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Rain S S Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research (ICaR-VU), Amsterdam, The - - 2014
Although pulmonary arterial hypertension originates in the lung and is caused by progressive remodeling of the small pulmonary arterioles, patients die from the consequences of pressure-overload-induced right heart failure. Prognosis is poor, and currently there are no selective treatments targeting the failing right ventricle. Therefore, it is of utmost importance ...
Wang Lifang - - 2014
Background & objectives: The association between α-adducin gene G614T polymorphism and essential hypertension (EH) is not clear. The present study was carried out to examine a possible association between α-adducin gene G614T mutation and essential hypertension in Chinese population. Methods: A total of 170 patients with essential hypertension (EH group) ...
Vilskersts Reinis R Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga, LV-1006, Latvia, Rigas Stradins University, Dzirciema Str. 16, Riga, LV-1007, - - 2014
The administration of magnesium supplements and nitrates/nitrites decreases arterial blood pressure and attenuates the development of hypertension-induced complications. This study was performed to examine the effects of treatment with magnesium nitrate on the development of hypertension and its complications in spontaneously hypertensive (SHR) rats. Male SHR rats with persistent hypertension ...
Andrzejczak Dariusz D Department of Pharmacodynamics, Medical University of Lodz, Lodz, Poland. Electronic address: - - 2014
A growing body of evidence suggests that some cardiovascular drugs could modulate the level of proinflammatory cytokines. Therefore, the aim of the present study was to investigate whether celiprolol, a third generation β-adrenoceptor blocker, affects lipopolysaccharide (LPS)-induced serum concentrations of TNF-α, IL-1β, IL-6 in normotensive (WKY) and spontaneously hypertensive (SHR) ...
Matsumoto Masayasu M Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, - - 2014
The majority of the patients enrolled in the rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation (J-ROCKET AF) trial had hypertension. In this subgroup analysis, we investigated differences in the safety and efficacy of rivaroxaban and warfarin in subjects with and without hypertension. The baseline blood pressure (BP) measurements ...
Lee Seitetsu L SL Department of Cardiovascular Medicine, University of - - 2014
Background: Right atrial pressure (RAP) is commonly estimated using inferior vena cava (IVC) diameter and its respirophasic variations. Although a guideline has been provided for estimation of RAP due to variation in IVC dimensions based on studies in Western subjects, echocardiographic values in Asian subjects are unknown. Methods and Results: We studied ...
Basson Jacob J Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, - - 2014
Blood pressure (BP) variability has a genetic component, most of which has yet to be attributed to specific variants. One promising strategy for gene discovery is analysis of interactions between single-nucleotide polymorphisms (SNPs) and BP-related factors, including age, sex, and body mass index (BMI). Educational attainment, a marker for socioeconomic ...
Hodson Bryan B Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South - - 2014
A reduced testosterone concentration characterizes heart failure and independently predicts outcomes. Although testosterone replacement therapy may have non-cardiac-related therapeutic benefits in heart failure, whether reduced testosterone concentrations protect against adverse left ventricular remodelling (LV dilatation) is uncertain. We therefore evaluated whether surgical castration modifies LV dilatation following 6 months of ...
Williams Sarah J - - 2014
Rationale: Diastolic dysfunction can lead to heart failure with preserved ejection fraction, for which there is no effective therapeutic. Ranolazine has been reported to reduce diastolic dysfunction, but the specific mechanisms of action are unclear. The effect of ranolazine on diastolic function was examined in spontaneously hypertensive rats (SHR), where ...
Sargento Luis L Heart Failure Unit, Cardiology Department, Pulido Valente Hospital, Lisbon North Hospital Centre, Rua Manuel Costa Silva no 7-2A, 1750-335, Lisbon, Portugal, - - 2014
In patients with acute decompensated systolic heart failure (ADSHF) high resting heart rate (HR) could be either a compensatory mechanism or contribute to worsening heart failure. The aim of this study was to evaluate, in patients with ADSHF and resting HR >70 bpm, the early (within 24 h) and late (at discharge) ...
Cevasco Marisa M Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, - - 2014
Right heart failure is poorly understood and treated. In left heart failure, ventricular restraint can reverse pathologic left ventricular remodeling. The effect of restraint in right heart failure, however, is not known. We hypothesize that ventricular restraint can be applied selectively to the right ventricle (RV) to promote RV reverse ...
Yaman Muhittin O MO Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. - - 2014
The effects of both chronic hypoxia and acute intermittent hypoxia (AIH) on cardiovascular system are unclear. We designed this study to develop a rabbit model of hypertension by exposure to chronic hypobaric hypoxia (CHH) and to investigate the effects of AIH on hypertensive rabbits. Present study was performed in 13 ...
Kadappu Krishna K KK South Western Sydney Clinical School, The University of New South Wales, Sydney, Australia; Cardiology Department, Liverpool Hospital, Liverpool, Australia; Cardiology Department, Campbelltown Hospital, University of West Sydney, Campbelltown, - - 2014
Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality; hence detection of early cardiovascular involvement in CKD is important to prevent future adverse cardiovascular events. Left atrial (LA) enlargement and dysfunction has been reported in end stage renal disease. However, there is a paucity of published data ...
Driessen Mieke M P MM Department of Cardiology, University Medical Center Utrecht, University of Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands, - - 2014
Cardiac magnetic resonance (CMR) imaging is the preferred method to measure right ventricular (RV) volumes and ejection fraction (RVEF). This study aimed to determine the impact of excluding trabeculae and papillary muscles on RV volumes and function in patients with RV pressure and/or volume overload and healthy controls and its ...
Ghossein-Doha Chahinda C 1Department of Obstetrics & Gynecology, Maastricht University Medical Center, Maastricht, the - - 2014
Introduction:Women with former preeclampsia (exPE) develop chronic hypertension 4 times more often than healthy parous controls. Women, destined to develop remote chronic hypertension, had increased left ventricular mass index (LVMI) and diastolic blood pressure (BP) prior to the onset of hypertension as compared to those remaining normotensive. However, longitudinal data ...
Scansen B A BA Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, - - 2014
The prevalence of systemic hypertension (SHT) in Shetland Sheepdogs has not been reported. SHT is common in Shetland Sheepdogs and positively correlated with proteinuria. Measurements of forelimb and hindlimb systolic arterial pressure (SAP) are comparable. Seventy-two clinically healthy, client-owned Shetland Sheepdogs. Forelimb and hindlimb SAP were recorded by Doppler ultrasonography. ...
Tsubone Hirokazu H 1 Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo, Japan - - 2014
Abstract The present study aimed to clarify the effects of Agaricus brasiliensis KA21 (i.e., Agaricus blazei) mushroom on circulatory function. Spontaneously hypertensive rats (SHRs) were fed 10% A. blazei-containing pellets (agaricus group) or normal pellets (control group) for 5 weeks from 6 to 11 weeks of age. For Experiment 1, ...
Courand Pierre-Yves PY Cardiology Department, European Society of Hypertension Excellence Centre, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France; Génomique Fonctionnelle de l'Hypertension Artérielle, EA 4173, Université Claude-Bernard Lyon-1, Villeurbanne, France; Hôpital Nord-Ouest, Villefranche-sur-Saône, France. Electronic address: - - 2014
Many epidemiological studies have demonstrated that resting heart rate is a risk marker but also a risk factor in patients with coronary artery disease and heart failure. In hypertensive subjects free from overt cardiac disease, the question has been less frequently addressed. A few cohort studies have shown that hypertensive ...
Peacock W Frank WF Baylor College of Medicine, Houston, TX. Electronic address: - - 2014
Rapid blood pressure (BP) control improves dyspnea in hypertensive acute heart failure (AHF). Although effective antihypertensives, calcium-channel blockers are poorly studied in AHF. Clevidipine is a rapidly acting, arterial selective intravenous calcium-channel blocker. Our purpose was to determine the efficacy and safety of clevidipine vs standard-of-care intravenous antihypertensive therapy (SOC) ...
Derad Inge I Department of Internal Medicine and Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany; and Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, - - 2014
Intranasal administration of angiotensin II (ANGII) affects blood pressure in a mode different from intravenously administered ANGII via a direct access to the brain bypassing the blood-brain barrier. This clinical study investigated blood pressure regulation after intranasal ANGII administration in healthy humans, whereas systemic, blood-mediated effects of ANGII were specifically ...
Witham Miles D MD Ageing and Health, Department of Clinical Pharmacology, Department of Clinical Imaging, and Hypertension Research Centre and Medicines Monitoring Unit, University of Dundee, Dundee, United Kingdom; and Department of Medical Physics, National Health Service Tayside, Dundee, United - - 2014
Low 25-hydroxyvitamin D levels are associated with higher prevalent blood pressure. We tested whether high-dose intermittent oral vitamin D therapy could reduce blood pressure and left ventricular mass in patients with hypertension resistant to conventional treatment. We conducted a parallel-group, double-blind, randomized placebo-controlled trial. Patients with supine office blood pressure ...
Yoshida Seiji S Department of Pediatrics, Osaka Medical College, Osaka, - - 2014
Postural tachycardia syndrome (POTS) shows a marked tachycardia while standing. We noticed two forms of circulatory response to orthostatic stress in POTS. We investigated cardiovascular and autonomic nervous response to orthostatic stress in two forms. We studied 79 patients with POTS and 38 healthy control subjects (Ct). Beat-to-beat blood pressure ...
Lang Nora N Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, - - 2014
Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well within wet and highly dynamic environments within the body. This is especially relevant to minimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe ...
Matsukawa Ryuichi R aDepartment of Cardiovascular Medicine bDepartment of Advanced Cardiovascular Regulation and Therapeutics, Kyushu University Graduate School of Medical Sciences, Maidashi, Higashi-ku, Fukuoka, - - 2014
Neuregulin-1 (NRG-1)/ErbB signaling in the heart is reported to have a crucial role in heart failure. We recently demonstrated that NRG-1 signaling has sympathoinhibitory effects in the brain cardiovascular control center. How this central signaling impacts sympathoexcitation in heart failure, however, is unknown. Here we examined the role of central ...
Thibodeau Jennifer T JT Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, - - 2014
This study sought to examine the frequency and hemodynamic correlates of shortness of breath when bending forward, a symptom we have termed "bendopnea." Many heart failure patients describe bendopnea such as when putting on their shoes. This symptom has not previously been characterized. We conducted a prospective study of 102 ...
Vikholm Per P Department of Cardiothoracic Surgery, Uppsala University Hospital, Uppsala, - - 2014
Right ventricular failure after left ventricular assist device implantation is a serious complication with high rates of mortality and morbidity. It has been demonstrated in experimental settings that volume exclusion of the right ventricle with a modified Glenn shunt can improve haemodynamics during ischaemic right ventricular failure. However, the concept ...
Ishizu Tomoko T Cardiovascular Division, Faculty of Medicine, and Department of Medical Science, University of Tsukuba, Tsukuba, - - 2014
Left ventricular (LV) systolic wall strain is a new candidate for prognostic indicator of hypertensive heart failure. It remains unclear how underlying transmural structural remodeling corresponds to LV wall systolic deformation as hypertensive hypertrophy progresses. We fed 68 Dahl salt-sensitive rats a high-salt (hypertensive group) or low-salt diet (control group) ...
Zile Michael R MR 1Division of Cardiology, Department of Medicine, Medical University of South Carolina, and RHJ Department of Veterans Affairs Medical Center, Charleston, - - 2014
-While matrix metalloproteinases (MMPs) were initially thought to primarily result in extracellular matrix degradation, certain MMP types such as membrane type-1 MMP (MT1-MMP) may also be involved in profibrotic cascades through hydrolysis of latency-associated transforming growth factor (TGF) binding protein (LTBP-1) and activation of TGF dependent profibrotic signaling. The present ...
Martina Jerson R JR *Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht †Laboratory for Clinical Cardiovascular Physiology, AMC Center for Heart Failure Research, Amsterdam ‡BMEYE BV, Amsterdam §Department of Cardiology, University Medical Center Utrecht, Utrecht ¶Julius Center, University Medical Center Utrecht **Department of Intensive Care, University Medical Center Utrecht, Utrecht ††Department of Medical Technology, University Medical Center Utrecht, Utrecht ‡‡ Department of Cardiothoracic Surgery, Academic Medical Center, University of Amsterdam, - - 2014
Arterial blood pressure and echocardiography may provide useful physiological information regarding cardiac support in patients with continuous-flow Left Ventricular Assist Devices (cf-LVADs). We investigated the accuracy and characteristics of non-invasive blood pressure during cf-LVAD support. Noninvasive arterial pressure waveforms were recorded with Nexfin (BMEYE, Amsterdam, Netherlands). First these measurements were ...
Keller-Ross Manda L ML Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN. Electronic address: - - 2014
Feedback from active locomotor muscles contributes to the exercise pressor response in healthy humans, and is thought to be more prominent in heart failure (HF). The purpose of this study was to examine the influence of metaboreflex stimulation on arterial pressure in HF. Eleven HF patients (51 ± 5 years, ...
Liu Chengyu - - 2014
It has been reported that Gaussian functions could accurately and reliably model both carotid and radial artery pressure waveforms (CAPW and RAPW). However, the physiological relevance of the characteristic features from the modeled Gaussian functions has been little investigated. This study thus aimed to determine characteristic features from the Gaussian ...
Gewillig Marc - - 2014
The essence of a Fontan circuit is the creation of the Fontan "neoportal system," which allows for oxygenation at near normal levels, but at the cost of a chronic state of systemic venous congestion and decreased cardiac output. The heart, while still the engine of the circuit, cannot compensate for ...
Kondo Hideaki H Center for Sleep Medicine, Saiseikai Nagasaki Hospital, Nagasaki, - - 2014
Cyclic alternating pattern (CAP) is frequently followed by changes in heart rate (HR) and blood pressure (BP), but the sequential associations between CAP and autonomic nerve activity have not been studied. The study aimed to reveal the precise changes in heart rate variability (HRV) during phase A of the CAP ...
Chávez Elibet E Ernesto Che Guevara Heart Center, Santa Clara, Cuba. - - 2014
INTRODUCTION Hypertension and obesity in adults have been linked to increased EKG P-wave dispersion; the association has been shown in relation to hypertension, left ventricular hypertrophy and atrial enlargement. Though studies in children have linked P-wave dispersion to left ventricular hypertrophy, scant pediatric literature relates P-wave dispersion to hypertension and ...
Topouchian Jirar J Centre de Diagnostic, Hôpital Hôtel-Dieu, Paris, - - 2014
Four oscillometric devices, including the Omron M6 Comfort, Omron HEM-7420, Withings BP-800, and Polygreen KP-7670, designed for self-blood pressure measurement (SBPM) were evaluated according to the European Society of Hypertension (ESH) International Protocol Revision 2010 in four separate studies. The four devices measure brachial blood pressure (BP) using the oscillometric ...
Aggarwal Saurabh - - 2014
In patients with sleep-disordered breathing and heart failure, continuous positive airway pressure has been found to be associated with an improvement in cardiovascular end points. We conducted a systematic review of the current literature and a meta-analysis to pool data from 15 published randomized controlled trials. End points analyzed were ...
Krishna Bandi Hari BH PhD scholar, Department of Physiology, JIPMER , Puducherry- 605006, India - - 2014
Background and Objective: It is well known that a hall mark of heart failure is adverse changes in autonomic function. Elevated blood pressure is a powerful predictor of congestive heart failure and other Cardiovascular Disease (CVD) outcomes. In this study, we planned to examine the effects of a 12 week ...
McKie Paul M PM Cardiorenal Research Laboratory, Mayo Clinic, Rochester, - - 2014
Systemic hypertension is a common characteristic in acute heart failure (HF). This increasingly recognized phenotype is commonly associated with renal dysfunction and there is an unmet need for renal enhancing therapies. In a canine model of HF and acute vasoconstrictive hypertension we characterized and compared the cardiorenal actions of M-atrial ...
Kalogeropoulos Andreas P AP Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University, Atlanta, - - 2014
Pulmonary hypertension (PH) in patients with heart failure (HF) is associated with worse outcomes and is rapidly being recognized as a therapeutic target. To facilitate pragmatic research efforts, data regarding the prognostic importance of noninvasively assessed pulmonary artery systolic pressure (PASP) in stable ambulatory patients with HF are needed. We ...
Lee Juyoung J 0000-0002-9966-3618 Korea Forest Service, Government Complex 1, 189 Cheongsa-ro, Daejeon 302-701, Republic of - - 2014
Background. Despite increasing attention toward forest therapy as an alternative medicine, very little evidence continues to be available on its therapeutic effects. Therefore, this study was focused on elucidating the health benefits of forest walking on cardiovascular reactivity. Methods. Within-group comparisons were used to examine the cardiovascular responses to walking ...
Berthe-Aucejo Aurore A 0000-0002-9457-6996 Service de Pharmacie, Hôpital Robert Debré, 48 boulevard Sérurier, 75019 Paris, - - 2014
A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension. Steroid therapy, plasma exchange, and rituximab failed to improve proteinuria and hypertension despite a normalization of the circulating sC5b9 complex. Eculizumab, a monoclonal antibody directed ...
Posokhov Igor N IN Hemodynamic Laboratory Ltd, Nizhny Novgorod, - - 2014
Arterial stiffness, as measured by the pulse wave velocity (PWV), is recommended for routine use in clinical practice as an important parameter for the evaluation of cardiovascular risk.1 New 24-hour monitors (eg, with Vasotens® technology; Petr Telegin Company, Nizhny Novgorod, Russian Federation) provide single PWV measurements as well as several ...
Skrzypczak P - - 2014
Ventricular tachycardia may lead to haemodynamic deterioration and, in the case of long term persistence, is associated with the development of tachycardiomyopathy. The effect of ventricular tachycardia on haemodynamics in individuals with tachycardiomyopathy, but being in sinus rhythm has not been studied. Rapid ventricular pacing is a model of ventricular ...
Hashimoto Junichiro J Department of Blood Pressure Research, Tohoku University Graduate School of - - 2014
Recent advances in technology have enabled the noninvasive evaluation of pulsatile hemodynamics in the central aorta; namely, central pressure and flow measurements. The central blood pressure represents the true load imposed on the heart, kidney and brain, and the central blood flow influences the local flow into these vital organs. ...
Shin Il-Woo IW 1. Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, - - 2014
Intravenous lipid emulsions (LEs) are effective in the treatment of toxicity associated with various drugs such as local anesthetics and other lipid soluble agents. The goals of this study were to examine the effect of LE on left ventricular hemodynamic variables and systemic blood pressure in an in vivo rat ...
Meyer Markus M Department of Medicine, Division of Cardiology and Gastroenterology, University of Vermont College of Medicine, Burlington, Vermont, - - 2014
We sought to evaluate if left ventricular filling pressures can be assessed from the esophagus. The invasive assessment of left ventricular filling pressures is of importance in the evaluation and monitoring of critically ill patients. The left atrium is in very close proximity to the esophagus. We hypothesized that the ...
Dutra Rosane Menezes Faria RM Heart Institute (InCor), Pulmonary Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, - - 2014
In this observational study, we evaluated the peripheral oxygen saturation (SpO2), heart rate, and blood pressure of children with cyanotic congenital heart disease who were undergoing dental extraction. Forty-four patients between the ages of 6 and 12 years who underwent upper primary tooth extraction were included in the study. Of ...
Fioresi Mirian M Department of Physiological Sciences, Federal University of Espírito Santo, Vitoria, Espírito Santo, Brazil; Department of Nursing, Federal University of Espírito Santo, Vitoria, Espírito Santo, - - 2014
We investigated the cardiovascular effects of lead exposure, emphasising its direct action on myocardial contractility. Male Wistar rats were sorted randomly into two groups: control (Ct) and treatment with 100 ppm of lead (Pb) in the drinking water. Blood pressure (BP) was measured weekly. At the end of the treatment ...
Tongyoo Surat - - 2014
Acute right ventricular dysfunction (RVD) is one of the hemodynamic alterations in patients with septic shock, pulmonary embolism and ARDS. This condition had previously been diagnosed by pulmonary artery catheters (PAC). This report is on the use of transthoracic echocardiography (TTE) to diagnose RVD in critically ill patients. To evaluate ...
Pezeshki Zahra Z Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, - - 2014
Introduction. Rennin-angiotensin system and salt diet play important roles in blood pressure control. We hypothesized that the high-salt intake during pregnancy influences the degree of angiotensin-dependent control of the blood pressure in adult offspring. Methods. Female Wistar rats in two groups (A and B) were subjected to drink tap and ...
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