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Sohn Min-Woong MW Center of Innovation for Complex Chronic Healthcare, Hines VA Hospital, Hines, IL; Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address: - - 2014
To examine the association between sedentary behavior and BP among Osteoarthritis Initiative (OAI) participants. We conducted a cross-sectional analysis of the OAI 48-month visit participants whose physical activity was measured using accelerometers. Participants were classified into four quartiles according to the percentage of wear time that was sedentary (<100 activity ...
Kim Mi Kyung MK Department of Preventive Medicine, Medical School Building A-Room 512, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, - - 2014
The inverse relationships of combined fruits and vegetables intake with blood pressure have been reported. However, whether there are such relationships with salty vegetables has rarely been investigated in epidemiologic studies. We evaluated the relation of combined and separate intake of fruits, vegetable intakes, and salty vegetables, as well as ...
Langefeld Carl D CD 1] Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA [2] Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, - - 2014
Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin:creatinine ratio (UACR), and prevalent cardiovascular disease (CVD) in 2571 AAs from the Systolic Blood Pressure ...
Aribas Alpay A Department of Cardiology, Necmettin Erbakan University Meram School of Medicine , Meram, Konya , - - 2014
Background. Endothelial dysfunction plays a major role in erectile dysfunction (ED). Uric acid (UA) is a marker of endothelial dysfunction. We hypothesized that increased UA levels may be associated with ED and aimed to investigate whether there is a relationship between, UA and ED in hypertensive patients. Methods. A total ...
Bushnik Tracey T Health Analysis Division, Statistics Canada, Ottawa, Ontario - - 2014
Hypertension is the leading risk factor for cardiovascular disease, but its cause is not always known. Interest is increasing in the potential role of environmental chemicals, including lead. Data are from the first two cycles of the Canadian Health Measures Survey. Lead in whole blood (PbB), and systolic (SBP) and ...
Terracciano Antonio A aFlorida State University College of Medicine, Tallahassee, Florida bNational Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA cHospital San Raffaele Pisana IRCCS, Rome dIstituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche eUnità Operativa Complessa Cardiologia, Presidio Ospedaliero A. Businco, Cagliari, - - 2014
Anxiety and other psychological dispositions are thought to be associated with blood pressure. This study tests whether personality traits have long-term associations with masked and white-coat effects. A community-based sample of 2838 adults from Sardinia (Italy) completed the Revised NEO Personality Inventory, and 7 years later, blood pressure was assessed ...
Akça Omer Faruk OF Assistant Professor, Necmettin Erbakan University, Meram School of Medicine, Department of Child and Adolescent Psychiatry, Konya, - - 2014
Anxiety sensitivity (AS) is a relatively stable dispositional variable that may increase the risk for anxiety-related symptoms, particularly panic attacks, among individuals of all age groups. However, changes in AS during adolescence in healthy individuals has not been previously investigated. We aimed to investigate the relationship of AS levels with ...
Cohen Lindsay L Royal College Emergency Medicine Residency Training Program, University of British Columbia, Vancouver, British Columbia, - - 2014
We synthesize the available evidence on the effect of ketamine on intracranial and cerebral perfusion pressures, neurologic outcomes, ICU length of stay, and mortality. We developed a systematic search strategy and applied it to 6 electronic reference databases. We completed a gray literature search and searched medical journals as well ...
Tatsumi Kazuhiro K Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, - - 2014
Early diastolic mitral inflow and annulus velocities ratio (E/e') is the parameter used to estimate left ventricular (LV) filling pressure, but their use for patients with reduced ejection fraction (EF) (<50 %) is controversial. LV endocardial area change rate with 3-dimensional (3-D) speckle-tracking can be used to evaluate the entire LV ...
Lee Sunghee S aInstitute of Human Genomic Study, School of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea bDepartment of Medicine, Division of Pulmonary, Critical care & Sleep, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA cDepartment of Radiology, School of Medicine, Korea University, Ansan Hospital, Ansan dDepartment of Foods and Nutrition, College of Natural Sciences, Kookmin University, Seoul eDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam fDivision of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University, Ansan Hospital, Ansan, Republic of - - 2014
A reverse dipping pattern, characterized by higher night-time blood pressure (BP) than daytime BP, is associated with the increased risk for cerebrovascular disease, cardiovascular events and all-cause mortality. However, little has known about the association between white matter change (WMC) and reverse dipping pattern, particularly in normotensive adults. We aimed ...
Khader A A United Nations Relief and Works Agency for Palestine Refugees in the Near East, Amman, - - 2014
In six United Nations Relief and Works Agency (UNRWA) primary health care clinics in Jordan serving Palestine refugees diagnosed with hypertension, to determine the number, characteristics, programme outcomes and measures of disease control for those registered up to 30 June, 2013, and in those who attended clinic in the second ...
Matsumoto Yuuki - - 2014
Thermodynamic stability boundary in the structure-H methane+bromocyclopentane mixed hydrate system was measured at pressures from 20 MPa to 100 MPa. The thermodynamic stability boundary of the methane+bromocyclopentane mixed hydrate exhibits anomalous behavior under conditions at high pressures and high temperatures. This phenomenon is due to the elimination and substitution reactions ...
Kalish Brian T BT Harvard Medical School, Boston, MA, United States. Electronic address: - - 2014
Childhood blood pressure (BP) is an important determinant of adult cardiovascular disease. Prenatal exposure to methylmercury through maternal fish consumption has been reported to increase the BP of children years later. Mother-child pairs were enrolled from Project Viva, a prospective cohort study in Massachusetts. From second trimester maternal blood samples, ...
Cao Zhongqiang Z aMOE Key Lab of Environment and Health bDepartment of Maternal and Child Health cDepartment of Social Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan dDongfeng General Hospital, Dongfeng Motor Corporation and Hubei University of Medicine, Shiyan, - - 2014
Evidence from epidemiological studies suggested that shorter and longer duration of nocturnal sleeping may increase the risk of hypertension for older adults. Little is known about the duration of midday nap on the variability of blood pressure among older adults. In this study, we examined whether duration of habitual midday ...
Hirayama Atsushi A Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Yamagata, - - 2014
Recent studies have suggested that urine albumin excretion in the high normal range predicts hypertension. However, the relationship between urinary albumin excretion in spot urine and incident hypertension remains unclear in the general Japanese population. To clarify this relationship, we conducted a cohort study in a community-based population of 412 ...
Strandberg Arto Y AY aDepartment of Medicine, Geriatric Clinic, University of Helsinki, and Helsinki University Central Hospital bInstitute of Health Sciences/Geriatrics, University of Oulu, and Oulu University Hospital, Oulu cDepartment of Public Health, University of Turku, Turku dTHL-National Institute for Health and Welfare eUnit of General Practice, Helsinki University Central Hospital fDepartment of General Practice, University of Helsinki, Helsinki, - - 2014
The aim of the present study was to examine the long-term impact of midlife blood pressure (BP) on mortality, comorbidity, and health-related quality of life (HRQoL) in old age. These are longitudinal analyses of the Helsinki Businessmen Study, a cohort of business executives, born in 1919-1934, whose BP was measured ...
Foraster Maria M Centre for Research in Environmental Epidemiology (CREAL); CIBER Epidemiología y Salud Pública (CIBERESP); Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut (UPF), Barcelona, - - 2014
Traffic noise has been associated with prevalence of hypertension, but reports are inconsistent for blood pressure (BP). People's noise exposure indoors might be essential to ascertain effects and disentangle them from those suspected for traffic-related air pollution. We analyzed associations of long-term exposure to indoor traffic noise at bedrooms with ...
Higgins Timothy P TP School of Biosciences, Cardiff University, Cardiff, United - - 2014
Hypertension, decreased glucose tolerance, adverse lipid profiles and low physical activity levels are associated with increased type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) risk. High intensity interval training (HIIT), a low volume, reduced time, high intensity programme, may be a useful alternative to current government guidelines which specify ...
Villela Patrícia Teixeira Meirelles PT Division of General Internal Medicine and Geriatrics, Ribeirão Preto Medical School, University of São Paulo-FMRP-USP, Ribeirão Preto, SP, - - 2014
The aim of this study was to evaluate the preference for salt in hypertensive and normotensive older individuals. Hypertensive (group 1: n=32, aged 73.7±6.3 years) or normotensive patients (group 2: n=26, aged 71.5±8.0 years) were submitted to a test to determine their preference for bread samples with different salt concentrations: 1.5%, 2.0% ...
Chia Yook Chin - - 2014
Patients with resistant hypertension are subjected to a higher risk of getting stroke, myocardial infarction, congestive heart failure and renal failure. However, the exact prevalence of resistant hypertension in treated hypertensive patients in Malaysia is not known. This paper examines the prevalence and determinants of resistant hypertension in a sample ...
Manios Efstathios E Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, - - 2014
Several studies have shown that blood pressure (BP) variability derived from ambulatory blood pressure monitoring (ABPM) is associated with target organ damage development. However, the use of discontinuous ABPM to assess rapid BP changes is unavoidably limited by the long frequency at which automated measures are scheduled. The aim of ...
Lu N N The Pediatric Cardiology, The First Hospital of Jilin University, Changchun, - - 2014
To explore the association between the dopamine β-hydroxylase (DBH) gene C-1021T polymorphism and the occurrence of orthostatic hypotension (OH) in Chinese patients, the DBH C-1021T polymorphism was genotyped in 317 patients with OH and 664 age- and sex-matched controls with orthostatic normotension. All subjects underwent an upright posture study for ...
Bizzarro Matthew M Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street WP493, P.O. Box 208064, New Haven, CT, USA, - - 2014
Nitric oxide (NO) is a prevalent molecule in humans that is responsible for many physiologic activities including pulmonary vasodilation. An exogenous, inhaled form (iNO) exists that mimics this action without affecting systemic blood pressure. This therapy has been implemented in the treatment of pulmonary hypertension. This review examines the efficacy ...
Smith L P LP Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, - - 2014
Hispanics comprise the most rapidly growing demographic in the US, but little is known about the cardiometabolic risk factors in Hispanic children. This study examined the association of high waist circumference (WC) and elevated blood pressure by race/ethnicity in a cohort of 9 to 13 year olds in New Haven, ...
Juraschek Stephen P SP School of Medicine, John Hopkins University, Baltimore, Maryland; Johns Hopkins Bloomberg School of Public Health and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, - - 2014
Recent evidence suggests that insufficient oxidative capacity or mitochondrial dysfunction may play a causal role in the development of high blood pressure. However, this hypothesis has not been tested in the general population. We hypothesized that lactate, a measure of oxidative capacity, would be positively associated with incident hypertension even ...
Bang Casper N CN Department of Medicine, Weill Cornell Medical College, NY, USA; Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen Denmark. Electronic address: - - 2014
Cornell product criteria, Sokolow-Lyon voltage criteria and electrocardiographic (ECG) strain (secondary ST-T abnormalities) are markers for left ventricular hypertrophy (LVH) and adverse prognosis in population studies. However, the relationship of regression of ECG LVH and strain during antihypertensive therapy to cardiovascular (CV) risk was unclear before the Losartan Intervention for ...
Pancholy Samir B SB The Commonwealth Medical College and The Wright Center for Graduate Medical Education, Scranton, Pennsylvania. Electronic address: - - 2014
Data comparing the effect of renal denervation (RD) with those of maximal medical therapy (MMT) have shown conflicting results. Also, effect of RD on pulse pressure (PP) has not been evaluated. The aim of this meta-analysis was to compare the effect of RD with that of MMT on blood pressure ...
Hu Dayi D Department of Cardiology, Peking University People's Hospital, Beijing, 100044, China, - - 2014
Single-pill combination (SPC) therapy of two drugs is recommended by international guidelines, including the Chinese guidelines (2010), for the treatment of hypertension in high-risk patients who require marked blood pressure (BP) reductions. Real-world data on the efficacy and safety of valsartan/amlodipine (Val/Aml) SPC are scarce. The present study is the ...
Masugata Hisashi H Department of Integrated Medicine, Kagawa University, Miki, Kagawa 761-0793, - - 2014
The present study aimed to investigate the association between plasma brain natriuretic peptide (BNP) levels and systolic blood pressure (SBP) variability over a one-year period. Blood pressure was measured in 44 patients treated for hypertension (73±9 years old) at an outpatient clinic every one to two months over a one-year ...
Li Yongling - - 2014
Background: Workers coming from lowland regions are at risk of developing acute mountain sickness (AMS) when working in low oxygen high-altitude areas. Objectives: The aim of this study was to improve the conditions that lead to hypoxia and ensure the safety of the high-altitude workers. We analyzed the influence of ...
Myasoedova Elena E From the Department of Health Sciences Research, and the Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. Funded by a grant from the US National Institutes of Health (NIH), US National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR46849). Research reported in this publication was supported by the National Institute on Aging of the NIH under Award Number R01AG034676. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. E. Myasoedova, MD, PhD; C.S. Crowson, MS, Department of Health Sciences Research, and the Division of Rheumatology; A.B. Green, MS, Department of Health Sciences Research; E.L. Matteson, MD, MPH; S.E. Gabriel, MD, MSc, Department of Health Sciences Research, and the Division of Rheumatology, Mayo Clinic College of Medicine. Address correspondence to C.S. Crowson, 200 First St. SW, Rochester, Minnesota 55905, USA. E-mail: crowson@mayo.edu. Accepted for publication March 28, - - 2014
To examine longterm visit-to-visit blood pressure (BP) variability in patients with rheumatoid arthritis (RA) versus non-RA subjects and to assess its effect on cardiovascular (CV) events and mortality in RA. Clinic BP measures were collected in a population-based incident cohort of patients with RA (1987 American College of Rheumatology criteria ...
Oh Yoon-Sang YS Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South - - 2014
Autonomic disturbances and sleep problems are common non-motor symptoms in patients with Parkinson's disease (PD). Orthostatic hypotension, supine hypertension (SH), and nocturnal hypertension (NH) are inter-related in patients with PD. These abnormalities might be associated with restless legs syndrome (RLS), which occurs predominantly at rest or during sleep. Few reports ...
Rakotz Michael K MK Feinberg School of Medicine, Northwestern University, Chicago, Illinois - - 2014
The goal of this study was to develop a technology-based strategy to identify patients with undiagnosed hypertension in 23 primary care practices and integrate this innovation into a continuous quality improvement initiative in a large, integrated health system. In phase 1, we reviewed electronic health records (EHRs) using algorithms designed ...
Teo Koon K aPopulation Health Research Institute bDepartment of Clinical Epidemiology and Biostatistics cDepartment of Medicine, McMaster University, Hamilton, Hamilton Health Sciences, Hamilton, Ontario, - - 2014
Current guidelines, based on extrapolations of observational studies or short-term relatively small clinical trials, recommend that daily sodium intake should be around 2 g/day or less. The assumption is that the relationship between sodium consumption and blood pressure (BP) levels is linear in all populations. Recent development suggests this may not ...
Bhavanani Ananda Balayogi AB Centre for Yoga Therapy, Education and Research, Mahatma Gandhi Medical College and Research Institute, Puducherry, - - 2014
This study planned to compare immediate cardiovascular effects of different yoga asanas in healthy young volunteers. Heart rate (HR), systolic pressure (SP), and diastolic pressure (DP), blood pressure (BP), were recorded using the non invasive blood pressure (NIBP) apparatus in 22 healthy young subjects, before and after the performance of ...
Lackland Daniel T DT Department of Neurosciences, Medical University of South Carolina, Charleston, South - - 2014
: The racial disparity in hypertension and hypertension-related outcomes has been recognized for decades with African Americans with greater risks than Caucasians. Blood pressure levels have consistently been higher for African Americans with an earlier onset of hypertension. Although awareness and treatment levels of high blood pressure have been similar, ...
Nomura Kyoko K From the Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.N., K.A., T.O.); Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium (K.A., L.T., A. Hara, J.A.S.); Graduate School of Pharmaceutical Sciences (K.A., Y.I.), Tohoku Medical Megabank Organization (A. Hozawa), and Graduate School of Medicine (I.T.), Tohoku University, Sendai, Japan; Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (T.J.N., J.K.J., A.M.J.); Department of Medicine, Turku University Hospital, Turku, Finland (T.J.N.); Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay (I.L., J.B.); the Asociación Española Primera de Socorros Mutuos, Montevideo, Uruguay (E.S.); Hypertension Center, Third Department of Medicine, University of Athens, Sotiria Hospital, Athens, Greece (A.K., G.S.S.); and Department of Epidemiology, Maastricht University, Maastricht, The Netherlands - - 2014
Whether blood pressure thresholds for hypertension should differ according to sex or age remains debated. We did a subject-level meta-analysis of 5018 people untreated for hypertension and randomly recruited from 5 populations (women, 56.7%; ≥60 years, 42.3%). We used multivariable-adjusted Cox regression and a bootstrap procedure to determine home blood ...
Tong Fei F Department of Chemistry, University of California Riverside , 501 Big Springs Road, Riverside, California 92521, United - - 2014
9-tert-Butylanthracene undergoes a photochemical reaction to form its strained Dewar isomer, which thermally back-reacts to reform the original molecule. When 9-tert-butylanthracene is dissolved in a polymer host, we find that both the forward and reverse isomerization rates are pressure-dependent. The forward photoreaction rate, which reflects the sum of contributions from ...
Blom Kim K Department of Geriatrics, University Medical Center Utrecht, PO Box 85500, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The - - 2014
The influence of vascular risk factors (VRFs) on the rate of cognitive decline in patients with established dementia is unclear. This study aims to examine the association between VRFs and the rate of cognitive decline in patients with Alzheimer's disease (AD). Data were obtained from patients visiting a memory clinic ...
Tang Chenglong C State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an, People's Republic of China. Electronic address: - - 2014
The explosion characteristics of high methane fraction natural gas were investigated in a constant volume combustion vessel at different initial conditions. Results show that with the increase of initial pressure, the peak explosion pressure, the maximum rate of pressure rise increase due to a higher amount (mass) of flammable mixture, ...
Fateh Mansooreh M aCenter for Health Related Social and Behavioral Sciences Research bDepartment of Epidemiology, School of Public Health, Shahroud University of Medical Sciences, Shahroud cCenter for Diseases Control, Ministry of Health and Medical Education, Tehran dDepartment of Public Health, School of Public Health; Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad eDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, - - 2014
Hypertension covers a large portion of burden of diseases, especially in the developing countries. The unequal distribution of hypertension in the population may affect 'health for all' goal. This study aimed to investigate the socioeconomic inequality of hypertension in Iran and to identify its influencing factors. We used data from ...
Zhang Bing B Beijing Institute of Pharmacology and Toxicology, Beijing, - - 2014
Combining drugs with complementary mechanisms of action may contribute to improved hypertension control in diabetic patients. Advanced glycation end-product (AGE) breakers, a new class of candidate drugs targeting aging-related cardiovascular dysfunction, may be useful as novel adjuvant agents to improve the efficacy of diabetic hypertension (DH) treatment. This study evaluated ...
Cheema Ejaz E Warwick Medical School, Gibbet Hill Campus, University of Warwick, Coventry, - - 2014
Hypertension is an important cause of morbidity and death, yet its control is poor in many patients with hypertension. Community pharmacists are an important resource for improving hypertension control. To undertake a systematic review and meta-analysis of randomised controlled trials concerned with the impact of community pharmacist-led interventions on blood ...
Kawamoto Ryuichi R 1] Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan [2] Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime, - - 2014
Central blood pressure (BP) has been shown to strongly associate with cardiovascular disease and outcome. Recent studies have demonstrated a relationship between changes in body size by exercise training and peripheral BP; however, the effect on changes in central BP is unknown. The aim of this study was to assess ...
Albert Phebe P Department of Psychology, University of Florida, Gainesville, FL, - - 2014
This pilot study examined the effects of perfectionism on blood pressure (BP) in response to repeated exposure to mental arithmetic stressors. College students (N = 30) in a laboratory setting were administered a series of challenging mathematical tasks. BP was measured at baseline and after each task. Multilevel modelling analyses revealed that ...
Ganesh Santhi K SK Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: - - 2014
Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby ...
Muntner Paul P Department of Epidemiology (PM), University of Alabama at Birmingham, Birmingham, Alabama; Department of Medicine (CBB), Emory University, Atlanta Veterans Affairs Medical Center (CBB) Atlanta, Georgia; and Department of Medicine (DS), Columbia University Medical Center, New York, New - - 2014
: The 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8) was recently published. This guideline recommended that older adults (≥60 years) without diabetes or chronic kidney disease with systolic blood pressure (SBP) ...
Afridi Hassan Imran HI National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan, - - 2014
The abnormal metabolism of metal ions plays an important role in health and disease conditions; hence, the studies about them have received much interest. The objective of this study was to evaluate the association between trace and toxic elements zinc (Zn), cadmium (Cd), selenium (Se), and mercury (Hg) in biological ...
Vimaleswaran Karani S KS Population, Policy and Practice, UCL Institute of Child Health, London, UK; Hugh Sinclair Unit of Human Nutrition, Department of Food & Nutritional Sciences, School of Chemistry, Food & Pharmacy, University of Reading, Reading, - - 2014
Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk. In this mendelian randomisation study, we ...
Schilders Joyce E M JE Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Room EE1418b, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, The - - 2014
Not all hypertensive patients respond well to ACE inhibition. Here we determined whether renin-angiotensin system (RAS) phenotyping, i.e., the measurement of renin or ACE, can predict the individual response to RAS blockade, either chronically (enalapril vs. enalapril + candesartan) or acutely (enalapril ± hydrochlorothiazide, HCT). Chronic enalapril + candesartan induced larger renin rises, but did not ...
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