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Ingaramo Oscar A OA 1Department of Pediatric Critical Care, Sunrise Children's Hospital, Las Vegas, NV. 2Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, - - 2014
To evaluate the impact of different levels of positive end-expiratory pressure on cardiac index in children receiving mechanical ventilation. To explore the effect of lung recruitment on the relationship between positive end-expiratory pressure and cardiac output. Prospective, single center, and interventional. PICU in a tertiary care children's hospital. Fifty mechanically ...
Cassu Renata Navarro RN Oeste Paulista University, Scholl of Veterinary Medicine, Department of Veterinary Surgery and Anestesiology, Presidente PrudenteSP, - - 2014
To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group ...
Cheng Hui-Wen HW Cardiac Muscle Research Labratory, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical - - 2014
Emerging clinical data support the notion that RV dysfunction is critical to the pathogenesis of cardiovascular disease and heart failure(1-3). Moreover, the RV is significantly affected in pulmonary diseases such as pulmonary artery hypertension (PAH). In addition, the RV is remarkably sensitive to cardiac pathologies, including left ventricular (LV) dysfunction, ...
Weldy Chad S CS Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America ; Department of Pathology, University of Washington School of Medicine, Seattle, Washington, United States of - - 2014
Exposure to fine particulate air pollution (PM2.5) is strongly associated with cardiovascular morbidity and mortality. Exposure to PM2.5 during pregnancy promotes reduced birthweight, and the associated adverse intrauterine conditions may also promote adult risk of cardiovascular disease. Here, we investigated the potential for in utero exposure to diesel exhaust (DE) ...
Nekooeian Ali Akbar AA Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; ; Cardiovascular Pharmacology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, - - 2014
Background: The cardiac effects simultaneously occurring during experimental hypertension and diabetes have rarely been investigated. This study aimed at examining the effects of short-term renovascular hypertension and type 2 diabetes on cardiac functions. Methods: Five groups (7 each) of male Sprague-Dawley rats, including a control group, a diabetes (induced by ...
Rokamp Kim Z KZ Departments of Anesthesia, Rigshospitalet, University of Copenhagen Copenhagen, - - 2014
This study addresses three questions for securing tissue oxygenation in brain (rScO2) and muscle (SmO2) for 100 patients (age 71 ± 6 years; mean ± SD) undergoing vascular surgery: (i) Does preoxygenation (inhaling 100% oxygen before anesthesia) increase tissue oxygenation, (ii) Does inhalation of 70% oxygen during surgery prevent a ...
Kanda Shigetaka S Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. - - 2014
Objectives: To evaluate the switching from an angiotensin receptor blocker (ARB) to a drug combination containing an ARB and a diuretic drug in terms of effects on hypertension, cardiac load, and cardiac function. Methods: In a study conducted on 82 patients with a history of heart failure and hypertension who ...
Zhang Xiakun X School of Atmospheric Sciences, Nanjing University of Information Sciences and Technology, 219 Ningliu Road, Nanjing 210044, China. - - 2014
The effects of cold air on cardiovascular and cerebrovascular diseases were investigated in an experimental study examining blood pressure and biochemical indicators. Zhangye, a city in Gansu Province, China, was selected as the experimental site. Health screening and blood tests were conducted, and finally, 30 cardiovascular disease patients and 40 ...
Chen Mei-Fen MF Department of Food Science, National Pingtung University of Science and Technology, Neipu, Pingtung City 91201, Taiwan ; College of Medicine and Life Science, Chung Hwa University of Medical Technology, Rende District, Tainan City 71703, - - 2014
The agonists of imidazoline I-1 receptors (I-1R) are widely used to lower blood pressure. It has been indicated that guanidinium derivatives show an ability to activate imidazoline receptors. Also, allantoin has a chemical stricture similar to guanidinium derivatives. Thus, it is of special interest to characterize the effect of allantoin ...
Popov Sergej S Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, - - 2014
Cardiac left ventricle hypertrophy (LVH) constitutes a major risk factor for heart failure. Although LVH is most commonly caused by chronic elevation in arterial blood pressure, reduction of blood pressure to normal levels does not always result in regression of LVH, suggesting that additional factors contribute to the development of ...
Bronzwaer Anne-Sophie G T AS Department of Internal Medicine, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands ; Laboratory for Clinical Cardiovascular Physiology, Center for Heart Failure Research, Academic Medical Center Amsterdam, - - 2014
Rationale: A critical reduction in central blood volume (CBV) is often characterized by hemodynamic instability. Restoration of a volume deficit may be established by goal-directed fluid therapy guided by respiration-related variation in systolic- and pulse pressure (SPV and PPV). Stroke volume index (SVI) serves as a surrogate end-point of a ...
Campen Matthew J MJ Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of - - 2014
Exposure to chronic hypoxia (CH) induces elevated pulmonary artery pressure/resistance, leading to an eventual maladaptive right ventricular hypertrophy (RVH). Muscle RING finger-1 (MuRF1) is a muscle-specific ubiquitin ligase that mediates myocyte atrophy and has been shown to play a role in left ventricular hypertrophy and altered cardiac bioenergetics in pressure ...
Le Victoria P VP Department of Biomedical Engineering, Saint Louis University, St. Louis, - - 2014
Abstract The large arteries serve as compliant vessels that store energy during systole and return it during diastole. This function is made possible by the elastic fibers in the arterial wall that are assembled during late embryonic and early postnatal development from various proteins, including fibulin-5. Mice and humans with ...
Lauro Figueroa-Valverde FV Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Avenida Agustín Melgar s/n, Colonia Buenavista, 24039 San Francisco de Campeche, CAM, - - 2014
Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R). Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its ...
Sirvente Raquel A RA Cardiomyopathy Unit of the Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Hypertension Unit of the Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, - - 2014
Sympathetic hyperactivity may be related to left ventricular (LV) dysfunction and baro- and chemoreflex impairment in hypertension. However, cardiac function, regarding the association of hypertension and baroreflex dysfunction, has not been previously evaluated by transesophageal echocardiography (TEE) using intracardiac echocardiographic catheter. We evaluated exercise tests, baroreflex sensitivity and cardiovascular autonomic ...
Chittawatanarat Kaweesak - - 2014
In addition to cardiopulmonary monitoring, non-cardiopulmonary monitoring (non-CPM) is considered to be an important parameter in intensive care units (ICUs). However no data on this subject has been reported for Thai ICUs. The objective of the present study is to describe the non-CPM situation in Thai ICUs. ICU RESOURCE I ...
Ruiz Roberto R Associate Postgraduate Program in Physical Education, UEM/UEL, Londrina, PR, - - 2014
Objective to analyze the morphological structure of cardiac, blood pressure (BP), heart rate (HR) and heart rate variability (HRV) of rats subjected to physical training with supplementation of caffeine. Methods 60 rats were divided into 4 groups: control (CO), control with caffeine (CAF), trained control (TRE) and trained with caffeine ...
Mansour Mojtaba M Department of Anaesthesia, Anaesthesiology and Critical Care Research Centre, Isfahan University of Medical Sciences, Isfahan, - - 2014
Cardiac and pulmonary veins de-airing are of the most important steps during open heart surgery. This study evaluates the effect of continuous positive airway pressure (CPAP) on air trapping in pulmonary veins and on quality of de-airing procedure. This randomized prospective double blind clinical trial conducted on 40 patients. In ...
Coelho-Filho Otavio R OR Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, MA (O.R.C.F., R.V.S., T.G.N., R.K.) Department of Internal Medicine, State University of Campinas (UNICAMP), São Paulo, Brazil (O.R.C.F., - - 2014
Nearly 50% of patients with heart failure (HF) have preserved LV ejection fraction, with interstitial fibrosis and cardiomyocyte hypertrophy as early manifestations of pressure overload. However, methods to assess both tissue characteristics dynamically and noninvasively with therapy are lacking. We measured the effects of mineralocorticoid receptor blockade on tissue phenotypes ...
Yadav Monu M Department of Anaesthesiology & Critical Care, Nizam's Institute of Medical Sciences, Hyderabad 500082, - - 2014
A one-year-old child operated on for arachnoid cyst in right frontoparietotemporal region had sudden bradycardia followed by cardiac arrest leading to death after connecting negative pressure to the subgaleal drain during craniotomy closure. The surgical procedure was uneventful. It is a common practice to place epidural or subgaleal drains connected ...
Hintsala Heidi H Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, - - 2014
The aim of our study was to assess the effect of short-term cold exposure, typical in subarctic climate, on cardiac electrical function among untreated middle-aged hypertensive men. We conducted a population-based recruitment of 51 hypertensive men and a control group of 32 men without hypertension (age 55-65 years) who underwent ...
Miao D M DM Department 2 of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, - - 2014
It has been well established that high-sensitivity cardiac troponin T (hs-TnT) is a specific and highly sensitive marker in acute coronary syndromes. On the other hand, studies on serum concentrations of hs-TnT in patients with hypertension in the absence of significant coronary stenosis are limited. Therefore, we hypothesized that hs-TnT ...
Convertino Victor A VA U.S. Army Institute of Surgical Research, Research Division JBSA Fort Sam Houston, TX, - - 2014
The inability to compensate for acute central hypovolemia underlies the clinical development of orthostatic hypotension and instability (e.g., syncope). Although neuro-humoral control of both cardiac output and peripheral vascular resistance contributes to hemodynamic stability during orthostasis, a notion has been proposed that the failure of adequate peripheral vascular constriction rather ...
Stengl Milan - - 2013
Hypercapnic acidosis (HCA) that accompanies lung-protective ventilation may be considered permissive (a tolerable side-effect) or it may be therapeutic by itself. Cardiovascular effects may contribute to, or limit, the potential therapeutic impact of HCA; therefore, a complex physiological study was performed in healthy pigs to evaluate the systemic and organ-specific ...
Holman Ellen Alison EA Program in Nursing Science (E.A.H.), and Department of Anatomy and Neurobiology (A.G., J.L., D.P.), University of California, Irvine; and Drug Discovery and Development (A.G., D.P.), Italian Institute of Technology, Genoa, - - 2013
ObjectiveTrauma exposure can precipitate acute stress (AS) and cardiovascular disorders (CVD). Identifying AS-related physiologic changes that affect CVD risk could inform development of early CVD prevention strategies. The endocannabinoid system (ECS) regulates hypothalamic-pituitary-adrenal axis and stress-related cardiovascular function. We examine stress-related ECS activity and its association with cardiovascular biochemistry/function after ...
Evenson Alissa A Pediatric Cardiovascular Research Center, Penn State Hershey Children's Hospital, Penn State Milton S. Hershey Medical Center, Department of Pediatrics, Penn State Hershey College of Medicine, Hershey, PA, - - 2013
One approach with the potential to improve morbidity and mortality rates following extracorporeal life support (ECLS) is the use of pulsatile perfusion. Currently, no ECLS pumps used in the United States can produce pulsatile flow. The objective of this experiment is to evaluate a novel diagonal pump used in Europe ...
Egnaczyk Gregory F GF The Heart and Vascular Center at The Christ Hospital, 2123 Auburn Ave, Ste 137, Cincinnati, OH, 45219, - - 2013
Cardiac resynchronization therapy (CRT) improves measures of systolic function and clinical status. However, its effect on diastolic function is not well established. Commonly used parameters of diastolic function are measured from echocardiography, using pulse wave and tissue Doppler technologies, as well as timing and deformation data. Review of the existing ...
Cruz-Lemini Mónica M Department of Maternal-Fetal Medicine (Institut Clínic de Ginecologia, Obstetrícia i Neonatologia), Hospital Clínic - Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona and Centro de Investigación Biomédica en Red en Enfermedades Raras, Barcelona, - - 2013
Intrauterine growth restricted (IUGR) fetuses suffer cardiovascular remodeling which persists into infancy and has been related to cardiovascular outcomes in adulthood. Hypertension in infancy has been demonstrated to be a strong risk factor for later cardiovascular disease. Close monitoring together with dietary interventions have shown to improve cardiovascular health in ...
Lancaster Jordan J JJ Cardiology and Medicine, Southern Arizona VA Health Care System; Sarver Heart Center; Department of Physiology. Electronic address: - - 2013
Varying strategies are currently being evaluated to develop tissue-engineered constructs for the treatment of ischemic heart disease. This study examines an angiogenic and biodegradable cardiac construct seeded with neonatal cardiomyocytes for the treatment of chronic heart failure (CHF). We evaluated a neonatal cardiomyocyte (NCM)-seeded 3-dimensional fibroblast construct (3DFC) in vitro ...
Morra Elis A EA aPhysical Education and Sports Centre bDepartment of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, - - 2013
There have been contradictory reports regarding resistance exercise and central arterial compliance. The American Heart Association has recommended its use in preventing/treating cardiovascular diseases. We examined the effects of long-term endurance running and intense resistance training on central hemodynamics, compared with healthy control (CON). Sixty-nine male participants, 25-50 years [19 ...
Jozwiak Mathieu M 1 Service de Réanimation Médicale - - 2013
The effects of prone positioning during acute respiratory distress syndrome on all the components of cardiac function have not been investigated under protective ventilation and maximal alveolar recruitment. To investigate the hemodynamic effects of prone positioning. We included 18 patients with acute respiratory distress syndrome ventilated with protective ventilation and ...
Cui Hua H Second Geriatric Cardiology Division, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China, - - 2013
Blood pressure control is closely related to target organ damage in elderly patients with hypertension. The aim of this study was to determine the relationship between ambulatory blood pressure monitoring (ABPM) indices and cardiac damage in elderly male patients with treated essential hypertension (EH). This study included 998 Chinese men ...
Nolte Froukje F Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2013
Aims: First, to establish the diagnostic performance of the pressure gradient at a standardised mean velocity (dPv) as derived from the cycle-averaged stenosis pressure gradient-velocity (dP-v) relationship obtained by administration of adenosine and second, to determine whether dPv can be assessed from contrast medium-induced submaximal hyperaemia. Methods and results: Distal ...
Chen Bin B Institute of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, - - 2013
Background: Abnormalities of the mevalonate pathway, an important cellular metabolic pathway, are common in many diseases including cardiovascular disease. The mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated diastolic dysfunction remains largely unknown. This study aims to investigate whether the expression of mevalonate pathway related enzyme ...
Santhanakrishnan Arvind A Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA - - - 2013
Purpose: Children requiring artificial heart-lung support through extracorporeal membrane oxygenation (ECMO) are at increased risk of developing acute kidney injury (AKI). Continuous renal replacement therapy (CRRT) is the preferred method of treatment in pediatric AKI patients. CRRT devices are noted to provide inaccurate fluid balance (FB) when operated under low ...
Chalkias Athanasios A National and Kapodistrian University of Athens, Medical School, MSc "Cardiopulmonary Resuscitation", Athens, - - 2013
Given the importance of increased coronary and cerebral perfusion pressure during cardiopulmonary resuscitation, the recommendation of limiting tidal volume and ventilation rate to 10 per minute in order not to inhibit venous return seems to be correct. However, although the resuscitation community believes that positive-pressure ventilation during cardiopulmonary resuscitation is ...
Lin Xinchun X Department of Research, Mount Sinai Medical Center, Miami Beach, - - 2013
The aim of the present study was to evaluate the efficacy of orally administered sabiporide, a selective Na(+)/H(+) exchanger inhibitor on whole body protection from severe sepsis in rats. Series 1: Sepsis was induced by cecal ligation and puncture (CLP). Animals received treatment of vehicle or sabiporide (10 mg/kg, p.o.). The ...
Wiese Signe - - 2013
Inflammation and cardiac dysfunction plays an important role in the development of complications leading to increased mortality in patients with cirrhosis. Novel cardiac markers such as proANP, copeptin, and high-sensitivity troponin T (hs-TnT) and proinflammatory markers including soluble urokinase-type plasminogen activator receptor (suPAR) and high-sensitive C-reactive protein (hs-CRP) are related ...
Rozen Thomas H - - 2013
In hospital cardiac arrests (CA) treated with Cardio-Pulmonary Resuscitation (CPR) outside of the Intensive Care Unit (ICU) have poor outcomes. Most are preceded by deranged vital signs. There are, however, limited studies assessing antecedents to CAs inside the ICU. To study the antecedents to, and characteristics of CAs in ICU ...
Lazzeri Chiara C Azienda Ospedaliero-Universitaria Careggi, Florence, - - 2013
The present investigation was aimed at assessing the dynamic behaviour of lactate values during hypothermia in 33 patients with cardiac arrest. Fifteen patients died during intensive care stay (15/33, 45.5%). When compared to survivors, they were older (survivors 50.7±14.7 vs. non-survivors 70.1±10.4 years, p<0.001) and exhibited a significantly higher APACHE ...
Yamakoshi Takehiro - - 2013
The purpose of this study was to investigate the cardiovascular hemodynamic effects of Red Bull® Energy Drink during prolonged, simulated, monotonous driving. This was a double-blind, within-subjects-design, crossover study. Twelve healthy volunteers (21.7 ± 0.8 years old) experienced each of three conditions at various times: 1) consumption of Red Bull® ...
Puwal Steffan - - 2013
Continuum approximations of tissue consider responses averaged over many cells in a region. This simplified approach allows consideration of macroscopic effects, such as deformation or action potential propagation. A bidomain (sometimes known as biphasic) approach retains the macroscopic character of a continuum approximation while allowing one to consider microscopic effects; ...
Lubin Dafney - - 2013
The current prehospital standard of care using a large bore intravenous catheter for tension pneumothorax (tPTX) decompression is associated with a high failure rate. We developed a modified Veress needle (mVN) for this condition. The purpose of this study was to evaluate the effectiveness and safety of the mVN as ...
Gan Heng - - 2013
Administration of fluid to improve cardiac output is the mainstay of hemodynamic resuscitation. Not all patients respond to fluid therapy, and excessive fluid administration is harmful. Predicting fluid responsiveness can be challenging, particularly in children. Numerous hemodynamic variables have been proposed as predictors of fluid responsiveness. Dynamic variables based on ...
Cherpanath T G V TG Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands, - - 2013
Predicting fluid responsiveness, the response of stroke volume to fluid loading, is a relatively novel concept that aims to optimise circulation, and as such organ perfusion, while avoiding futile and potentially deleterious fluid administrations in critically ill patients. Dynamic parameters have shown to be superior in predicting the response to ...
Okonko Io I Medical Microbiology & Virology Unit, Department of Microbiology, University of Port Harcourt, East-West Road, P.M.B. 5323, Choba, Port Harcourt, Rivers State, - - 2013
Human enteroviruses have long been associated with various diseases of man resulting into a wide range of acute symptoms involving the cardiac and skeletal muscles, central nervous system, pancreas, skin and mucous membranes. To assess the role of enteroviruses in the etiology of hypertension, DCM and HHF. We obtained stool ...
Judd Eric K EK Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, School of Medicine, The University of Alabama at Birmingham , Birmingham, Alabama, - - 2013
Resistant hypertension, defined as blood pressure (BP) remaining above goal despite the use of 3 or more antihypertensive medications at maximally tolerated doses (one ideally being a diuretic) or BP that requires 4 or more agents to achieve control, occurs in a substantial proportion (>10%) of treated hypertensive patients. Refractory ...
Marik Paul E - - 2013
The birth of the intermittent injectate-based conventional pulmonary artery catheter (fondly nicknamed PAC) was proudly announced in the New England Journal of Medicine in 1970 by his parents HJ Swan and William Ganz. PAC grew rapidly, reaching manhood in 1986 where, in the US, he was shown to influence the ...
Liu Yi - - 2013
Toll-interacting protein (Tollip) is a critical regulator of the Toll-like receptor-mediated signalling pathway. However, the role of Tollip in chronic pressure overload-induced cardiac hypertrophy remains unclear. This study aimed to determine the functional significance of Tollip in the regulation of aortic banding-induced cardiac remodelling and its underlying mechanisms. First, we ...
Hobolth Lise - - 2013
Newer studies suggest that carvedilol, a beta-blocker with a moderate anti-alpha-1 activity, is superior to propranolol in reducing the portal pressure and risk of variceal bleeding. The effect on arterial blood pressure is a matter of concern especially in decompensated patients. to assess potential differential effects of beta-blockers and beta-blockers ...
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