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Sutherasan Y Y Ramathibodi hospital, Mahidol University, Bangkok Thailand - - - 2014
The mortality of post cardiac arrest patients was gradually reduced with years but still as high as 50%, despite advancements in the diagnostic and therapeutic approaches i.e. revascularization and therapeutic moderate hypothermia. However, recent evidence suggests that other therapeutic interventions aimed to minimize progressive deterioration of the brain and other ...
Dubin Ruth F RF Department of Medicine/Nephrology, San Francisco VA Medical Center/University of California, San Francisco, - - 2014
Diastolic dysfunction is common and associated with higher mortality in the end-stage renal disease (ESRD) population. E/E', a measure derived from tissue Doppler imaging (TDI), is a correlate of left ventricular (LV) filling pressures. E/E' may be viewed as a confirmatory marker of diastolic dysfunction, but it is not routinely ...
Yue Wen-Wei WW The Fourth People's Hospital of Ji'nan, Ji'nan Institute of Cardiovascular Disease, Second Affiliated Hospital, Tai Shan Medical College, Jinan, 250031, - - 2014
To investigate heart rate variability (HRV) in patients with masked hypertension (MH), participants were classified based on clinic and 24-h ambulatory blood-pressure monitoring: essential hypertension (EH, n = 40; MH, n = 36) and normotension (NT, n = 48). The HRV parameters were observed using a 24-h Holter monitor. Compared with NT controls, the parameters of ...
Russell James A JA From the Center for Heart Lung Innovation and the Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, BC, - - 2014
As fundamental as the issue is, there is no clear, high-level evidence to determine the most effective mean arterial pressure (MAP) for resuscitation of patients with septic shock. During hypotension, three salient aspects of cardiovascular physiology are important. First, the autoregulation of cerebral blood flow maintains an adequate level over ...
Alraies M Chadi MC Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, - - 2014
The ratio of early transmitral flow velocity (E) to mitral annular velocity (E') is considered a predictor of pulmonary capillary wedge pressure (PCWP). In a previous small study, the paradoxical relation between PCWP and E/E' ratio has been described in patients with constrictive pericarditis (CP). We sought to test this ...
Hirashiki Akihiro A Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of - - 2014
Background: Pulmonary hypertension (PH) because of left-sided heart disease carries a poor prognosis. We investigated whether non-ischemic dilated cardiomyopathy (DCM) with PH is associated with poor prognosis. Methods and Results: A total of 256 consecutive DCM patients were enrolled. We measured the ratio of the maximum first derivative of left ventricular pressure ...
Hulkkonen Janne - - 2014
Novel parameters derived from peak maximal oxygen uptake (VO2) and exercise arterial blood pressure, such as peak circulatory power (CP) and exercise cardiac power (ECP), can be used in the risk assessment of cardiovascular disease and stroke. However, the determinants of these factors are poorly characterized in the general population. ...
Li Jun J Department of Cardiology, Qilu Hospital, Shandong University , Jinan , PR China - - 2014
Abstract Context: Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora alopecuroides Linn. (Kudouzi). Sophocarpine injection was found to have significant antiviral effects against coxsackievirus B3 and therapeutic effects for viral myocarditis in the clinic. Objective: This study assessed the effects of sophocapine on ...
Spencer Andrew G AG Ardelyx Inc., Fremont, CA 94555, - - 2014
The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. When administered orally to rats, tenapanor acted ...
Azau A A Department of Anesthesia and Surgical Intensive Care, LUNAM Université, Université d'Angers, Angers, Larrey, - - 2014
We hypothesized that the optimization of renal haemodynamics by maintaining a high level of mean arterial blood pressure (MAP) during cardiopulmonary bypass (CPB) could reduce the rate of acute kidney injury (AKI) in high-risk patients. In this randomized, controlled study, we enrolled 300 patients scheduled for elective cardiac surgery under ...
Gimelli Alessia A Fondazione Toscana G. Monasterio, Via Moruzzi, 1, 56124 Pisa, - - 2014
To evaluate the relationships between measures of left ventricular (LV) filling dynamics at cadmium-zinc-telluride (CZT) imaging and indexes of LV diastolic function at transthoracic echocardiography. Two hundred and forty-seven patients underwent myocardial perfusion imaging at rest and after stress with a low-dose CZT protocol and a baseline transthoracic echocardiography study. ...
Lang Sean M SM aYale University School of Medicine, New Haven bConnecticut Children's Medical Center, Hartford cUniversity of Connecticut School of Medicine, Farmington, Connecticut, - - 2014
Blood pressure monitoring is an essential vital sign when caring for critically ill children. Invasive monitoring is considered the gold standard, but is not always feasible. The following study compared the CAS model 740 noninvasive blood pressure monitor with the Orion/MaxIQ NIBP module with the reference (invasive arterial measurement). We ...
Perrodin Stéphanie F SF Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, - - 2014
Most ventricular assist devices (VADs) currently used in infants are extracorporeal. These VAD require long-term anticoagulation therapy and extensive surgery, and two devices are needed for biventricular support. We designed a biventricular assist device based on shape memory alloy that reproduces the hemodynamic effects of cardiomyoplasty, supporting the heart with ...
Killu Ammar M AM Division of Cardiovascular Diseases, Mayo Clinic, Rochester, - - 2014
Cardiac resynchronization therapy (CRT) has been shown to improve heart failure (HF) symptoms and survival. We hypothesized that a greater improvement in left-ventricular ejection fraction (LVEF) after CRT is associated with greater survival benefit. In 693 patients across two international centers, the improvement in LVEF post-CRT was determined. Patients were ...
Zhu Jiang J First Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, - - 2014
Retinoid X receptor (RXR) has been demonstrated to play an important role in cardiac development and has been implicated in cardiovascular diseases. This study aimed to examine the effects of RXRα agonist bexarotene on pathological left ventricular hypertrophy (LVH) in a spontaneously hypertensive rat (SHR) model and the underlying mechanism. ...
Chen Szu-Ying SY Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan; Division of Surgical Intensive Care, Department of Critical Care Medicine, E-Da Hospital, I-Shou University, Kaohsiung, - - 2014
Particulate matter with aerodynamic diameter of <2.5μm (PM2.5) is associated with blood pressure and hemodynamic changes. Blunted nocturnal blood pressure dipping is a major risk factor for cardiovascular events; limited information is available on whether PM2.5 exposure-related hemodynamic changes vary with day-night blood pressure circadian rhythms. In this study, we ...
Semenas E E Department of Surgical Sciences/Anaesthesiology and Intensive Care, Faculty of Medicine, Uppsala University, Uppsala, - - 2014
Adrenaline (ADR) and vasopressin (VAS) are used as vasopressors during cardiopulmonary resuscitation. Data regarding their effects on blood-brain barrier (BBB) integrity and neuronal damage are lacking. We hypothesised that VAS given during cardiopulmonary resuscitation (CPR) after haemorrhagic circulatory arrest will preserve BBB integrity better than ADR. Twenty-one anaesthetised sexually immature ...
Fu Mingqiang M *Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; †Department of Medicine, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden; and ‡Institutes of Biomedical Sciences, Fudan University, Shanghai, - - 2014
To test whether olmesartan ameliorates cardiac diastolic dysfunction in spontaneously hypertensive rats (SHRs) through calcineurin pathway. Twenty-four male SHRs of 6 months were divided into saline- (n = 12) and olmesartan-treated (n = 12) groups. Age-matched WKY (n = 12) rats served as controls. Saline (10 mL·kg·d) or the same ...
Wang Yanfei Y Department of Cardiovascular Disease, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, - - 2014
Balloon release pressure may increase the incidence of no reflow after direct percutaneous coronary intervention (PCI). This randomized controlled study was designed to analyze the correlation between balloon release pressure and no-reflow in patients with acute myocardial infarction (AMI) undergoing direct PCI. There were 156 AMI patients who underwent PCI ...
Chatpun Surapong S Institute of Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, - - 2014
Increased vascular wall shear stress by elevated plasma viscosity significantly enhances the endothelial nitric oxide synthase (eNOS) activity during an acute isovolemic hemodilution. Also the modulation of plasma viscosity has effects on the cardiac function that were revealed if a left ventricular (LV) pressure-volume (PV) measurement was used. The aim ...
Brguljan-Hitij Jana J Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, - - 2014
Guidelines propose classification of conventional blood pressure (CBP) into normotension (<120/<80mm Hg), prehypertension (120-139/80-89mm Hg), and hypertension (≥140/≥90mm Hg). To assess the potential differential contribution of ambulatory blood pressure (ABP) in predicting risk across CBP strata, we analyzed outcomes in 7,826 untreated people recruited from 11 populations. During an 11.3-year ...
Dong Jinghui J Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. - - 2014
Vitamin D is essential for maintaining calcium and phosphate homeostasis, and vitamin D analogues have been prescribed to treat osteoporosis and hyperparathyroidism. Emerging evidence suggests that cardiovascular and chronic kidney diseases are closely associated with vitamin D deficiency resulting from either decreased sunshine exposure or inadequate intake. Vitamin D is ...
Pereira Renata O RO Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, 84112; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City - - 2014
To determine whether endogenous GLUT1 induction and the increased glucose utilization that accompanies pressure overload hypertrophy (POH) are required to maintain cardiac function during hemodynamic stress, and to test the hypothesis that lack of GLUT1 will accelerate the transition to heart failure. To determine the contribution of endogenous GLUT1 to ...
Cooke Andrew A School of Sport, Health & Exercise Sciences, Bangor University, Bangor, - - 2014
Knowledge of the psychophysiological responses that characterize optimal motor performance is required to inform biofeedback interventions. This experiment compared cortical, cardiac, muscular, and kinematic activity in 10 experts and 10 novices as they performed golf putts in low- and high-pressure conditions. Results revealed that in the final seconds preceding movement, ...
Ambrosy Andrew P AP Department of Medicine, Stanford University School of Medicine, Stanford, CA, - - 2014
Digoxin is the oldest cardiac drug still in contemporary use, yet its role in the management of patients with heart failure (HF) remains controversial. A purified cardiac glycoside derived from the foxglove plant, digoxin increases ejection fraction (EF), augments cardiac output, and reduces pulmonary capillary wedge pressure without causing deleterious ...
Mizutani Yasuaki Y Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, - - 2014
Olfactory dysfunction is considered to precede motor symptoms and early markers of Parkinson's disease (PD), while the relative time at which cardiovascular dysautonomia appears in PD is not well understood. To assess the appearance of cardiovascular dysautonomia in PD, we evaluated its relation to olfactory dysfunction in early-stage PD patients. ...
Katare Charu C Department of Food & Nutrition, Kamla Raja Girls (PG), Autonomous College, Gwalior, Madhya Pradesh, - - 2014
The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < ...
Milan Alberto A Department of Medical Sciences, Division of Internal Medicine, Hypertension Unit, University Hospital 'S. Giovanni Battista', Turin, Italy, - - 2014
Volume overload is typical of haemodialysis patients; correct volume status evaluation is crucial in achieving blood pressure homeostasis, hypertension management and good treatment planning. This study evaluates the effect of acute volume depletion on ultrasonographic parameters and suggests two of them as able to predict patients volume overload. 27 patients ...
Lozo Mislav M Department of Integrative Physiology, University of Split School of Medicine, Split, - - 2014
Self-contained underwater breathing apparatus (SCUBA) diving is regularly associated with numerous asymptomatic changes in cardiovascular function. Freshwater SCUBA diving presents unique challenges compared with open sea diving related to differences in water density and the potential for dive locations at altitude. The aim of this study was to evaluate the ...
Burger Dylan - - 2014
The somatic isozyme of angiotensin I-converting enzyme (ACE) is comprised of two distinct, zinc-dependent catalytic domains with different substrate specificities for angiotensin I (cleaved selectively by the C- domain) and bradykinin (cleaved equally efficiently by both the N and C- domains). Classical ACE inhibitors (ACEI) target both domains, with side ...
Oliveira-Sales Elizabeth B EB School of Physiology & Pharmacology, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK; Department of Physiology, Federal University of Sao Paulo, UNIFESP, SP 04023-062, - - 2014
Despite extensive use of the renovascular/Goldblatt model of hypertension-2K-1C, and the use of renal denervation to treat drug resistant hypertensive patients, autonomic mechanisms that underpin the maintenance of this hypertension are important yet remain unclear. Our aim was to analyse cardiovascular autonomic function by power spectral density analysis of both ...
Schroeder Christoph C Institute of Clinical Pharmacology, Hannover Medical School, Hannover, - - 2014
Hyperpolarization-activated cyclic nucleotide-gated 4 channels (HCN4) comprise the final pathway for autonomic heart rate (HR) regulation. We hypothesized that HCN4 inhibition could reverse autonomic imbalance in a human model of cardiac sympathetic activation. Nineteen healthy men ingested oral metoprolol+reboxetine, ivabradine+reboxetine, or placebo+reboxetine in a double-blind, randomized, crossover fashion. We assessed ...
Chalyan David A DA From the Department of Radiological Sciences, University of California-Irvine, Irvine, CA (D.A.C., Z.Z., S.M.); Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA (D.A.C.); Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Z.Z.); Division of Cardiology, University of California-Irvine, Orange, CA - - 2014
Diastolic fractional flow reserve (dFFR) has been shown to be highly sensitive for detection of inducible myocardial ischemia. However, its reliance on measurement of left-ventricular pressure for zero-flow pressure correction, as well as manual extraction of the diastolic interval, has been its major limitation. Given previous reports of minimal zero-flow ...
Garisto Cristiana C Pediatric Cardiac Intensive Care Unit, Department of Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital, IRCCS, Rome, - - 2014
It is currently uncertain which hemodynamic monitoring device reliably measures stroke volume and tracks cardiac output changes in pediatric cardiac surgery patients. To evaluate the difference between stroke volume index (SVI) measured by pressure recording analytical method (PRAM) and bioreactance and their ability to track changes after a therapeutic intervention. ...
Hofhuizen Charlotte - - 2014
Nexfin (Edwards Lifesciences, Irvine, CA) allows for noninvasive continuous monitoring of blood pressure (ABPNI) and cardiac output (CONI) by measuring finger arterial pressure (FAP). To evaluate the accuracy of FAP in measuring ABPNI and CONI as well as the adequacy of detecting changes in ABP and CO, we compared FAP ...
Orbegozo Cortes D D Intensive Care Department,Hôpital Erasme,Université Libre de Bruxelles, Brussels, Belgium - - - 2014
Excessive adrenergic stimulation may be associated with several adverse events and contribute to increase mortality in critically ill septic patients. Few clinical data exist on the effects of adrenergic blockade in this setting. The objective of this study was to investigate the effect of a short acting b-blocker (esmolol) in ...
Hahn Robert G RG Södertälje Hospital, Research Unit, Södertälje, Sweden, Södertälje Hospital, Research Unit, Södertälje, - - 2014
To evaluate whether the pathophysiology of shock syndromes can be better understood by comparing central hemodynamics with kinetic data on fluid and electrolyte shifts. We studied the dilutional hyponatremic shock that developed in response to overhydration with electrolyte-free irrigating fluid - the so-called 'transurethral resection syndrome' - by comparing cardiac ...
Yin Wenpeng W Department of Emergency Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, - - 2014
Epinephrine has been used as a first-choice vasopressor drug for cardiac arrest (CA) since 1974. However, the administration of epinephrine is controversial. This study aims to compare the effects of Shen-Fu injection (SFI) and epinephrine on resuscitation outcomes in a porcine model of prolonged CA. Ventricular fibrillation (VF) was electrically ...
Camarço João Paulo Figueiredo JP Federal University of Goias, GoianiaGO, Brazil, Fellow Master degree, Postgraduate Program in Health Sciences, Federal University of Goias (UFG), Goiania-GO, Brazil. Intellectual and scientific contents of the study, technical procedures, manuscript - - 2014
To evaluate the feasibility of an experimental model of donors after cardiac death in remote ischemic preconditioning studies. Twelve Landrace pigs were used as organ donors. They underwent cardiac arrest by coronary en block suture and interruption of ventilatory support. Haemodynamic data regarding the donor surgical protocol were evaluated. Studies ...
Jennings Brett L BL Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN, 38163, - - 2014
We investigated the contribution of cytochrome P450 (CYP) 1B1 to hypertension and its pathogenesis by examining the effect of its selective inhibitor, 2,4,3',5'-tetramethoxystilbene (TMS), in spontaneously hypertensive rats (SHR). Blood pressure (BP) was measured bi-weekly. Starting at 8 weeks, TMS (600 μg/kg, i.p.) or its vehicle was injected daily. At 14 ...
Severo Mateus Dornelles MD Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, - - 2014
This study was conducted among individuals with diabetes and hypertension in order to assess the prevalence of erectile dysfunction (ED) and the association between ED and cardiovascular risk variables such as echocardiographic changes. We evaluated 114 men with type 2 diabetes mellitus and hypertension. ED was assessed by IIEF-5 score. ...
Paunović Katarina K Institute of Hygiene and Medical Ecology, Faculty of Medicine, University of Belgrade, Dr Subotića 8, 11000 Belgrade, Serbia. Electronic address: - - 2014
Noise exposure increases blood pressure in both experimental and field studies. The underlying mechanisms may be evaluated by thoracic bioelectrical impedance. The aim of this experimental study was to assess changes in blood pressure, cardiac and hemodynamic parameters provoked by recorded traffic noise in young adults. The study included 130 ...
Gammon Cheryl S CS Institute of Food, Nutrition and Human Health, Massey University, Auckland, New - - 2014
Increasing fruit and vegetable consumption is a key lifestyle modification in the prevention and treatment of hypertension. Kiwifruit has previously been shown to have favorable effects on blood pressure (BP), likely through inhibiting angiotensin I-converting enzyme activity. We hypothesized that the replacement of 2 fruit servings in a healthy diet ...
Tamargo Juan J Universidad Complutense, School of Medicine, Department of Pharmacology , Madrid , - - 2014
Introduction: Diuretics enhance the renal excretion of Na(+) and water due to a direct action at different tubular sites of the nephron where solute re-absorption occurs. Areas covered: This paper focuses on the mechanism of action, pharmacodynamics, antihypertensive effects, adverse effects, interactions and contraindications of loop diuretics and potassium-sparing agents ...
Fedecostante Massimiliano M Internal Medicine and Geriatrics and "Hypertension Excellence Centre" of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University "Politecnica delle Marche", Italian National Research Centre on Aging "U. Sestilli", IRCCS-INRCA, Ancona, - - 2014
Hypertension plays a key role in chronic kidney disease (CKD), but CKD itself affects the blood pressure (BP) profile. The aim of this study was to assess the association of BP profile with CKD and the presence of cardiac organ damage. We studied 1805 patients, referred to our Hypertension Centre, ...
Xu Jiefeng J Weil Institute of Critical Care Medicine, Rancho Mirage, CA, United States; Department of Emergency Medicine, Yuyao People's Hospital, Medical School of Ningbo University, Ningbo, China. Electronic address: - - 2014
One of the major goals of cardiopulmonary resuscitation (CPR) is to provide adequate oxygen delivery to the brain for minimizing cerebral injury resulted from cardiac arrest. The optimal chest compression during CPR should effectively improve brain perfusion without compromising intracranial pressure (ICP). Our previous study has demonstrated that the miniaturized ...
- - 2014
Data on cardiovascular disease (CVD) risk in adolescents with type 2 diabetes (T2D) are limited. Echocardiography was performed in the last year of the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial (median 4½ yr from diagnosis of T2D, average age 18 yr), including MMode and 2D ...
Ocaranza Maria Paz MP aDivision de Enfermedades Cardiovasculares, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago bMillennium Institute on Immunology and Immunotherapy cInstituto de Ciencias Biomedicas, Facultad de Medicina, Santiago dAdvanced Center for Chronic Diseases & Centro Estudios Moleculares de la Celula, Facultad Ciencias Quimicas y Farmaceuticas & Facultad Medicina, Universidad de Chile, Santiago, Chile eDepartment of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas, Texas, - - 2014
Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. In this study, we evaluated whether angiotensin-(1-9) decreases hypertension and reverses experimental cardiovascular damage in the rat. Angiotensin-(1-9) (600 ng/kg per min for 2 weeks) reduced already-established hypertension in ...
Chen Zhidan Z Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, - - 2014
Cardiac side population cells (CSPs) are promising cell resource for the regeneration in diseased heart as intrinsic cardiac stem cells. However, the relative low ratio of CSPs in the heart limited the ability of CSPs to repair heart and improve cardiac function effectively under pathophysiological condition. Which factors limiting the ...
Schmidt Matthieu M The Australian & New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Level 6, The Alfred Centre, Commercial Road, Melbourne, Victoria 3004, Australia. - - 2014
The timing of extracorporeal membrane oxygenation (ECMO) initiation and its outcome in the management of respiratory and cardiac failure have received considerable attention, but very little attention has been given to mechanical ventilation during ECMO. Mechanical ventilation settings in non-ECMO studies have been shown to have an effect on survival ...
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