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Moss Robert R 1Duke - - 2014
We have developed a whole-kidney model of the urine concentrating mechanism and renal autoregulation. The model represents the tubuloglomerular feedback (TGF) and myogenic mechanisms, which together affect the resistance of the afferent arteriole and thus glomerular filtration rate. TGF is activated by fluctuations in macula densa [Cl(-)] and myogenic mechanism ...
Gao Ying Y State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, - - 2014
The genetic susceptibility to orthostatic blood pressure dysregulation remains poorly understood. The association between polymorphisms of beta-adrenergic receptor (β-AR) genes and orthostatic blood pressure dysregulation in hypertensive patients was investigated. Two polymorphisms of β1 -AR (Arg389/Gly) and β2 -AR (Arg16/Gly) were genotyped in untreated hypertensive patients and normotensive patients. In ...
Inamasu Joji J Departments of aNeurocritical Care bNeurosurgery, Fujita Health University Hospital, Toyoake, - - 2014
High blood pressure (HBP) is observed frequently in patients with spontaneous intracerebral haemorrhage (SICH). Although HBP at admission has been associated with poor outcomes, most studies from which such conclusions were derived had been carried out decades earlier, when aggressive BP management was not implemented. In our institution, SICH patients ...
Tragante Vinicius V Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the - - 2014
Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated ...
Erlkamp M M TU Dortmund University, Department of Chemistry and Chemical Biology, Physical Chemistry I - Biophysical Chemistry, D-44221 Dortmund, Germany. - - 2014
FT-IR spectroscopic, small-angle X-ray scattering and calorimetric measurements have been applied to explore the effect of the macromolecular crowder agent Ficoll on the temperature- and pressure-dependent stability diagram and folding reaction of the protein Staphylococcal Nuclease (SNase). Additionally, we compare the experimental data with approximate theoretical predictions. We found that ...
Laucevičius Aleksandras A Department of Cardiovascular Medicine, Vilnius University , - - 2014
Hypertension is the most common non-communicable disease and the leading cause of cardiovascular disease in the world. It presents an important public health challenge in both economically developed and developing countries. In 2006, the Lithuanian High Cardiovascular Risk programme was launched. The programme recruited men aged 40-54 and women aged ...
Li Yan Y Center for Epidemiological Studies and Clinical Trials, Shanghai Institute of Hypertension, Shanghai Key Lab of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2014
Experts proposed blood pressure (BP) load derived from 24-hour ambulatory BP recordings as a more accurate predictor of outcome than level, in particular in normotensive people. We analyzed 8711 subjects (mean age, 54.8 years; 47.0% women) randomly recruited from 10 populations. We expressed BP load as percentage (%) of systolic/diastolic ...
Tudor-Locke Catrine - - 2014
Pedometer-based programs have elicited increased walking behaviors associated with improvements in blood pressure in sedentary/low active postmenopausal women, a population at increased risk of cardiovascular disease. Such programs typically encourage increasing the volume of physical activity with little regard for its intensity. Recent advances in commercially available pedometer technology now ...
Studer Joseph J Alcohol Treatment Centre, Lausanne University Hospital CHUV, Av. Beaumont 21 bis, Pavillon 2, CH-1011 Lausanne, Switzerland. Electronic address: - - 2014
Peer pressure (PP) has been shown to play a major role in the development and continuation of alcohol use and misuse. To date, almost all the studies investigating the association of PP with alcohol use only considered the PP for misconduct but largely ignored other aspects of PP, such as ...
Wang Ji-Guang JG Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: - - 2014
Blood pressure (BP) is monitored and managed to prevent cardiovascular complications of hypertension, but BP variability (BPV) has not been sufficiently studied. This analysis assessed whether patients receiving amlodipine vs other antihypertensive agents had lower BPV after ≥12 weeks of treatment. Studies were included if individual subject data were available, had ...
Patel Milesh M - - 2014
High blood pressure is a major cardiovascular disease risk factor and contributed to >362,895 deaths in the United States during 2010. Approximately 67 million persons in the United States have high blood pressure, and only half of those have their condition under control. An estimated 46,000 deaths could be avoided ...
Pusuroglu Hamdi H Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul/TURKEY. - - 2014
Isolated systolic hypertension (ISHT) is a subtype of hypertension (HT) that often exhibits wide pulse pressure, and pulse pressure has a strong predictive value for future adverse cardiovascular events. Previous studies have shown the effects of : leukocyte count on prognosis of ischemic heart disease and HT. Thus, in this ...
Rana Brinda K BK Department of Psychiatry, University of California-San Diego, La Jolla, California, - - 2014
Elevated blood pressure (BP), a heritable risk factor for many age-related disorders, is commonly investigated in population and genetic studies, but antihypertensive use can confound study results. Routine methods to adjust for antihypertensives may not sufficiently account for newer treatment protocols (i.e., combination or multiple drug therapy) found in contemporary ...
Brown Todd M TM Department of Medicine, University of Alabama at Birmingham, Birmingham, AL. Electronic address: - - 2014
In a non-clinical trial setting, to determine the proportion of individuals with coronary artery disease (CAD) with optimal risk factor levels based on the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial. In COURAGE, the addition of percutaneous coronary intervention (PCI) to optimal medical therapy did not reduce ...
Rommel Nathalie N *KU Leuven, Neurosciences, ExpORL, Faculty of Medicine, Leuven, Belgium †University Hospital Leuven, Neurogastroenterology & Motility Clinic, Department of Gastroenterology, Leuven, Belgium ‡KU Leuven, Translational Research Centre for Gastrointestinal Disease (TARGID), Belgium §University Hospital Leuven, Pediatric Gastroenterology, Hepatology & Nutrition, Leuven, Belgium ||University Hospital Leuven, Radiology, Leuven, Belgium ¶Child, Youth & Women's Health Service, Gastroenterology Unit, North Adelaide, SA, Australia #University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, SA, - - 2014
The purpose of this study was to apply a new method, pharyngeal automated impedance manometry (AIM), as an objective assessment tool of swallow function relevant to aspiration, in a cohort of pediatric patients with dysphagia. We studied 20 children (mean age 6 yrs (5months-13.4yrs)) referred for videofluoroscopy to assess aspiration ...
Foraster Maria M Centre for Research in Environmental Epidemiology (CREAL); CIBER Epidemiología y Salud Pública (CIBERESP); and Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut (UPF), Barcelona, - - 2014
Long-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension; however evidence is limited and this association may be confounded by traffic noise, and biased due to inappropriate control for BP-lowering medications. We evaluated the association between long-term traffic-related air pollution, BP and prevalent hypertension, adjusting ...
Qian Shaowen S Department of Medical Imaging, Jinan Military General Hospital, Shandong, People's Republic of - - 2014
Environmental hyperthermia is a very common risk factor for many occupations, however, its potential influences on cerebral circulation remain obscure. In this study, 20 participants underwent two simulated environmental thermal conditions (50°C/25°C, 1hour), and their cerebral blood flows (CBFs) were quantified using a pseudo-continuous arterial spin labeling (ASL) MR imaging. ...
Huntington-Moskos Luz L College of Nursing, Clean Indoor Air Partnership, University of Kentucky, 751 Rose Street, 447 College of Nursing Building, Lexington, KY, 40536-0232, USA, - - 2014
The pathogenesis of hypertension begins in youth. An estimated 4 % of US adolescents have diagnosed hypertension and 17 % have elevated blood pressures, predisposing them to hypertension and cardiovascular disease (CVD) later in life. There is limited research on the clustering of CVD risk factors such as tobacco exposure and weight ...
Welsh Tomas J - - 2014
Hypertension is very common in older people and a number of trials of antihypertensives have demonstrated benefit from treatment in even the oldest old. However, people with dementia were significantly under-represented in these studies and as a population are more likely to be physically frail, to suffer orthostatic hypotension and ...
Manning Lisa L Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, - - 2014
High blood pressure is a prognostic factor for acute stroke, but blood pressure variability might also independently predict outcome. We assessed the prognostic value of blood pressure variability in participants of INTERACT2, an open-label randomised controlled trial (ClinicalTrials.gov number NCT00716079). INTERACT2 enrolled 2839 adults with spontaneous intracerebral haemorrhage (ICH) and ...
Malik Aaqib Habib AH Department of Internal and Preventive Medicine, Griffin Hospital, Derby, Connecticut; Yale-Griffin Prevention Research Center, Derby, Connecticut. Electronic address: - - 2014
The impact of sugar-sweetened beverages (SSBs) on blood pressure (BP) has been debated, with some evidence suggesting that their increased intake is related to higher risk of developing hypertension. We conducted a systematic review exploring the relation between consumption of SSB and BP. A comprehensive search in 5 electronic databases ...
Zuo Xiao-Cong XC Center of Clinical Pharmacology and Pharmacy Department, The Third Xiangya Hospital, Central South - - 2014
Summary: The effects of genetic polymorphisms of ABCB1 C3435T, POR*28, CYP3A4*1G and CYP3A5*3 variants and gender relating to metabolism on the exposure and response of amlodipine in Chinese hypertensive patients were determined. Population pharmacokinetic analyses were performed on data which were collected prospectively from 60 Chinese patients with mild to ...
Agarwal Rajiv R Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Ind., - - 2014
To test the hypothesis that thiazide-type diuretics effectively lower blood pressure (BP) in moderate to advanced chronic kidney disease (CKD; estimated GFR 20-45 ml/min/ 1.73 m(2)), after confirming poorly controlled hypertension with 24-hour ambulatory BP monitoring, chlorthalidone was added to existing medications in a dose of 25 mg/day, and the ...
Xu Jianwei - - 2014
High levels of dietary sodium are associated with raised blood pressure and adverse cardiovascular health. To determine baseline salt intake, we investigated the average dietary salt intake from 24-hour urinary sodium excretion with a small sample of Yantai adults in the Shandong province of China. One hundred ninety one adults ...
Ushigome E E Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, - - 2014
Recent studies have shown that variability in home blood pressure has an important role in the progression of organ damage. The objective of this study was to investigate the factors that affect variability in home blood pressure in patients with type 2 diabetes. We assessed the relationship between home blood ...
Hermida R C RC Bioengineering and Chronobiology Laboratories, Atlantic Research Center for Information and Communication Technologies, University of Vigo, E.I. Telecomunicación, Campus Universitario, Vigo, - - 2014
Diagnosis of hypertension and clinical decisions regarding its treatment are typically based upon daytime clinic blood pressure (BP) measurements, occasionally supplemented by wake-time patient self-assessment. Yet, correlation between BP level and target organ damage, cardiovascular disease (CVD) risk, and long-term prognosis is higher for ambulatory BP monitoring (ABPM) measurements. Numerous ...
Kris-Etherton Penny M PM Department of Nutritional Sciences, Pennsylvania State University, University Park, - - 2014
Given the pressing need to reduce cardiovascular disease (CVD) morbidity and mortality, there has been a focus on optimizing dietary patterns to reduce the many contributing risk factors. Over the past 2 decades, many studies have been conducted that have evaluated the effects of walnut consumption on CVD risk factors. ...
Causland Finnian R Mc FR aRenal Division, Department of Medicine, Brigham and Women's Hospital bHarvard Medical School cDepartment of Medicine, Brigham and Women's Hospital dDepartment of Nutrition, Harvard School of Public Health eChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, - - 2014
Blood pressure normally declines during the night ('dipping'); a blunted nocturnal decline is an important cardiovascular risk factor. Marriage may be associated with lower ambulatory blood pressure, although this may be confounded by socio-economic and dietary factors. We examined the association of marital status with nocturnal dipping and night-time SBP ...
He Jiang J Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China2Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana3Department of Medicine, Tulane - - 2014
Although the benefit of reducing blood pressure for primary and secondary prevention of stroke has been established, the effect of antihypertensive treatment in patients with acute ischemic stroke is uncertain. To evaluate whether immediate blood pressure reduction in patients with acute ischemic stroke would reduce death and major disability at ...
James Paul A PA University of Iowa, Iowa - - 2014
Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. Patients want to be assured that blood pressure (BP) treatment will reduce their disease burden, while clinicians want guidance on hypertension management using ...
Bays Harold H Louisville Metabolic and Atherosclerosis Research Center Inc. (L-MARC), Louisville, KY, USA, - - 2014
Lowering blood pressure (BP) in patients with high blood pressure reduces cardiovascular risk. Studies support health benefits when BP goals are achieved earlier in the course of treatment. Many patients require combination therapy to achieve BP goals; initial use of combination therapy may improve earlier BP goal attainment. This analysis ...
Sung Joo-Wook JW Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of - - 2014
An association has been described between high sensitivity C-reactive protein (hs-CRP) and cardiovascular disease (CVD) in some studies but not in others. This finding may be explained by a differential impact of inflammation according to the absence or presence of certain co-existing risk factors. Because hypertension may be an effect ...
Gijón-Conde Teresa T Centro de Salud Universitario Cerro del Aire, Dirección Asistencial Noroeste, Majadahonda, Madrid, España; Departamento de Medicina Preventiva y Salud Pública, Universidad Autónoma de Madrid/IdiPaz, CIBER de Epidemiología y Salud Pública (CIBEResp), Madrid, España. Electronic address: - - 2014
The prevalence of resistant hypertension has recently been reported, but there are no studies on its demography. This study aimed to examine the demography and clinical characteristics of resistant hypertension in a large sample of primary care patients. A cross-sectional study was performed of all computerized medical records of hypertensive ...
Park Chang G CG Department of Internal Medicine, Korea University College of Medicine , Seoul , - - 2014
Abstract Lipocalin families including lipocalin-2 and adipocyte fatty acid binding protein (A-FABP) were recently identified as novel adipokines to be associated with the cardiovascular risk variables of the metabolic syndrome. We evaluated the lipocalin-2 and A-FABP levels in 62 patients with essential hypertension (EHT) and 16 age-, gender- and body ...
Pandey Arti S AS Department of Biochemistry, Xxx Medical College Basic Sciences Block, Xxx, Xxx, - - 2014
Tobacco consumption is high amongst the people of Xxx. This study was carried out in 2011 in a rural community of Xxx, to compare pathological parameters associated with tobacco use in relation to nicotine metabolism between smokers, chewers, and a control group. A total of 216 volunteers provided blood and ...
Komori Takahiro T Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine , Shimotsuke, Tochigi , - - 2014
Abstract Background: Masked uncontrolled hypertension (MUH), defined as controlled office blood pressure (BP) but uncontrolled out-of-office BP in treated hypertensives, is a risk factor for cardiovascular disease. We tested the hypothesis that MUH is associated with a greater degree of diastolic dysfunction than controlled hypertension (CH) or uncontrolled hypertension (UH). ...
Banegas José R JR Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid/IdiPAZ - CIBER in Epidemiology and Public Health (CIBERESP), AvdaArzobispoMorcillo 2, 28029 Madrid, - - 2014
There are limited data on the quality of treated blood pressure (BP) control during normal daily life, and in particular, the prevalence of 'masked uncontrolled hypertension' (MUCH) in people with treated and seemingly well-controlled BP is unknown. This is important because masked hypertension in 'treatment naïve' patients is associated with ...
Aoqui Cristiane - - 2014
Metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease (CVD). One important feature underlying the pathophysiology of many types of CVD is microvascular dysfunction. Although components of MetS are themselves CVD risk factors, the risk is increased when the syndrome is considered as one entity. We aimed to ...
Alsmadi Osama O Dasman Genome Centre, Dasman Diabetes Institute, - - 2014
Recent research illustrates the role of central melanocortin signaling and leptin in the regulation of arterial blood pressure in animal models. Unraveling the genetic basis of interactions between melanocortin and leptin in humans will provide new insight into the regulation of arterial pressure. Our study population consisted of 332 Kuwaiti ...
Spinasse Lizania Borges LB Laboratory of Molecular Biology Applied to Mycobacteria - Oswaldo Cruz Institute - Fiocruz, Av. Brazil 4365, CEP: 21040-360, Manguinhos, Rio de Janeiro, - - 2014
Aim: Hydralazine, a vasodilator used in resistant hypertension (RH) treatment is metabolized by an acetylation reaction mediated by N-acetyltransferase 2, the activity of which depends on NAT2 polymorphisms. Our aim was to evaluate whether different acetylation phenotypes influenced the antihypertensive effect of hydralazine in patients with RH. Patients & methods: ...
Chaturvedi Swasti S Department of Paediatrics, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu, India, - - 2014
Hypertension is a major risk factor for stroke, coronary artery disease and kidney damage in adults. There is a paucity of data on the long-term sequelae of persistent hypertension in children, but it is known that children with hypertension have evidence of end organ damage and are at risk of ...
Elperin Dina T DT Kaiser Permanente Woodland Hills Medical Center, Woodland Hills, - - 2014
Hypertension is the most common primary diagnosis in the United States. Risks for long-term consequences such as myocardial infarction, heart failure, stroke, and kidney disease continue to significantly increase as long as hypertension remains uncontrolled. This retrospective cohort study of 661,075 patients identified with uncontrolled hypertension, defined as systolic blood ...
Senan Mahavir M National Institute of Govt, Kolkata, India; Yerevan State Medical University after M. Heratsi, - - 2014
The aim of the article was to study the relation between socioeconomic factors and mortality from CVS diseases. The study was performed among 346 native Indians (260 males and 86 females), aged 41-54 years and employed by the Civil Service. The study was carried out during 7 years. At 24 ...
Ringoir L L Department of Medical and Clinical Psychology, Centre of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, PO Box: 90153, 5000 LE, Tilburg, the - - 2014
Recent guidelines on cardiovascular disease prevention advocate the importance of psychological risk factors, as they contribute to the risk of developing cardiovascular disease. However, most previous research on psychological distress and cardiovascular factors has focused on selected populations with cardiovascular disease. The primary aim was to determine the prevalence of ...
Ko Seung-Hyun SH Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, - - 2014
We investigated the prevalence, awareness, treatment, and control rate of hypertension in Korean adults with diabetes using nationally representative data. Using data of 5,105 adults from the fifth Korea National Health and Nutrition Examination Survey in 2011 (4,389 nondiabetes mellitus [non-DM]), 242 newly diagnosed with DM (new-DM), and 474 previously ...
Onakpoya I I Department of Primary Care Health Sciences, University of Oxford, United Kingdom. Electronic address: - - 2014
Many different dietary supplements are currently marketed for the management of hypertension, but the evidence for effectiveness is mixed. The aim of this systematic review was to evaluate the evidence for or against the effectiveness of green tea (Camellia sinensis) on blood pressure and lipid parameters. Electronic searches were conducted ...
Hoshide Satoshi S Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, - - 2014
Several guidelines recommend that home blood pressure (HBP) be measured both in the morning and in the evening. However, there have been fewer reports about the clinical significance of morning HBP than about the clinical significance of evening HBP. Our study included 4,310 patients recruited for the Japan Morning Surge ...
Cheng Hao-Min HM Department of Medical Education, Taipei Veterans General Hospital, Taipei, - - 2014
Oscillometric central blood pressure (CBP) monitors have emerged as a new technology for blood pressure (BP) measurements. With a newly proposed diagnostic threshold for CBP, we investigated the diagnostic performance of a novel CBP monitor. We recruited a consecutive series of 138 subjects (aged 30-93 years) without previous use of ...
Aribisala Benjamin S BS Division of Neuroimaging Sciences, Brain Research Imaging - - 2014
White matter hyperintensities (WMH) are associated with hypertension. We examined interactions among blood pressure (BP), internal carotid artery (ICA) flow velocity parameters, and WMH. We obtained BP measurements from 694 community-dwelling subjects at mean ages 69.6 (±0.8) years and again at 72.6 (±0.7) years, plus brain MRI and ICA ultrasound ...
Lopes Liane M LM Laboratory of Neuromechanics, Center for Health Sciences, Federal University of Pampa, Uruguaiana, RS, - - 2014
Previous studies suggested that skin stimulation by using medical tape glued to the skin over the Achilles tendon can improve postural control in young adults. Such strategy can be valuable if helping to improve postural control in the elderly. Here we tested the effects of skin stimulation on the postural ...
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