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Results 251 - 300 of 1545
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Midoh Naoki - - 2013
The repeated once-daily oral administration of a hot-water extract of porcini, Boletus aestivalis, mushrooms (WEP) to spontaneously hypertensive rats (SHR) for 18 weeks decreased the systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate. The WEP administration also decreased blood urea nitrogen (BUN), creatinine (Cre), and triglyceride (TG), ...
Janssen Wiebke - - 2013
Pulmonary arterial hypertension (PAH) is a progressive disease that is associated with a poor prognosis and results in right heart dysfunction. While pulmonary vascular disease is the obvious primary pathological focus, right ventricular hypertrophy (RVH) and right ventricular (RV) dysfunction are major determinants of prognosis in PAH. Our knowledge about ...
Zhang Siyuan - - 2013
The acoustic pressure distribution, thermal ablation, and sonochemiluminescence (SCL) generated by cavitation near the surface of an ex vivo bovine femur were investigated at normal and oblique incidences of high intensity focused ultrasound (HIFU), as were the characteristics of bone surface vibrations. The acoustic pressure at the HIFU focus, the ...
Pejović Janko - - 2013
Identification of patients with arterial hypertension and a possible onset of heart failure by determining the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) enables timely intensification of treatment and allows clinicians to prescribe and implement optimal and appropriate care. The aim of this study was to evaluate NT-proBNP in patients ...
De Meester Pieter - - 2013
Although closure of an atrial septal defect type secundum often normalizes right heart dimensions and pressures, mild tricuspid insufficiency might persist. This study aimed at (1) identification of determinants explaining the persistence of tricuspid insufficiency after atrial septal defect closure, and (2) evaluation of functional capacity of patients with persistent ...
Ghosh Erina E Cardiovascular Biophysics Laboratory, Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine St. Louis, Missouri ; Department of Biomedical Engineering, School of Engineering and Applied Science, Washington University in St. Louis St. Louis, - - 2013
The pressure phase plane (PPP), defined by dP(t)/dt versus P(t) coordinates has revealed novel physiologic relationships not readily obtainable from conventional, time domain analysis of left ventricular pressure (LVP). We extend the methodology by introducing the normalized pressure phase plane (nPPP), defined by 0 ≤ P ≤ 1 and -1 ...
Tang Hong H Department of Biomedical Engineering, Dalian University of Technology Dalian, - - 2013
The relationships between the amplitude of the first heart sound (S1) and the rising rate of left ventricular pressure (LVP) concluded in previous studies were not consistent. Some researchers believed the relationship was positively linear; others stated the relationship was only positively correlated. To further investigate this relationship, this study ...
Weiner Rory B - - 2013
Hypertension, a strong determinant of cardiovascular disease risk, has been documented among elite, professional American-style football (ASF) players. The risk of increased blood pressure (BP) and early adulthood hypertension among the substantially larger population of collegiate ASF athletes is not known. We conducted a prospective, longitudinal study to examine BP, ...
Grabowski Katja - - 2013
An abnormal increase in left ventricular (LV) mass, i.e. LV hypertrophy (LVH), represents an important target organ damage in arterial hypertension and has been associated with poor clinical outcome. Genetic factors are contributing to variation in LV mass in addition to blood pressure and other factors such as dietary salt ...
Kutty Shelby - - 2013
The aim of this study was to investigate the left ventricular (LV) myocardial contractility index-Emax using transesophageal real time three-dimensional echocardiography (RT3DE) combined with catheterization. Transesophageal RT3DE (single beat, X7-2 × matrix, iE33, Philips) was used to obtain real time LV volumes in pigs. Volumes were integrated with LV pressures from conductance ...
Pagonas Nikolaos N Department of Nephrology, Charité-Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, - - 2013
The introduction of automated oscillometric blood pressure monitors was the basis for today's widespread use of blood pressure self-measurement. However, in atrial fibrillation, there is a controversial debate on the use of oscillometry because there is a high variability of heart rate and stroke volume. To date, the accuracy of ...
Turak Osman - - 2013
Left ventricular (LV) synchronous contraction is impaired in patients with hypertension (HT). The deleterious effects of HT on cardiovascular system are more evident in patients with nondipper HT than dippers. In this study, we aimed to investigate the effect of nondipping HT on LV systolic synchronicity compared with dippers and ...
Reil Jan-Christian - - 2013
The study aimed to determine whether isolated heart rate reduction with ivabradine reduces afterload of patients with systolic heart failure. The effective arterial elastance (Ea) represents resistive and pulsatile afterload of the heart derived from the pressure volume relation. Heart rate modulates Ea, and, therefore, afterload burden. Among the patients ...
Kikuchi Shohei - - 2013
Background: The pathophysiology of abnormal relaxation pattern in the transmitral flow (TMF) velocity waveform has not been fully elucidated. Methods and Results: A total of 173 patients who underwent comprehensive Doppler echocardiography and diagnostic cardiac catheterization for coronary artery disease were enrolled in the study. Peak early and late diastolic TMF velocities ...
Esteves William A M - - 2013
We aimed to explore the relationship between brain natriuretic peptide (BNP) levels and right ventricular (RV) function in patients with mitral stenosis (MS), and to investigate the hemodynamic parameters that predict reduction of BNP levels after percutaneous mitral valvuloplasty (PMV). Few studies have evaluated BNP in the context of MS, ...
Goldring Natalie - - 2013
Abstract The isometric wall squat could be utilised in home-based training aimed at reducing resting blood pressure, but first its suitability must be established. The aim of this study was to determine a method of adjusting wall squat intensity and explore the cardiovascular responses. Twenty-three participants performed one 2 minute ...
Espinoza Andreas - - 2013
Therapeutic hypothermia is used after cardiac arrest. The aim of this study was to investigate the effects of therapeutic hypothermia on left ventricular (LV) function assessed by ultrasonic imaging. In 10 pigs, LV volumes, ejection fractions, and longitudinal strain were measured using two-dimensional echocardiography. Midwall fractional shortening and end-systolic wall stress ...
Leonardi Robert A - - 2013
Fractional flow reserve (FFR), the hyperemic ratio of distal (Pd) to proximal (Pa) coronary pressure, is used to identify the need for coronary revascularization. Changes in left ventricular end-diastolic pressure (LVEDP) might affect measurements of FFR. LVEDP was recorded simultaneously with Pd and Pa during conventional FFR measurement as well ...
Giles Thomas D - - 2013
Nebivolol, a vasodilatory β1 -blocker, may be well suited for the hemodynamics of the younger hypertensive patient. In this 8-week trial, 18- to 54-year-olds with a diastolic blood pressure (DBP) of 95 mm Hg to 109 mm Hg who completed a 4-week placebo-only phase were randomized to receive nebivolol (5 mg/d, titrated to ...
Drynan Eleanor A - - 2013
To determine the agreement between blood pressure obtained with a noninvasive technique and direct technique using the Surgivet V9203 at varying blood pressure levels created using a canine hemorrhage model. Experimental study. University Teaching Hospital. Twenty-nine greyhounds with an average weight of 30 kg. Approval from the Murdoch University Animal ...
Seker Taner - - 2013
Vitamin D regulates the renin-angiotensin system, suppresses proliferation of vascular smooth muscle and improves endothelial cell dependent vasodilatation. These mechanisms may play a role on pathogenesis of arterial and left ventricular stiffness. We aimed to investigate the association between serum 25-hydroxyvitamin D with arterial and left ventricular stiffness in healthy ...
Marwan Norbert - - 2013
The asymmetry of coupling between complex systems can be studied by conditional probabilities of recurrence, which can be estimated by joint recurrence plots. This approach is applied for the first time on experimental data: time series of the human cardiorespiratory system in order to investigate the couplings between heart rate, ...
Beigel Roy - - 2013
In current practice, right atrial pressure (RAP) is an essential component in the hemodynamic assessment of patients and a requisite for the noninvasive estimation of the pulmonary artery pressures. RAP provides an estimation of intravascular volume, which is a critical component for optimal patient care and management. Increased RAP is ...
Millar Philip J - - 2013
Atrial mechanoreceptors, stimulated by increased pressure or volume, elicit in healthy humans a net sympathoinhibitory response. The co-existence of an atrial reflex eliciting muscle sympathoexcitation has been postulated but undetected by conventional multi-unit muscle sympathetic nerve activity (MSNA). We hypothesized that in response to a selective increase in atrial pressure, ...
De Meester Pieter - - 2013
The value of the right heart morphology is not well established for the evaluation of elevated pulmonary artery pressure (PAP). We aimed (1) to assess the relationship between right heart morphology and PAP and (2) to evaluate whether morphology can help to exclude elevated PAP. From 11-2010 until 01-2011, 1640 ...
Munte Claudia Elisabeth - - 2013
Folding under pressure: High-pressure NMR spectroscopy detects three different conformational states of the Aβ-peptide in solution: a compactly folded state 1, a partially folded state 2', and a random-coil like state 2'' (see plot, p=population). At ambient pressure the folded state 1 dominates which probably has a high affinity to ...
Roush George C - - 2013
How chlorthalidone (CTDN) reduces risk for cardiovascular events (CVEs) can be considered in light of its ability to lower blood pressure (BP) and its non-BP related, pleiotropic effects. The mechanism by which CTDN lowers BP is unclear but may include alterations in whole body regulation and vasodilatory actions on vasculature, ...
Figueroa-Valverde L - - 2013
Experimental studies indicate that some steroid derivatives have inotropic activity; nevertheless, there is scarce information about the effects of the dehydroisoandrosterone and its derivatives at cardiovascular level. In addition, to date the cellular site and mechanism of action of dehydroisoandrosterone at cardiovascular level is very confusing. In order, to clarify ...
Andrikou Ioannis - - 2013
Left ventricular hypertrophy (LVH) conveys an increased risk of cardiovascular morbidity and mortality. We aimed to compare the prognostic value of daytime and nighttime blood pressure (BP) on the changes in LVH status in newly diagnosed hypertensive subjects. Three hundred and five hypertensive, nondiabetic subjects (mean age 51.1±10.2 years, 190 ...
de Solis Cristobal Navas - - 2013
Objective-To describe the prognosis and clinical, echocardiographic, and pathological features of hypertensive cardiomyopathy in horses. Design-Retrospective case series. Animals-5 horses with cardiac hypertrophy and systemic hypertension. Procedures-Demographics, history, physical and cardiological examination findings, diagnosis, clinical progression, prognosis, and pathological findings were obtained from medical records. Results-The primary diagnosis was chronic ...
Lange S A - - 2013
Closure of atrial septal defects (ASD) prevents pulmonary hypertension, right heart failure and thromboembolic stroke. The exact timing for ASD closure is controversial. In a prospective study to address the question whether unapparent pulmonary hypertension can be revealed prior to right ventricular (RV) remodelling, patients were investigated before and 6, ...
Wu Sheng-Yuan - - 2013
The present control method used in our helical flow total artificial heart (HFTAH) would only need four parameters. Nowadays, gauge pressure sensors are being used to obtain the pressure needed for control parameters. Nevertheless, there are also many following problems such as calibration, maintenance, offset drift and infection due to ...
Shiga Takuya - - 2013
Hemodynamic effects of atrial contraction with centrifugal pump type total artificial heart is unknown. In this study, we simulated an atrial contraction in a mock model. By the driving condition with higher pressure in the mock atrial model, the load during atrial contraction increased. Based on these findings, we examined ...
Soergel David G - - 2013
TRV027 is a novel β-arrestin biased peptide ligand of the angiotensin II type 1 receptor (AT1R). The compound antagonizes G protein coupling while simultaneously stimulating β-arrestin-mediated signaling. In preclinical studies, TRV027 reversibly reduced blood pressure while preserving renal function in a dog tachypaced heart failure model and stimulating cardiomyocyte contractility ...
Ziemssen Tjalf - - 2013
Biological rhythms, describing the temporal variation of biological processes, are a characteristic feature of complex systems. The analysis of biological rhythms can provide important insights into the pathophysiology of different diseases, especially, in cardiovascular medicine. In the field of the autonomic nervous system, heart rate variability (HRV) and baroreflex sensitivity ...
Katz Daniel H - - 2013
Although concentric remodeling (CR) and concentric hypertrophy (CH) are common forms of left ventricular (LV) remodeling in heart failure with preserved ejection fraction (HFpEF), eccentric hypertrophy (EH) can also occur in these patients. However, clinical characteristics and outcomes of EH have not been well described in HFpEF. We prospectively studied ...
Borlaug Barry A - - 2013
-Cross sectional studies suggest that left ventricular (LV) and arterial elastance (stiffness) increase with age, but data examining longitudinal changes within human subjects are lacking. Additionally it remains unknown whether age-related LV stiffening is merely a reaction to arterial stiffening or caused by other processes. -Comprehensive echo-Doppler cardiography was performed ...
Leibold Nicole K - - 2013
Inhaling carbon dioxide (CO2)-enriched air induces fear and panic symptoms resembling real-life panic attacks, the hallmark of panic disorder. The present study aimed to describe the emotional and cardiovascular effects evoked by inhaling CO2, taking shortcomings of previous studies into account. Healthy volunteers underwent a double inhalation of 0, 9, ...
Tatasciore Alfonso - - 2013
Twenty-four-hour blood pressure (BP) variability, by ambulatory BP monitoring (ABPM), has been related to left ventricular hypertrophy, independent of mean BP values. We tested the hypothesis that short-term BP variability (BPV) is also related to subclinical left ventricular systolic dysfunction. We assessed 24-h SBP and DBP variabilities, quantified as standard ...
Lanier Gregg M - - 2013
-Doppler ultrasound is the clinical gold standard for non-invasive blood pressure (BP) measurement among Continuous-Flow Left Ventricular Assist Device (CF-LVAD) patients. The relationship of Doppler BP to systolic BP (SBP) and mean arterial pressure (MAP) is uncertain and Doppler measurements require a clinic visit. We studied the relationship between Doppler ...
M'buyamba-Kabangu J R - - 2013
To address the epidemic of hypertension in blacks born and living in sub-Saharan Africa, we compared in a randomised clinical trial (NCT01030458) single-pill combinations of old and new antihypertensive drugs in patients (30-69 years) with uncomplicated hypertension (140-179/90-109 mm Hg). After 4 weeks off treatment, 183 of 294 screened patients were assigned ...
Nemati Shamim - - 2013
Aging and disease are accompanied with a reduction of complex variability in the temporal patterns of heart rate. This reduction has been attributed to a break down of the underlying regulatory feedback mechanisms that maintain a homeodynamic state. Previous work has established the utility of entropy as an index of ...
Linhart Markus - - 2013
Identification of reliable risk factors for recurrence of atrial fibrillation (AF) after pulmonary vein isolation (PVI) has important implications. Left atrial (LA) pressure is a largely observator-independent parameter that can easily be determined after transseptal puncture. The purpose of this study was to investigate the predictive value of LA pressure ...
Blaudszun Grégoire - - 2013
The classical indicators of left ventricular (LV) performances have been derived from pressure-volume (PV) and stroke work-volume plots obtained during varying loading or pharmacological interventions. More recently, the preload-adjusted to the maximal change in pressure over time (PAdP/dtmax) - derived from single beat PV analysis - has been shown to ...
Kovacs Gabor - - 2013
Although in the pulmonary circulation small pressure differences may alter the categorization of patients, there is no consensus on a standard zero reference level (ZRL). In the supine position, ZRL is mostly set at "5 cm below anterior thorax-surface", "1/3-thoracic diameter below anterior thorax-surface", "mid-thoracic level" or "10 cm above ...
Lim Young-Hyo - - 2013
Abstract We investigated the association of heart rate (HR) and estimated glomerular filtration rate (eGFR) with left ventricular (LV) structure in a multi-rural cohort project in Korea. A total of 3215 subjects were analyzed for factors related to Echo-LV mass index (LVMI). eGFR was positively associated with both types of ...
Zheng Huan - - 2013
Abstract The study was designed to assess left ventricular (LV) systolic and diastolic function in hypertensive patients with or without Hhcy. The study participants consisted of 40 hypertensive patients with Hhcy, 40 hypertensive patients without Hhcy and 40 age-matched healthy control participants. Cardiac functions were determined using echocardiography and the ...
Bonderman Diana - - 2013
BACKGROUND: Pulmonary hypertension due to systolic left ventricular dysfunction (PH-sLVD) is associated with significant morbidity and mortality; however, no treatment is approved for this indication. We hypothesized that riociguat, a novel soluble guanylate cyclase stimulator, would have beneficial hemodynamic effects in patients with PH-sLVD. METHODS AND RESULTS: Overall, 201 patients ...
Tadic Marijana - - 2013
OBJECTIVE: The aim of our study was to define the relationship between the metabolic syndrome (MS), nondipping pattern, and their interaction on right ventricular (RV) structural and functional changes in untreated hypertensive patients. METHODS: This cross-sectional study included 318 recently diagnosed hypertensive patients. MS was defined by the presence of ...
Cuspidi Cesare - - 2013
Aim. Diastolic dysfunction related to hypertensive left ventricular hypertrophy (LVH) has been shown to affect right-sided cardiac morphology and haemodynamics. As left atrial enlargement (LAE) is a marker of chronically elevated left ventricular (LV) filling pressure and diastolic dysfunction, we investigated the relationship between LAE and right ventricular hypertrophy (RVH) ...
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