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Results 351 - 400 of 2368
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Coelho-Filho Otavio R - - 2013
Cardiomyocyte hypertrophy is a critical precursor to the development of heart failure. Methods to phenotype cellular hypertrophy non-invasively are limited. The goal was to validate a CMR-based approach for the combined assessment of extracellular matrix expansion and cardiomyocyte hypertrophy. Two murine models of a) hypertension (N=18, with N=15 controls) induced ...
Ferro Lopes Patrícia C - - 2013
To evaluate the influence of different inspired oxygen fractions (FiO2 ) on pulmonary oxygen exchange and Tei-index of myocardial performance in propofol-anesthetized dogs. Prospective crossover, randomized, experimental trial. Eight adult dogs weighing 8.6 ± 1.8 kg. The animals were anesthetized on five occasions, receiving either an FiO2  = 1.0 (F100), 0.8 (F80), 0.6 (F60), ...
Iliescu Radu R Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, - - 2013
The sensitivity of baroreflex control of heart rate is depressed in subjects with obesity hypertension, which increases the risk for cardiac arrhythmias. The mechanisms are not fully known, and there are no therapies to improve this dysfunction. To determine the cardiovascular dynamic effects of progressive increases in body weight leading ...
Mazza A - - 2013
Aim: Longitudinal study aimed to evaluate the antihypertensive efficacy, safety and the effect on cardiac damage of Aliskiren, administered to a group of high-risk hypertensive patients with mild impairment of renal function and uncontrolled blood pressure (BP) despite a two-drug antihypertensive treatment. Methods: One hundred and six patients (56 men ...
Fettiplace Michael R MR University of Illinois College of Medicine, Chicago, IL, USA. - - 2013
Bolus infusion of lipid emulsion can reverse cardiac pharmacotoxicity caused by local anesthetics and other lipophilic drugs. The mechanisms of this effect are not completely elucidated. The authors test the hypothesis that lipid emulsion infusion exerts direct, positive inotropic effects. Prospective, randomized animal study. University research laboratory. Adult male Sprague-Dawley ...
Jessup Jewell A JA Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157-1009, - - 2013
mRen2.Lewis rats exhibit exacerbated increases in blood pressure, left ventricular (LV) remodeling, and diastolic impairment after the loss of estrogens. In this same model, depletion of estrogens has marked effects on the cardiac biopterin profile concomitant with suppressed nitric oxide release. With respect to the establishment of overt systolic hypertension ...
Kristensen Kasper Kyhl - - 2013
Objective Positive pressure ventilation (PPV) is widely used for treatment of acute car-dio-respiratory failure, occasionally at the expense of compromised cardiac function and arterial blood pressure. The explanation why has largely rested on interpretation of in-tracardiac pressure changes. We evaluated the effect of PPV on the central circulation by studying ...
Seiler Christian - - 2013
To expand the limited information on the prognostic impact of quantitatively obtained collateral function in patients with coronary artery disease (CAD) and to estimate causality of such a relation. Prospective cohort study with long-term observation of clinical outcome. University Hospital. One thousand one hundred and eighty-one patients with chronic stable ...
Russo Christopher - - 2013
Abstract Background: The diagnosis of cardiac amyloidosis often requires a right heart catheterization with an endomyocardial biopsy. Although the central hemodynamics of the three main types of cardiac amyloidosis (AL, ATTRm, ATTRwt) have previously been described, the prognostic significance of these variables have not been fully explored. Objective: To compare ...
Jahren Silje E - - 2013
The clinical importance of pulsatility is a recurring topic of debate in mechanical circulatory support. Lack of pulsatility has been identified as a possible factor responsible for adverse events and has also demonstrated a role in myocardial perfusion and cardiac recovery. A commonly used method for restoring pulsatility with rotodynamic ...
Prasad Kailash - - 2013
The pathophysiology of endotoxic shock is complex. This review emphasizes the role of reactive oxygen species (ROS) in the pathophysiology of endotoxic shock and the effectiveness of flaxseed in amelioration of the deleterious effects of endotoxic shock on the cardiovascular function and health of the tissue. Endotoxic shock is associated ...
Friess Stuart H - - 2013
During cardiopulmonary resuscitation, adequate coronary perfusion pressure is essential for establishing return of spontaneous circulation. Current American Heart Association guidelines recommend standardized interval administration of epinephrine for patients in cardiac arrest. The objective of this study was to compare short-term survival using a hemodynamic directed resuscitation strategy versus chest compression ...
Trummer G - - 2013
Sudden cardiac arrest is one of the leading causes of death. Conventional CPR techniques after cardiac arrest provide circulation with reduced and varying blood flow and pressure. We hypothesize that using pressure- and flow-controlled reperfusion of the whole body improves neurological recovery and survival after 15 min of normothermic cardiac ...
Natalini Giuseppe - - 2013
The beneficial effect of low tidal volume (TV) ventilation strategy on mortality in patients with acute respiratory distress syndrome (ARDS) has been attributed to the protective effect on ventilator-induced lung injury, and yet its effect on cardiovascular function might also play an important role. The aim of this study was ...
Chang Yu-Wang YW Molecular Medicine Program, Taiwan International Graduate Program, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, - - 2013
Pressure-overload stress to the heart causes pathological cardiac hypertrophy, which increases the risk of cardiac morbidity and mortality. However, the detailed signaling pathways induced by pressure overload remain unclear. Here we used phosphoproteomics to delineate signaling pathways in the myocardium responding to acute pressure overload and chronic hypertrophy in mice. ...
Gademan Maaike G J - - 2013
Adverse intrauterine conditions can program hypertension. Because one of the underlying mechanisms is thought to be cardiac autonomic balance, we investigated the association between prepregnancy body mass index (BMI) and blood pressure and indicators of the autonomic balance in the child at age 5 to 6 years. Also investigated was ...
Glatz Andrew C - - 2013
Force due to leaning during cardiopulmonary resuscitation (CPR) negatively affects haemodynamics and intrathoracic airway pressures (ITP) in animal models and adults, but has not been studied in children. We sought to characterize the effects of sternal force (SF) comparable to leaning force on haemodynamics and ITP in anaesthetized children. Children ...
Carll Alex P AP * Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina - - 2013
Cardiac disease exacerbation is associated with short-term exposure to vehicular emissions. Diesel exhaust (DE) might impair cardiac performance in part through perturbing efferent sympathetic and parasympathetic autonomic nervous system (ANS) input to the heart. We hypothesized that acute changes in ANS balance mediate decreased cardiac performance upon DE inhalation. Young ...
Schulz Steffen - - 2013
Besides the well-known cardiac risk factors for schizophrenia, increasing concerns have been raised regarding the cardiac side-effects of antipsychotic medications. A bivariate analysis of autonomic regulation, based on cardiovascular coupling, can provide additional information about heart rate (HR) and blood pressure regulatory patterns within the complex interactions of the cardiovascular ...
Shields Denise L - - 2013
Blood pressure (BP) control is central to health promotion and maintenance across the health care continuum. Optimal control has been associated with improved microvascular end organ outcomes, reduced morbidity and mortality, and improved quality of life. Calcium channel blockers (CCBs) are a frequently utilized first-line antihypertensive agent, either as a ...
Escoubet Brigitte - - 2013
-High plasma aldosterone (aldo) has deleterious cardiovascular effects which are independent of blood pressure (BP), but the role of the mineralocorticoid receptor (MR) remains unclear. Renal pseudohypoaldosteronism type 1 (PHA1) is a rare autosomal dominant disease caused by NR3C2 loss-of-function mutations which is characterized by renal salt loss and compensatory ...
Menke Jan - - 2013
Near-infrared spectroscopy (NIRS) can monitor changes in cerebral regional oxygen saturation (rSO2) and tissue hemoglobin content (HbT). The relation between cerebral NIRS readings and vital parameters has not been analyzed before at a fine temporal scale. This study analyzed this relation during cardiopulmonary bypass (CPB) surgery in 10 children (0-9 years, ...
Yu Ting-Ting - - 2013
XinJiErKang (XJEK), a Chinese herbal formula, is identified as an effective preparation to treat coronary heart disease and myocarditis. The aim of the study is to investigate the anti-hypertensive effects of XJEK by oral administration and also to find out whether the drug has any role in oxidative stress and ...
Vass A - - 2013
Background/Purpose: Cardiac tamponade is a medical emergency situation associated with a high rate of life-threatening complications, even after immediate interventions. Our aim was to characterize the acute inflammatory consequences of this event in a clinically relevant large animal model. Methods: Cardiac tamponade was induced for 60 min in anesthetized, ventilated ...
Sutendra Gopinath - - 2013
Right ventricular (RV) failure is an important clinical problem with no available therapies, largely because its molecular mechanisms are unknown. Mitochondrial remodeling resulting to a metabolic shift toward glycolysis has been described in RV hypertrophy (RVH), but it is unknown whether this is beneficial or detrimental. While clinically RV failure ...
Kakkavas Apostolos - - 2013
The authors investigated whether erectile dysfunction (ED) in the early stages of hypertension is associated with heightened end-organ damage. A total of 174 consecutive men with untreated, newly diagnosed essential hypertension (aged 50.3 years, office blood pressure [BP] 150/98 mm Hg) were studied. All participants underwent 24-hour ambulatory BP monitoring, blood examination, albumin-creatinine ...
Hultström Michael - - 2013
Haemorrhagic shock is a common cause of acute kidney injury, which is a major risk factor for developing chronic kidney disease. The mechanism is superficially straightforward. An arterial pressure below the kidney's autoregulatory region leads to a direct reduction in filtration pressure and perfusion, which in turn cause renal failure ...
Nilsson Lena M - - 2013
The pulse oximeter measurement pleth variability index (PVI) can detect hypovolaemia during positive pressure ventilation. We studied whether PVI can detect a hypovolaemic state in spontaneously breathing humans and whether better discrimination is obtained by modifying the breathing patterns. Experimental study. Clinical physiology department in a university hospital. Fourteen healthy ...
Boly C A CA Department of Anaesthesiology - - 2013
Left-ventricular end-systolic elastance (Ees) is an index of cardiac contractility, but the invasive nature of its assessment has limited perioperative application. We explored the feasibility of a minimally invasive method of Ees estimation for perioperative assessment of cardiac function and evaluated the suitability of phenylephrine as a loading intervention. In ...
Rinehart Joseph - - 2013
BACKGROUND:Closed-loop systems have been designed to assist practitioners in maintaining stability of various physiologic variables in the clinical setting. In this context, we recently performed in silico testing of a novel closed-loop fluid management system that is designed for cardiac output and pulse pressure variation monitoring and optimization. The goal ...
Petit A M - - 2013
The objective of this prospective observational study was to assess systolic arterial blood pressure (SABP) in small-breed dogs with degenerative mitral valve disease (MVD) from different International Small Animal Cardiac Health Council (ISACHC) heart failure classes. For this purpose, 103 client-owned dogs weighing <20kg (mean±standard deviation, 8.5±3.0kg; aged 9.8±2.9years) and ...
Waldréus Nana - - 2013
The present study measured self-perceived thirst and plasma angiotensin II (ATII) concentrations during graded hypovolaemic stress, induced by lower body negative pressure (LBNP), to elucidate the dependence of thirst on haemodynamics. A total of 24 women aged between 20 and 36 (mean age, 23) years rated their thirst on a ...
Jia Xinwei - - 2013
A load-independent index of myocardial contractility provides a measure of cardiac function. Previous contractility indices have been shown to be either load-dependent or invasive. We sought to determine the extent of load (preload and afterload)-independence of dσ*/dtmax (σ* is pressure-normalized stress) in comparison with other well-established indices. Six anaesthetized pigs ...
Demchenko Ivan T - - 2013
The cardiovascular system responds to hyperbaric hyperoxia (HBO2) with vasoconstriction, hypertension, bradycardia and reduced cardiac output. We tested the hypothesis that these responses are linked by a common mechanism, activation of the arterial baroreflex. Baroreflex function in HBO2 was assessed in anesthetized and conscious rats after deafferentation of aortic or ...
Juhl-Olsen Peter - - 2013
Ultrasonography of the cardiovascular system is pivotal for hemodynamic assessment. Diastolic function is evaluated with a combination of tissue Doppler (e' and a') and pulsed Doppler (E and A) measures of transmitral- and mitral valve annuli velocities. However, accurate echocardiographic evaluation in the intensive care unit or perioperative setting is ...
Sainio Marko - - 2013
A 2-year-old boy found in cardiac arrest secondary to drowning received standard CPR for 35 minutes and was transported to a tertiary hospital for rewarming from hypothermia. Chest compressions in hospital were started using two-thumb encircling hands technique. Subsequently two-thumbs direct sternal compression technique and after sternal force/depth sensor placement, ...
Dalfino Lidia L Emergency and Organ Transplantation Department, Anesthesia and Intensive Care Unit, University of Bari, Bari, - - 2013
The occurrence of intra-abdominal hypertension (IAH), as well as its promoting factors in cardiac surgery, has been poorly explored. The aim of the present study was to characterize intra-abdominal pressure (IAP) variations in patients undergoing cardiac surgical procedures, and to identify the risk factors for IAH in this setting. All ...
Silva Serena - - 2013
: A 15-second end-expiratory occlusion increases cardiac preload and allows detection of preload dependence. We tested whether the reliability of this test depends upon positive end-expiratory pressure. : Prospective study. : Medical ICU. : Thirty-four patients presenting with acute circulatory failure and acute respiratory distress syndrome ventilated with a tidal ...
Kim Sang-Hyun - - 2013
Hemodynamic optimization improves postoperative outcomes in high-risk surgery patients. The monitoring of cardiac output (CO) and dynamic parameters of fluid responsiveness can guide hemodynamic optimization. We conducted a survey to assess the current hemodynamic monitoring and management practices of Korean anesthesiologists during high-risk surgery. E-mails containing a link to our ...
Shu Aihua - - 2013
Heart rate variability (HRV) was used in the present study to evaluate a target-controlled approach compared with a constant-rate infusion for remifentanil anesthesia during off-pump coronary artery bypass grafting (OP-CABG) surgery. A total of 65 patients with American Society of Anesthesiologists (ASA) physical status II or III, who were aged ...
Jalali Ali - - 2013
This paper is concerned with predicting the occurrence of Periventricular Leukomalacia (PVL) using vital data which are collected over a period of twelve hours after neonatal cardiac surgery. The vital data contain heart rate (HR), mean arterial pressure (MAP), right atrium pressure (RAP), and oxygen saturation (SpO2). Various features are ...
Fukushima Hayato - - 2013
This study provides cuffless blood pressure estimation. In general, blood pressure changes when the subject's condition changes, and it is important to estimate it continuously and noninvasively. In many previous studies, they used PTT (Pulse Transmission Time) for estimating. However, PTT needs both electrocardiogram and photoplethysmography to be measured. Our ...
Liu An-Bang - - 2013
Cardiac autonomic dysfunction is a serious condition in the elder subjects. Baroreflex sensitivity (BRS) by measuring pulse intervals and blood pressure has been proven as an effective indicator. This paper proposes a novel index by substitution blood pressure with amplitudes of pressure pulse. We recruited 61 subjects divided into two ...
Uemura Kazunori - - 2013
Myocardial performance index (MPI), or Tei index, is measured by Doppler echocardiography in clinical practice. MPI has been shown to be useful in evaluating left ventricular (LV) performance and predicting prognosis in cardiac patients. However, the effects of LV load and contractile states on MPI remain to be thoroughly investigated. ...
Yamane T - - 2013
We are developing an axial-flow pump with a cylindrical-impeller without airfoils. In the mock experiments of HA02 model a pressure of 13.3 kPa was obtained at a rotational speed of 12500 rpm and flow of 5L/min. The obtained pressure with HA02 was almost double than an airfoil-type impeller. The 2D ...
Sarlabous L - - 2013
A recursive least square (RLS) adaptive filtering algorithm for reduction of cardiac interference in diaphragmatic mecanomyographic (MMGdi) signals is addressed in this paper. MMGdi signals were acquired with a capacitive accelerometer placed between 7th and 8th intercostal spaces, on the right anterior axillary line, during a maintained inspiratory pressure test. ...
Morariu S S University "Vasile Goldis"- - - 2013
A great physical effort associated with work during night shifts can lead to negative effects on the worker's health. THE AIM of our study is to evaluate the risk of associating great physical effort with night shifts in hypertensive patients. We have studied 2 groups of hypertensive patients, each group ...
Hart Emma C EC School of Physiology and Pharmacology, Bristol Heart Institute, Medical Science Bldg, University of Bristol, Bristol, United - - 2013
Renal denervation has shown promise in the treatment of resistant hypertension, although the mechanisms underlying the blood pressure (BP) reduction remain unclear. In a translational study of spontaneously hypertensive rats (n=7, surgical denervation) and resistant hypertensive human patients (n=8; 5 men, 33-71 years), we examined the relationship among changes in ...
Takei Yoshio - - 2013
Vertebrates have expanded their habitats from aquatic to terrestrial environments, which has accompanied the evolution of cardiovascular and osmoregulatory hormones. Specifically, mammals have developed mechanisms to maintain high blood pressure and blood volume, while extant fishes have developed hypotensive and Na-extruding mechanisms to adapt to the marine environment where they ...
Dillenburg Denise Ruttke - - 2013
Polyphenols consumption detected in red wine and grape juice may prevent or help in the treatment of hypertension. However, cardiovascular autonomic effects of polyphenols were poorly studied. Therefore, we evaluated the effects of resveratrol and grape juice treatments in hemodynamics, baroreflex sensitivity, heart rate (HR) and blood pressure (BP) variability ...
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