?M. Aresu?, University of Cagliari, Cagliari, - - 2014
Cigarette smoking is an important modifiable cardiovascular risk factor associated with increased stiffness of the large arteries in adulthood. This study aimed to 1) evaluate arterial distensibility and echocardiographic measures in adolescent smokers before and after participation in a successful smoking cessation program and to 2) compare the findings obtained ...
Wang Lu L Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, - - 2014
Vitamin D is involved in blood pressure (BP) regulation. Genetic variations may influence the effect of vitamin D on BP, but data from epidemiologic studies remain inconsistent. We conducted a comprehensive genetic association study in the Women's Genome Health Study (WGHS) with genome-wide genotype data among 23,294 women of European ...
Linz Dominik D Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, Geb. 40, 66421, Homburg/Saar, Germany, - - 2014
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Currently, atrial endocardial catheter ablation, mainly targeting focal discharges in the pulmonary veins, is the most widely used interventional treatment of drug-refractory AF. Despite technical improvements, results are not yet optimal. There is ...
Peters Christian D CD 1] Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark [2] Institute of Clinical Medicine, Aarhus University, Aarhus, - - 2014
Agents blocking the renin-angiotensin-aldosterone system are frequently used in patients with end-stage renal disease, but whether they exert beneficial cardiovascular effects is unclear. Here the long-term effects of the angiotensin II receptor blocker, irbesartan, were studied in hemodialysis patients in a double-blind randomized placebo-controlled 1-year intervention trial using a predefined ...
Finkelhor Robert S RS Heart and Vascular Center, Case Western Reserve University at the MetroHealth Medical Center Campus, Cleveland, - - 2014
Because many recent studies have questioned the accuracy of Doppler echocardiography (D) in determining pulmonary artery systolic pressure (PASP), we performed a detailed literature analysis attempting add clarity. Studies through 2011 comparing D and right heart catheterization (RHC) PASP, with at least 25 studied patients and reporting correlation coefficients (r) ...
Stevens Michael C MC Innovative Cardiovascular Engineering and Technology Laboratory, The Prince Charles Hospital, Brisbane, Queensland, Australia; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia; School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Queensland, - - 2014
Dual rotary left ventricular assist devices (LVADs) have been used clinically to support patients with biventricular failure. However, due to the lower vascular resistance in the pulmonary circulation compared with its systemic counterpart, excessively high pulmonary flow rates are expected if the right ventricular assist device (RVAD) is operated at ...
Rajagopal Sudarshan S Department of Medicine, Duke University Medical Center, Durham, North Carolina. Electronic address: - - 2014
Right ventricular (RV) function is a strong predictor of mortality in pulmonary hypertension (PH), but two-dimensional (2D) echocardiography-derived assessments of RV function that could aid in risk assessment and management of patients with PH are of limited utility. RV longitudinal peak systolic strain (RVLS) derived from 2D speckle-tracking echocardiography is ...
Mariño Guillermo G Equipe 11 labelisée par la Ligue Nationale contre le Cancer; INSERM U1138; Centre de Recherche des Cordeliers; Paris, France; Metabolomics and Molecular Cell Biology Platforms; Gustave Roussy; Villejuif, France; Université Paris Descartes/Paris 5; Paris, - - 2014
It has been a longstanding problem to identify specific and efficient pharmacological modulators of autophagy. Recently, we found that depletion of acetyl-coenzyme A (AcCoA) induced autophagic flux, while manipulations designed to increase cytosolic AcCoA efficiently inhibited autophagy. Thus, the cell permeant ester dimethyl α-ketoglutarate (DMKG) increased the cytosolic concentration of ...
Phan Jennifer K JK Doctor of Pharmacy Program, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, - - 2014
To evaluate the effects of caffeinated energy shots compared with noncaffeinated energy shots as assessed by changes in peripheral and central hemodynamic parameters in healthy subjects. Randomized, double-blind, controlled crossover study. University campus. Ten healthy volunteers. Subjects were randomized to receive either a caffeinated or noncaffeinated energy shot; after a ...
Park Seong-Mi SM Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of - - 2014
Percutaneous coronary interventions (PCIs) are increasingly being used to treat unprotected left main coronary artery (ULMCA) lesions. However, research is sparse on the acute changes of left ventricular (LV) hemodynamics and function during PCI in patients with ULMCA stenosis. We aimed to assess the acute changes of LV function using ...
Fenster Brett E BE Division of Cardiology, National Jewish Health, Denver, Colorado, - - 2014
Cystatin C (CysC), a novel marker of renal function, predicts left heart failure and cardiovascular mortality. The hypothesis that serum CysC levels correlate with right ventricular (RV) morphology, function and pressure in pulmonary arterial hypertension (PAH) was tested. As part of a prospective study, 14 PAH subjects and 10 matched ...
Parajuli Nirmal - - 2014
Oxidative stress plays a key pathogenic role in experimental and human heart failure. However, the source of the reactive oxygen species is a key determinant of the cardiac adaptation to pathological stressors. Human dilated cardiomyopathy is associated with increased NOX2 levels, increased oxidative stress with adverse myocardial remodeling, and activation ...
Tsioufis C C First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, - - 2014
Transluminal renal sympathetic denervation (RDN) reduces blood pressure (BP) in patients with drug-resistant uncontrolled hypertension. We assessed the effect of RDN on heart rate, supraventricular and ventricular ectopic activity and indexes of heart rate variability in 14 patients with drug-resistant uncontrolled hypertension who were all responders to RDN (defined as ...
Aune Sverre E SE Gazes Cardiac Research Institute, 114 Doughty St., Medical University of South Carolina, Charleston, SC 29425, - - 2014
While inhibition of class I/IIb histone deacetylases (HDACs) protects the mammalian heart from ischemia reperfusion (IR) injury, class selective effects remain unexamined. We hypothesized that selective inhibition of class I HDACs would preserve left ventricular contractile function following IR in isolated hearts. Male Sprague Dawley rats (n=6 per group) were ...
Sundblad Patrik P 1Swedish Aerospace Physiology - - 2014
Changes in posture cause blood volume redistribution, affecting cardiac filling and stroke volume (SV). We hypothesized that the time courses of ventricular filling would differ between the right and left ventricle during a rapid (2 sec) tilt, and that changes in right ventricular filling pressure would be more swift because ...
Reuter Stefanie S Klinik für Innere Medizin III, AG Experimentelle Nephrologie, Universitätsklinikum Jena, D-07743, Jena, - - 2014
The diffusion of oxygen as the sole mechanism is by far too inefficient to meet the required energy demand of human life. The mechanism of convection by an oxygen transporter made higher multicellular live on earth possible. In this context evolution has brought up the cardiovascular system with the heart ...
Antonakis Velissaris V First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, - - 2014
The evolution of QT interval and its dispersion (QTd) were studied in 135 newly diagnosed nondiabetic patients, as well as the relationship between changes of these left ventricular (LV) repolarization parameters with blood pressure (BP) and LV mass changes, which were prospectively studied for a median period of 3.8 years. At ...
Schampaert S S Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands. Department of Cardiology, Catharina Hospital Eindhoven, PO Box 1350, 5602 ZA Eindhoven, The - - 2014
The aim of this study was to develop an integrated mock circulation system that functions in a physiological manner for testing cardiovascular devices under well-controlled circumstances. In contrast to previously reported mock loops, the model includes a systemic, pulmonary, and coronary circulation, an elaborate heart contraction model, and a realistic ...
Macinnis Martin J MJ School of Kinesiology (Mr MacInnis, Ms Koch, Ms MacLeod, Mr Carter, Ms Jain, and Drs Koehle and Rupert). Electronic address: - - 2014
The purposes of this experiment were to determine the repeatability of acute mountain sickness (AMS), AMS symptoms, and physiological responses across 2 identical hypoxic exposures. Subjects (n = 25) spent 3 nights at simulated altitude in a normobaric hypoxia chamber: twice at a partial pressure of inspired oxygen (PIO2) of ...
Nadir M Adnan MA 1Department of Cardiology, University Hospital Birmingham NHS Foundation Trust, Birmingham, United - - 2014
-A paradoxical inspiratory rise in right atrial pressure (RAp, in contrast to the normal fall during inspiration), Kussmaul's sign, has been described in CHF. However, the clinical and hemodynamic characteristics, and clinical outcomes of patients with CHF and Kussmaul physiology have not been studied. -This is a single-centre study of ...
Witschey Walter R T WR Gorman Cardiovascular Research Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, - - 2014
Rapid determination of the left ventricular (LV) pressure-volume (PV) relationship as loading conditions are varied is the gold standard for assessment of LV function. Cine magnetic resonance imaging (MRI) does not have sufficient spatiotemporal resolution to assess beat-to-beat changes of the LV PV relationship required to measure the LV end-systolic ...
Kitagawa Yoji Y Department of Health Sciences, Kansai University of Health Sciences, , Osaka, - - 2014
To clarify changes in the cardiovascular autonomic nervous system function due to trigger point acupuncture, we evaluated differences in responses between acupuncture at trigger points and those at other sites using spectral analysis of heart rate variability. Subjects were 35 healthy men. Before measurements began the subjects were assigned to ...
Ram C V S CV 1] Apollo Institute for Blood Pressure Management, Apollo Blood Pressure Clinics, Apollo Hospitals, Hyderabad, India [2] Texas Blood Pressure Institute, University of Texas Southwestern Medical School, Dallas, TX, - - 2014
Severe hypertension (systolic blood pressure (BP) 160 mm Hg) resistant to treatment with multiple antihypertensive medications, poses a serious challenge to therapeutic treatment. Catheter-based renal denervation (RDN) is being increasingly proposed and researched as a safe and effective method of treating this condition. This article evaluates the existing evidence on the effects ...
Iwanami Jun J Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Shitsukawa, Ehime, - - 2014
The possible counteracting effect of angiotensin (Ang)-converting enzyme (ACE)2/Ang-(1-7)/Mas axis against the ACE/Ang II/Ang II type 1 (AT1) receptor axis in blood pressure control has been previously described. We examined the possibility that this pathway might be involved in the anti-hypertensive effect of a newly developed AT1 receptor blocker (ARB), ...
Benetti Elisabetta E Department of Medicine, University of Padova, Padua, - - 2014
The objective of this study was to determine the accuracy of the Thermor BIOS BD215 device for home blood pressure (BP) measurement according to the International Protocol of the European Society of Hypertension (ESH). Device evaluation was carried out in 33 patients. The mean age of the patients was 57.0±15.0 ...
Chowdhury Shahryar M SM Division of Cardiology, Department of Pediatrics, Medical University of South Carolina, 165 Ashley Avenue, MSC 915, Charleston, SC, 29425, USA, - - 2014
Echocardiographic measurements of diastolic function have not been validated against invasive pressure-volume loop (PVL) analysis in the single-ventricle population. The authors hypothesized that echocardiographic measures of diastolic function would correlate with PVL indices of diastolic function in patients with a single-ventricle physiology. The conductance-derived PVL measures of diastolic function included ...
Gruss H J HJ Medical & Safety Services, ICON Clinical Research, Eastleigh, - - 2014
NRL001 is a highly specific α1 -adrenoceptor agonist currently under evaluation for the treatment of faecal incontinence caused by a weak internal anal sphincter. The aim of this meta-analysis was to quantify the effect of NRL001 on cardiovascular parameters including heart rate, blood pressure and QT interval. Data from the ...
Sénage Thomas T From the *Department of Thoracic and Cardiovascular Surgery, Thorax Institut, Nantes Hospital University, Nantes, France; and †Department of Thoracic and Cardiovascular Surgery, Papworth Hospital NHS Foundation, Cambridge, United - - 2014
Hemodynamic performances comparisons between different types of left ventricular assist devices (LVADs) remain difficult in a clinical context. The aim of this study was to create an experimental model to assess and compare two types of LVAD under hemodynamic conditions that simulated physical effort and pulmonary hypertension. An experimental mock ...
Givvimani Srikanth S Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY-40202, - - 2014
Parstatin, a novel protease activated receptor-1 (PAR-1) derived peptide is a potent inhibitor of angiogenesis. We and others have reported that imbalance between angiogenic growth factors and anti-angiogenic factors results in transition from compensatory cardiac hypertrophy to heart failure in a pressure overload condition. Though cardio protective role of parstatin ...
Raimundo Joana J IPMA, Portuguese Institute of Sea and Atmosphere, Av. Brasília, 1449-006 Lisbon, Portugal. Electronic address: - - 2014
Mercury, methylmercury and selenium were determined in digestive gland, branchial hearts, mantle, kidney and gills of Sepia officinalis from two areas of the south Portuguese coast. To the best of our knowledge these are the first data on Hg, MeHg and Se in branchial hearts, kidney and gills of cuttlefish. ...
Kusuyama Takanori T Department of Cardiology, Himeji, Hyogo, - - 2014
Hypertension is a major risk factor for cardiovascular and cerebrovascular events, and most patients with hypertension are administered antihypertensive drugs. However, not all patients achieve normal blood pressure levels. The new angiotensin receptor blocker azilsartan (Takeda Pharmaceutical Company Limited, Osaka, Japan) has been reported to have a strong hypotensive effect. ...
Morris Daniel A DA Charité University Hospital, Berlin, Germany. Electronic address: - - 2014
The aim of this multicenter study was to determine the normal ranges and the clinical relevance of multidirectional systolic parameters to evaluate global left ventricular (LV) systolic function. Three hundred twenty-three healthy adult subjects prospectively included at 10 centers and a cohort of 310 patients with hypertension were analyzed. Multidirectional ...
Bopda Orelien Sylvain Mtopi OS Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, P.O. Box 63 Buea, Cameroon. Electronic address: - - 2014
The leaves of Kalanchoe pinnata (Crassulaceae) are used in Cameroon folk medicine to manage many diseases such as cardiovascular dysfunctions. In this work, we aimed to evaluate the activities of aqueous leaf extract of Kalanchoe pinnata on the blood pressure of normotensive rat (NTR) and salt hypertensive rats (SHR), as ...
Mancusi Costantino C Department of Clinical Science, University of Bergen , Bergen , - - 2014
Objective. We tested the impact of isolated systolic hypertension (ISH) on normalization of left ventricular (LV) structure during antihypertensive treatment. Methods. Baseline and annual echocardiograms were recorded in 873 hypertensive patients with electrocardiographic signs of LV hypertrophy during 4.8 years randomized losartan- or atenolol-based antihypertensive treatment in the Losartan Intervention ...
Elgendi Mohamed M Department of Mathematics and Computing Science, University of Alberta, Edmonton, - - 2014
Pulmonary artery hypertension (PAH) is difficult to recognize clinically. Digital stethoscopes offer an opportunity to re-evaluate the diagnosis of PAH. We hypothesized that spectral analysis of heart sound frequencies using recordings from a digital stethoscope would differ between children with and without PAH. We recorded heart sounds using a digital ...
Witt Chance M CM Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA, - - 2014
The stiff left atrial (LA) syndrome is defined as pulmonary hypertension (PH) secondary to reduced LA compliance and has recently been shown to be one cause of PH after atrial fibrillation (AF) ablation. We aimed to determine the incidence of an increase in pulmonary arterial (PA) pressure post-ablation and examine ...
Ambrosi Pierre P 1 Department of Cardiology, La Timone Hospital, Aix-Marseille University, Marseille, France. 2 Department of Cardiac Surgery, La Timone Hospital, Aix-Marseille University, Marseille, France. 3 Address correspondence to: Pierre Ambrosi, M.D., Ph.D., Department of Cardiology, La Timone Hospital, Aix-Marseille University, 13385 Marseille, - - 2014
How reliable is home blood pressure monitoring (HBPM) in heart transplant recipients is not known. Possibly, it may underestimate hypertensive burden, because blood pressure (BP) nondipper profile is frequent among these patients. This prospective study has been designed to determine whether HBPM adequately identifies hypertension in heart transplant recipients. We ...
Konecny Tomas T Mayo Clinic, Rochester, MN; International Clinical Research Center (ICRC), St. Anne's Hospital, Brno, Czech - - 2014
Objectives We set to measure the inter-atrial pressure gradient during simulated obstructive sleep apnea (OSA). Background OSA occurs when a sleeping patient attempts to inhale against an obstructed airway. How this event affects the inter-atrial pressure gradient has not been defined. We hypothesized that simulated OSA in a conscious subject ...
Aksoy Sukru S Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey. Electronic address: - - 2014
It has been shown that left ventricular diastolic dysfunction (LVDD) develops in patients with metabolic syndrome (MetS). However, there is not sufficient evidence in the literature to determine whether this condition is due to increase in blood pressure, which is frequently encountered in MetS. The purpose of this study was ...
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