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Song Kangxing K Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT; The Cardiology Department, Chinese Peoples' Liberation Army General Hospital, Beijing, - - 2014
Cardiotrophin-1 (CT-1) is a member of the interleukin 6 cytokine superfamily. Plasma CT-1 levels have been associated with heart failure and hypertension in small independent studies. Whether plasma CT-1 levels are associated with progression of hypertensive heart disease is poorly understood. The authors carried out a meta-analysis using published studies ...
Meltzer Christian C Institute of Particle Technology (LFG), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) , Cauerstrasse 4, 91058 Erlangen, - - 2014
A combination of in situ vibrational sum-frequency generation (SFG) spectroscopy and molecular-dynamics (MD) simulations has allowed us to study the effects of indentation of self-assembled octadecylphosphonic acid (ODPA) monolayers on α-Al2O3(0001). Stress-induced changes in the vibrational signatures of C-H stretching vibrations in SFG spectra and the results of MD simulations ...
Vaz-de-Melo Renan Oliveira RO Hospital de Base, Faculdade de Medicina de São José do Rio Preto, São Paulo, - - 2014
Assessment of central blood pressure (BP) has grown substantially over recent years because evidence has shown that central BP is more relevant to cardiovascular outcomes than peripheral BP. Thus, different classes of antihypertensive drugs have different effects on central BP despite similar reductions in brachial BP. The aim of this ...
Zakovicova Eva E Diabetology and Endocrinology Outpatient Clinic service Hospital Medissimo, Bratislava, - - 2014
The aim of this study was to evaluate the impact of the optimal diabetes control on the left ventricular parameters and ambulatory blood pressure in women with gestational diabetes mellitus (GDM). The patients with GDM were followed up according to predetermined protocol in order to optimize blood glucose and optimal ...
Taskin Eylem E Department of Physiotherapy and Rehabilitation, School of Health Sciences, Istanbul Bilim University, Yazarlar Sokak No:17, 34394, Esentepe-Şişli/Istanbul, Turkey, - - 2014
Adriamycin (ADR) increases the production of reactive oxygen species (ROS), which diminishes mitochondrial function. Angiotensin-II stimulates mitochondrial ROS generation. The aim of the study was to examine whether angiotensin converting enzyme (ACE) or renin inhibitors protect against ADR-induced mitochondrial function impairment. Rats were divided into five groups as control, ADR, ...
Richards Jacob J Departments of aMedicine bBiochemistry and Molecular Biology, University of Florida, Gainesville, Florida, - - 2014
The circadian clock plays an integral role in the regulation of physiological processes, including the regulation of blood pressure. However, deregulation of the clock can lead to pathophysiological states including hypertension. Recent work has implicated the circadian clock genes in the regulation of processes in the heart, kidney, vasculature, and ...
Li Shan-Bing SB Pharmacy College, Jinan University, Guangzhou, - - 2014
Heavy tea consumption is suggested to be unsuitable for hypertensive people. However, the bioactive substances in different varieties of tea leaves are very different. This study is aimed to compare the effects of three Chinese tea, Camellia sinensis, Camellia ptilophylla and Camellia assamica var. kucha on blood pressure (BP) and ...
Smith Benjamin C F BC Department of Cardiology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom; School of Medicine, Imperial College, London, United - - 2014
Quantitative assessment of right ventricular (RV) systolic function largely depends on right ventricular ejection fraction (RVEF). Three-dimensional speckle tracking (3D-ST) has been used extensively to quantify left ventricular function, but its value for RV assessment has not been established. This study sought to prospectively assess whether 3D-ST would be a ...
Toker Rabia Tutuncu - - 2014
The aim of this study was to explore the circadian blood pressure rhythm using ambulatory blood pressure monitoring in normotensive children with a family history of essential hypertension. Group1 consisted of children with hypertensive mothers and/or fathers (n=20), Group2 consisted of children with hypertensive grandparents (n=20), and Group3 consisted of ...
Sheward Victoria E VE Evelina Children's Hospital, London, - - 2014
Prior to Norwood 1 surgery, neonates with hypoplastic left heart syndrome (HLHS) are at risk of decompensation from systemic underperfusion secondary to pulmonary overcirculation. We examined whether preoperative temporal profiles of physiological and laboratory variables differed between neonates who did and did not decompensate preoperatively. Case control study. Paediatric Intensive ...
Weng Li-Qing LQ Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institute of Biomedical Science, Fudan University, Shanghai 200032, - - 2014
Aim:Aliskiren (ALK) is a renin inhibitor that has been used in the treatment of hypertension. The aim of this study was to determine whether ALK could ameliorate pressure overload-induced heart hypertrophy and fibrosis, and to elucidate the mechanisms of action.Methods:Transverse aortic constriction (TAC) was performed in mice to induce heart ...
Ozeki Atsuko A Department of Cardiovascular Medicine, Graduate School of Medicine, the University of Tokyo, Tokyo, - - 2014
The aim of this study was to evaluate the add-on effect of aliskiren to valsartan on endothelial-dependent vasodilation in hypertensive patients with ischemic heart disease (IHD). After 4 weeks of treatment with 80 mg of valsartan, 28 patients were allocated to either continued treatment with valsartan or an add-on treatment with valsartan ...
Yeh Jay J Department of Pediatrics, Division of Pediatric Cardiology, University of California Davis Medical Center, Sacramento, - - 2014
Pulmonary capillary wedge pressure (PCWP) is an important indicator in pediatric heart transplant patients, but commonly used noninvasive surrogates, such as ratio of early diastolic mitral inflow velocity to annular velocity (E/E'), have limitations in this population. This study aimed to evaluate the relation of left atrial (LA) peak systolic ...
Manolas Jan J Mobile Unit for Diastolic Stress Test, Department of Check Up, Diagnostic & Therapeutic Center of Athens, Hygeia Hospital, Erythrou Stavrou 4 and Kifissias Ave. Maroussi, Athens 151 23, Greece. - - 2014
Left ventricular (LV) pressure curve shows early high-magnitude changes in presence of induced ischemia. A dramatic rise in LV and left atrial end-diastolic pressures occurs within seconds to minutes in presence of ischemia induced by dynamic or handgrip exercise as well as pacing of 38 to 183% and during short ...
Bech-Hanssen Odd O Heart Center, King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi - - 2014
Diastolic dysfunction is a recognized complication in heart transplant (HTx) recipients that limits exercise capacity and is a risk factor for mortality. We investigated the ability of echocardiography to detect elevated pulmonary capillary wedge pressure (mean PCWP>15 mmHg) in HTx recipients. This retrospective study comprised HTx recipients with echocardiography and right ...
Lane Abbi D AD Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, USA Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, USA - - 2014
Aging is commonly accompanied by increased arterial and ventricular stiffness (determined by arterial elastance (Ea) and ventricular elastance (Elv)), augmented ventricular-vascular coupling ratios (Ea/Elv) and systemic inflammation. Acute inflammation may impact ventricular-vascular coupling and predispose older adults to cardiovascular events. However, physically active older adults have more compliant large arteries ...
Karamanzanis George G Department of Cardiology, Athens General Hospital, Athens, - - 2014
Obstructive sleep apnea (OSA) is a highly prevalent condition related to several cardiovascular complications. We assessed the effects of continuous positive airway pressure (CPAP) treatment on myocardial performance and various somatometric parameters in patients with severe OSA receiving CPAP. This is a prospective longitudinal study of 44 patients aged 55.8 ± 10.6 years ...
Bonderman Diana - - 2014
Background:Deficient nitric oxide- soluble guanylate cyclase (sGC)-cGMP signaling results from endothelial dysfunction and may underlie impaired cardiac relaxation in patients with heart failure with preserved left ventricular ejection fraction (HFpEF) and pulmonary hypertension (PH). The acute hemodynamic effects of riociguat, a novel sGC stimulator, were characterized in patients with PH ...
Hutchinson Kate K Department of Cardiology, Hull York Medical School, Hull and East Yorkshire Medical Research and Teaching Centre, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, - - 2014
Heart failure is one of the most important medical problems facing societies in developed economies and its prevalence is predicted to rise inexorably in the next few decades as longevity increases. Worsening heart failure leading to hospitalization is associated with a poor prognosis and imposes a substantial burden on health ...
Kannan Arun A Section of Cardiology, Sarver Heart Center, University of Arizona College of Medicine, Tucson, AZ, USA, - - 2014
Hypertension remains a significant risk factor for development of congestive heart failure CHF), with various mechanisms contributing to both systolic and diastolic dysfunction. The pathogenesis of myocardial changes includes structural remodeling, left ventricular hypertrophy, and fibrosis. Activation of the sympathetic nervous system and renin-angiotensin system is a key contributing factor ...
Magill Steven B SB Division of Endocrinology, Metabolism, and Clinical Nutrition, Department of Medicine, Medical College of Wisconsin, Menomonee Falls, - - 2014
The renin-angiotensin-aldosterone system (RAAS) is a major regulator of blood pressure control, fluid, and electrolyte balance in humans. Chronic activation of mineralocorticoid production leads to dysregulation of the cardiovascular system and to hypertension. The key mineralocorticoid is aldosterone. Hyperaldosteronism causes sodium and fluid retention in the kidney. Combined with the ...
Ferdinand Keith C KC From the Tulane University School of Medicine, New Orleans, LA (K.C.F.); Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington (W.B.W.); University of Alabama at Birmingham (D.A.C.); McMaster University, Hamilton, Ontario, Canada (E.M.L.); Sager Consulting, San Francisco, CA (P.T.S.); B2S Consulting, Carmel, IN (R.B.); and Lilly Diabetes, Eli Lilly and Company, Indianapolis, IN (H.H.J., R.J.T., K.E.R., M.J.G.). - - 2014
Glucagon-like peptide-1 receptor agonists, used to treat type 2 diabetes mellitus, are associated with small reductions in systolic blood pressure (SBP) and increases in heart rate. However, findings based on clinic measurements do not adequately assess a drug's 24-hour pharmacodynamic profile. The effects of dulaglutide, a once-weekly glucagon-like peptide-1 receptor ...
Ojala Tiina T Department of Pediatric Cardiology, Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, - - 2014
Left ventricular mass (LVM) and synchrony have prognostic value for many cardiovascular disease states. We report the agreement and repeatability of LVM estimation by three-dimensional (3D) versus M-mode and repeatability of 3D estimation of systolic dyssynchrony. 3DLVM was computed by subtraction of endocardial from epicardial volume X1.05 both at end-diastole ...
Valera Beatriz B a Axe Santé des Populations et Environnement, Centre de Recherche du CHUQ , Quebec , CANADA (B.V., E.D.); Institut Louis Malardé , Papeete , POLYNÉSIE FRANÇAISE (E.S.); École des Hautes Études en Santé Publique, Département épidémiologie et biostatistiques , Paris , FRANCE (E.C.); IRIS , UMR 8156-997, Bobigny , FRANCE (E.C.); Quebec Heart and Lung Institute, Laval Hospital Research Centre (P.P.), Faculty of Pharmacy (P.P.), Department of Social and Preventive Medicine (E.D.), Laval University , Quebec , - - 2014
Objective: To analyze the associations between marine n-3 polyunsaturated fatty acids (PUFAs) and blood pressure (BP), resting heart rate (HR), and heart rate variability (HRV) in a population highly exposed to methylmercury through the diet. Methods: Concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in erythrocytes membranes were measured ...
Deshpande G G University of Cape Town, Medicine, Cape Town, South - - 2014
Acute heart failure (AHF) is a clinical emergency, with high mortality and re-hospitalizations. We established a model of de novo AHF to study the molecular survivor activating factor enhancement (SAFE) pathway activated by sphingosine-1-phosphate (S1P), a component of HDL. S1P activates SAFE pathway by binding to its receptors which via ...
Ytrehus K K University of Tromso, Faculty of Health Sciences, Cardiovascular Research Group, Tromso, - - 2014
Although uric acid is known as the most effective reactive oxygen species (ROS) scavenger within the extracellular space of the body, elevated serum concentration is correlated with inflammation, kidney pathology and impaired prognosis of heart disease. This experimental study in the isolated rat heart investigated the effect of A) extracellular ...
Dhillon Santokh S Division of Pediatric Cardiology, Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, - - 2014
Clinical hemodynamic parameters (heart rate, systolic arterial pressure [SAP], and arterial and venous oxygen saturation saturations [SaO2 and SvO2 ]) are commonly used to guide management to optimize oxygen transport after the Norwood procedure. The adequacy of this practice has not been demonstrated. We examined the correlations between these clinical ...
Tomimatsu Takuji T Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki, Okayama, - - 2014
The current study tested the hypothesis that abnormal pressure-wave reflection may have an important role in identifying pregnant women with chronic hypertension who might develop pre-eclampsia (PE) and/or fetal growth restriction. Pulse-wave analyses were performed to assess maternal arterial stiffness during 26-32 weeks of gestation in 41 women with chronic ...
Toyoda Daisuke D Department of Anesthesiology, Toho University Ohashi Medical Center, 2-17-6, Ohashi, Meguro, Tokyo, 153-8515, - - 2014
The purpose of this prospective, observational study was to respiratory variation of stroke volume (stroke volume variation, SVV) against central venous pressure (CVP) and pulmonary artery diastolic pressure (PADP) as an estimate of right and left ventricular preload. With IRB approval and informed consent, 31 patients undergoing living related renal ...
Xie Feng F Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang 421001, - - 2014
This study is designed to investigate whether APJ receptor acts as a sensor in static pressure-induced cardiomyocyte hypertrophy and to investigate the mechanism of PI3K-autophagy pathway. The left ventricular hypertrophy rat model was established by coarctation of abdominal aorta. H9c2 rat cardiomyocytes were cultured in the presence of static pressure ...
Komajda Michel M Institute of Cardiometabolism and Nutrition (ICAN), Pierre et Marie Curie Paris VI University, La Pitié-Salpétrière Hospital, Paris, - - 2014
Low systolic blood pressure (SBP) is associated with poor outcomes in heart failure and complicates management. In a post hoc analysis, we investigated the efficacy and safety of ivabradine in the SHIFT population divided by tertiles of baseline SBP. The analysis comprised 2110 patients with SBP <115 mmHg, 1968 with 115≤ SBP <130 mmHg, ...
Søndergaard Lars L Department of Cardiology, Rigshospitalet, Copenhagen, - - 2014
Heart failure with preserved or mildly reduced ejection fraction (HFpEF) is common and, to date, therapeutic options are limited. Increased left atrial pressure is a key contributor to the symptoms associated with HFpEF, particularly during physical activity. We report the 30-day outcome of patients treated with a novel device intended ...
Figueroa Juan J JJ Department of Neurology, Mayo Clinic, Rochester, MN, United - - 2014
Whether non-dipping - the loss of the physiologic nocturnal drop in blood pressure - among patients with postural tachycardia syndrome (POTS) is secondary to autonomic neuropathy, a hyperadrenergic state, or other factors remains to be determined. In 51 patients with POTS (44 females), we retrospectively analyzed 24-hour ambulatory blood pressure ...
Schwarzer Michael M Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich Schiller University of Jena, Jena, - - 2014
Aim: We investigated the impact of cardiac reactive oxygen species (ROS) during the development of pressure overload (PO) induced heart failure (HF). We used our previously described rat model where transverse aortic constriction (TAC) induces compensated hypertrophy after 2 weeks, heart failure with preserved ejection fraction at 6 and 10 ...
Pliquett Rainer U - - 2014
Dysregulation of the autonomic nervous system is frequent in subjects with cardiovascular disease. The contribution of different forms of renovascular hypertension and the mechanisms contributing to autonomic dysfunction in hypertension are incompletely understood. Here, murine models of renovascular hypertension with preserved (2-kidneys-1 clip, 2K1C) and reduced (1-kidney-1 clip, 1K1C) kidney ...
Sala-Mercado Javier A JA Wayne State - - 2014
The cardiopulmonary baroreflex responds to an increase in central venous pressure (CVP) by decreasing total peripheral resistance and increasing heart rate (HR) in dogs. However, the direction of ventricular contractility change is not well understood. The aim was to elucidate the cardiopulmonary baroreflex control of ventricular contractility during normal physiologic ...
DuBay Shane G SG Department of Biology, Museum of Southwestern Biology, University of New Mexico, 167 Castetter Hall MSC03 2020, 1 University of New Mexico, 87131, Albuquerque, - - 2014
The tropical Andes are a global hotspot of avian diversity that is characterized by dramatic elevational shifts in community composition and a preponderance of recently evolved species. Bird habitats in the Andes span a nearly two-fold range of atmospheric pressure that poses challenges for respiration, thermoregulation, water balance, and powered ...
Brehm Christoph C Heart and Vascular Institute, Penn State Milton S. Hershey Medical Center, Hershey, PA, - - 2014
The impact of extracorporeal membrane oxygenation (ECMO) support on coronary blood flow and left ventricular unloading is still debated. This study aimed to further characterize the influence of ECMO on coronary artery blood flow and its ability to unload the left ventricle in a short-term model of acute cardiogenic shock. ...
Maharaj Nirvarthi N Division of Cardiology, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South - - 2014
Left ventricular (LV) twist may be a compensatory mechanism to preserve ejection fraction (EF). In patients with hypertension, twist varies depending on the left ventricle's degree of remodeling and systolic function; it is increased in those with hypertension with normal EF (HTNEF) and diminished in those with hypertension with low ...
Sparks Joshua D JD Division of Pediatric Cardiology, Department of Pediatrics, University of Louisville, Louisville, KY, - - 2014
BNP is increasingly utilized in the management of pediatric HT recipients. Performing a retrospective single-center chart review, we sought to describe BNP changes during the first year after HT and identify factors that affect its trend. After exclusion for rejection, 316 BNP levels from 50 patients were evaluated. BNP underwent ...
Castro Pedro Miguel PM Hospital São João, Faculty of Medicine, University of Porto - - 2014
The role of autonomic nervous system (ANS) in adapting cerebral blood flow (CBF) to arterial blood pressure (ABP) fluctuations (cerebral autoregulation, CA), is still controversial. We aimed to study the repercussion of autonomic failure (AF) on dynamic CA during the Valsalva maneuver (VM). Eight AF subjects with familial amyloidotic polineuropahty ...
Tilman V V The Sheba Medical Center, Rehabilitation Hospital, Ramat Gan, Israel. Electronic address: - - 2014
Atrial fibrillation in heart failure often occur together. The relationship between atrial fibrillation and heart failure has remained a subject of research. The main manifestation of the violation of hydrodynamics in heart failure is the increased end-diastolic pressure, which is transmitted through the intercommunicated system (left ventricle-left atrium-pulmonary veins-alveolar capillaries) ...
Biondi David M DM US Medical Affairs, Janssen Scientific Affairs, LLC, 1125 Trenton Harbourton Road, Titusville, NJ, 08560, USA, - - 2014
Hypertension is one of the most common co-existing conditions in patients with chronic pain, and the potential effects of an analgesic on heart rate and blood pressure are of particular concern for patients with hypertension. The purpose of this analysis was to evaluate changes in blood pressure and heart rate ...
Yoo Kyung Y KY Departments of *Anesthesiology and Pain Medicine ‡Physiology, Chonnam National University Medical School, Gwangju, South Korea †Cephalogics, LLC, Cambridge, - - 2014
Near-infrared spectroscopy assesses cerebral tissue oxygen saturation (Scto2) based on the absorption spectra of oxygenated and deoxygenated hemoglobin. It has been reported that IV-administered dyes including methylene blue, indigo carmine, and indocyanine green (ICG) may cause falsely low-pulse oximetry readings (Spo2). Although methylene blue and indigo carmine may also decrease ...
Chen Wan W aDepartment of Cardiology, First People's Hospital, Chongqing Departments of bCardiology cNursing, Tangdu Hospital dSchool of Public Health, Fourth Military Medical University, Xi'an, - - 2014
This study aimed to validate the Pangao PG-800B5 upper arm blood pressure monitor according to the European Society of Hypertension International Protocol revision 2010. A total of 33 participants, 16 men and 17 women, were included in the device evaluation. The mean age of the participants was 56.4±21.0 years (range ...
Bettex Dominique A DA Anesthesiology, University Hospital Zürich, Rämistrasse 100, Zurich, ZH 8091, Switzerland - - 2014
A carrier system for gases and nutrients became mandatory when primitive animals grew larger and developed different organs. The first circulatory systems are peristaltic tubes pushing slowly the haemolymph into an open vascular tree without capillaries (worms). Arthropods developed contractile bulges on the abdominal aorta assisted by accessory hearts for ...
Kamali Hacer - - 2014
Hemodynamically significant muscular ventricular septal defects in children after the infantile period are a rare occurrence and ideal for transcatheter closure. In cases of severe concomitant pulmonary hypertension, it may be necessary to fenestrate the device. In this report, we present an 18-year old patient with a large mid-trabecular ventricular ...
Barin Gokhan G Department of Chemistry, Northwestern University , 2145 Sheridan Road Evanston, Illinois 60208, United - - 2014
We successfully demonstrate an approach based on linker fragmentation to create defects and tune the pore volumes and surface areas of two metal-organic frameworks, NU-125 and HKUST-1, both of which feature copper paddlewheel nodes. Depending on the linker fragment composition, the defect can be either a vacant site or a ...
Fujimoto Kazuto K Department of Pediatrics,National Cerebral and Cardiovascular - - 2014
To date, no transcatheter valve has been approved for placement in the pulmonary position in Japan. Consequently, percutaneous balloon dilatation may be advised for stenotic right ventricular outflow lesions; however, technical difficulties persist, particularly in adults. We describe the acute haemodynamic changes and outcome of balloon dilatation of right ventricular ...
Boe Espen E Institute for Surgical - - 2014
Cardiac resynchronization therapy (CRT) has been proposed in heart failure patients with narrow QRS, but the mechanism of a potential beneficial effect is unknown. This study investigates the hypothesis that LV pacing increases LV end-diastolic volume (EDV) by allowing the LV to start filling before the RV during narrow QRS ...
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