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Chowdhury Shahryar M SM Division of Cardiology, Department of Pediatrics, Medical University of South Carolina, 165 Ashley Avenue, MSC 915, Charleston, SC, 29425, USA, - - 2014
Echocardiographic measurements of diastolic function have not been validated against invasive pressure-volume loop (PVL) analysis in the single-ventricle population. The authors hypothesized that echocardiographic measures of diastolic function would correlate with PVL indices of diastolic function in patients with a single-ventricle physiology. The conductance-derived PVL measures of diastolic function included ...
Gruss H J HJ Medical & Safety Services, ICON Clinical Research, Eastleigh, - - 2014
NRL001 is a highly specific α1 -adrenoceptor agonist currently under evaluation for the treatment of faecal incontinence caused by a weak internal anal sphincter. The aim of this meta-analysis was to quantify the effect of NRL001 on cardiovascular parameters including heart rate, blood pressure and QT interval. Data from the ...
Sénage Thomas T From the *Department of Thoracic and Cardiovascular Surgery, Thorax Institut, Nantes Hospital University, Nantes, France; and †Department of Thoracic and Cardiovascular Surgery, Papworth Hospital NHS Foundation, Cambridge, United - - 2014
Hemodynamic performances comparisons between different types of left ventricular assist devices (LVADs) remain difficult in a clinical context. The aim of this study was to create an experimental model to assess and compare two types of LVAD under hemodynamic conditions that simulated physical effort and pulmonary hypertension. An experimental mock ...
Givvimani Srikanth S Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY-40202, - - 2014
Parstatin, a novel protease activated receptor-1 (PAR-1) derived peptide is a potent inhibitor of angiogenesis. We and others have reported that imbalance between angiogenic growth factors and anti-angiogenic factors results in transition from compensatory cardiac hypertrophy to heart failure in a pressure overload condition. Though cardio protective role of parstatin ...
Raimundo Joana J IPMA, Portuguese Institute of Sea and Atmosphere, Av. Brasília, 1449-006 Lisbon, Portugal. Electronic address: - - 2014
Mercury, methylmercury and selenium were determined in digestive gland, branchial hearts, mantle, kidney and gills of Sepia officinalis from two areas of the south Portuguese coast. To the best of our knowledge these are the first data on Hg, MeHg and Se in branchial hearts, kidney and gills of cuttlefish. ...
Liu Yang Y Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Cardiac Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, - - 2014
Device availability of mechanical circulatory or respiratory support to the right heart has been limited. The purpose of this study was to investigate the effect of right heart unloading and respiratory support with a wearable integrated artificial pump-lung (APL). The APL device was placed surgically between the right atrium and ...
Nagy Anikó I AI Heart and Vascular Centre, Semmelweis University, Budapest, - - 2014
Pulmonary capillary wedge pressure (PCWP) is routinely used as an indirect measure of the left atrial pressure (LAP), although the accuracy of this estimate, especially under pathological hemodynamic conditions, remains controversial. The aim of this prospective study was to investigate the reliability of PCWP for the evaluation of LAP under ...
Kusuyama Takanori T Department of Cardiology, Himeji, Hyogo, - - 2014
Hypertension is a major risk factor for cardiovascular and cerebrovascular events, and most patients with hypertension are administered antihypertensive drugs. However, not all patients achieve normal blood pressure levels. The new angiotensin receptor blocker azilsartan (Takeda Pharmaceutical Company Limited, Osaka, Japan) has been reported to have a strong hypotensive effect. ...
Morris Daniel A DA Charité University Hospital, Berlin, Germany. Electronic address: - - 2014
The aim of this multicenter study was to determine the normal ranges and the clinical relevance of multidirectional systolic parameters to evaluate global left ventricular (LV) systolic function. Three hundred twenty-three healthy adult subjects prospectively included at 10 centers and a cohort of 310 patients with hypertension were analyzed. Multidirectional ...
Bopda Orelien Sylvain Mtopi OS Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, P.O. Box 63 Buea, Cameroon. Electronic address: - - 2014
The leaves of Kalanchoe pinnata (Crassulaceae) are used in Cameroon folk medicine to manage many diseases such as cardiovascular dysfunctions. In this work, we aimed to evaluate the activities of aqueous leaf extract of Kalanchoe pinnata on the blood pressure of normotensive rat (NTR) and salt hypertensive rats (SHR), as ...
Mancusi Costantino C Department of Clinical Science, University of Bergen , Bergen , - - 2014
Objective. We tested the impact of isolated systolic hypertension (ISH) on normalization of left ventricular (LV) structure during antihypertensive treatment. Methods. Baseline and annual echocardiograms were recorded in 873 hypertensive patients with electrocardiographic signs of LV hypertrophy during 4.8 years randomized losartan- or atenolol-based antihypertensive treatment in the Losartan Intervention ...
Elgendi Mohamed M Department of Mathematics and Computing Science, University of Alberta, Edmonton, - - 2014
Pulmonary artery hypertension (PAH) is difficult to recognize clinically. Digital stethoscopes offer an opportunity to re-evaluate the diagnosis of PAH. We hypothesized that spectral analysis of heart sound frequencies using recordings from a digital stethoscope would differ between children with and without PAH. We recorded heart sounds using a digital ...
Witt Chance M CM Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA, - - 2014
The stiff left atrial (LA) syndrome is defined as pulmonary hypertension (PH) secondary to reduced LA compliance and has recently been shown to be one cause of PH after atrial fibrillation (AF) ablation. We aimed to determine the incidence of an increase in pulmonary arterial (PA) pressure post-ablation and examine ...
Ambrosi Pierre P 1 Department of Cardiology, La Timone Hospital, Aix-Marseille University, Marseille, France. 2 Department of Cardiac Surgery, La Timone Hospital, Aix-Marseille University, Marseille, France. 3 Address correspondence to: Pierre Ambrosi, M.D., Ph.D., Department of Cardiology, La Timone Hospital, Aix-Marseille University, 13385 Marseille, - - 2014
How reliable is home blood pressure monitoring (HBPM) in heart transplant recipients is not known. Possibly, it may underestimate hypertensive burden, because blood pressure (BP) nondipper profile is frequent among these patients. This prospective study has been designed to determine whether HBPM adequately identifies hypertension in heart transplant recipients. We ...
Konecny Tomas T Mayo Clinic, Rochester, MN; International Clinical Research Center (ICRC), St. Anne's Hospital, Brno, Czech - - 2014
Objectives We set to measure the inter-atrial pressure gradient during simulated obstructive sleep apnea (OSA). Background OSA occurs when a sleeping patient attempts to inhale against an obstructed airway. How this event affects the inter-atrial pressure gradient has not been defined. We hypothesized that simulated OSA in a conscious subject ...
Aksoy Sukru S Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey. Electronic address: - - 2014
It has been shown that left ventricular diastolic dysfunction (LVDD) develops in patients with metabolic syndrome (MetS). However, there is not sufficient evidence in the literature to determine whether this condition is due to increase in blood pressure, which is frequently encountered in MetS. The purpose of this study was ...
Pieterse Chiné C Hypertension in Africa Research Team, North-West University, Potchefstroom, South - - 2014
Evidence exists that leptin enhances sympathetic activity and may thereby contribute to the development of obesity-related hypertension. Sympathetic activation also seems more prominent in Africans than whites. We compared leptin levels, and different markers of autonomic activity between Africans and whites, and determined whether a relationship exists between leptin and ...
Chompoosan Chayanon C Graduate Program in Animal Physiology, Faculty of Veterinary Science, Chulalongkorn University, Henri Dunant Rd, Patumwan, Bangkok 10330, - - 2014
Heart rate variability (HRV) and echocardiography were performed in 14 dogs with mitral regurgitation (MR) before and after 14days of 0.5mg/kg/day of enalapril treatment. All dogs were in heart failure stages B1 and B2. After enalapril treatment, left ventricular end diastolic diameter (LVEDd), left ventricular end diastolic diameter normalized for ...
Tadic Marijana M University Clinical Hospital Center "Dr. Dragisa Misovic", Heroja Milana Tepica 1, 11000, Belgrade, Serbia, - - 2014
To assess the presence of subclinical left ventricular myocardial dysfunction in subjects with high-normal blood pressure (BP) and untreated arterial hypertension, using three-dimensional (3D) echocardiography strain analysis. This cross-sectional study included 49 subjects with optimal BP, 50 subjects with high-normal BP, and 50 newly diagnosed untreated hypertensive patients matched by ...
Barletta Gina-Marie GM Pediatric Nephrology, Dialysis and Transplantation, Phoenix Children's Hospital, 1919 E Thomas Road, Phoenix, AZ, 85016, USA, - - 2014
Autonomic nervous system dysfunction and sympathetic nervous system over-activity play important roles in the development of hypertension associated with chronic kidney disease (CKD). In adults, increased blood pressure variability (BPV) appears to be directly related to sympathetic over-activity with increased risk of end-organ damage and cardiovascular events. Decreased heart rate ...
Rain S S Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research (ICaR-VU), Amsterdam, The - - 2014
Although pulmonary arterial hypertension originates in the lung and is caused by progressive remodeling of the small pulmonary arterioles, patients die from the consequences of pressure-overload-induced right heart failure. Prognosis is poor, and currently there are no selective treatments targeting the failing right ventricle. Therefore, it is of utmost importance ...
Wang Lifang - - 2014
Background & objectives: The association between α-adducin gene G614T polymorphism and essential hypertension (EH) is not clear. The present study was carried out to examine a possible association between α-adducin gene G614T mutation and essential hypertension in Chinese population. Methods: A total of 170 patients with essential hypertension (EH group) ...
Vilskersts Reinis R Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga, LV-1006, Latvia, Rigas Stradins University, Dzirciema Str. 16, Riga, LV-1007, - - 2014
The administration of magnesium supplements and nitrates/nitrites decreases arterial blood pressure and attenuates the development of hypertension-induced complications. This study was performed to examine the effects of treatment with magnesium nitrate on the development of hypertension and its complications in spontaneously hypertensive (SHR) rats. Male SHR rats with persistent hypertension ...
Andrzejczak Dariusz D Department of Pharmacodynamics, Medical University of Lodz, Lodz, Poland. Electronic address: - - 2014
A growing body of evidence suggests that some cardiovascular drugs could modulate the level of proinflammatory cytokines. Therefore, the aim of the present study was to investigate whether celiprolol, a third generation β-adrenoceptor blocker, affects lipopolysaccharide (LPS)-induced serum concentrations of TNF-α, IL-1β, IL-6 in normotensive (WKY) and spontaneously hypertensive (SHR) ...
Saggar Rajeev R Thoracic Transplantation, Heart-Lung Institute, St Joseph Hospital & Medical Center, , Phoenix, Arizona, - - 2014
Pulmonary hypertension (PH)-targeted therapy in the setting of pulmonary fibrosis (PF) is controversial; the main clinical concern is worsening of systemic hypoxaemia. We sought to determine the effects of gentle initiation and chronic administration of parenteral treprostinil on right heart function in patients with PF associated with an advanced PH ...
Williams J D JD Department of Physics, Wittenberg University, Springfield, Ohio 45504, - - 2014
The spatiotemporal evolution of the naturally occurring dust acoustic wave mode is experimentally investigated in a weakly coupled dc glow discharge dusty plasma system over a range of neutral gas pressures through the application of a time-resolved Hilbert Transform. Frequency clusters are observed over a range of neutral gas pressures, ...
Matsumoto Masayasu M Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, - - 2014
The majority of the patients enrolled in the rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation (J-ROCKET AF) trial had hypertension. In this subgroup analysis, we investigated differences in the safety and efficacy of rivaroxaban and warfarin in subjects with and without hypertension. The baseline blood pressure (BP) measurements ...
Lee Seitetsu L SL Department of Cardiovascular Medicine, University of - - 2014
Background: Right atrial pressure (RAP) is commonly estimated using inferior vena cava (IVC) diameter and its respirophasic variations. Although a guideline has been provided for estimation of RAP due to variation in IVC dimensions based on studies in Western subjects, echocardiographic values in Asian subjects are unknown. Methods and Results: We studied ...
Basson Jacob J Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, - - 2014
Blood pressure (BP) variability has a genetic component, most of which has yet to be attributed to specific variants. One promising strategy for gene discovery is analysis of interactions between single-nucleotide polymorphisms (SNPs) and BP-related factors, including age, sex, and body mass index (BMI). Educational attainment, a marker for socioeconomic ...
Hodson Bryan B Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South - - 2014
A reduced testosterone concentration characterizes heart failure and independently predicts outcomes. Although testosterone replacement therapy may have non-cardiac-related therapeutic benefits in heart failure, whether reduced testosterone concentrations protect against adverse left ventricular remodelling (LV dilatation) is uncertain. We therefore evaluated whether surgical castration modifies LV dilatation following 6 months of ...
Williams Sarah J - - 2014
Rationale: Diastolic dysfunction can lead to heart failure with preserved ejection fraction, for which there is no effective therapeutic. Ranolazine has been reported to reduce diastolic dysfunction, but the specific mechanisms of action are unclear. The effect of ranolazine on diastolic function was examined in spontaneously hypertensive rats (SHR), where ...
Sargento Luis L Heart Failure Unit, Cardiology Department, Pulido Valente Hospital, Lisbon North Hospital Centre, Rua Manuel Costa Silva no 7-2A, 1750-335, Lisbon, Portugal, - - 2014
In patients with acute decompensated systolic heart failure (ADSHF) high resting heart rate (HR) could be either a compensatory mechanism or contribute to worsening heart failure. The aim of this study was to evaluate, in patients with ADSHF and resting HR >70 bpm, the early (within 24 h) and late (at discharge) ...
Cevasco Marisa M Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, - - 2014
Right heart failure is poorly understood and treated. In left heart failure, ventricular restraint can reverse pathologic left ventricular remodeling. The effect of restraint in right heart failure, however, is not known. We hypothesize that ventricular restraint can be applied selectively to the right ventricle (RV) to promote RV reverse ...
Yaman Muhittin O MO Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. - - 2014
The effects of both chronic hypoxia and acute intermittent hypoxia (AIH) on cardiovascular system are unclear. We designed this study to develop a rabbit model of hypertension by exposure to chronic hypobaric hypoxia (CHH) and to investigate the effects of AIH on hypertensive rabbits. Present study was performed in 13 ...
Kadappu Krishna K KK South Western Sydney Clinical School, The University of New South Wales, Sydney, Australia; Cardiology Department, Liverpool Hospital, Liverpool, Australia; Cardiology Department, Campbelltown Hospital, University of West Sydney, Campbelltown, - - 2014
Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality; hence detection of early cardiovascular involvement in CKD is important to prevent future adverse cardiovascular events. Left atrial (LA) enlargement and dysfunction has been reported in end stage renal disease. However, there is a paucity of published data ...
Driessen Mieke M P MM Department of Cardiology, University Medical Center Utrecht, University of Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands, - - 2014
Cardiac magnetic resonance (CMR) imaging is the preferred method to measure right ventricular (RV) volumes and ejection fraction (RVEF). This study aimed to determine the impact of excluding trabeculae and papillary muscles on RV volumes and function in patients with RV pressure and/or volume overload and healthy controls and its ...
Ghossein-Doha Chahinda C 1Department of Obstetrics & Gynecology, Maastricht University Medical Center, Maastricht, the - - 2014
Introduction:Women with former preeclampsia (exPE) develop chronic hypertension 4 times more often than healthy parous controls. Women, destined to develop remote chronic hypertension, had increased left ventricular mass index (LVMI) and diastolic blood pressure (BP) prior to the onset of hypertension as compared to those remaining normotensive. However, longitudinal data ...
Scansen B A BA Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, - - 2014
The prevalence of systemic hypertension (SHT) in Shetland Sheepdogs has not been reported. SHT is common in Shetland Sheepdogs and positively correlated with proteinuria. Measurements of forelimb and hindlimb systolic arterial pressure (SAP) are comparable. Seventy-two clinically healthy, client-owned Shetland Sheepdogs. Forelimb and hindlimb SAP were recorded by Doppler ultrasonography. ...
Tsubone Hirokazu H 1 Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo, Japan - - 2014
Abstract The present study aimed to clarify the effects of Agaricus brasiliensis KA21 (i.e., Agaricus blazei) mushroom on circulatory function. Spontaneously hypertensive rats (SHRs) were fed 10% A. blazei-containing pellets (agaricus group) or normal pellets (control group) for 5 weeks from 6 to 11 weeks of age. For Experiment 1, ...
Courand Pierre-Yves PY Cardiology Department, European Society of Hypertension Excellence Centre, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France; Génomique Fonctionnelle de l'Hypertension Artérielle, EA 4173, Université Claude-Bernard Lyon-1, Villeurbanne, France; Hôpital Nord-Ouest, Villefranche-sur-Saône, France. Electronic address: - - 2014
Many epidemiological studies have demonstrated that resting heart rate is a risk marker but also a risk factor in patients with coronary artery disease and heart failure. In hypertensive subjects free from overt cardiac disease, the question has been less frequently addressed. A few cohort studies have shown that hypertensive ...
Peacock W Frank WF Baylor College of Medicine, Houston, TX. Electronic address: - - 2014
Rapid blood pressure (BP) control improves dyspnea in hypertensive acute heart failure (AHF). Although effective antihypertensives, calcium-channel blockers are poorly studied in AHF. Clevidipine is a rapidly acting, arterial selective intravenous calcium-channel blocker. Our purpose was to determine the efficacy and safety of clevidipine vs standard-of-care intravenous antihypertensive therapy (SOC) ...
Derad Inge I Department of Internal Medicine and Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany; and Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, - - 2014
Intranasal administration of angiotensin II (ANGII) affects blood pressure in a mode different from intravenously administered ANGII via a direct access to the brain bypassing the blood-brain barrier. This clinical study investigated blood pressure regulation after intranasal ANGII administration in healthy humans, whereas systemic, blood-mediated effects of ANGII were specifically ...
Witham Miles D MD Ageing and Health, Department of Clinical Pharmacology, Department of Clinical Imaging, and Hypertension Research Centre and Medicines Monitoring Unit, University of Dundee, Dundee, United Kingdom; and Department of Medical Physics, National Health Service Tayside, Dundee, United - - 2014
Low 25-hydroxyvitamin D levels are associated with higher prevalent blood pressure. We tested whether high-dose intermittent oral vitamin D therapy could reduce blood pressure and left ventricular mass in patients with hypertension resistant to conventional treatment. We conducted a parallel-group, double-blind, randomized placebo-controlled trial. Patients with supine office blood pressure ...
Yoshida Seiji S Department of Pediatrics, Osaka Medical College, Osaka, - - 2014
Postural tachycardia syndrome (POTS) shows a marked tachycardia while standing. We noticed two forms of circulatory response to orthostatic stress in POTS. We investigated cardiovascular and autonomic nervous response to orthostatic stress in two forms. We studied 79 patients with POTS and 38 healthy control subjects (Ct). Beat-to-beat blood pressure ...
Lang Nora N Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, - - 2014
Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well within wet and highly dynamic environments within the body. This is especially relevant to minimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe ...
Matsukawa Ryuichi R aDepartment of Cardiovascular Medicine bDepartment of Advanced Cardiovascular Regulation and Therapeutics, Kyushu University Graduate School of Medical Sciences, Maidashi, Higashi-ku, Fukuoka, - - 2014
Neuregulin-1 (NRG-1)/ErbB signaling in the heart is reported to have a crucial role in heart failure. We recently demonstrated that NRG-1 signaling has sympathoinhibitory effects in the brain cardiovascular control center. How this central signaling impacts sympathoexcitation in heart failure, however, is unknown. Here we examined the role of central ...
Thibodeau Jennifer T JT Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, - - 2014
This study sought to examine the frequency and hemodynamic correlates of shortness of breath when bending forward, a symptom we have termed "bendopnea." Many heart failure patients describe bendopnea such as when putting on their shoes. This symptom has not previously been characterized. We conducted a prospective study of 102 ...
Vikholm Per P Department of Cardiothoracic Surgery, Uppsala University Hospital, Uppsala, - - 2014
Right ventricular failure after left ventricular assist device implantation is a serious complication with high rates of mortality and morbidity. It has been demonstrated in experimental settings that volume exclusion of the right ventricle with a modified Glenn shunt can improve haemodynamics during ischaemic right ventricular failure. However, the concept ...
Ishizu Tomoko T Cardiovascular Division, Faculty of Medicine, and Department of Medical Science, University of Tsukuba, Tsukuba, - - 2014
Left ventricular (LV) systolic wall strain is a new candidate for prognostic indicator of hypertensive heart failure. It remains unclear how underlying transmural structural remodeling corresponds to LV wall systolic deformation as hypertensive hypertrophy progresses. We fed 68 Dahl salt-sensitive rats a high-salt (hypertensive group) or low-salt diet (control group) ...
Zile Michael R MR 1Division of Cardiology, Department of Medicine, Medical University of South Carolina, and RHJ Department of Veterans Affairs Medical Center, Charleston, - - 2014
-While matrix metalloproteinases (MMPs) were initially thought to primarily result in extracellular matrix degradation, certain MMP types such as membrane type-1 MMP (MT1-MMP) may also be involved in profibrotic cascades through hydrolysis of latency-associated transforming growth factor (TGF) binding protein (LTBP-1) and activation of TGF dependent profibrotic signaling. The present ...
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