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Stevenson Alec T - - 2014
Cardiovascular reflexes that regulate blood pressure (BP) adapt during repeated exposure to +Gz acceleration separated by short (< 20 s) breaks, but whether this effect is preserved with longer intervals remains unknown. There were 17 subjects who completed 5 repeated gradual onset (0.1 G x s(-1)) runs (GOR1-5) to 60 ...
Kang Woon-Seok WS Department of Anesthesiology and Pain Medicine, Konkuk University Hospital, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. ; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, - - 2014
The usefulness of dynamic parameters derived by heart-lung interaction for fluid responsiveness in pediatric patients has been revealed. However, the effects of peak inspiratory pressure (PIP) that could affect the absolute values and the accuracy in pediatric patients have not been well established. Participants were 30 pediatric patients who underwent ...
Lakshmikanthan Sribalaji S From the Blood Research Institute, BloodCenter of Wisconsin, Milwaukee (S.L., M.C.W.); Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville (B.J.Z., K.M., M.V.A., A.V.S.); and Department of Pharmacology and Toxicology (Z.-D.G., J.A.A.), Cardiovascular Center (Z.-D.G., X.Z., J.E.M., D.X.Z., J.A.A.), Department of Medicine (X.Z., J.E.M., D.X.Z.), Department of Physiology (H.L., D.L.M.), and Division of Biostatistics (A.S.), Medical College of Wisconsin, - - 2014
Small GTPase Ras-related protein 1 (Rap1b) controls several basic cellular phenomena, and its deletion in mice leads to several cardiovascular defects, including impaired adhesion of blood cells and defective angiogenesis. We found that Rap1b(-/-) mice develop cardiac hypertrophy and hypertension. Therefore, we examined the function of Rap1b in regulation of ...
Khan Munasib M Natural Products Research Unit, Department of Biological and Biomedical, Sciences, Aga Khan University Medical College , Karachi , Pakistan - - 2014
Abstract In current study, we describe blood pressure (BP)-lowering, endothelium-dependent, and independent vasodilator and cardio-modulatory actions of Carum roxburghianum seed. The crude extract of C. roxburghianum seed (Cr.Cr) induced dose-dependent (10-100 mg/kg) fall in arterial BP of anaesthetized rats. In isolated rabbit aorta, Cr.Cr (0.3-10 mg/mL) inhibited high K(+) (80 mM) and phenylephrine ...
Noack Cornelia C Department of Neurology, Charité - University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, - - 2014
Levodopa is one of the most effective symptomatic treatment options for Parkinsonism with a favorable safety and tolerability profile. In some patients, particularly those suffering from orthostatic intolerance, the hypotensive effect of levodopa limits its therapeutic use. We used continuous noninvasive cardiovascular and ventilatory monitoring in 17 patients suffering from ...
Pereira Renata O RO *Fraternal Order of Eagles Diabetes Research Center, Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, - - 2014
During pathological hypertrophy, peroxisome proliferator-activated receptor coactivator 1α (PGC-1α) is repressed in concert with reduced mitochondrial oxidative capacity and fatty acid oxidation (FAO). We therefore sought to determine if maintaining or increasing PGC-1α levels in the context of pressure overload hypertrophy (POH) would preserve mitochondrial function and prevent contractile dysfunction. ...
Su Shaoyong S Georgia Prevention - - 2014
Growing evidence suggests that adverse childhood experiences (ACEs) increase the risks for coronary heart disease and hypertension in mid and late adulthood. We previously reported that early life stress induces a hyperreactive endothelin-dependent cardiovascular phenotype in a rat model. In the present study, we evaluated whether exposure to ACEs is ...
Vasileiou Panagiotis V S PV National and Kapodistrian University of Athens, Medical School, MSc "Cardiopulmonary Resuscitation", Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece. Electronic address: - - 2014
In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. However, its role in the cardiac arrest (CA) setting has not yet been adequately investigated. The aim of this study is to examine ...
Pinsky Michael R MR Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA, - - 2014
In 1992, we published a report on the effect of positive end-expiratory pressure (PEEP) on right ventricular (RV) function in humans. We measured RV volumes and pressures and pericardial pressure (Ppc) as PEEP was increased from zero to 15 cm H20 in 12 patients after thoracotomy, using a pulmonary arterial ...
Hartmann Silvia M SM Pediatric Critical Care Medicine, Seattle Children's Hospital, Seattle, WA, - - 2014
End-tidal carbon dioxide (ETCO2) measurements during cardiopulmonary resuscitation (CPR) reflect variable cardiac output over time, and low values have been associated with decreased survival. The goals of this review are to confirm and quantify this relationship and to determine the mean ETCO2 value among patients with return of spontaneous circulation ...
Lee Candice Y CY From the *University of Rochester Medical Center, Rochester, NY USA; and †LSI SOLUTIONS, Victor, NY - - 2014
This study compared the strength, consistency, and speed of prosthetic attachment sutures secured with automated fasteners with those of manual knots using an ex vivo porcine mitral valve annuloplasty model. A novel miniature pressure transducer system was developed to quantify pressures between sutured prosthetic rings and underlying cardiac tissue. Sixteen ...
Kato Daiki D Department of Cardiology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, - - 2014
Fractional flow reserve (FFR) is a useful modality to assess the functional significance of coronary stenoses. Although adenosine triphosphate (ATP) is generally used as the hyperemic stimulus, we sometimes encounter adverse events like hypotension during FFR measurement. Nicorandil, an ATP-sensitive potassium channel opener, recognized as an epicardial and resistance vessel ...
May Ross W RW Family Institute, Department of Family and Child Sciences, Florida State University, Tallahassee, Florida. Electronic address: - - 2014
High trait anger is linked to adverse cardiovascular outcomes. A potential antidote to the cardiotoxic influence of anger is trait forgiveness (TF), as it has shown associations with improved blood pressure (BP) and cardiovagal tone regulation in cardiac patients. However, it has yet to be determined if anger and forgiveness ...
Perel Azriel A Department of Anesthesiology and Intensive Care, Sheba Medical Center, Tel Aviv University, Tel Hashomer, 52621, Tel Aviv, Israel, - - 2014
Optimal fluid management is one of the main challenges in the care of the critically ill. However, the physiological parameters that are commonly monitored and used to guide fluid management are often inadequate and even misleading. From 1987 to 1989 we published four experimental studies which described a method for ...
Bebarta Vikhyat S VS Medical Toxicology, San Antonio Military Medical Center, San Antonio, TX. Electronic address: - - 2014
Hydroxocobalamin is a Food and Drug Administration-approved antidote for cyanide poisoning. Cobinamide is a potential antidote that contains 2 cyanide-binding sites. To our knowledge, no study has directly compared hydroxocobalamin with cobinamide in a severe, cyanide-toxic large-animal model. Our objective is to compare the time to return of spontaneous breathing ...
Redfors Bjorn B Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address: - - 2014
Takotsubo cardiomyopathy (TCM) is characterized by regional left ventricular dysfunction that cannot be explained by an occlusive lesion in a coronary artery. Catecholamines are implicated in the pathogenesis of TCM but the mechanisms involved are unknown. Because the endogenous and the most commonly used exogenous catecholamines have well defined adrenoceptor ...
Nikolaou Panayiotis - - 2014
We present a systematic, multi-parameter study of Rb/(129)Xe spin-exchange optical pumping (SEOP) in the regimes of high xenon pressure and photon flux using a 3D-printed, clinical-scale stopped-flow hyperpolarizer. In situ NMR detection was used to study the dynamics of (129)Xe polarization as a function of SEOP-cell operating temperature, photon flux, ...
Armstrong David W J DW Department of Biomedical and Molecular Sciences, Queen's University, Room 850 Botterell Hall, Kingston, ON, K7L 3N6, - - 2014
The developmental origins of health and disease refer to the theory that adverse maternal environments influence fetal development and the risk of cardiovascular disease in adulthood. We used the chronically hypertensive atrial natriuretic peptide knockout (ANP-/-) mouse as a model of gestational hypertension, and attempted to determine the effect of ...
Aronson Solomon S Department of Anesthesiology, Duke University Medical Center, Durham, NC. Electronic address: - - 2014
To examine the impact of blood pressure control on hospital health resource utilization using data from the ECLIPSE trials. Post-hoc analysis of data from 3 prospective, open-label, randomized clinical trials (ECLIPSE trials). Sixty-one medical centers in the United States. Patients 18 years or older undergoing cardiac surgery. Clevidipine was compared ...
Pinsky Michael R MR Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, - - 2014
Functional haemodynamic monitoring is the assessment of the dynamic interactions of haemodynamic variables in response to a defined perturbation. Fluid responsiveness can be predicted during positive pressure breathing by variations in venous return or left ventricular output using numerous surrogate markers, such as arterial pulse pressure variation (PPV), left ventricular ...
Merry Alan F AF Faculty of Medical and Health Sciences, School of Medicine, The University of Auckland, Private Bag 92019, Auckland, 1003, New Zealand, - - 2014
We tested the hypothesis that clevidipine, a rapidly acting dihydropyridine calcium channel blocker, is not inferior to nitroglycerin (NTG) in controlling blood pressure before cardiopulmonary bypass (CPB) during coronary artery bypass grafting (CABG). In this double-blind study from October 4, 2003 to April 26, 2004, 100 patients undergoing CABG with ...
Ameloot K K Department of Intensive Care Medicine. Ziekenhuis Netwerk Antwerpen. ZNA Stuivenberg, Antwerpen, Belgium - - - 2014
Nexfin® (BMEYE, Amsterdam, The Netherlands) is a totally noninvasive blood pressure and cardiac output (CO) monitor based on finger arterial pulse contour analysis. We performed an open observational study in a mix of medical-surgical-burns critically ill patients (n=45) to validate Nexfin obtained blood pressures (MAPnex) against PiCCO (MAPfem). derived blood ...
Verdier-Watts Florence F Interventional Cardiology Department, Hospices Civils de Lyon, Bron, - - 2014
Aims: To assess fractional flow reserve (FFR) variability in case of arterial hypotension in the clinical setting. FFR measurement is supposed to be independent of haemodynamics; there is, however, a strong relationship between trans-stenotic pressure variation and coronary flow. Non-clinical models suggest an inverse relationship between arterial pressure and FFR, ...
Schwerdtfeger Andreas R AR Department of Psychology, University of Graz, Graz, - - 2014
Cardiovascular reactivity to laboratory stress might predict cardiovascular load in everyday life. However, previous research throws doubt on this hypothesis. This study examined associations between heart rate (HR) to a public speaking task and ambulatory HR throughout a day. Electrocardiogram, bodily movement, and psychosocial variables (affect, context) were recorded in ...
Cinotti Raphaël R Service Anesthésie-Réanimation chirurgicale, Hôtel Dieu, 1 place Alexis Ricordeau, CHU de Nantes, Nantes 44093 cedex, France. Electronic address: - - 2014
Preload responsiveness parameters could be useful in the hemodynamic management of septic shock. A multicentric prospective echocardiographic observational study was conducted from March 2009 to August 2011. Clinically brain-dead subjects were included. Pulse pressure variations (ΔPPs) were recorded. Cardiac index, variation of the maximum flow velocity of aortic systolic blood ...
Carthy Elliott R ER Inflammation and Healing Research Cluster, School of Health and Sport Sciences, University of the Sunshine Coast, Maroochydore, Qld, - - 2014
This study compared blood pressure, heart rate variability (HRV) and forearm blood flow, at rest and in response to sympathoexcitatory stressors between normotensive and mildly hypertensive participants. Participants aged 30-79 years with normal blood pressure (n = 49) or mild hypertension (n = 17), with no history of taking antihypertensive medication, were recruited. Participants completed ...
Charkoudian N N U.S. Army Research Institute of Environmental Medicine, Natick, - - 2014
The sympathetic nervous system is a ubiquitous, integrating controller of myriad physiological functions. In the present article, we review the physiology of sympathetic neural control of cardiovascular function with a focus on integrative mechanisms in humans. Direct measurement of sympathetic neural activity (SNA) in humans can be accomplished using microneurography, ...
Kostas Vladimir I - - 2014
In this study we compare two models [head-up tilt (HUT) vs. body unweighting using lower body positive pressure (LBPP)] to simulate Moon, Mars, and Earth gravities. A literature search did not reveal any comparisons of this type performed previously. We hypothesized that segmental fluid volume shifts (thorax, abdomen, upper and ...
Lin T-W TW Department of Anesthesiology, Chang Gung Memorial Hospital-Linkou, Taoyuan, - - 2014
Fluid restriction has been used to decrease central venous pressure as a strategy of fluid management during living donor liver donation (LDLD). However, potential risks such as hemodynamic instability are also involved during the procedure. Monitoring of preload or preload responsiveness is therefore crucial during LDLD. The aim of this ...
Enekvist Bruno - - 2014
Atelectasis formation can be reduced by positive end-expiratory pressure (PEEP), but resulting increases in intrathoracic pressure could affect circulation. We have earlier demonstrated that increased tidal volumes with larger apparatus dead space improves oxygenation and sevoflurane uptake. In the present study, we hypothesize that isocapnic ventilation with increased tidal volumes ...
Arora Shubhangi S Department of Anaesthesia, All India Institute of Medical Sciences, Delhi, - - 2014
Hemodynamic monitoring in the form of invasive arterial, central venous pressure and pulmonary capillary wedge pressure monitoring may be required in seriously ill Intensive care unit patients, in patients undergoing surgeries involving gross hemodynamic changes and in patients undergoing cardiac surgeries. These techniques are considered the gold standards of hemodynamic ...
Cornelis Tom T Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address: - - 2014
Intensive hemodialysis (HD) may have significant benefits. Recently, the role of extended hemodiafiltration (HDF) has gained interest. The aim of this study was to evaluate the acute effects of extended HD and HDF on hemodynamic response and solute removal. Randomized crossover trial. Stable patients with end-stage renal disease undergoing conventional ...
Tran Linda T LT Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, V6T 1Z3, - - 2014
The purpose of this study was to investigate the effect of chronic treatment with prazosin, a selective α1-adrenoceptor antagonist, on the development of hypertension in fructose-fed rats (FFR). High-fructose feeding and treatment with prazosin (1 mg/kg/day via drinking water) were initiated simultaneously in male Wistar rats. Systolic blood pressure, fasted plasma ...
Bergström-Isacsson Märith M Rett Center Jämtland County Council, Östersund, Sweden. Electronic address: - - 2014
People with Rett syndrome (RTT) have severe communicative difficulties. They have as well an immature brainstem that implies dysfunction of the autonomic nervous system. Music plays an important role in their life, is often used as a motivating tool in a variety of situations and activities, and caregivers are often ...
Salla Kati K Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, - - 2014
To compare the cardiopulmonary effects of intravenous (IV) and intramuscular (IM) medetomidine and butorphanol with or without MK-467. Prospective, randomized experimental cross-over. Eight purpose-bred beagles (two females, six males), 3-4 years old and weighing 14.5 ±1.6 kg (mean ± SD). All dogs received four different treatments as follows: medetomidine 20 μg kg(-1) and butorphanol tartrate 0.1 mg kg(-1) IV ...
Petrie Colin J CJ aDepartment of Cardiology, Monklands Hospital, Monkscourt Avenue Airdrie, Glasgow, Scotland, UK bDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands cBritish Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, - - 2014
A low pulse pressure (PP) may reflect poor cardiac output (CO), but has not been well characterized by invasive haemodynamic studies. We investigated the relationship between PP and cardiac index (CI) in patients with cardiovascular disease including those with normal and impaired cardiac function. Cardiac catheterization data from 1897 patients ...
Kooijman Marjolein N MN aThe Generation R Study Group bDepartment of Epidemiology cDepartment of Pediatrics dDepartment of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, the - - 2014
Low birth weight is associated with cardiovascular disease in adulthood. Hemodynamic adaptations related to fetal growth restriction may underlie these associations, through persistent influences on cardiovascular development. We examined the associations of third trimester fetal hemodynamics with cardiovascular outcomes in childhood. In a prospective cohort study among 917 pregnant women ...
Dange Rahul B RB Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, - - 2014
Understanding the novel signaling pathways involved in the pathogenesis of hypertension is vital for development of effective therapeutic strategies. Recent evidence suggest a role for toll-like receptor (TLR) 4 in the development of cardiovascular diseases. Although brain has been implicated in the pathogenesis of hypertension, role of brain TLR4 in ...
Wang Shigang S Pediatric Cardiovascular Research Center, Penn State Hershey Children's Hospital, Penn State Milton S. Hershey Medical Center, Department of Pediatrics, Penn State Hershey College of Medicine, Hershey, PA, - - 2014
The objective of this study is to evaluate two extracorporeal life support (ECLS) circuits and determine the effect of pulsatile flow on pressure drop, flow/pressure waveforms, and hemodynamic energy levels in a pediatric pseudopatient. One ECLS circuit consisted of a Medos Deltastream DP3 diagonal pump and Hilite 2400 LT oxygenator ...
Bigal Marcelo E ME Labrys Biologics Inc., San Mateo, CA, - - 2014
The vascular effects of acute calcitonin gene-related peptide (CGRP) inhibition are well described, but the effects of sustained inhibition warrant further exploration in humans. The objective of this article is to assess the effects of sustained CGRP inhibition on blood pressure, heart rate, and ECGs in healthy women ≥40 years ...
Antonini Lanfranco L Cardiovascular Department, San Filippo Neri Hospital, Rome, Italy, - - 2014
To propose a clinical prognostic index for death and heart failure in patients with ischemic cardiomyopathy implanted with an ICD. This prospective study included 192 consecutive patients (age 68 ± 10) recruited from 2004 to 2009 and implanted with an ICD for MADIT II criteria. All patients performed 24-h ambulatory blood pressure ...
Lazzeri Chiara C Intensive Cardiac Coronary Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi , Florence , - - 2014
Background: Data on the hemodynamic and cardiovascular effects of hypothermia in patients with cardiac arrest are scarce. The aim of this study was to evaluate the hemodynamic changes induced by hypothermia by means of Most Care(®) (pressure recording analytical method, PRAM methodology), a beat-to-beat hemodynamic monitoring method. Methods: We enrolled ...
Miao Na N Department of Extracorporeal Circulation, Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, - - 2014
Human albumin is the conventional cardiopulmonary bypass circuit primer. However, it has high manufacturing costs. Crystalloid and colloid solutions have been developed as alternatives, including a new generation of non-ionic hydroxyethyl starch (HES). The efficacy of hydroxyethyl starch with a 130 molecular weight and substitution degree of 0.4 (hydroxyethyl starch ...
Fine D M DM Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, - - 2014
Doxorubicin is a common antineoplastic agent with dose-dependent cardiotoxic adverse effects, and pre-existing myocardial dysfunction is a contraindication to its use. To systematically define the hemodynamic and biochemical alterations in dogs undergoing chemotherapy for newly diagnosed lymphoma and assess the reversibility of these alterations with fluid administration. Twenty-one client-owned dogs ...
Legrand Matthieu M 1AP-HP, Hôpital Lariboisière, Department of Anesthesiology and Critical Care and Burn unit, Hôpitaux universitaires St-Louis-Lariboisière, F-75475, Paris, France 2Univ Paris Diderot, EA-3509, F-75475, Paris, - - 2014
Dissolved oxygen (i.e. unbound to hemoglobin) is often neglected as a determinant of central venous oxygen saturation (ScvO2) in review articles and textbooks. These statements may lead to potential misinterpretation of SCvO2 value across FiO2 changes. With this study, we aimed to explore the influence of PaO2 and FiO2 on ...
Sutherasan Y Y Ramathibodi hospital, Mahidol University, Bangkok Thailand - - - 2014
The mortality of post cardiac arrest patients was gradually reduced with years but still as high as 50%, despite advancements in the diagnostic and therapeutic approaches i.e. revascularization and therapeutic moderate hypothermia. However, recent evidence suggests that other therapeutic interventions aimed to minimize progressive deterioration of the brain and other ...
Dubin Ruth F RF Department of Medicine/Nephrology, San Francisco VA Medical Center/University of California, San Francisco, - - 2014
Diastolic dysfunction is common and associated with higher mortality in the end-stage renal disease (ESRD) population. E/E', a measure derived from tissue Doppler imaging (TDI), is a correlate of left ventricular (LV) filling pressures. E/E' may be viewed as a confirmatory marker of diastolic dysfunction, but it is not routinely ...
Yue Wen-Wei WW The Fourth People's Hospital of Ji'nan, Ji'nan Institute of Cardiovascular Disease, Second Affiliated Hospital, Tai Shan Medical College, Jinan, 250031, - - 2014
To investigate heart rate variability (HRV) in patients with masked hypertension (MH), participants were classified based on clinic and 24-h ambulatory blood-pressure monitoring: essential hypertension (EH, n = 40; MH, n = 36) and normotension (NT, n = 48). The HRV parameters were observed using a 24-h Holter monitor. Compared with NT controls, the parameters of ...
Russell James A JA From the Center for Heart Lung Innovation and the Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, BC, - - 2014
As fundamental as the issue is, there is no clear, high-level evidence to determine the most effective mean arterial pressure (MAP) for resuscitation of patients with septic shock. During hypotension, three salient aspects of cardiovascular physiology are important. First, the autoregulation of cerebral blood flow maintains an adequate level over ...
Alraies M Chadi MC Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, - - 2014
The ratio of early transmitral flow velocity (E) to mitral annular velocity (E') is considered a predictor of pulmonary capillary wedge pressure (PCWP). In a previous small study, the paradoxical relation between PCWP and E/E' ratio has been described in patients with constrictive pericarditis (CP). We sought to test this ...
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