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Figueroa Juan J JJ Department of Neurology, Mayo Clinic, Rochester, MN, United - - 2014
Whether non-dipping - the loss of the physiologic nocturnal drop in blood pressure - among patients with postural tachycardia syndrome (POTS) is secondary to autonomic neuropathy, a hyperadrenergic state, or other factors remains to be determined. In 51 patients with POTS (44 females), we retrospectively analyzed 24-hour ambulatory blood pressure ...
Schwarzer Michael M Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich Schiller University of Jena, Jena, - - 2014
Aim: We investigated the impact of cardiac reactive oxygen species (ROS) during the development of pressure overload (PO) induced heart failure (HF). We used our previously described rat model where transverse aortic constriction (TAC) induces compensated hypertrophy after 2 weeks, heart failure with preserved ejection fraction at 6 and 10 ...
Pliquett Rainer U - - 2014
Dysregulation of the autonomic nervous system is frequent in subjects with cardiovascular disease. The contribution of different forms of renovascular hypertension and the mechanisms contributing to autonomic dysfunction in hypertension are incompletely understood. Here, murine models of renovascular hypertension with preserved (2-kidneys-1 clip, 2K1C) and reduced (1-kidney-1 clip, 1K1C) kidney ...
Sala-Mercado Javier A JA Wayne State - - 2014
The cardiopulmonary baroreflex responds to an increase in central venous pressure (CVP) by decreasing total peripheral resistance and increasing heart rate (HR) in dogs. However, the direction of ventricular contractility change is not well understood. The aim was to elucidate the cardiopulmonary baroreflex control of ventricular contractility during normal physiologic ...
DuBay Shane G SG Department of Biology, Museum of Southwestern Biology, University of New Mexico, 167 Castetter Hall MSC03 2020, 1 University of New Mexico, 87131, Albuquerque, - - 2014
The tropical Andes are a global hotspot of avian diversity that is characterized by dramatic elevational shifts in community composition and a preponderance of recently evolved species. Bird habitats in the Andes span a nearly two-fold range of atmospheric pressure that poses challenges for respiration, thermoregulation, water balance, and powered ...
Badheka Apurva O AO Detroit Medical Center, Detroit, - - 2014
Many medications used to treat atrial fibrillation (AF) also reduce blood pressure (BP). The relation between BP and mortality is unclear in patients with AF. We performed a post hoc analysis of 3,947 participants from the Atrial Fibrillation Follow-Up Investigation of Rhythm Management trial. Systolic blood pressure (SBP) and diastolic ...
Brehm Christoph C Heart and Vascular Institute, Penn State Milton S. Hershey Medical Center, Hershey, PA, - - 2014
The impact of extracorporeal membrane oxygenation (ECMO) support on coronary blood flow and left ventricular unloading is still debated. This study aimed to further characterize the influence of ECMO on coronary artery blood flow and its ability to unload the left ventricle in a short-term model of acute cardiogenic shock. ...
Maharaj Nirvarthi N Division of Cardiology, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South - - 2014
Left ventricular (LV) twist may be a compensatory mechanism to preserve ejection fraction (EF). In patients with hypertension, twist varies depending on the left ventricle's degree of remodeling and systolic function; it is increased in those with hypertension with normal EF (HTNEF) and diminished in those with hypertension with low ...
Sparks Joshua D JD Division of Pediatric Cardiology, Department of Pediatrics, University of Louisville, Louisville, KY, - - 2014
BNP is increasingly utilized in the management of pediatric HT recipients. Performing a retrospective single-center chart review, we sought to describe BNP changes during the first year after HT and identify factors that affect its trend. After exclusion for rejection, 316 BNP levels from 50 patients were evaluated. BNP underwent ...
Castro Pedro Miguel PM Hospital São João, Faculty of Medicine, University of Porto - - 2014
The role of autonomic nervous system (ANS) in adapting cerebral blood flow (CBF) to arterial blood pressure (ABP) fluctuations (cerebral autoregulation, CA), is still controversial. We aimed to study the repercussion of autonomic failure (AF) on dynamic CA during the Valsalva maneuver (VM). Eight AF subjects with familial amyloidotic polineuropahty ...
Tilman V V The Sheba Medical Center, Rehabilitation Hospital, Ramat Gan, Israel. Electronic address: - - 2014
Atrial fibrillation in heart failure often occur together. The relationship between atrial fibrillation and heart failure has remained a subject of research. The main manifestation of the violation of hydrodynamics in heart failure is the increased end-diastolic pressure, which is transmitted through the intercommunicated system (left ventricle-left atrium-pulmonary veins-alveolar capillaries) ...
Yoo Kyung Y KY Departments of *Anesthesiology and Pain Medicine ‡Physiology, Chonnam National University Medical School, Gwangju, South Korea †Cephalogics, LLC, Cambridge, - - 2014
Near-infrared spectroscopy assesses cerebral tissue oxygen saturation (Scto2) based on the absorption spectra of oxygenated and deoxygenated hemoglobin. It has been reported that IV-administered dyes including methylene blue, indigo carmine, and indocyanine green (ICG) may cause falsely low-pulse oximetry readings (Spo2). Although methylene blue and indigo carmine may also decrease ...
Chen Wan W aDepartment of Cardiology, First People's Hospital, Chongqing Departments of bCardiology cNursing, Tangdu Hospital dSchool of Public Health, Fourth Military Medical University, Xi'an, - - 2014
This study aimed to validate the Pangao PG-800B5 upper arm blood pressure monitor according to the European Society of Hypertension International Protocol revision 2010. A total of 33 participants, 16 men and 17 women, were included in the device evaluation. The mean age of the participants was 56.4±21.0 years (range ...
Biondi David M DM US Medical Affairs, Janssen Scientific Affairs, LLC, 1125 Trenton Harbourton Road, Titusville, NJ, 08560, USA, - - 2014
Hypertension is one of the most common co-existing conditions in patients with chronic pain, and the potential effects of an analgesic on heart rate and blood pressure are of particular concern for patients with hypertension. The purpose of this analysis was to evaluate changes in blood pressure and heart rate ...
Bettex Dominique A DA Anesthesiology, University Hospital Zürich, Rämistrasse 100, Zurich, ZH 8091, Switzerland - - 2014
A carrier system for gases and nutrients became mandatory when primitive animals grew larger and developed different organs. The first circulatory systems are peristaltic tubes pushing slowly the haemolymph into an open vascular tree without capillaries (worms). Arthropods developed contractile bulges on the abdominal aorta assisted by accessory hearts for ...
Kamali Hacer - - 2014
Hemodynamically significant muscular ventricular septal defects in children after the infantile period are a rare occurrence and ideal for transcatheter closure. In cases of severe concomitant pulmonary hypertension, it may be necessary to fenestrate the device. In this report, we present an 18-year old patient with a large mid-trabecular ventricular ...
Barin Gokhan G Department of Chemistry, Northwestern University , 2145 Sheridan Road Evanston, Illinois 60208, United - - 2014
We successfully demonstrate an approach based on linker fragmentation to create defects and tune the pore volumes and surface areas of two metal-organic frameworks, NU-125 and HKUST-1, both of which feature copper paddlewheel nodes. Depending on the linker fragment composition, the defect can be either a vacant site or a ...
Fujimoto Kazuto K Department of Pediatrics,National Cerebral and Cardiovascular - - 2014
To date, no transcatheter valve has been approved for placement in the pulmonary position in Japan. Consequently, percutaneous balloon dilatation may be advised for stenotic right ventricular outflow lesions; however, technical difficulties persist, particularly in adults. We describe the acute haemodynamic changes and outcome of balloon dilatation of right ventricular ...
Boe Espen E Institute for Surgical - - 2014
Cardiac resynchronization therapy (CRT) has been proposed in heart failure patients with narrow QRS, but the mechanism of a potential beneficial effect is unknown. This study investigates the hypothesis that LV pacing increases LV end-diastolic volume (EDV) by allowing the LV to start filling before the RV during narrow QRS ...
Cameli Matteo M Department of Medical Biotechnologies, University of Siena, Italy; Unit of Cardiovascular Diseases, University of Siena, - - 2014
Pulse pressure variation (PPV) is a dynamic index of fluid responsiveness. This parameter helps clinicians in improving haemodynamic status while avoiding potential fluid overload. Echocardiographic indices, such as E/E' ratio and left atrial (LA) strain by speckle tracking echocardiography (STE), are used to estimate left ventricular (LV) filling pressures. This ...
Wienemann H H Department of Cardiology Asklepios Clinic St. Georg, Hamburg, Germany - - - 2014
Arterial hypertension is a frequent, chronic disease, which is one of the main risk factor for cardiovascular and renal diseases such as heart failure, chronic kidney disease, hypertensive heart disease, stroke as well as cardiac arrhythmias. In the clinical setting it remains challenging to accomplish the thresholds of guideline blood ...
Tadic Marijana M aUniversity Clinical Hospital Center 'Dr Dragisa Misovic' bClinical Centre of Serbia, Clinic for Cardiology cMedical School of Belgrade, University of Belgrade, Belgrade, - - 2014
The influence of arterial hypertension on functional capacity is poorly understood. Studies have shown that peak oxygen consumption has been reduced in hypertensive patients, but the mechanisms are unclear. Left ventricular systolic and diastolic dysfunction, as well as left ventricular hypertrophy, are associated with lower functional capacity in patients with ...
Uemura Kazunori K Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, 565-8565, Japan, - - 2014
Assessing left ventricular (LV) filling pressure (pulmonary capillary wedge pressure, PCWP) is an important aspect in the care of patients with heart failure (HF). Physicians rely on right ventricular (RV) filling pressures such as central venous pressure (CVP) to predict PCWP, assuming concordance between CVP and PCWP. However, the use ...
Shin Soo-Myoung SM Korea University School of Medicine , Seoul , Republic of Korea - - 2014
Abstract The number of young adults with hypertension (HT) is increasing. We investigated the changes of left ventricular (LV) function and their relationship to the ambulatory blood pressure monitoring (ABPM) parameters in young adults with never-treated HT and no LV hypertrophy. Consecutive young patients (29.5 ± 5.9 years) with first diagnosed primary ...
Stembridge Mike M Cardiff Metropolitan University - - 2014
Short-term high altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left ventricular (LV) volumes. However, relatively little is known of the long-term cardiac consequences of prolonged exposure in Sherpa, a highly-adapted HA population. To investigate short-term adaptation and potential long-term cardiac remodelling, we studied ventricular structure and ...
Johnson Blair D BD Mayo Clinic - - 2014
The purpose of this study was to compare hemodynamic and blood analyte responses to reduced central venous pressure (CVP) and pulse pressure (PP) elicited during graded LBNP to those observed during graded BL in conscious humans. We hypothesized that the stimulus-response relationships of CVP and PP to hemodynamic responses during ...
Ruhui L L Department of Cardiology, Tongji Hospital, Tongji University, No. 389 Xincun Road, 200065, Shanghai, - - 2014
The aim of this study was to assess the effect of plasma homocysteine (Hcy) on left ventricular (LV) diastolic function in Chinese patients with essential hypertension. A total of 74 patients with hypertension were enrolled in the present study and were divided into two groups according to the plasma levels ...
Godfraind Theophile T Universite Catholique de Louvain, Brussels, Belgium - - 2014
This paper summarizes the pharmacological properties of calcium channel blockers (CCBs), their established therapeutic uses for cardiovascular disorders and the current improvement of their clinical effects through drug combinations. Their identification resulted from study of small molecules including coronary dilators, which were named calcium antagonists. Further experiments showed that they ...
Butts Ryan J RJ Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, SC, - - 2014
Differences in ventricular geometry and physiology of patients with single ventricle anatomy complicate the application of traditional, noninvasive measurements of systolic function. We compared noninvasive measures of ventricular systolic function in single ventricle patients with invasive measures to evaluate their validity in this population. A secondary analysis of patients with ...
van Hateren Kornelis Jj KJ Kornelis JJ van Hateren, Gijs WD Landman, Susan JJ Logtenberg, Henk JG Bilo, Nanne Kleefstra, Diabetes Centre, Isala, 8000 GK Zwolle, The - - 2014
The American Heart Association considers device-guided breathing as a reasonable treatment modality in their statement on non-pharmacological options for lowering blood pressure. This review discusses all randomized controlled trials that have investigated the effects of device-guided breathing on blood pressure in patients with hypertension. Thirteen studies were included in this ...
Grandi Giovanni G Department of Obstetrics Gynecology and Pediatrics, Obstetrics and Gynecology Unit, Azienda Policlinico of Modena, 41121 Modena, - - 2014
Combined oral contraceptives (COCs) containing ethinyl-estradiol are known to increase blood pressure (BP). We evaluated whether COCs containing estradiol (E2) influence 24-h ambulatory BP and heart rate (HR) in normotensive and normal-weight women. Twenty-four-hour BP and HR were measured every 30 min with an ambulatory BP device in 18 normotensive ...
La Rovere Maria Teresa MT Department of Cardiology and Biomedical Engineering, Fondazione "Salvatore Maugeri," IRCCS, Istituto Scientifico di Montescano (Pavia), - - 2014
The baroreflex mechanisms, by controlling autonomic outflow to the heart and circulation, contribute importantly to neural circulatory control. The main function of the baroreflex is to prevent wide fluctuations in arterial blood pressure and to maintain the physiological homeostasis under basal resting conditions and in response to acute stress. Baroreflex-mediated ...
Guo Wan-Gang WG Departments of aCardiology bPharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou cDepartment of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, - - 2014
To validate the Andon KD-5917 automatic upper arm blood pressure monitor according to the European Society of Hypertension International Protocol revision 2010. Sequential same-left-arm measurements of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were obtained in 33 participants using the mercury sphygmomanometer and the test device. According to ...
Johnson James A JA Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA. Electronic address: - - 2014
Phenethylaminoheterocycles have been prepared and assayed for inhibition of the Kv1.5 potassium ion channel as a potential approach to the treatment of atrial fibrillation. A diverse set of heterocycles were identified as potent Kv1.5 inhibitors and were advanced to pharmacodynamic evaluation based on selectivity and pharmacokinetic profile. Heterocycle optimization and ...
Malamud-Kessler C C Departamento de Neurología y Psiquiatría, Laboratorio de Neurofisiología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición «Salvador Zubirán», México, D.F. Electronic address: - - 2014
Neurally-mediated syncope (NMS) is defined as a transient loss of consciousness due to an abrupt and intermittent drop in blood pressure (BP). This study describes the putative pathophysiological mechanisms giving rise to NMS, the role of baroreflex (BR), and the interaction of its main haemodynamic variables: heart rate (HR) and ...
Child Nicholas N Department of Cardiology, Guys and St. Thomas's Hospital & Department of Cardiovascular Imaging, Division of Imaging Sciences and Biomedical Engineering, King's College, London, United - - 2014
-Mental stress and emotion have long been associated with ventricular arrhythmias and sudden death in animal models and humans. The effect of mental challenge on ventricular action potential duration (APD) in conscious healthy humans has not been reported. -Activation recovery intervals (ARI) measured from unipolar electrograms as a surrogate for ...
von Lueder Thomas G TG Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia; Department of Cardiology B, Oslo University Hospital Ullevål, and Faculty of Medicine, University of Oslo, - - 2014
Cardiovascular diseases (CVD) continue to represent the major cause of death, morbidity and healthcare expenditure worldwide. Current medical therapy fails to effectively halt disease progression and to reduce adverse clinical outcomes, reflecting incomplete understanding of pathomechanisms as well as the need to expand current pharmacotherapeutic strategies. Hypertension and heart failure, ...
Bozkurt Selim S Biomedical Engineering, Materials Technology, Eindhoven University of Technology, Eindhoven - The - - 2014
Continuous flow left ventricular assist devices (CF-LVADs) generally operate at a constant speed, which causes a decrease in pulse pressure and pulsatility in the arteries and allegedly may lead to late complications such as aortic insufficiency and gastrointestinal bleeding. The purpose of this study is to increase the arterial pulse ...
Daryadel Arezoo - - 2014
Left ventricular hypertrophy (LVH) is a potent risk factor for sudden death and congestive heart failure. We tested the effect of sorafenib, a multikinase inhibitor (10 mg/kg, given orally, starting 2 days prior to banding, till sacrifice on day 14), on the development of LVH following aortic banding in rats. ...
Kadhum Murtaza M Cardiothoracic Medicine, St. George's Hospital Medical School, London SW17 0RE, - - 2014
To investigate the acute cardiovascular effects of smoking shisha. A cross-sectional study was carried out in six shisha cafes. Participants smoked shisha for a period between 45 min (minimum) and 90 min (maximum). The same brand of tobacco and coal was used. London, UK. Participants were those who had ordered a shisha ...
Lovic Dragan D Clinic for internal disease, InterMedica; Nis-Serbia. - - 2014
Left ventricular hypertrophy (LVH) is a structural remodeling of the heart developing as a response to volume and/or pressure overload. Previous studies have shown that hypertension is not an independent factor in the development of LVH and occurrence does not depend on the length and severity of hypertension, but the ...
Donazzan Luca L Klinik für Innere Medizin III (Kardiologie, Angiologie und Internistische Intensivmedizin), Universitätsklinikum des Saarlandes, Kirrberger Str. 1, Geb. 40, 66421, Homburg, Saar, - - 2014
Hypertension has wide (30-45 %) prevalence in the general population and is related to important increases in overall cardiovascular morbidity and mortality. Despite lifestyle modifications and optimal medical therapy (three drugs, one being diuretic), about 5-20 % of hypertensives are affected by resistant hypertension. Chronic high blood pressure has adverse effects on ...
Larochelle Pierre P Institut de recherches cliniques de Montréal, Montréal, Québec, Canada. Electronic address: - - 2014
β-Blockers are among the most commonly used medications in the treatment of hypertension. However, 45 years after their initial indication for that treatment, their place in the treatment of hypertensive patients is under evaluation and their usefulness has been questioned based on evidence from meta-analyses of clinical trials. The β-blocker ...
Hong Lei L School of Biology and Food Engineering, Hefei University of Technology, Hefei, - - 2014
The antibradycardia effect of extract of RAE (Radix Aconiti and Astragalus) on bradycardia animal models were evaluated. Bradycardia rat model was induced by amiodarone or propranolol, and sick sinus syndrome (SSS) rabbit model was induced by chemical stimulation on surface of sinus node. The heart rates of the animal models ...
Akintunde Aa A Department of Medicine, Division of Cardiology, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Nigeria ; Goshen Heart Clinic, Osogbo, - - 2014
Systemic hypertension (HTN) and obstructive sleep apnea (OSA) are individually associated with left ventricular structural and functional adaptations. However, little is known about the impact of OSA on the left ventricle in Africans with HTN. The aim of this study is to determine the association between OSA and left ventricular ...
Barnes Justin J Department of Medicine (LJD), Birmingham Veteran Affairs Medical Center, Birmingham, Alabama; and Division of Cardiovascular Disease (JB, LJD), University of Alabama Medical Center, Birmingham, - - 2014
: Mitral regurgitation and other conditions marked by a pure isolated volume overload (VO) of the heart result in a progressive form of eccentric left ventricular remodeling and dysfunction. As opposed to the more extensively studied pressure overload, there are no approved medical therapies because an understanding of the underlying ...
da Cunha Daise N Q DN Veterinary Department, Federal University of Viçosa, Viçosa, - - 2014
The mechanisms of production, and gross, microscopic and electrocardiograhic findings of surgically-induced complete heart block (CHB) in the adult rat are presented. This is an effective in vivo model for establishing alternative methods to electronic pacemakers and for providing detailed information aimed at replacement, reduction and refinement of the technique. ...
Hankey Graeme J GJ From the School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Duke Clinical Research Institute (S.R.S., J.P.P., Y.L., M.R.P.) and Duke Translational Medicine Institute (R.M.C.), Duke University Medical Center, Durham, NC; Department of Medicine, Stanford University, CA (K.W.M.); Cardiovascular Institute, Mount Sinai Medical Center, New York (J.L.H.); Department of Cardiovascular Medicine, Hospital of the University of Münster, Münster, Germany (G.B.); Massachusetts General Hospital and Harvard Medical School, Boston (D.E.S.); University of Cincinnati College of Medicine, OH (R.C.B.); Department of Global Clinical Development, Bayer HealthCare Pharmaceuticals, Whippany, NJ (S.D.B.); Cerenis Therapeutics, Labege, France (J.F.P.); Janssen Research and Development, Raritan, NJ (C.C.N.); Ruprecht- Karls-University, Heidelberg, Germany (W.H.); and University of Edinburgh and Royal Infirmary of Edinburgh, Edinburgh, United Kingdom - - 2014
Intracranial hemorrhage (ICH) is a life-threatening complication of anticoagulation. We investigated the rate, outcomes, and predictors of ICH in 14 264 patients with atrial fibrillation from Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET ...
Hoshino Atsushi A 1Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, - - 2014
-Mitochondrial compromise is a fundamental contributor to heart failure. Recent studies have revealed that several surveillance systems maintain mitochondrial integrity. The present study evaluated the role of mitochondrial AAA+ protease in a mouse model of pressure overload heart failure. -The FITC-casein assay and immunoblotting for endogenous mitochondrial proteins revealed a ...
Muntner Paul P Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL; Department of Medicine, University of Alabama at Birmingham, Birmingham, - - 2014
Few randomized trials have compared visit-to-visit variability (VVV) of systolic blood pressure (SBP) across drug classes. The authors compared VVV of SBP among 24,004 participants randomized to chlorthalidone, amlodipine, or lisinopril in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). VVV of SBP was calculated across 5 ...
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