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Zygner Wojciech W Division of Parasitology and Parasitic Diseases, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, 02-786, Warsaw, Poland, - - 2014
The increase of the serum urea to creatinine ratio (UCR) was observed in dogs infected with Babesia canis. Previous studies have suggested that decrease of blood pressure can be one of the reasons for this phenomenon. In this work statistically significant increase of the UCR was observed in dogs with ...
Shaw Brett H BH Departments of aBiomedical Physiology and Kinesiology bStatistics and Actuarial Sciences, Simon Fraser University cCentre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, British Columbia, - - 2014
We aimed to compare the cardiovascular responses of a novel orthostatic stress test, the passive seated orthostatic stress test (PSOST), with those during passive head-up tilt testing (HUTT). We hypothesized that cardiovascular responses during PSOST would be similar to those during HUTT (the 'gold standard'). We tested 15 healthy volunteers, ...
Zohdi Vladislava V Department of Anatomy and Developmental Biology, Monash University, Wellington Rd, Clayton, VIC, 3800, Australia, - - 2014
Epidemiological and experimental studies demonstrate that intrauterine growth restriction (IUGR) followed by accelerated postnatal growth leads to increased risk of developing cardiac disease in adulthood. The aim of this study was to examine the effect of early life growth restriction on cardiac structure and function in young adult rats. IUGR ...
Schrauwen Jelle T C JT Department of Biomedical Engineering, Erasmus Medical Center, 's-Gravendijkwal 230, Faculty Building, Ee 2302, 3000 CA, Rotterdam, The Netherlands, - - 2014
Atherosclerotic disease progression in coronary arteries is influenced by wall shear stress. To compute patient-specific wall shear stress, computational fluid dynamics (CFD) is required. In this study we propose a method for computing the pressure-drop in regions proximal and distal to a plaque, which can serve as a boundary condition ...
Boardman Wayne S J WS 1  School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy, South Australia 5371, - - 2014
Abstract We immobilized 47 white rhinoceroses (Ceratotherium simum) for dehorning with 1-4 mg of etorphine HCl, 10-40 mg of azaperone, and 7,500 IU of hyaluronidase, at a game ranch in South Africa in November 2012. Forty-four received butorphanol intravenously 5 min after recumbency, at the rate of 10 mg of butorphanol per 1 mg of etorphine, ...
Yoshida Tadashi T Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA 70112, - - 2014
Recurrent or sustained inflammation plays a causal role in the development and progression of left ventricular hypertrophy (LVH) and its transition to failure. Interleukin (IL)-18 is a potent pro-hypertrophic inflammatory cytokine. We report that induction of pressure overload in the rabbit, by constriction of the descending thoracic aorta induces compensatory ...
Ilies Christoph C From the Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel (CI, GG, JR, MS, BB, RH), Department of Anaesthesiology and Intensive Care Medicine, Herz- und Gefäßklinik, Bad Neustadt an der Saale (GI), Department of Cardiovascular Surgery, School of Medicine, University of Schleswig-Holstein (NH), and Institute for Medical Informatics and Statistics, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany - - 2014
Arterial pressure monitoring using the a continuous noninvasive arterial pressure (CNAP) device during general anaesthesia is known to be interchangeable with continuous invasive arterial pressure (CIAP) monitoring. Agreement with invasive measurements in cardiovascular postsurgical intensive care patients has not been assessed. The objective of this study is to assess the ...
McKee Jeffrey S JS From the Medical Products, Baxter Healthcare Corporation, Round Lake, - - 2014
Esmolol is marketed as a racemate (RS-esmolol) with hypotension being the most frequently reported adverse event. Previously, it has been shown that the S-enantiomer (S-esmolol) possesses all of the heart rate (HR) control. The authors studied whether S-esmolol alone mitigates hypotension at similar degrees of HR control compared with RS-esmolol. ...
Papaioannou Theodore G TG Biomedical Engineering Unit, 1st Dept. of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Laboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, Swiss Federal Institute of Technology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Electronic address: - - 2014
Surgical or critically ill patients often require continuous assessment of cardiac output (CO) for diagnostic purposes or for guiding therapeutic interventions. A new method of non-invasive CO estimation has been recently developed, which is based on pressure wave analysis. However, its validity has been examined only in silico. Aim of ...
Seth Henrik H Department of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. Electronic address: - - 2014
The bulbus arteriosus is a compliant structure between the ventricle and ventral aorta of teleost fish. It serves as a "wind-kessel" that dampens pressure variations during the cardiac cycle allowing a continuous flow of blood into the gills. The bulbus arteriosus receives sympathetic innervation and is affected by several circulating ...
Iliescu Radu R Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216-4505, USA, - - 2014
Recent technical advances have led to the development of a medical device that can reliably activate the carotid baroreflex with an acceptable degree of safety. Because activation of the sympathetic nervous system plays an important role in the pathogenesis of hypertension and heart failure, the unique ability of this device ...
Vorselaars V M M VM Department of Cardiology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, the Netherlands, - - 2014
Transcatheter embolisation is widely used to close pulmonary arteriovenous malformations (PAVMs) in patients with hereditary haemorrhagic telangiectasia (HHT). Data on the direct cardiovascular haemodynamic changes induced by this treatment are scarce. We investigated the direct haemodynamic effects of transcatheter embolisation of PAVMs, using non-invasive finger pressure measurements. During the procedure, ...
Pascoe Peter J PJ Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, - - 2014
To determine the cardiopulmonary changes associated with intravenous (IV) infusions of dexmedetomidine at equipotent isoflurane-dexmedetomidine concentrations compared with isoflurane alone. Prospective, randomized, crossover experiment. Six adult intact female mixed-breed dogs weighing (mean ± SD [range]) 23.3 ± 3.8 (17.8-29.4) kg. Anesthesia was induced and maintained with isoflurane in oxygen. Measurements of respiratory rate (fR ...
de Witt Benjamin B Department of Emergency Medicine, University of Arizona, Tucson, - - 2014
Assessing volume responsiveness, defined as an increase in cardiac index after infusion of fluids, is important when caring for critically ill patients in septic shock, as both under- and over-resuscitation can worsen outcomes. This review article describes the currently available methods of assessing volume responsiveness for critically ill patients in ...
Rosendal Christian C Hirslanden Clinics Berne, Klinik Beau-Site, Schänzlihalde 11, 3000 Bern 25, Switzerland; Department of Anesthesiology, University of Heidelberg, INF 110, 69120 Heidelberg, Germany. Electronic address: - - 2014
To determine and interpret the changes in preload, afterload, and cardiac function in the different phases of robot-assisted laparoscopic prostatectomy. Prospective, observational monocenter study. Operating room at a university hospital. 31 consecutive, ASA physical status 1, 2, and 3 patients. Observations were made at 5 distinct time points: baseline after ...
Phan Nam Nhut NN Graduate Institute of Biotechnology, Chinese Culture University, 55 Hwa-Kang Road, Yang-Ming-Shan, Taipei 11114, Taiwan; Department of Applied Science, Ton Duc Thang University, Nguyen Huu Tho St., Tan Phong Ward, Dist. 7, Ho Chi Minh City, Viet - - 2014
Arsenic is a ubiquitous toxic compound that exists naturally in many sources such as soil, groundwater, and food; in which vast majority forms are arsenite (As(3+)) or arsenate (As(5+)). The mechanism of arsenic detoxification in humans still remains obscured. Epidemiologic studies documented that arsenic pollution caused black foot disease, cardiovascular ...
Asmar Ali A Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, 2200, Copenhagen, Denmark, - - 2014
We have previously shown that Afghans residing in Denmark for at least 12 years exhibit a lower 24-h ambulatory blood pressure compared to Danes. The purpose of this study was to test the hypothesis that the lower blood pressure reflects attenuated compensatory baroreflex responses in the Afghans. On a controlled diet ...
Martelli Davide D Florey Institute of Neuroscience and Mental - - 2014
The lack of non-invasive approaches to measure cardiac sympathetic nerve activity (CSNA) has driven the development of indirect estimates such as the low-frequency (LF) power of heart rate variability (HRV). Recently it has been suggested that LF HRV can be used to estimate the baroreflex modulation of heart period (HP) ...
Lucking Eric F EF UCD School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland - - 2014
Chronic intermittent hypoxia (CIH) in animal models has been shown to result in hypertension and elevation of sympathetic nervous system activity. Sympathetic mediated vasoconstriction is believed to be the primary mechanism underpinning CIH induced hypertension, however the potential contribution of the heart is largely overlooked. We sought to determine the ...
Bozkurt Selim S Eindhoven University of Technology, Department of Biomedical Engineering, The Netherlands. Electronic address: - - 2014
Continuous flow left ventricular assist devices (CF-LVADs) reduce arterial pulsatility, which may cause long-term complications in the cardiovascular system. The aim of this study is to improve the pulsatility by driving a CF-LVAD at a varying speed, synchronous with the cardiac cycle in an ex-vivo experiment. A Micromed DeBakey pump ...
Zhang Peizhen P University of North Texas Health Science - - 2014
Intermittent-hypoxia (IH) is extensively applied to challenge cardiovascular and respiratory function, and to induce physiological acclimatization. The purpose of this study was to test the hypothesis that oxyhemoglobin equilibrium and tachycardiac responses during hypoxemia were enhanced after 14-day IH exposures. Normobaric-poikilocapnic hypoxia was induced with inhalation of 10% O2 for ...
Guo Kun K Department of Pharmacology, Key Laboratory of Antiinflammation and Immunopharmacology of Ministry of Education, Basic Medical College, Anhui Medical University, Hefei 230032, - - 2014
Xin-Ji-Er-Kang(XJEK),a a Chinese herbal formula,is effective against hypertension induced coronary heart disease, viral myocarditis and toxic myocarditis.In this study,the effect of XJEK on cardiovasuclar system were investigated. To test the hypothesis that Xin-Ji-Er-Kang (XJEK) has an anti-hypertensive effect mediated through attenuation of cardiac remodeling,and amelioration of vascular endothelial dysfunction and ...
Laszikova Eva E Department of Anaesthesiology, Resuscitation, and Intensive Care, 1st Faculty of Medicine and General Faculty Hospital, Charles University, Prague, Czech - - 2014
Acute liver failure (ALF) is a rare disease with a bad prognosis. Its start is accompanied by haemodynamic instability. The aim of our study was to evaluate the influence of fractionated plasmatic separation and adsorption (FPSA) on body haemodynamics using a large animal experimental model of ALF. ALF was induced ...
Nakagawa Hitoshi H Institute of Physiology and Comprehensive Heart Failure Center, University Würzburg, Würzburg, - - 2014
-The endocrine balance between atrial natriuretic peptide (ANP) and the renin-angiotensin-aldosterone system is critical for the maintenance of arterial blood pressure and volume homeostasis. This study investigated whether a cardiac imbalance between ANP and aldosterone, towards increased mineralcorticoid receptor (MR) signaling, contributes to adverse left ventricular (LV) remodeling in response ...
Paschoal Mario Augusto - - 2014
Background: When performing the Valsalva maneuver (VM), adults and preadolescents produce the same expiratory resistance values. Objective: To analyze heart rate (HR) in preadolescents performing VM, and propose a new method for selecting expiratory resistance. Method: The maximal expiratory pressure (MEP) was measured in 45 sedentary children aged 9-12 years ...
Armelin Vinicius Araújo VA Department of Physiological Sciences, Federal University of São Carlos (UFSCar), Via Washington Luiz, km 235, São Carlos, SP, 13565-905, - - 2014
Orthostasis dramatically influences the hemodynamics of terrestrial vertebrates, especially large and elongated animals such as snakes. When these animals assume a vertical orientation, gravity tends to reduce venous return, cardiac filling, cardiac output and blood pressure to the anterior regions of the body. The hypotension triggers physiological responses, which generally ...
Hoshida Shiro S Department of Cardiovascular Medicine, Yao Municipal Hospital, Yao, - - 2014
This study aimed to define the difference in cardiac hypertrophy between hypertensive patients with and without renal artery stenosis (RAS). When cardiac ultrasonographic examination was performed in 971 consecutive hypertensive outpatients, renal peak systolic velocity (PSV) was examined. Compared with patients without RAS, those with RAS (PSV ≥180 cm/s, 4.1%) were ...
Linz Dominik D Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany; - - 2014
Hypertension and metabolic syndrome (MetS) are associated with increased sympathetic activation possibly contributing to the progression of renal damage and cardiac remodeling. Renal sympathetic denervation (RDN) decreases sympathetic renal efferent and afferent nerve activity. Obese spontaneously hypertensive rats (SHRs-ob) were subjected to RDN at the age of 34 weeks (SHRs-ob ...
Rhee C J CJ Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, - - 2014
Objective:To quantify cerebrovascular autoregulation as a function of gestational age (GA) and across the phases of the cardiac cycle.Study design:The present study is a hypothesis-generating re-analysis of previously published data. Premature infants (n=179) with a GA range of 23 to 33 weeks were monitored with umbilical artery catheters and transcranial ...
Kelly Aaron S AS Department of Pediatrics, University of Minnesota Medical School, and University of Minnesota Children's Hospital, Minneapolis, MN; Department of Medicine, University of Minnesota Medical School, Minneapolis, MN. Electronic address: - - 2014
To compare markers of cardiovascular health in youth diagnosed with attention deficit hyperactivity disorder (ADHD) by the use of stimulant medication with healthy controls. Children and adolescents (n = 85; mean age 11.2 ± 2.8 years; 66 boys) diagnosed with ADHD using a stimulant and 53 siblings without ADHD (mean age 11.1 ± 3.8 years; 28 boys) were ...
Kasahara Hirofumi - - 2014
Hemorrhage from the left ventricle can be critical and sutureless repair using a fibrin-based haemostat (TachoComb) is one effective option. When active hemorrhage is not controlled by the haemostat, we have used a polyglycolic acid (PGA) sheet and fibrin glue in addition. Here we investigated whether the PGA sheet and ...
Paustian Joel S JS Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. - - 2014
We report on a microfluidic AC-driven electrokinetic pump that uses Induced Charge Electro-Osmosis (ICEO) to generate on-chip pressures. ICEO flows occur when a bulk electric field polarizes a metal object to induce double layer formation, then drives electroosmotic flow. A microfabricated array of metal-dielectric Janus micropillars breaks the symmetry of ...
Akcay Salaheddin S aDepartment of Cardiology, Celal Bayar University Faculty of Medicine, Manisa bDepartment of Cardiology, Duzce University Faculty of Medicine, Duzce cDepartment of Cardiology, Elazig Education and Research Hospital, Elazıg, - - 2014
Hypertension has been reported to affect both the left and the right ventricular functions, but its effect on the coronary sinus has not been investigated. The aim of this study was to investigate the effect of systemic hypertension on the cardiac venous system by evaluating the coronary sinus strain (CSS). ...
Kuroki Marcos T MT University of - - 2014
Angiotensin II (AngII) induced hypertension is a commonly studied model of experimental hypertension, particularly in rodents, and is often generated by subcutaneous delivery of AngII using Alzet osmotic minipumps chronically implanted under the skin. We have observed that, in a subset of animals subjected to this protocol, mean arterial pressure ...
Murakami Tomoaki T Department of Cardiology, Chiba Children's Hospital, 579-1 Heta-cho, Midori-ku, Chiba, 266-0007, Japan, - - 2014
It is well known that the reflected pressure wave in small children returns earlier than that in adolescent. The reason of early return of the reflected pressure wave in infancy is their height. The short distance between heart and reflection point makes the reflected pressure wave returning to the heart ...
Lawler Patrick R PR Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, - - 2014
Hypertension is an important risk factor implicated in the development of multiple common cardiac conditions, including coronary atherosclerosis, heart failure, and atrial fibrillation. Epidemiologic studies have provided insights into the shared pathogenesis of hypertension and subclinical as well as clinically evident cardiac diseases. The mechanistic common ground between chronic blood ...
Tennant Ingrid A IA From the Tropical Medicine Research Institute (D.S.T., M.S.B.), Departments of Surgery, Radiology, Anaesthesia, and Intensive Care (I.A.T., A.T.B.), Medicine (Cardiology) (E.E.C., A.P.C.), and UWI Solutions for Developing Countries (T.E.F.), University of the West Indies, Mona, Kingston, Jamaica; Institute Biomedical Technology, Ghent University, Gent, Belgium (J.K., P.S.); MRC Lifecourse Epidemiology Unit (C.O.) and DOHAD Division (M.A.H.), University of Southampton, Southampton, United Kingdom; Centre for Human Evolution, Adaptation, and Disease, Liggins Institute, University of Auckland, Auckland, New Zealand (P.D.G.); and Division of Diabetes, Cardiovascular Medicine, and Nutrition, King's College and King's Health Partners, London, United Kingdom - - 2014
Malnutrition below 5 years remains a global health issue. Severe acute malnutrition (SAM) presents in childhood as oedematous (kwashiorkor) or nonoedematous (marasmic) forms, with unknown long-term cardiovascular consequences. We hypothesized that cardiovascular structure and function would be poorer in SAM survivors than unexposed controls. We studied 116 adult SAM survivors, ...
Aoki Yuji Y Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of - - 2014
Background:It has been shown that increased short-term blood pressure (BP) variability (BPV) aggravates hypertensive cardiac remodeling in spontaneously hypertensive rats (SHRs) through a cardiac angiotensin II (angII) system. However, little was known about the renal damage induced by large BPV. Thus, histological changes in the kidney were investigated and candesartan, ...
Chen Zhang Z Department of Pediatric Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing - - 2014
Objective To assess the accuracy of cardiac output(CO)measured by transpulmonary thermodilution technique(TPTD)and explore the validity of intrathoracic blood volume index(ITBVI)for assessment of circulatory volume status. Methods Ten immature pigs with a mean weight of(20.6±1.9)kg were studied during the conditions including normovolemia,hypervolemia,and hypovolemia. Simultaneous CO was measured in each condition using ...
Snijder P M PM Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the - - 2014
Hypertension is an important mediator of cardiac damage and remodelling. Hydrogen sulfide (H2 S) is an endogenously produced gasotransmitter with cardioprotective properties. However, clinical use is not within reach. We therefore investigated the protective effects of sodium thiosulfate (STS), a clinically applicable H2 S donor substance, in Angiotensin II (Ang ...
Laranjo Sérgio S 1Institute of Physiology and Cardiovascular Autonomic Lab, Faculty of Medicine of - - 2014
Around 15% of children and adolescents experience at least one episode of syncope until adulthood. Excluding cardiac disease, the majority of syncopes are of reflex origin and benign in nature. In this situation, a tilt test is conducted to reproduce symptoms and to evaluate cardiovascular adaptations to orthostatism, but its ...
Adedayo Pelumi P Department of Pediatrics, Penn State Hershey Pediatric Cardiovascular Research Center, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA, - - 2014
The objective of this study was to evaluate the pump performance of the novel diagonal Medos Deltastream DP3 diagonal pump (MEDOS Medizintechnik AG, , Stolberg, Germany) under nonpulsatile to pulsatile mode with varying differential speed values in a simulated pediatric extracorporeal life support system. The experimental circuit consisted of a ...
Leung Joanne Y T JY Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, The University of British Columbia, Vancouver, British Columbia, Canada, V6T - - 2014
Treatment with antipsychotics is associated with adverse cardiovascular effects such as orthostatic hypotension and arrhythmias. Despite the higher prevalence of cardiovascular complications in patients with schizophrenia, the effects of antipsychotic drugs on vascular tone and cardiac contractility have received little attention. In order to better understand the cardiovascular effects of ...
Yun So Hui SH Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine, Aran 13gil 15, Jeju, Jeju Special Self-governing Province, 690-767, Republic of - - 2014
Controlled hypotension (CH) is a well-established technique to decrease blood loss and improve surgical visibility. Although nitroprusside and remifentanil have been safely and effectively used for this purpose, the hemodynamic changes that occur during CH are unclear. This study compared the effects of nitroprusside and remifentanil on hemodynamics using a ...
Badagliacca Roberto R Departments of a?>Cardiovascular and Respiratory Science. Electronic address: - - 2014
Right ventricular (RV) dyssynchrony has been described in pulmonary arterial hypertension (PAH), but no evidence is available on its morphologic determinants and its effect on systolic function. The aim of this study was to evaluate the morphologic determinants of RV dyssynchrony by echocardiographic and cardiac magnetic resonance imaging and its ...
Dschietzig Thomas Bernd TB Immundiagnostik AG, Stubenwaldallee 8a, 64625, Bensheim, Germany, - - 2014
Acute heart failure (AHF) syndrome, characterized by pulmonary and/or venous congestion owing to increased cardiac filling pressures with or without diminished cardiac output, is still associated with high post-discharge mortality and hospitalization rates. Many novel and promising therapeutic approaches, among them endothelin-1, vasopressin and adenosine antagonists, calcium sensitization, and recombinant ...
Moore-Morris Thomas - - 2014
Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular matrix deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia, are key contributors to heart failure progression. Recently, endothelial-to-mesenchymal transition (EndoMT) and the recruitment of circulating hematopoietic progenitors to the heart have been reported to generate substantial numbers of ...
Friess Stuart H SH St. Louis Children's Hospital Washington University in St. Louis School of Medicine Department of Pediatrics 660 S. Euclid Avenue, St. Louis MO 63110. Electronic address: - - 2014
Advances in cardiopulmonary resuscitation (CPR) have focused on the generation and maintenance of adequate myocardial blood flow to optimize the return of spontaneous circulation and survival. Much of the morbidity associated with cardiac arrest survivors can be attributed to global brain hypoxic ischemic injury. The objective of this study was ...
Crispi Fàtima F BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, - - 2014
-Fetal growth restriction (FGR) is associated with global adverse cardiac remodeling in utero and increased cardiovascular mortality in adulthood. Prenatal myocardial deformation has not been evaluated in FGR so far. We aimed to comprehensively evaluate prenatal cardiac remodeling in FGR including myocardial deformation imaging. -Echocardiography was performed in 37 consecutive ...
Rizzi Elen E Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, - - 2014
Hypertension induces left ventricular hypertrophy (LVH) by mechanisms involving oxidative stress and imbalanced cardiac matrix metalloproteinase (MMP) activity. We hypothesized that β1-adrenergic receptor blockers with antioxidant properties (nebivolol) could reverse hypertension-induced LVH more effectively than conventional β1-blockers (metoprolol) when used at doses that exert similar antihypertensive effects. Two kidney one ...
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