Search Results
Results 201 - 250 of 2368
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Stuckey Daniel J DJ 1British Heart Foundation Centre of Research Excellence, National Heart and Lung Institute, Imperial College London, London, United Kingdom; Centre for Advanced Biomedical Imaging, University College London, London, United - - 2014
-Diffuse interstitial fibrosis is present in diverse cardiomyopathies and associated with poor prognosis. We investigated whether MRI-based T1 mapping could quantify the induction and pharmacological suppression of diffuse cardiac fibrosis in murine pressure-overload hypertrophy. -Mice were subjected to transverse aortic constriction (TAC) or sham surgery. The angiotensin receptor blocker Losartan ...
Slagt C C Department of Anaesthesiology and Intensive Care, Zaans Medical Centre, Koningin Julianaplein 58, 1502 DV Zaandam, The - - 2014
The FloTrac/Vigileo™, introduced in 2005, uses arterial pressure waveform analysis to calculate cardiac output (CO) and stroke volume variation (SVV) without external calibration. The aim of this systematic review is to evaluate the performance of the system. Sixty-five full manuscripts on validation of CO measurements in humans, published in English, ...
Zhang Congcong C Beijing AnZhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, - - 2014
Inflammatory responses mediate the development of perivascular fibrosis and heart dysfunction induced by hypertension. Complement is an important inflammatory system, and we aimed to evaluate the effect of a specific C5a receptor antagonist (C5aRA), PMX53, on inflammation and perivascular fibrosis in the hypertensive heart of the mouse. Hypertension was induced ...
Nisenbaum Marcelo Gil MG Gynecology Department, Clinics Hospital, University of São Paulo Medical School, São Paulo 05403-000, Brazil. Electronic address: - - 2014
The use of combined oral contraceptives has been associated with an increased risk of adverse cardiovascular events. Whether these drugs alter cardiac autonomic nervous system control is not completely determined. To evaluate the effect of a contraceptive containing 20mcg of ethinyl estradiol and 3mg of drospirenone on the heart rate ...
Zhang Yan Y Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, - - 2014
Dickkopf-3 (DKK3), a secreted protein in the Dickkopf family, is expressed in various tissues, including the heart, and has been shown to play an important role in tissue development. However, the biological function of DKK3 in the heart remains largely unexplored. This study aimed to examine the role of DKK3 ...
Sandroni C C Department of Anesthesiology and Intensive Care, Catholic University School of Medicine, Rome, Italy - - - 2014
Experimental evidence shows that derangements of arterial partial pressures of either oxygen (PaO2) and carbon dioxide (PaCO2) immediately after resuscitation from cardiac arrest may increase the severity of organ dysfunction due to whole body ischemia and subsequent reperfusion. Hyperoxia is believed to increase reperfusion injury, especially to mitochondrial membrane due ...
Aprea Francesco F Dick White Referrals, Station Farm, Cambridgeshire, CB8 0UH, - - 2014
To describe bispectral index (BIS) findings and compare them with cardiovascular and respiratory trends during cardiac arrest and successful CPR in a propofol-anesthetized calf. A 3-month-old calf was anesthetized as part of a research project. A thromboxane analog drug (U46619) was administered IV to induce pulmonary hypertension. Within 10 minutes ...
Gkaliagkousi Eugenia E 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, - - 2014
Cardiotrophin 1 (CT-1) is an interleukin 6-related cytokine recently implicated in cardiac hypertrophy and vascular damage in essential hypertension (EH). We aimed first to determine CT-1 levels in naive, untreated patients with grade I EH (UH) as compared with normotensive (NT) individuals and, second, to investigate a possible association of ...
Singh Vikas V King George's Medical University, Lucknow, - - 2014
The present study was undertaken to assess the effect of volume expansion on cardiac haemodynamics in patients with cardiac tamponade and to ascertain an optimum amount of fluid that can produce the maximum benefit in tamponade patients. In patients of tamponade, interim measures may occasionally be needed when facilities for ...
Echavarría-Pinto Mauro M From the Cardiovascular Institute, Hospital Clínico San Carlos and Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (M.E.-P., B.I., A.Q., A.F.-O., J.E.); Cardiovascular Institute, Hospital Clínico San Carlos, Madrid, Spain (N.G., P.J.-Q., F.A., I.J.N.-G., C.B., C.M.); International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (R.P., S.S., S.N., J.T., J.D.); and Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea - - 2014
Intravenous adenosine infusion produces coronary and systemic vasodilatation, generally leading to systemic hypotension. However, adenosine-induced hypotension during stable hyperemia is heterogeneous, and its relevance to coronary stenoses assessment with fractional flow reserve (FFR) remains largely unknown. FFR, coronary flow reserve, and index of microcirculatory resistance were measured in 93 stenosed ...
Niewinski Piotr P 4th Military Hospital, - - 2014
Low-dose dopamine inhibits peripheral chemoreceptors and attenuates the hypoxic ventilatory response (HVR) in humans. However, it is unknown whether it also modulates: (1) the hemodynamic reactions to acute hypoxia, (2) cardiac baroreflex sensitivity (BRS) and (3) if there is any effect of dopamine withdrawal. We performed a double-blinded, placebo controlled ...
Smart C M CM Ayr Hospital, Ayr, - - 2014
To maximise the effect of a small fluid load, it is occasionally desirable to bolus manually with multiple depressions of a large-capacity syringe. This is usually achieved by placing the syringe on the side port of a three-way tap. We modified this technique by placing two-one-way valves in line with ...
Cinel Ismail I Department of Medicine, Cooper University Hospital , Camden, NJ 08103 , USA - - 2014
Abstract Preservation of cardiac output (CO) and pulmonary artery pressure (PAP) is vital to maintaining tissue oxygenation in sepsis. This feasibility study tested the hypothesis that therapeutic intra-thoracic pressure regulation (tIPR), delivered with a novel device, was designed to non-invasively enhance venous return by creating sub-atmospheric intra-thoracic pressure during the ...
Ingaramo Oscar A OA 1Department of Pediatric Critical Care, Sunrise Children's Hospital, Las Vegas, NV. 2Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, - - 2014
To evaluate the impact of different levels of positive end-expiratory pressure on cardiac index in children receiving mechanical ventilation. To explore the effect of lung recruitment on the relationship between positive end-expiratory pressure and cardiac output. Prospective, single center, and interventional. PICU in a tertiary care children's hospital. Fifty mechanically ...
Cassu Renata Navarro RN Oeste Paulista University, Scholl of Veterinary Medicine, Department of Veterinary Surgery and Anestesiology, Presidente PrudenteSP, - - 2014
To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group ...
Cheng Hui-Wen HW Cardiac Muscle Research Labratory, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical - - 2014
Emerging clinical data support the notion that RV dysfunction is critical to the pathogenesis of cardiovascular disease and heart failure(1-3). Moreover, the RV is significantly affected in pulmonary diseases such as pulmonary artery hypertension (PAH). In addition, the RV is remarkably sensitive to cardiac pathologies, including left ventricular (LV) dysfunction, ...
Weldy Chad S CS Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America ; Department of Pathology, University of Washington School of Medicine, Seattle, Washington, United States of - - 2014
Exposure to fine particulate air pollution (PM2.5) is strongly associated with cardiovascular morbidity and mortality. Exposure to PM2.5 during pregnancy promotes reduced birthweight, and the associated adverse intrauterine conditions may also promote adult risk of cardiovascular disease. Here, we investigated the potential for in utero exposure to diesel exhaust (DE) ...
Rokamp Kim Z KZ Departments of Anesthesia, Rigshospitalet, University of Copenhagen Copenhagen, - - 2014
This study addresses three questions for securing tissue oxygenation in brain (rScO2) and muscle (SmO2) for 100 patients (age 71 ± 6 years; mean ± SD) undergoing vascular surgery: (i) Does preoxygenation (inhaling 100% oxygen before anesthesia) increase tissue oxygenation, (ii) Does inhalation of 70% oxygen during surgery prevent a ...
Kanda Shigetaka S Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. - - 2014
Objectives: To evaluate the switching from an angiotensin receptor blocker (ARB) to a drug combination containing an ARB and a diuretic drug in terms of effects on hypertension, cardiac load, and cardiac function. Methods: In a study conducted on 82 patients with a history of heart failure and hypertension who ...
Zhang Xiakun X School of Atmospheric Sciences, Nanjing University of Information Sciences and Technology, 219 Ningliu Road, Nanjing 210044, China. - - 2014
The effects of cold air on cardiovascular and cerebrovascular diseases were investigated in an experimental study examining blood pressure and biochemical indicators. Zhangye, a city in Gansu Province, China, was selected as the experimental site. Health screening and blood tests were conducted, and finally, 30 cardiovascular disease patients and 40 ...
Chen Mei-Fen MF Department of Food Science, National Pingtung University of Science and Technology, Neipu, Pingtung City 91201, Taiwan ; College of Medicine and Life Science, Chung Hwa University of Medical Technology, Rende District, Tainan City 71703, - - 2014
The agonists of imidazoline I-1 receptors (I-1R) are widely used to lower blood pressure. It has been indicated that guanidinium derivatives show an ability to activate imidazoline receptors. Also, allantoin has a chemical stricture similar to guanidinium derivatives. Thus, it is of special interest to characterize the effect of allantoin ...
Popov Sergej S Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, - - 2014
Cardiac left ventricle hypertrophy (LVH) constitutes a major risk factor for heart failure. Although LVH is most commonly caused by chronic elevation in arterial blood pressure, reduction of blood pressure to normal levels does not always result in regression of LVH, suggesting that additional factors contribute to the development of ...
Campen Matthew J MJ Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of - - 2014
Exposure to chronic hypoxia (CH) induces elevated pulmonary artery pressure/resistance, leading to an eventual maladaptive right ventricular hypertrophy (RVH). Muscle RING finger-1 (MuRF1) is a muscle-specific ubiquitin ligase that mediates myocyte atrophy and has been shown to play a role in left ventricular hypertrophy and altered cardiac bioenergetics in pressure ...
Le Victoria P VP Department of Biomedical Engineering, Saint Louis University, St. Louis, - - 2014
Abstract The large arteries serve as compliant vessels that store energy during systole and return it during diastole. This function is made possible by the elastic fibers in the arterial wall that are assembled during late embryonic and early postnatal development from various proteins, including fibulin-5. Mice and humans with ...
Lauro Figueroa-Valverde FV Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Avenida Agustín Melgar s/n, Colonia Buenavista, 24039 San Francisco de Campeche, CAM, - - 2014
Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R). Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its ...
Sirvente Raquel A RA Cardiomyopathy Unit of the Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Hypertension Unit of the Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, - - 2014
Sympathetic hyperactivity may be related to left ventricular (LV) dysfunction and baro- and chemoreflex impairment in hypertension. However, cardiac function, regarding the association of hypertension and baroreflex dysfunction, has not been previously evaluated by transesophageal echocardiography (TEE) using intracardiac echocardiographic catheter. We evaluated exercise tests, baroreflex sensitivity and cardiovascular autonomic ...
Chittawatanarat Kaweesak - - 2014
In addition to cardiopulmonary monitoring, non-cardiopulmonary monitoring (non-CPM) is considered to be an important parameter in intensive care units (ICUs). However no data on this subject has been reported for Thai ICUs. The objective of the present study is to describe the non-CPM situation in Thai ICUs. ICU RESOURCE I ...
Ruiz Roberto R Associate Postgraduate Program in Physical Education, UEM/UEL, Londrina, PR, - - 2014
Objective to analyze the morphological structure of cardiac, blood pressure (BP), heart rate (HR) and heart rate variability (HRV) of rats subjected to physical training with supplementation of caffeine. Methods 60 rats were divided into 4 groups: control (CO), control with caffeine (CAF), trained control (TRE) and trained with caffeine ...
Mansour Mojtaba M Department of Anaesthesia, Anaesthesiology and Critical Care Research Centre, Isfahan University of Medical Sciences, Isfahan, - - 2014
Cardiac and pulmonary veins de-airing are of the most important steps during open heart surgery. This study evaluates the effect of continuous positive airway pressure (CPAP) on air trapping in pulmonary veins and on quality of de-airing procedure. This randomized prospective double blind clinical trial conducted on 40 patients. In ...
Coelho-Filho Otavio R OR Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, MA (O.R.C.F., R.V.S., T.G.N., R.K.) Department of Internal Medicine, State University of Campinas (UNICAMP), São Paulo, Brazil (O.R.C.F., - - 2014
Nearly 50% of patients with heart failure (HF) have preserved LV ejection fraction, with interstitial fibrosis and cardiomyocyte hypertrophy as early manifestations of pressure overload. However, methods to assess both tissue characteristics dynamically and noninvasively with therapy are lacking. We measured the effects of mineralocorticoid receptor blockade on tissue phenotypes ...
Yadav Monu M Department of Anaesthesiology & Critical Care, Nizam's Institute of Medical Sciences, Hyderabad 500082, - - 2014
A one-year-old child operated on for arachnoid cyst in right frontoparietotemporal region had sudden bradycardia followed by cardiac arrest leading to death after connecting negative pressure to the subgaleal drain during craniotomy closure. The surgical procedure was uneventful. It is a common practice to place epidural or subgaleal drains connected ...
Hintsala Heidi H Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, - - 2014
The aim of our study was to assess the effect of short-term cold exposure, typical in subarctic climate, on cardiac electrical function among untreated middle-aged hypertensive men. We conducted a population-based recruitment of 51 hypertensive men and a control group of 32 men without hypertension (age 55-65 years) who underwent ...
Miao D M DM Department 2 of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, - - 2014
It has been well established that high-sensitivity cardiac troponin T (hs-TnT) is a specific and highly sensitive marker in acute coronary syndromes. On the other hand, studies on serum concentrations of hs-TnT in patients with hypertension in the absence of significant coronary stenosis are limited. Therefore, we hypothesized that hs-TnT ...
Nekooeian Ali Akbar AA Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; ; Cardiovascular Pharmacology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, - - 2014
The cardiac effects simultaneously occurring during experimental hypertension and diabetes have rarely been investigated. This study aimed at examining the effects of short-term renovascular hypertension and type 2 diabetes on cardiac functions. Five groups (7 each) of male Sprague-Dawley rats, including a control group, a diabetes (induced by Streptozocin and ...
Bronzwaer Anne-Sophie G T AS Department of Internal Medicine, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands ; Laboratory for Clinical Cardiovascular Physiology, Center for Heart Failure Research, Academic Medical Center Amsterdam, - - 2014
A critical reduction in central blood volume (CBV) is often characterized by hemodynamic instability. Restoration of a volume deficit may be established by goal-directed fluid therapy guided by respiration-related variation in systolic- and pulse pressure (SPV and PPV). Stroke volume index (SVI) serves as a surrogate end-point of a fluid ...
Convertino Victor A VA U.S. Army Institute of Surgical Research, Research Division JBSA Fort Sam Houston, TX, - - 2014
The inability to compensate for acute central hypovolemia underlies the clinical development of orthostatic hypotension and instability (e.g., syncope). Although neuro-humoral control of both cardiac output and peripheral vascular resistance contributes to hemodynamic stability during orthostasis, a notion has been proposed that the failure of adequate peripheral vascular constriction rather ...
Chen Hongfei H Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, 2 Fuxue Road, 325000 Zhejiang, - - 2014
The reversal efficacy of 2% lipid emulsion in cardiac asystole induced by different concentrations of bupivacaine is poorly defined and needs to be determined. Forty-two male Sprague-Dawley rats were randomly divided into seven groups: B40, B60, B80, B100, B120, B140 and B160, n = 6. The Langendorff isolated heart perfusion model was ...
Sharma Jagdish N - - 2014
Cardiovascular diseases are the most common causes of mortality worldwide. Hypertension and diabetes are the two major risk factors in the development of cardiac hypertrophy, ischemic heart disease, and cardiac failure. In Kuwait, high rate of prevalence of hypertension and diabetes has been documented. Previous studies have indicated altered activities ...
Engi Sheila A SA Laboratory of Pharmacology, Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences, Univ. Estadual Paulista-UNESP, Araraquara, SP, Brazil; Joint UFSCar-UNESP Graduate Program in Physiological Sciences, São Carlos, SP, - - 2014
Concomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we investigated the effects of treatment for 10 consecutive days with testosterone and cocaine alone or in combination on ...
Stengl Milan - - 2013
Hypercapnic acidosis (HCA) that accompanies lung-protective ventilation may be considered permissive (a tolerable side-effect) or it may be therapeutic by itself. Cardiovascular effects may contribute to, or limit, the potential therapeutic impact of HCA; therefore, a complex physiological study was performed in healthy pigs to evaluate the systemic and organ-specific ...
Holman Ellen Alison EA Program in Nursing Science (E.A.H.), and Department of Anatomy and Neurobiology (A.G., J.L., D.P.), University of California, Irvine; and Drug Discovery and Development (A.G., D.P.), Italian Institute of Technology, Genoa, - - 2013
ObjectiveTrauma exposure can precipitate acute stress (AS) and cardiovascular disorders (CVD). Identifying AS-related physiologic changes that affect CVD risk could inform development of early CVD prevention strategies. The endocannabinoid system (ECS) regulates hypothalamic-pituitary-adrenal axis and stress-related cardiovascular function. We examine stress-related ECS activity and its association with cardiovascular biochemistry/function after ...
Evenson Alissa A Pediatric Cardiovascular Research Center, Penn State Hershey Children's Hospital, Penn State Milton S. Hershey Medical Center, Department of Pediatrics, Penn State Hershey College of Medicine, Hershey, PA, - - 2013
One approach with the potential to improve morbidity and mortality rates following extracorporeal life support (ECLS) is the use of pulsatile perfusion. Currently, no ECLS pumps used in the United States can produce pulsatile flow. The objective of this experiment is to evaluate a novel diagonal pump used in Europe ...
Egnaczyk Gregory F GF The Heart and Vascular Center at The Christ Hospital, 2123 Auburn Ave, Ste 137, Cincinnati, OH, 45219, - - 2013
Cardiac resynchronization therapy (CRT) improves measures of systolic function and clinical status. However, its effect on diastolic function is not well established. Commonly used parameters of diastolic function are measured from echocardiography, using pulse wave and tissue Doppler technologies, as well as timing and deformation data. Review of the existing ...
Cruz-Lemini Mónica M Department of Maternal-Fetal Medicine (Institut Clínic de Ginecologia, Obstetrícia i Neonatologia), Hospital Clínic - Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona and Centro de Investigación Biomédica en Red en Enfermedades Raras, Barcelona, - - 2013
Intrauterine growth restricted (IUGR) fetuses suffer cardiovascular remodeling which persists into infancy and has been related to cardiovascular outcomes in adulthood. Hypertension in infancy has been demonstrated to be a strong risk factor for later cardiovascular disease. Close monitoring together with dietary interventions have shown to improve cardiovascular health in ...
Lancaster Jordan J JJ Cardiology and Medicine, Southern Arizona VA Health Care System; Sarver Heart Center; Department of Physiology. Electronic address: - - 2013
Varying strategies are currently being evaluated to develop tissue-engineered constructs for the treatment of ischemic heart disease. This study examines an angiogenic and biodegradable cardiac construct seeded with neonatal cardiomyocytes for the treatment of chronic heart failure (CHF). We evaluated a neonatal cardiomyocyte (NCM)-seeded 3-dimensional fibroblast construct (3DFC) in vitro ...
Morra Elis A EA aPhysical Education and Sports Centre bDepartment of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, - - 2013
There have been contradictory reports regarding resistance exercise and central arterial compliance. The American Heart Association has recommended its use in preventing/treating cardiovascular diseases. We examined the effects of long-term endurance running and intense resistance training on central hemodynamics, compared with healthy control (CON). Sixty-nine male participants, 25-50 years [19 ...
Jozwiak Mathieu M 1 Service de Réanimation Médicale - - 2013
The effects of prone positioning during acute respiratory distress syndrome on all the components of cardiac function have not been investigated under protective ventilation and maximal alveolar recruitment. To investigate the hemodynamic effects of prone positioning. We included 18 patients with acute respiratory distress syndrome ventilated with protective ventilation and ...
Cui Hua H Second Geriatric Cardiology Division, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China, - - 2013
Blood pressure control is closely related to target organ damage in elderly patients with hypertension. The aim of this study was to determine the relationship between ambulatory blood pressure monitoring (ABPM) indices and cardiac damage in elderly male patients with treated essential hypertension (EH). This study included 998 Chinese men ...
Nolte Froukje F Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2013
Aims: First, to establish the diagnostic performance of the pressure gradient at a standardised mean velocity (dPv) as derived from the cycle-averaged stenosis pressure gradient-velocity (dP-v) relationship obtained by administration of adenosine and second, to determine whether dPv can be assessed from contrast medium-induced submaximal hyperaemia. Methods and results: Distal ...
Chen Bin B Institute of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, - - 2013
Background: Abnormalities of the mevalonate pathway, an important cellular metabolic pathway, are common in many diseases including cardiovascular disease. The mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated diastolic dysfunction remains largely unknown. This study aims to investigate whether the expression of mevalonate pathway related enzyme ...
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