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Results 201 - 250 of 1278
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Ke Qingen - - 2009
Combretastatin A-4 phosphate (CA4P) is a novel and promising anti-neoplastic agent. However, it is associated with transient hypertension in both animal and human models. In this study, we examined the potential cardiac toxicity and hypertensive effects of CA4P, and defined the most effective pharmacological inhibition of CA4P-induced hypertension in rats. ...
Belmokhtar Mounia - - 2009
Cistus ladaniferus L. (Cistaceae) is a medicinal plant originated from the Mediterranean region which exerts different pharmacological effects. In the present study, our goal was to examine whether the plant possessed antihypertensive properties. Aqueous extract of Cistus leaves (AEC, 500mg/kg/day) reduced systemic blood pressure (SBP) in two animal models of ...
Mohan Mahalaxmi - - 2009
ETHNOPHARMACOLOGICAL RELEVANCE: Solanum torvum (Solanaceae) is a plant used in Cameroon ethnomedicine for the treatment of hypertension. AIM OF THE STUDY: The present study was aimed to determine the effect of ethanolic extract of Solanum torvum (100 and 300 mg/kg; p.o. for 6 weeks) on systolic blood pressure (SBP), vascular ...
Zeman Michal - - 2009
OBJECTIVES: Plasma melatonin concentrations in non-dipping patients show a blunted daily rhythm. Melatonin has a capacity to improve disturbances in biological rhythms. Hypertensive TGR(mRen2)27 (TGR) rats with an upregulated renin-angiotensin system and inverted blood pressure profile were used to elucidate whether melatonin is able to influence the control of blood ...
Laugero Kevin D - - 2009
BACKGROUND: Exenatide is a peptide incretin mimetic that has glucoregulatory actions associated with weight reduction. Previous reports demonstrated acute increases in blood pressure after systemic or intracerebroventricular administration of exenatide or glucagon like peptide 1 (GLP 1) in rats. However, there are limited studies testing the chronic effects of these ...
Ong Sharon Leng Hong - - 2009
Although dexamethasone (DEX) is known to cause hypertension in humans and in animals, the hemodynamic characteristics of DEX-induced hypertension (DEX-HT) in the rat remain unclear. This study evaluated central and regional hemodynamics, and the role of total peripheral resistance (TPR) using a vasodilator minoxidil. Rats were divided into four groups, ...
Li Zhao-Feng - - 2009
Ghrelin, an endogenous ligand for the GH secretagogue receptor, has been shown to decrease arterial pressure. Obestatin, a sibling of ghrelin derived from preproghrelin, opposes several physiological actions of ghrelin. The aim of this study was to determine the effects of bolus intravenous injection of obestatin on blood pressure in ...
Chandler Derrick L - - 2009
An elevated plasma level of homocysteine (hyperhomocysteinemia) is thought to be an important risk factor for a variety of cardiovascular diseases including preeclampsia. Although clinical studies have reported a two- to threefold elevation in plasma levels of homocysteine in women who developed preeclampsia, the importance of hyperhomocysteinemia in causing endothelial ...
Lee Tae-Yeon - - 2009
OBJECTIVES: To test the hypothesis that orthodontic pressure does not induce gene transcription of IL-1beta, MMP-9, and TIMP-1 in pressure gingival soft tissue. MATERIALS AND METHODS: A total of 14 male Wistar rats were used with three rats as no appliance controls and another three as the sham appliance group. ...
Augustyniak Robert A - - 2010
1. Chronically increased sympathetic nerve activity is present during chronic kidney disease (CKD); however, its role in contributing to hypertension or the progression of CKD remains poorly understood. The aim of the present study was to determine whether neonatal sympathectomy attenuates hypertension in 5/6 nephrectomized rats and affects renal structure ...
Friedemann Thomas - - 2009
Effect of manual acupuncture (twisting; lifting and thrusting; combination of them) at acupoints Nei-guan (PL-6) in the fore limb and Zu-san-li (ST-36) in the hind limb on mean arterial blood pressure was investigated in anesthetized rats. During acupuncture treatment mean arterial blood pressure was decreased but fluctuated in intact rats, ...
Kaygisiz Ziya - - 2009
OBJECTIVE: There are evidences that proadrenomedullin N-terminal 20 peptide (PAMP) and calcitonin may be involved in cardiovascular function. Therefore, we studied effects of rat PAMP and human PAMP as well as rat calcitonin and salmon calcitonin on coronary perfusion pressure, heart rate and contractile force. METHODS: Isolated rat hearts were ...
Han Jing-Jun - - 2009
Inhibition of cardiac hypertrophy leads to a significant reduction in cardiovascular mortality and morbidity. Quercetin is by far the most abundant flavonoid and believed to ameliorate cardiovascular disease. Therefore, we investigated whether quercetin supplementation could attenuate the development of cardiac hypertrophy induced by pressure overload. Three weeks after suprarenal transverse ...
Matsumoto Mika - - 2009
We examined the effect of high salt intake on mean arterial pressure and circadian blood pressure rhythm in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type II diabetes mellitus. Mean arterial pressure, fasting blood glucose, and fasting plasma insulin in OLETF rats were higher than those in LETO ...
Rizzoni Damiano - - 2009
The Milan hypertensive rat strain (MHS) is a genetic strain in which cardiovascular phenotypes seem to be dependent, at least in part, on adducin gene polymorphisms. The aim of our study was to evaluate the structure, contractile responses and endothelium-dependent vasodilation in mesenteric small resistance arteries in 12-week-old MHS, (n=7), ...
Erbanová Michaela - - 2009
OBJECTIVE: The present study was performed to characterize the autoregulatory efficiency of renal blood flow and glomerular filtration rate and the pressure-natriuresis relationship in transgenic rats with inducible angiotensin II (ANG II)-dependent hypertension (Cyp1a1-Ren-2 rats). METHODS: The renin gene was induced in Cyp1a1-Ren-2 rats through dietary administration of the natural ...
Linder A Elizabeth - - 2009
Hypertension is closely associated with erectile dysfunction (ED) as it has been observed in many experimental models of hypertension. Additionally, epidemiological studies show that approximately a third of hypertensive patients have ED. To test the hypothesis that the two-kidney, one-clip (2K-1C) rat model of hypertension displays normal erectile function due ...
Inta Ioana I Department of Neurology, University of Heidelberg, Heidelberg, - - 2009
An increased blood pressure can elicit remodeling of the cardiovascular system. Experimental data have implicated gp130, a subunit of the receptor for interleukin-6 (IL-6)-related cytokines, in the regulation of proliferation and apoptosis of cardiomyocytes and vascular smooth muscle cells (VSMC). Here, we investigate whether serum soluble gp130 concentrations correlate with ...
Castro Michele M - - 2009
Mounting evidence indicates that structural and functional vascular changes associated with two-kidney, one-clip (2K-1C) hypertension result, at least in part, from altered activity of matrix metalloproteinases (MMPs). Because MMPs are upregulated by increased formation of reactive oxygen species (ROS), we hypothesized that antioxidant approaches could attenuate the increases in MMP-2 ...
Dieterle Thomas - - 2009
Recently, novel corticotropin-releasing factor-related peptides, named urocortin 1, 2, and 3, and a distinct cardiac and peripheral vascular receptor (corticotropin-releasing factor receptor 2) were described being part of a peripheral corticotropin-releasing factor system modulating cardiovascular function in response to stress. Vasorelaxation and blood pressure lowering have been reported after acute ...
Radenkovic Mirjana - - 2009
Acute effects of different extracts of mistletoe stem (Viscum album) were investigated on values of arterial blood pressure in Wistar rats. Arterial blood pressure was registered by direct method in the left carotid artery and the investigated extracts (total ethanol, ether and ethyl acetate) of mistletoe stem were administered into ...
O.Z. Ameer
In the present study, &lt;I&gt;Loranthus ferrugineus &lt;/I&gt;was evaluated for blood pressure lowering activity using &lt;I&gt;in vitro&lt;/I&gt; and &lt;I&gt;in vivo&lt;/I&gt; animal experimental approaches. The fresh aerial parts of the plant were dried, pulverized into powder and successively extracted with petroleum ether, chloroform, ethyl acetate, methanol and water using hot extraction methods. ...
Roysommuti Sanya - - 2009
The present study tests the sex-dependent effect of perinatal taurine exposure on arterial pressure control in adults. Female Sprague-Dawley rats were fed normal rat chow with 3% beta-alanine (taurine depletion,TD), 3% taurine (taurine supplementation,TS) or water alone (C) from conception to weaning. Their male and female offspring were then fed ...
Perez-Vizcaino Francisco - - 2009
The blood pressure lowering effect of a fruit and vegetable-rich diet is a necessary dietary lifestyle measure now included the guidelines for the management of arterial hypertension. Furthermore, flavonoids represent a major class of plant polyphenolics. The present review addresses the antihypertensive effect of quercetin, one of the most abundant ...
Azurmendi Pablo J - - 2009
The kallikrein-kinin system (KKS) appears to be involved in blood pressure regulation. We showed that ovariectomy (oVx) stimulates urinary kallikrein activity (UKa). So, we test whether gonadectomy (Gx) would affect blood pressure through an increase in KKS activity and which mechanism(s) were involved. We studied adult Wistar rats of either ...
Xu Ping - - 2009
The renin-angiotensin system plays an important role in the etiology of cardiovascular diseases. Three transgenic mouse lines overexpressing rat angiotensinogen (rAOGEN) were generated. The aim of our study was to characterize the originally undescribed second transgenic line TGM(rAOGEN)102. The transgene tissue distribution and expression of brain natriuretic peptide and collagen ...
Lee Sae-Won - - 2009
Transplantation of autologous skeletal myoblasts (SMBs) is a potential therapeutic approach for myocardial infarction. However, their clinical efficacy and safety is still controversial. Electrical coupling through gap junction between SMBs and host myocardium is essential for synchronized contraction and electrical stability. Here, we investigated the effect of heart beat-simulating environment, ...
Bahgat Ashraf - - 2008
Solanum indicum ssp. distichum is used as a vegetable in some parts of Africa and claimed in folk medicine to guard against cardiovascular disorders. It was of interest to study the potential blood pressure lowering effects of a standardized extract of the fruit. An ethanolic extract of the fruit, standardized ...
Chen Qixuan - - 2009
The aim of the present study was to determine the impact of increased consumption of phytosterols or phytostanols on blood pressure and renal blood pressure regulatory gene expression in stroke-prone spontaneously hypertensive (SHRSP) and normotensive Wistar-Kyoto (WKY) inbred rats. SHRSP and WKY inbred rats (10/group) were fed a control diet ...
Ren Yijin - - 2008
OBJECTIVE: To investigate the age-dependent morphology of the periodontal ligament (PDL) tissue and changes in its surface area (SA) during force application provided with a standardized orthodontic setup for a period of 12 weeks in young and adult rats. METHODS: Two groups of 30 rats, age 6 weeks and 9 ...
Lehmann Artur - - 2009
Parathyroid hormone (PTH) is secreted by parathyroid glands and is the main known factor that control plasma calcium concentration. There are many indications that PTH or products of PTH degradation influence the mean arterial blood pressure (MAP). These observations might be important in diseases accompanied with the overproduction of PTH ...
Yzydorczyk Catherine - - 2008
Long-term vascular and renal consequences of neonatal oxidative injury are unknown. Using a rat model, we sought to investigate whether vascular function and blood pressure are altered in adult rats exposed to hyperoxic conditions as neonates. We also questioned whether neonatal O(2) injury causes long-term renal damage, important in the ...
Liu Chengyun - - 2008
The effect of atorvastatin on warfarin-induced aortic medial calcification and systolic blood pressure (SBP) of rats induced by warfarin was studied. Thirty healthy and adult rats were randomly divided into Warfarin group (n=10), Atorvastatin group (n=10) and normal control group (n=10). Caudal arterial pressure of rats was measured once a ...
Zeller J - - 2008
Calcitonin gene-related peptide (CGRP) receptor antagonists effectively abort migraine headache and inhibit neurogenic vasodilatation in humans as well as rat models. Monoclonal antibodies typically have long half-lives, and we investigated whether or not function-blocking CGRP antibodies would inhibit neurogenic vasodilatation with a long duration of action and therefore be a ...
Musabayane Cephas T CT Department of Human Physiology, School of Medical Sciences, University of KwaZulu-Natal, Durban. - - 2008
The aim of this study was to examine some in vivo and in vitro cardiovascular effects of Helichrysum ceres leaf ethanolic extract (HCE) in experimental animal paradigms. The acute effects of HCE on blood pressure were studied in anaesthetised normotensive male Wistar rats challenged with intravenous hypotonic saline infusion after ...
Gulia K K - - 2008
The effects of electrical stimulation to the septum on penile erections in rats were examined to clarify the mechanisms for regulation of erectile responses during different states of vigilance. Penile responses were assessed by changes in pressure in the corpus spongiosum of penis (CSP) and electromyography (EMG) of the bulbospongiosus ...
Verma, Subodh
The general purpose of this thesis was to examine the effect of chronic metformin treatment on isolated cardiac function in rats made diabetic with STZ and secondly to explore the effect of metformin treatment on the hyperinsulinemic status of two rodent models of hypertension, the spontaneously hypertensive rat and the ...
Ishii M - - 2008
An understanding of aminopeptidase A in hypertension is important, given its ability to cleave the N-terminal aspartic acid of potent vasoconstrictor angiotensin II. However, the role of aminopeptidase A in hypertension has received limited attention. Because we have succeeded in producing recombinant human aminopeptidase A, the effect of aminopeptidase A ...
Zhou Li-Min - - 2008
BACKGROUND: The authors' previous study showed a closed-loop chip system that was used to control arterial pressure in normal rabbits and rats. In the present study the anti-hypertensive effects of the chip system were investigated in anaesthetized two-kidney one-clip (2K1C) renovascular hypertensive rats and compared with sham-operated rats. MATERIAL/METHODS: The ...
Leong Xin Fang - - 2008
BACKGROUND: Palm oil used worldwide contains considerable amounts of antioxidants, namely, vitamin E and carotenes. The purpose of the study was to observe the effect of heated palm oil on blood pressure and observe the cardiac histological changes in rats. METHODS: Forty male Sprague Dawley rats were divided equally into ...
Zheng Yan-Hong - - 2008
The possible effects of cervical lymphatic blockade (CLB) on a series of parameters in conscious freely moving rats were analysed. Blood pressure (BP) and heart rate (HR) for conscious male Sprague-Dawley rats at 1, 3, 7, 11, 15 and 21 days after a CLB or a sham operation were monitored ...
Stauss Harald M - - 2008
BACKGROUND: Cerebrovascular myogenic function, which protects the brain from hemorrhagic stroke, is impaired in stroke-prone spontaneously hypertensive rats. Furthermore, myogenic function contributes to very low frequency blood pressure variability and dynamic autoregulation of cerebral blood flow is most effective at very low frequency in rats. Therefore, we hypothesized that very ...
de Cássia Cypriano Ervati Pinter Rita - - 2008
The present study investigated the effects of 8 week of resistance training (RT) on hemodynamic and ventricular function on cardiac myosin ATPase activity, and on contractility of papillary muscles of rats. Groups: control (CO), electrically stimulated (ES), trained at 60% (TR 60%) and 75% of one repetition maximum (1RM) (TR ...
Wlodek Mary E - - 2008
Impaired growth in utero predicts a low nephron number and high blood pressure later in life as does slowed or accelerated growth after a normal birth weight. We measured the effects of early postnatal growth restriction, with or without prenatal growth restriction, on blood pressure and nephron number in male ...
Resstel Leonardo B M - - 2008
1. Increased plasma homocysteine content and increased blood pressure are independently associated with higher cardiovascular risks. The present study was designed to determine the effects of hyperhomocysteinaemia (HHcys) on the activity of the cardiovascular system in rats. 2. Using male Wistar rats, the effect of moderate HHcys, induced by treating ...
Hernández Prada José A JA McKnight Brain Institute and Department of Physiology, College of Medicine, University of Florida, Gainesville, - - 2008
Angiotensin-converting enzyme 2 (ACE2) is a key renin-angiotensin system enzyme involved in balancing the adverse effects of angiotensin II on the cardiovascular system, and its overexpression by gene transfer is beneficial in cardiovascular disease. Therefore, our objectives were 2-fold: to identify compounds that enhance ACE2 activity using a novel conformation-based ...
Avital Shmuel - - 2009
INTRODUCTION: Many studies have reported on the effects of pneumoperitoneum in a rat model, using a wide range of intra-abdominal pressures. The correlation between pneumoperitoneal pressures in rodents to pressures in humans has not been established. This study evaluates changes in various physiological parameters in different pneumoperitoneum pressures in the ...
Ruiz Antonio - - 2008
The objective of this study was to re-examine whether the effect of the nitric oxide synthesis inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), on blood pressure depends on peripheral vascular tone. The effects of L-NAME (10 mg/kg, i.v.) on diastolic blood pressure (DBP), systolic blood pressure (SBP), pulse pressure (PP) and heart ...
Shidyak, Amjad
We have reported that rats subjected to partial nephrectomy (PNx) or administration of marinobufagenin (MBG) developed an increase in blood pressure, heart size, diastolic dysfunction, and cardiac fibrosis. Spironolactone (S) has been demonstrated to attenuate cardiac fibrosis in both experimental animals and humans with heart failure. We investigated the effects ...
Kang Hyung-Sub - - 2008
Bee venom (BV) has been used in Oriental medicine to treat inflammatory diseases, such as tendonitis, bursitis, and rheumatoid arthritis, despite the sensitivity of the victims and toxicity of the venom. This study examined the mechanisms for the effects of BV on the cardiovascular system in rats. The arterial pressure ...
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