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Results 101 - 150 of 1706
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da Cunha Daise N Q DN Veterinary Department, Federal University of Viçosa, Viçosa, - - 2014
The mechanisms of production, and gross, microscopic and electrocardiograhic findings of surgically-induced complete heart block (CHB) in the adult rat are presented. This is an effective in vivo model for establishing alternative methods to electronic pacemakers and for providing detailed information aimed at replacement, reduction and refinement of the technique. ...
Hankey Graeme J GJ From the School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Duke Clinical Research Institute (S.R.S., J.P.P., Y.L., M.R.P.) and Duke Translational Medicine Institute (R.M.C.), Duke University Medical Center, Durham, NC; Department of Medicine, Stanford University, CA (K.W.M.); Cardiovascular Institute, Mount Sinai Medical Center, New York (J.L.H.); Department of Cardiovascular Medicine, Hospital of the University of Münster, Münster, Germany (G.B.); Massachusetts General Hospital and Harvard Medical School, Boston (D.E.S.); University of Cincinnati College of Medicine, OH (R.C.B.); Department of Global Clinical Development, Bayer HealthCare Pharmaceuticals, Whippany, NJ (S.D.B.); Cerenis Therapeutics, Labege, France (J.F.P.); Janssen Research and Development, Raritan, NJ (C.C.N.); Ruprecht- Karls-University, Heidelberg, Germany (W.H.); and University of Edinburgh and Royal Infirmary of Edinburgh, Edinburgh, United Kingdom - - 2014
Intracranial hemorrhage (ICH) is a life-threatening complication of anticoagulation. We investigated the rate, outcomes, and predictors of ICH in 14 264 patients with atrial fibrillation from Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET ...
Hoshino Atsushi A 1Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, - - 2014
-Mitochondrial compromise is a fundamental contributor to heart failure. Recent studies have revealed that several surveillance systems maintain mitochondrial integrity. The present study evaluated the role of mitochondrial AAA+ protease in a mouse model of pressure overload heart failure. -The FITC-casein assay and immunoblotting for endogenous mitochondrial proteins revealed a ...
Muntner Paul P Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL; Department of Medicine, University of Alabama at Birmingham, Birmingham, - - 2014
Few randomized trials have compared visit-to-visit variability (VVV) of systolic blood pressure (SBP) across drug classes. The authors compared VVV of SBP among 24,004 participants randomized to chlorthalidone, amlodipine, or lisinopril in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). VVV of SBP was calculated across 5 ...
Salinas Carlos E CE Instituto Boliviano de Biología de Altura, Facultad de Medicina, Universidad Mayor de San - - 2014
Background: By combining the chick embryo model with incubation at high altitude (HA), the effects of chronic hypoxia on fetal growth, fetal cardiac and aortic wall remodeling and systemic arterial blood pressure at adulthood were reported. Using non-invasive functional echocardiography, here we investigated the in vivo effects of HA hypoxia on ...
Naderi Nasim N Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences; Tehran-Iran. - - 2014
There is conflicting data regarding the tricuspid annular velocities and their relation to right ventricular filling pressures. We aimed to assess if the time interval between the onset of tricuspid E wave and annular Ea wave has any correlation with right sided filling pressure in patients with heart failure. Thirty ...
Wang Wang W Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, T6G 2S2, - - 2014
Angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II into Ang 1-7 thereby negatively regulating the renin-angiotensin system. However, heart disease in humans and in animal models is associated with only a partial loss of ACE2. ACE2 is an X-linked gene; and as such, we tested the clinical relevance of a partial ...
Strowd Roy E RE From the Department of Neurology, Wake Forest School of Medicine, Winston-Salem, - - 2014
A 32-year-old woman with a history of bipolar disorder, polycystic ovarian syndrome, and hypertension and a 4-year history of uncontrolled type 2 diabetes mellitus (DM) presented with bifrontal headache, elevated blood sugars (>500 mg/dL), and abrupt-onset left homonymous hemianopia upon awakening. Vital signs included temperature 98.0°F, blood pressure 160/89 mm ...
Oliver Jose M JM Adult Congenital Heart Disease Unit, La Paz University Hospital Madrid, Spain; Division of Cardiology, La Paz University Hospital Madrid, Spain. Electronic address: - - 2014
Adults with repaired coarctation of the aorta (CoA) are at risk for premature cardiovascular death or heart failure (HF). We sought to evaluate risk factors for death or HF in young adults with repaired CoA in childhood. The medical records of a cohort of 159 adults diagnosed with CoA repaired ...
Neumayr Günther G Medical Practice, Lienz, Austria (Dr Neumayr). Electronic address: - - 2014
Physical activity is a cornerstone in therapy for patients with metabolic syndrome. Walking and hiking in a mountain scenery represents an ideal approach to make them move. The Austrian Moderate Altitude Study (AMAS) 2000 main study is a randomized controlled trial to investigate the cardiovascular effects of hiking at moderate ...
Ulanovsky I I Departments of Neonatology, Rambam Health Care Campus, Technion-Israel Institute of Technology, Haifa, - - 2014
Objective:Apnea of prematurity is a common complication in premature newborns and caffeine is a widespread medication used to treat this complication. Caffeine may have adverse effects on the cardiovascular and central nervous system, yet its effects on the autonomic nervous system modulation of heart rate have not been studied in ...
Tomkiewicz-Pajak Lidia - - 2014
Objectives: Increased arterial stiffness is a risk factor of atherosclerosis and cardio-vascular complications. The aim of the study was to determine whether peripheral vascular function might be an early marker of impaired health status in patients with a single ventricle after Fontan procedure.Methods and results: Twenty five consecutive adults (11 ...
Gorter Thomas M TM Department of Pediatric Cardiology, Center for Congenital Heart Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, - - 2014
In patients with severe pulmonary valve regurgitation or stenosis, pulmonary valve replacement (PVR) has a favourable effect on right ventricular (RV) volume and pressure unloading. PVR thereby decreases the progression of RV dilatation and/or hypertrophy. This study investigates RV remodelling patterns after PVR in patients with either pressure, volume or ...
Minkley Nina N Faculty of Biology and Biotechnology, Behavioural Biology and Biology Education, Ruhr-Universität Bochum, Bochum, Germany. Electronic address: - - 2014
The combined administration of physiological (cold pressor) and psychological (social-evaluative threat) stressors, as in the socially evaluated cold pressor test (SECPT; Schwabe et al., 2008) activates the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. Thus far, the SECPT has been administered exclusively to individual participants, which requires substantial ...
López-Candales Angel A Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, - - 2014
Even though systolic eccentricity index has been traditionally categorized based on right ventricular (RV) pressure overload, which hemodynamic component is particularly responsible for modulating leftward ventricular septal bowing (LVSB) in chronic pulmonary arterial hypertension (PAH) is less well-known. Therefore, currently used echocardiographic variables, as suggested by the American Society of ...
Schöbel Christoph C Sleep Medicine Center, Charité Universitätsmedizin Berlin, Berlin, Germany; Center for Cardiology and Angiology, Charité Universitätsmedizin Berlin, Berlin, - - 2014
In patients with obstructive sleep apnea heart rate variability and baroreceptor sensitivity during night and daytime are impaired. Snoring without obstructive sleep apnea may already influence heart rate variability and baroreceptor sensitivity during daytime. Cardiovascular daytime testing was performed in 11 snorers and age, BMI, and gender matched controls. Sleep ...
Díez Javier J Department of Cardiovascular Sciences, Centre of Applied Medical Research, Pamplona, Spain; Department of Cardiology and Cardiac Surgery, University Clinic, Pamplona, Spain; University of Navarra, Pamplona, Spain. Electronic address: - - 2014
Hypertensive heart disease (HHD) has been considered the adaptive hypertrophy of the left ventricle wall to increased blood pressure. Recent findings in hypertensive animals and patients now challenge this paradigm by showing that HHD also results from pathologic structural remodeling of the myocardium in response to hemodynamic and nonhemodynamic factors ...
Jhund Pardeep S PS Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, - - 2014
The first in class angiotensin receptor neprilysin inhibitor, LCZ696 has been shown to reduce levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), reduce left atrial size and improve New York Heart Association (NYHA) class in patients with heart failure with preserved ejection fraction (HFpEF). We examined whether the effects of LCZ696 ...
Ruhparwar Arjang A Department of Cardiac Surgery, University Hospital of Heidelberg, Heidelberg, - - 2014
Research into the development of artificial heart muscle has been limited to assembly of stem cell-derived cardiomyocytes seeded around a matrix, while nonbiological approaches to tissue engineering have rarely been explored. The aim of the study was to apply electrically contractile polymer-based actuators as cardiomyoplasty for positive inotropic support of ...
Tadic Marijana M aUniversity Clinical Hospital Center 'Dr Dragisa Misovic' bClinical Centre of Serbia, Clinic of Cardiology cUniversity Clinical Hospital Center 'Zemun' dFaculty of Medicine, University of Belgrade, Belgrade, Serbia eClinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, - - 2014
The aim of this study was to examine the relationship between increasing blood pressure (BP) and right ventricular (RV) and right atrial (RA) mechanics using two-dimensional echocardiography (2DE) strain analysis and three-dimensional echocardiography (3DE). This cross-sectional study included 58 individuals with optimal BP, 57 individuals with high-normal BP, and 59 ...
Bassareo Pier Paolo PP Unit of Cardiology and Angiology, Department of Medical Sciences ?M. Aresu?, University of Cagliari, Cagliari, - - 2014
Cigarette smoking is an important modifiable cardiovascular risk factor associated with increased stiffness of the large arteries in adulthood. This study aimed to 1) evaluate arterial distensibility and echocardiographic measures in adolescent smokers before and after participation in a successful smoking cessation program and to 2) compare the findings obtained ...
Bajpai Jugal Kishore JK Post Graduate-III, Department of Physiology, Shri Ram Murti Smarak Institute of Medical Sciences , Bareilly, Uttar Pradesh, India - - 2014
Awareness of prevalence, determinants, and prognosis of asymptomatic untreated prehypertension is still lacking especially in India and subcontinent. The present study was to assess the effects of prehypertension on structure, function and geometrical pattern of left ventricle on the basis of left ventricular mass (LVM), left ventricular mass indexed to ...
Tanasă Ionela-Alina - - 2014
The analysis of supraventricular rhythm disorders encountered in hypertensive patients and the establishment of correlations with other associated risk factors, duration of hypertension, the evolution and prognosis. The study included a group of 110 patients, 80 men and 30 women, aged between 40 and 85, admitted in the 1st Cardiology ...
Amirkhizi Alireza A Mech. Eng., Univ. of Massachusetts, Lowell, Perry Hall 331, 197 Riverside St., Lowell, MA 01854, - - 2014
Metamaterials have shown great potential to transform the design of acoustic components in many applications. Many composites with extreme properties have been envisioned, designed, fabricated, and experimentally verified. The next step involves testing such composites in realistic application environments. Oceans are one such environment in which the mechanical effects of ...
Wang Lu L Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, - - 2014
Vitamin D is involved in blood pressure (BP) regulation. Genetic variations may influence the effect of vitamin D on BP, but data from epidemiologic studies remain inconsistent. We conducted a comprehensive genetic association study in the Women's Genome Health Study (WGHS) with genome-wide genotype data among 23,294 women of European ...
Linz Dominik D Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, Geb. 40, 66421, Homburg/Saar, Germany, - - 2014
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Currently, atrial endocardial catheter ablation, mainly targeting focal discharges in the pulmonary veins, is the most widely used interventional treatment of drug-refractory AF. Despite technical improvements, results are not yet optimal. There is ...
Peters Christian D CD 1] Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark [2] Institute of Clinical Medicine, Aarhus University, Aarhus, - - 2014
Agents blocking the renin-angiotensin-aldosterone system are frequently used in patients with end-stage renal disease, but whether they exert beneficial cardiovascular effects is unclear. Here the long-term effects of the angiotensin II receptor blocker, irbesartan, were studied in hemodialysis patients in a double-blind randomized placebo-controlled 1-year intervention trial using a predefined ...
Pai Vidya B VB Department of Internal Medicine-Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. Electronic address: - - 2014
Platypnea-orthodeoxia is a rare syndrome characterized by dyspnea and hypoxemia that is exacerbated by assuming an upright position. The most common cause is intracardiac shunting through an atrial septal defect or patent foramen ovale (PFO). We present a 63-year-old man with dyspnea after right pneumonectomy for lung cancer, who was ...
Finkelhor Robert S RS Heart and Vascular Center, Case Western Reserve University at the MetroHealth Medical Center Campus, Cleveland, - - 2014
Because many recent studies have questioned the accuracy of Doppler echocardiography (D) in determining pulmonary artery systolic pressure (PASP), we performed a detailed literature analysis attempting add clarity. Studies through 2011 comparing D and right heart catheterization (RHC) PASP, with at least 25 studied patients and reporting correlation coefficients (r) ...
Vallecilla Carolina C Group of Biomedical Engineering, Universidad de los Andes, Bogotá, - - 2014
The considerable blood mixing in the bidirectional Glenn (BDG) physiology further limits the capacity of the single working ventricle to pump enough oxygenated blood to the circulatory system. This condition is exacerbated under severe conditions such as physical activity or high altitude. In this study, the effect of high altitude ...
Stevens Michael C MC Innovative Cardiovascular Engineering and Technology Laboratory, The Prince Charles Hospital, Brisbane, Queensland, Australia; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia; School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Queensland, - - 2014
Dual rotary left ventricular assist devices (LVADs) have been used clinically to support patients with biventricular failure. However, due to the lower vascular resistance in the pulmonary circulation compared with its systemic counterpart, excessively high pulmonary flow rates are expected if the right ventricular assist device (RVAD) is operated at ...
Rajagopal Sudarshan S Department of Medicine, Duke University Medical Center, Durham, North Carolina. Electronic address: - - 2014
Right ventricular (RV) function is a strong predictor of mortality in pulmonary hypertension (PH), but two-dimensional (2D) echocardiography-derived assessments of RV function that could aid in risk assessment and management of patients with PH are of limited utility. RV longitudinal peak systolic strain (RVLS) derived from 2D speckle-tracking echocardiography is ...
Mariño Guillermo G Equipe 11 labelisée par la Ligue Nationale contre le Cancer; INSERM U1138; Centre de Recherche des Cordeliers; Paris, France; Metabolomics and Molecular Cell Biology Platforms; Gustave Roussy; Villejuif, France; Université Paris Descartes/Paris 5; Paris, - - 2014
It has been a longstanding problem to identify specific and efficient pharmacological modulators of autophagy. Recently, we found that depletion of acetyl-coenzyme A (AcCoA) induced autophagic flux, while manipulations designed to increase cytosolic AcCoA efficiently inhibited autophagy. Thus, the cell permeant ester dimethyl α-ketoglutarate (DMKG) increased the cytosolic concentration of ...
Phan Jennifer K JK Doctor of Pharmacy Program, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, - - 2014
To evaluate the effects of caffeinated energy shots compared with noncaffeinated energy shots as assessed by changes in peripheral and central hemodynamic parameters in healthy subjects. Randomized, double-blind, controlled crossover study. University campus. Ten healthy volunteers. Subjects were randomized to receive either a caffeinated or noncaffeinated energy shot; after a ...
Park Seong-Mi SM Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of - - 2014
Percutaneous coronary interventions (PCIs) are increasingly being used to treat unprotected left main coronary artery (ULMCA) lesions. However, research is sparse on the acute changes of left ventricular (LV) hemodynamics and function during PCI in patients with ULMCA stenosis. We aimed to assess the acute changes of LV function using ...
Fenster Brett E BE Division of Cardiology, National Jewish Health, Denver, Colorado, - - 2014
Cystatin C (CysC), a novel marker of renal function, predicts left heart failure and cardiovascular mortality. The hypothesis that serum CysC levels correlate with right ventricular (RV) morphology, function and pressure in pulmonary arterial hypertension (PAH) was tested. As part of a prospective study, 14 PAH subjects and 10 matched ...
Parajuli Nirmal - - 2014
Oxidative stress plays a key pathogenic role in experimental and human heart failure. However, the source of the reactive oxygen species is a key determinant of the cardiac adaptation to pathological stressors. Human dilated cardiomyopathy is associated with increased NOX2 levels, increased oxidative stress with adverse myocardial remodeling, and activation ...
Tsioufis C C First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, - - 2014
Transluminal renal sympathetic denervation (RDN) reduces blood pressure (BP) in patients with drug-resistant uncontrolled hypertension. We assessed the effect of RDN on heart rate, supraventricular and ventricular ectopic activity and indexes of heart rate variability in 14 patients with drug-resistant uncontrolled hypertension who were all responders to RDN (defined as ...
Aune Sverre E SE Gazes Cardiac Research Institute, 114 Doughty St., Medical University of South Carolina, Charleston, SC 29425, - - 2014
While inhibition of class I/IIb histone deacetylases (HDACs) protects the mammalian heart from ischemia reperfusion (IR) injury, class selective effects remain unexamined. We hypothesized that selective inhibition of class I HDACs would preserve left ventricular contractile function following IR in isolated hearts. Male Sprague Dawley rats (n=6 per group) were ...
Sundblad Patrik P 1Swedish Aerospace Physiology - - 2014
Changes in posture cause blood volume redistribution, affecting cardiac filling and stroke volume (SV). We hypothesized that the time courses of ventricular filling would differ between the right and left ventricle during a rapid (2 sec) tilt, and that changes in right ventricular filling pressure would be more swift because ...
Reuter Stefanie S Klinik für Innere Medizin III, AG Experimentelle Nephrologie, Universitätsklinikum Jena, D-07743, Jena, - - 2014
The diffusion of oxygen as the sole mechanism is by far too inefficient to meet the required energy demand of human life. The mechanism of convection by an oxygen transporter made higher multicellular live on earth possible. In this context evolution has brought up the cardiovascular system with the heart ...
Antonakis Velissaris V First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, - - 2014
The evolution of QT interval and its dispersion (QTd) were studied in 135 newly diagnosed nondiabetic patients, as well as the relationship between changes of these left ventricular (LV) repolarization parameters with blood pressure (BP) and LV mass changes, which were prospectively studied for a median period of 3.8 years. At ...
Schampaert S S Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands. Department of Cardiology, Catharina Hospital Eindhoven, PO Box 1350, 5602 ZA Eindhoven, The - - 2014
The aim of this study was to develop an integrated mock circulation system that functions in a physiological manner for testing cardiovascular devices under well-controlled circumstances. In contrast to previously reported mock loops, the model includes a systemic, pulmonary, and coronary circulation, an elaborate heart contraction model, and a realistic ...
Macinnis Martin J MJ School of Kinesiology (Mr MacInnis, Ms Koch, Ms MacLeod, Mr Carter, Ms Jain, and Drs Koehle and Rupert). Electronic address: - - 2014
The purposes of this experiment were to determine the repeatability of acute mountain sickness (AMS), AMS symptoms, and physiological responses across 2 identical hypoxic exposures. Subjects (n = 25) spent 3 nights at simulated altitude in a normobaric hypoxia chamber: twice at a partial pressure of inspired oxygen (PIO2) of ...
Nadir M Adnan MA 1Department of Cardiology, University Hospital Birmingham NHS Foundation Trust, Birmingham, United - - 2014
-A paradoxical inspiratory rise in right atrial pressure (RAp, in contrast to the normal fall during inspiration), Kussmaul's sign, has been described in CHF. However, the clinical and hemodynamic characteristics, and clinical outcomes of patients with CHF and Kussmaul physiology have not been studied. -This is a single-centre study of ...
Witschey Walter R T WR Gorman Cardiovascular Research Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, - - 2014
Rapid determination of the left ventricular (LV) pressure-volume (PV) relationship as loading conditions are varied is the gold standard for assessment of LV function. Cine magnetic resonance imaging (MRI) does not have sufficient spatiotemporal resolution to assess beat-to-beat changes of the LV PV relationship required to measure the LV end-systolic ...
Kitagawa Yoji Y Department of Health Sciences, Kansai University of Health Sciences, , Osaka, - - 2014
To clarify changes in the cardiovascular autonomic nervous system function due to trigger point acupuncture, we evaluated differences in responses between acupuncture at trigger points and those at other sites using spectral analysis of heart rate variability. Subjects were 35 healthy men. Before measurements began the subjects were assigned to ...
Ram C V S CV 1] Apollo Institute for Blood Pressure Management, Apollo Blood Pressure Clinics, Apollo Hospitals, Hyderabad, India [2] Texas Blood Pressure Institute, University of Texas Southwestern Medical School, Dallas, TX, - - 2014
Severe hypertension (systolic blood pressure (BP) 160 mm Hg) resistant to treatment with multiple antihypertensive medications, poses a serious challenge to therapeutic treatment. Catheter-based renal denervation (RDN) is being increasingly proposed and researched as a safe and effective method of treating this condition. This article evaluates the existing evidence on the effects ...
Iwanami Jun J Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Shitsukawa, Ehime, - - 2014
The possible counteracting effect of angiotensin (Ang)-converting enzyme (ACE)2/Ang-(1-7)/Mas axis against the ACE/Ang II/Ang II type 1 (AT1) receptor axis in blood pressure control has been previously described. We examined the possibility that this pathway might be involved in the anti-hypertensive effect of a newly developed AT1 receptor blocker (ARB), ...
Benetti Elisabetta E Department of Medicine, University of Padova, Padua, - - 2014
The objective of this study was to determine the accuracy of the Thermor BIOS BD215 device for home blood pressure (BP) measurement according to the International Protocol of the European Society of Hypertension (ESH). Device evaluation was carried out in 33 patients. The mean age of the patients was 57.0±15.0 ...
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