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Iliescu Radu R Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216-4505, USA, - - 2014
Recent technical advances have led to the development of a medical device that can reliably activate the carotid baroreflex with an acceptable degree of safety. Because activation of the sympathetic nervous system plays an important role in the pathogenesis of hypertension and heart failure, the unique ability of this device ...
Laszikova Eva E Department of Anaesthesiology, Resuscitation, and Intensive Care, 1st Faculty of Medicine and General Faculty Hospital, Charles University, Prague, Czech - - 2014
Acute liver failure (ALF) is a rare disease with a bad prognosis. Its start is accompanied by haemodynamic instability. The aim of our study was to evaluate the influence of fractionated plasmatic separation and adsorption (FPSA) on body haemodynamics using a large animal experimental model of ALF. ALF was induced ...
Deckx S S Maastricht University, Cardiology, Maastricht, - - 2014
Hypertension and/or aging impose stress on the heart with consecutive cardiac hypertrophy, inflammation and fibrosis, processes that lead to heart failure. Our group has previously shown that non-structural matrix proteins such as TSP-2 and SPARC are critical during hypertension, fibrosis, and age-related cardiac dysfunction. Osteoglycin (OGN) is a class III ...
Schroen B B Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, - - 2014
Cardiac hypertrophy and consequent contractile dysfunction continue to burden Western society. Cardiomyocyte cyclic AMP (cAMP) and calcium are driving forces behind cardiomyocyte contraction. Distortion of their balance may induce HF, but specific therapies aiming at restoring physiological cAMP/calcium signaling are lacking. We recently identified microRNA-139 (miR-139) to be downregulated in ...
Nakagawa Hitoshi H Institute of Physiology and Comprehensive Heart Failure Center, University Würzburg, Würzburg, - - 2014
-The endocrine balance between atrial natriuretic peptide (ANP) and the renin-angiotensin-aldosterone system is critical for the maintenance of arterial blood pressure and volume homeostasis. This study investigated whether a cardiac imbalance between ANP and aldosterone, towards increased mineralcorticoid receptor (MR) signaling, contributes to adverse left ventricular (LV) remodeling in response ...
Paschoal Mario Augusto - - 2014
Background: When performing the Valsalva maneuver (VM), adults and preadolescents produce the same expiratory resistance values. Objective: To analyze heart rate (HR) in preadolescents performing VM, and propose a new method for selecting expiratory resistance. Method: The maximal expiratory pressure (MEP) was measured in 45 sedentary children aged 9-12 years ...
Armelin Vinicius Araújo VA Department of Physiological Sciences, Federal University of São Carlos (UFSCar), Via Washington Luiz, km 235, São Carlos, SP, 13565-905, - - 2014
Orthostasis dramatically influences the hemodynamics of terrestrial vertebrates, especially large and elongated animals such as snakes. When these animals assume a vertical orientation, gravity tends to reduce venous return, cardiac filling, cardiac output and blood pressure to the anterior regions of the body. The hypotension triggers physiological responses, which generally ...
Linz Dominik D Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany; - - 2014
Hypertension and metabolic syndrome (MetS) are associated with increased sympathetic activation possibly contributing to the progression of renal damage and cardiac remodeling. Renal sympathetic denervation (RDN) decreases sympathetic renal efferent and afferent nerve activity. Obese spontaneously hypertensive rats (SHRs-ob) were subjected to RDN at the age of 34 weeks (SHRs-ob ...
Rhee C J CJ Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, - - 2014
Objective:To quantify cerebrovascular autoregulation as a function of gestational age (GA) and across the phases of the cardiac cycle.Study design:The present study is a hypothesis-generating re-analysis of previously published data. Premature infants (n=179) with a GA range of 23 to 33 weeks were monitored with umbilical artery catheters and transcranial ...
Kelly Aaron S AS Department of Pediatrics, University of Minnesota Medical School, and University of Minnesota Children's Hospital, Minneapolis, MN; Department of Medicine, University of Minnesota Medical School, Minneapolis, MN. Electronic address: - - 2014
To compare markers of cardiovascular health in youth diagnosed with attention deficit hyperactivity disorder (ADHD) by the use of stimulant medication with healthy controls. Children and adolescents (n = 85; mean age 11.2 ± 2.8 years; 66 boys) diagnosed with ADHD using a stimulant and 53 siblings without ADHD (mean age 11.1 ± 3.8 years; 28 boys) were ...
Kasahara Hirofumi - - 2014
Hemorrhage from the left ventricle can be critical and sutureless repair using a fibrin-based haemostat (TachoComb) is one effective option. When active hemorrhage is not controlled by the haemostat, we have used a polyglycolic acid (PGA) sheet and fibrin glue in addition. Here we investigated whether the PGA sheet and ...
Paustian Joel S JS Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. - - 2014
We report on a microfluidic AC-driven electrokinetic pump that uses Induced Charge Electro-Osmosis (ICEO) to generate on-chip pressures. ICEO flows occur when a bulk electric field polarizes a metal object to induce double layer formation, then drives electroosmotic flow. A microfabricated array of metal-dielectric Janus micropillars breaks the symmetry of ...
Akcay Salaheddin S aDepartment of Cardiology, Celal Bayar University Faculty of Medicine, Manisa bDepartment of Cardiology, Duzce University Faculty of Medicine, Duzce cDepartment of Cardiology, Elazig Education and Research Hospital, Elazıg, - - 2014
Hypertension has been reported to affect both the left and the right ventricular functions, but its effect on the coronary sinus has not been investigated. The aim of this study was to investigate the effect of systemic hypertension on the cardiac venous system by evaluating the coronary sinus strain (CSS). ...
Kuroki Marcos T MT University of - - 2014
Angiotensin II (AngII) induced hypertension is a commonly studied model of experimental hypertension, particularly in rodents, and is often generated by subcutaneous delivery of AngII using Alzet osmotic minipumps chronically implanted under the skin. We have observed that, in a subset of animals subjected to this protocol, mean arterial pressure ...
Murakami Tomoaki T Department of Cardiology, Chiba Children's Hospital, 579-1 Heta-cho, Midori-ku, Chiba, 266-0007, Japan, - - 2014
It is well known that the reflected pressure wave in small children returns earlier than that in adolescent. The reason of early return of the reflected pressure wave in infancy is their height. The short distance between heart and reflection point makes the reflected pressure wave returning to the heart ...
Lawler Patrick R PR Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, - - 2014
Hypertension is an important risk factor implicated in the development of multiple common cardiac conditions, including coronary atherosclerosis, heart failure, and atrial fibrillation. Epidemiologic studies have provided insights into the shared pathogenesis of hypertension and subclinical as well as clinically evident cardiac diseases. The mechanistic common ground between chronic blood ...
Tennant Ingrid A IA From the Tropical Medicine Research Institute (D.S.T., M.S.B.), Departments of Surgery, Radiology, Anaesthesia, and Intensive Care (I.A.T., A.T.B.), Medicine (Cardiology) (E.E.C., A.P.C.), and UWI Solutions for Developing Countries (T.E.F.), University of the West Indies, Mona, Kingston, Jamaica; Institute Biomedical Technology, Ghent University, Gent, Belgium (J.K., P.S.); MRC Lifecourse Epidemiology Unit (C.O.) and DOHAD Division (M.A.H.), University of Southampton, Southampton, United Kingdom; Centre for Human Evolution, Adaptation, and Disease, Liggins Institute, University of Auckland, Auckland, New Zealand (P.D.G.); and Division of Diabetes, Cardiovascular Medicine, and Nutrition, King's College and King's Health Partners, London, United Kingdom - - 2014
Malnutrition below 5 years remains a global health issue. Severe acute malnutrition (SAM) presents in childhood as oedematous (kwashiorkor) or nonoedematous (marasmic) forms, with unknown long-term cardiovascular consequences. We hypothesized that cardiovascular structure and function would be poorer in SAM survivors than unexposed controls. We studied 116 adult SAM survivors, ...
Aoki Yuji Y Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of - - 2014
Background:It has been shown that increased short-term blood pressure (BP) variability (BPV) aggravates hypertensive cardiac remodeling in spontaneously hypertensive rats (SHRs) through a cardiac angiotensin II (angII) system. However, little was known about the renal damage induced by large BPV. Thus, histological changes in the kidney were investigated and candesartan, ...
Chen Zhang Z Department of Pediatric Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing - - 2014
Objective To assess the accuracy of cardiac output(CO)measured by transpulmonary thermodilution technique(TPTD)and explore the validity of intrathoracic blood volume index(ITBVI)for assessment of circulatory volume status. Methods Ten immature pigs with a mean weight of(20.6±1.9)kg were studied during the conditions including normovolemia,hypervolemia,and hypovolemia. Simultaneous CO was measured in each condition using ...
Sanchez Ruderisch H H Charite - University Medicine Berlin, Center for Cardiovascular Research, Berlin, - - 2014
Sex differences have been observed in patient with aortic stenosis, women develop a more concentric form of myocardial hypertrophy than men and men have a stronger activation of profibrotic genes. Transverse aortic constriction induces more ventricular dilatation and fibrosis in male than in female mice which is partially mediated by ...
Melik Z Z University of Ljubljana, Faculty of Medicine, Insitute of Physiology, Ljubljana, - - 2014
Postocclusive reactive hyperaemia (PORH) is one of the provocation tests for registering differences in vasodilation capabilities in healthy and diseased subjects. One of the hypotheses of essential hypertension is that endothelial dysfunction due to reduced availability of nitric oxide plays a key role in initiation, development and progression of the ...
Maarman G J GJ University of Cape Town, Hatter Cardiovascular Research Institute, Department of Medicine, Cape Town, South - - 2014
Pulmonary arterial hypertension (PAH) is a disorder characterized by elevated pulmonary arterial pressure which leads to cardiac hypertrophy and dysfunction. Current treatments have marginal impact and additional therapies are required. Melatonin is a natural product shown to be cardioprotective against hypertension and myocardial ischemia. We propose that melatonin treatment may ...
Snijder P M PM Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the - - 2014
Hypertension is an important mediator of cardiac damage and remodelling. Hydrogen sulfide (H2 S) is an endogenously produced gasotransmitter with cardioprotective properties. However, clinical use is not within reach. We therefore investigated the protective effects of sodium thiosulfate (STS), a clinically applicable H2 S donor substance, in Angiotensin II (Ang ...
Laranjo Sérgio S 1Institute of Physiology and Cardiovascular Autonomic Lab, Faculty of Medicine of - - 2014
Around 15% of children and adolescents experience at least one episode of syncope until adulthood. Excluding cardiac disease, the majority of syncopes are of reflex origin and benign in nature. In this situation, a tilt test is conducted to reproduce symptoms and to evaluate cardiovascular adaptations to orthostatism, but its ...
Adedayo Pelumi P Department of Pediatrics, Penn State Hershey Pediatric Cardiovascular Research Center, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA, - - 2014
The objective of this study was to evaluate the pump performance of the novel diagonal Medos Deltastream DP3 diagonal pump (MEDOS Medizintechnik AG, , Stolberg, Germany) under nonpulsatile to pulsatile mode with varying differential speed values in a simulated pediatric extracorporeal life support system. The experimental circuit consisted of a ...
Leung Joanne Y T JY Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, The University of British Columbia, Vancouver, British Columbia, Canada, V6T - - 2014
Treatment with antipsychotics is associated with adverse cardiovascular effects such as orthostatic hypotension and arrhythmias. Despite the higher prevalence of cardiovascular complications in patients with schizophrenia, the effects of antipsychotic drugs on vascular tone and cardiac contractility have received little attention. In order to better understand the cardiovascular effects of ...
Yun So Hui SH Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine, Aran 13gil 15, Jeju, Jeju Special Self-governing Province, 690-767, Republic of - - 2014
Controlled hypotension (CH) is a well-established technique to decrease blood loss and improve surgical visibility. Although nitroprusside and remifentanil have been safely and effectively used for this purpose, the hemodynamic changes that occur during CH are unclear. This study compared the effects of nitroprusside and remifentanil on hemodynamics using a ...
Dschietzig Thomas Bernd TB Immundiagnostik AG, Stubenwaldallee 8a, 64625, Bensheim, Germany, - - 2014
Acute heart failure (AHF) syndrome, characterized by pulmonary and/or venous congestion owing to increased cardiac filling pressures with or without diminished cardiac output, is still associated with high post-discharge mortality and hospitalization rates. Many novel and promising therapeutic approaches, among them endothelin-1, vasopressin and adenosine antagonists, calcium sensitization, and recombinant ...
Moore-Morris Thomas - - 2014
Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular matrix deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia, are key contributors to heart failure progression. Recently, endothelial-to-mesenchymal transition (EndoMT) and the recruitment of circulating hematopoietic progenitors to the heart have been reported to generate substantial numbers of ...
Friess Stuart H SH St. Louis Children's Hospital Washington University in St. Louis School of Medicine Department of Pediatrics 660 S. Euclid Avenue, St. Louis MO 63110. Electronic address: - - 2014
Advances in cardiopulmonary resuscitation (CPR) have focused on the generation and maintenance of adequate myocardial blood flow to optimize the return of spontaneous circulation and survival. Much of the morbidity associated with cardiac arrest survivors can be attributed to global brain hypoxic ischemic injury. The objective of this study was ...
Crispi Fàtima F BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, - - 2014
-Fetal growth restriction (FGR) is associated with global adverse cardiac remodeling in utero and increased cardiovascular mortality in adulthood. Prenatal myocardial deformation has not been evaluated in FGR so far. We aimed to comprehensively evaluate prenatal cardiac remodeling in FGR including myocardial deformation imaging. -Echocardiography was performed in 37 consecutive ...
Rizzi Elen E Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, - - 2014
Hypertension induces left ventricular hypertrophy (LVH) by mechanisms involving oxidative stress and imbalanced cardiac matrix metalloproteinase (MMP) activity. We hypothesized that β1-adrenergic receptor blockers with antioxidant properties (nebivolol) could reverse hypertension-induced LVH more effectively than conventional β1-blockers (metoprolol) when used at doses that exert similar antihypertensive effects. Two kidney one ...
Surgit Ozgur O Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology , Istanbul , - - 2014
Objective. Left ventricular (LV) hypertrophy (LVH) predicts increased mortality in part due to an elevated incidence of sudden cardiac death in hypertension. The aim of the present study was to investigate the relation of microvolt T-wave alternans (MTWA) with different LV geometric patterns in patient with sustained hypertension. Methods. This ...
Simons Ap A Deptartment of Cardiothoracic Surgery, Maastricht University Medical Centre and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands - - 2014
The aim of this study was to examine the hydrodynamic performance and gaseous microemboli (GME) activity of two centrifugal pumps for possible use in low-flow extracorporeal CO2 removal. The performance of a Rotassist 2.8 and a Rotaflow 32 centrifugal pump (Maquet Cardiopulmonary AG, Hirrlingen, Germany) was evaluated in a water-glycerine ...
Savalia Krupa K Department of Cellular and Integrative Physiology, University of Nebraska Medical - - 2014
Excessive production of superoxide (O2(●-)) in the central nervous system has been widely implicated in the pathogenesis of cardiovascular diseases, including chronic heart failure and hypertension. In an attempt to overcome the failed therapeutic impact of currently available antioxidants in cardiovascular disease, we developed a nanomedicine-based delivery system for the ...
Mosing Martina M Division of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland, - - 2014
The aim of this study was to test the effect of cardiac output (CO) and pulmonary artery hypertension (PHT) on volumetric capnography (VCap) derived-variables. Nine pigs were mechanically ventilated using fixed ventilatory settings. Two steps of PHT were induced by IV infusion of a thromboxane analogue: PHT25 [mean pulmonary arterial ...
Krishnaveni G V GV Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India; *Centre for Cardiovascular Imaging, UCL Institute of Child Health, London, UK; Diabetes Unit, KEM Hospital Research Centre, Pune, India;Department of Psychology, University of Trier, Germany; St. Johns Research Institute, Bangalore, India; and MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK. Correspondence to: Dr GV Krishnaveni, Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, PO Box 38, Mandi Mohalla, Mysore 570 021, India. - - 2014
To test the Trier Social Stress Test for children (TSST-C) in a cohort of Indian adolescents. Cohort study. Holdsworth Memorial Hospital, Mysore, India. Adolescent children (N=273, 134 males; mean age 13.6 yrs) selected from an ongoing birth cohort; 269 completed the test. Performance of 5-minutes each of public- speaking and ...
Zafar Haroon H Tissue Optics & Microcirculation Imaging Facility, National University of Ireland, - - 2014
Frequency domain optical coherence tomography (FD-OCT) provides cross-sectional images of coronary arteries and deployed stents with micron resolution and measures lumen dimensions with excellent reproducibility. FD-OCT combined with a blood flow resistances model can overcome many limitations of conventional measures of stenosis severity based on quantitative coronary angiography (QCA) and ...
Alian Aymen A AA Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, PO Box 208051, New Haven, CT 06520-8051, - - 2014
Lower body negative pressure (LBNP) creates a reversible hypovolemia by sequestrating blood volume in the lower extremities. This study sought to examine the impact of central hypovolemia on peripheral venous pressure (PVP) waveforms in spontaneously breathing subjects. With IRB approval, 11 healthy subjects underwent progressive LBNP (baseline, -30, -75, and -90 mmHg ...
Andersen L J LJ Department of Cardiology, Roskilde Hospital, Roskilde, Denmark; Department of Cardiology, Gentofte University Hospital, Hellerup, - - 2014
We investigated the effects of 3 and 6 months of regular football training on cardiac structure and function in hypertensive men. Thirty-one untrained males with mild-to-moderate hypertension were randomized 2:1 to a football training group (n = 20) and a control group receiving traditional recommendations on healthy lifestyle (n = 11). Cardiac measures were ...
Molcan L L Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University Bratislava, Bratislava, Slovak Republic. - - 2014
Disturbed circadian activity of the sympathetic system may be involved in negative consequences of chronodisruption on the cardiovascular system. We studied daily changes in pressure response to adrenergic stimulation in rats exposed to repeated phase advance shifts (PAS) of light/dark (LD) regimen. Blood pressure (BP), heart rate (HR) and locomotor ...
Kawashiri Masa-Aki MA Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, - - 2014
A line of epidemiological studies suggests that the accumulation of coronary risk factors promotes the progression of coronary atherosclerosis. Recent clinical studies showed that aggressive low-density lipoprotein (LDL) cholesterol-lowering therapy using statins could regress coronary atheroma and reduce major cardiovascular events. Additionally, therapy that controlled amlodipine-based blood pressure reduced major ...
Kilgannon J Hope JH 1Department of Emergency Medicine, Cooper University Hospital, Camden, NJ. 2Department of Emergency Medicine, The University of Mississippi Medical Center, Jackson, MS. 3Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, Camden, - - 2014
Guidelines for post-cardiac arrest care recommend blood pressure optimization as one component of neuroprotection. Although some retrospective clinical studies suggest that postresuscitation hypotension may be harmful, and laboratory studies suggest that a postresuscitation hypertensive surge may be protective, empirical data are few. In this study, we prospectively measured blood pressure ...
Hillman Stan S SS Portland State University, United States; - - 2014
Amphibians have a single ventricle and common conus arteriosus that produces an equal pressure to the parallel pulmocutaneous and systemic vascular circuits. The distribution of blood flows between the pulmocutaneous (Qpul) and systemic (Qsys) circuits (net cardiac shunt) vary with a number of environmental conditions and behaviours; although autonomic regulation ...
Goodwill Adam G AG Department of Cellular & Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, 462025111, - - 2014
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has been shown to have hemodynamic and cardioprotective capacity in addition to its better characterized glucoregulatory actions. Because of this, emerging research has focused on the ability of GLP-1 based therapies to drive myocardial substrate selection, enhance cardiac performance and regulate heart ...
Poole Aaron T AT Maternal-Fetal Medicine Division, Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, United States. Electronic address: - - 2014
Lactation is associated with reduction in maternal metabolic disease and hypertension later in life; however, findings in humans may be confounded by socioeconomic factors. We sought to determine the independent contribution of lactation on cardiovascular parameters and adiposity in a murine model. Following delivery, CD-1 female mice were randomly divided ...
Zoerner Frank F From the Department of Operative and Intensive Care Medicine (F.Z.), Hallands Hospital Halmstad, Halmstad; and Department of Surgical Sciences/Anaesthesiology and Intensive Care (E.S.), Faculty of Medicine, Uppsala University, Uppsala, - - 2014
Supplemental digital content is available in the text. The aim of this experimental study was to compare survival and hemodynamic effects of a low-dose amiodarone and vasopressin compared with vasopressin in hypovolemic cardiac arrest model in piglets. Eighteen anesthetized male piglets (with a weight of 25.3 [1.8] kg) were bled ...
You Beian B Department of Geriatrics, Qilu Hospital of Shandong University; Shandong Provincial Key Laboratory of Cardiovascular Proteomics, Jinan, Shandong 250012, - - 2014
Ouabain is a mammalian adrenocortical hormone that is involved in the pathogenesis of hypertension by inhibiting Na-K ATPase activity. It also participates in a variety of kinase-mediated signaling pathways associated with Na-K ATPase. Previous studies have shown that ouabain can cause cardiac remodeling independent of elevated blood pressure and that ...
Sahmeddini Mohammad Ali MA Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, - - 2014
Context-Attenuating postreperfusion syndrome during orthotopic liver transplant is very important for transplant anesthesiologists because of the syndrome's complications. Oxygen-derived free radicals play an important role in the genesis of postreperfusion syndrome, but the effect of mannitol (a free radical scavenger) on attenuating the syndrome is unclear.Objectives-To investigate the effectiveness of ...
Lee Eveline E University Hospital of - - 2014
Preload reduction during haemodialysis causes change in cardiac filling and contractility. This can be accurately assessed using standard echocardiography. We hypothesise that simple ECG parameters approximate Echo derived measurements and can be used as an initial tool. Thirty subjects (Age 59 ± 18 years, 35% female, LVEF 64 ± 6%, ...
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