Search Results
Results 101 - 150 of 2343
1 2 3 4 5 6 7 8 9 10 >
Aronson Solomon S Department of Anesthesiology, Duke University Medical Center, Durham, NC. Electronic address: - - 2014
To examine the impact of blood pressure control on hospital health resource utilization using data from the ECLIPSE trials. Post-hoc analysis of data from 3 prospective, open-label, randomized clinical trials (ECLIPSE trials). Sixty-one medical centers in the United States. Patients 18 years or older undergoing cardiac surgery. Clevidipine was compared ...
Pinsky Michael R MR Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, - - 2014
Functional haemodynamic monitoring is the assessment of the dynamic interactions of haemodynamic variables in response to a defined perturbation. Fluid responsiveness can be predicted during positive pressure breathing by variations in venous return or left ventricular output using numerous surrogate markers, such as arterial pulse pressure variation (PPV), left ventricular ...
Merry Alan F AF Faculty of Medical and Health Sciences, School of Medicine, The University of Auckland, Private Bag 92019, Auckland, 1003, New Zealand, - - 2014
We tested the hypothesis that clevidipine, a rapidly acting dihydropyridine calcium channel blocker, is not inferior to nitroglycerin (NTG) in controlling blood pressure before cardiopulmonary bypass (CPB) during coronary artery bypass grafting (CABG). In this double-blind study from October 4, 2003 to April 26, 2004, 100 patients undergoing CABG with ...
Ameloot K K Department of Intensive Care Medicine. Ziekenhuis Netwerk Antwerpen. ZNA Stuivenberg, Antwerpen, Belgium - - - 2014
Nexfin® (BMEYE, Amsterdam, The Netherlands) is a totally noninvasive blood pressure and cardiac output (CO) monitor based on finger arterial pulse contour analysis. We performed an open observational study in a mix of medical-surgical-burns critically ill patients (n=45) to validate Nexfin obtained blood pressures (MAPnex) against PiCCO (MAPfem). derived blood ...
Verdier-Watts Florence F Interventional Cardiology Department, Hospices Civils de Lyon, Bron, - - 2014
Aims: To assess fractional flow reserve (FFR) variability in case of arterial hypotension in the clinical setting. FFR measurement is supposed to be independent of haemodynamics; there is, however, a strong relationship between trans-stenotic pressure variation and coronary flow. Non-clinical models suggest an inverse relationship between arterial pressure and FFR, ...
Schwerdtfeger Andreas R AR Department of Psychology, University of Graz, Graz, - - 2014
Cardiovascular reactivity to laboratory stress might predict cardiovascular load in everyday life. However, previous research throws doubt on this hypothesis. This study examined associations between heart rate (HR) to a public speaking task and ambulatory HR throughout a day. Electrocardiogram, bodily movement, and psychosocial variables (affect, context) were recorded in ...
Cinotti Raphaël R Service Anesthésie-Réanimation chirurgicale, Hôtel Dieu, 1 place Alexis Ricordeau, CHU de Nantes, Nantes 44093 cedex, France. Electronic address: - - 2014
Preload responsiveness parameters could be useful in the hemodynamic management of septic shock. A multicentric prospective echocardiographic observational study was conducted from March 2009 to August 2011. Clinically brain-dead subjects were included. Pulse pressure variations (ΔPPs) were recorded. Cardiac index, variation of the maximum flow velocity of aortic systolic blood ...
Carthy Elliott R ER Inflammation and Healing Research Cluster, School of Health and Sport Sciences, University of the Sunshine Coast, Maroochydore, Qld, - - 2014
This study compared blood pressure, heart rate variability (HRV) and forearm blood flow, at rest and in response to sympathoexcitatory stressors between normotensive and mildly hypertensive participants. Participants aged 30-79 years with normal blood pressure (n = 49) or mild hypertension (n = 17), with no history of taking antihypertensive medication, were recruited. Participants completed ...
Charkoudian N N U.S. Army Research Institute of Environmental Medicine, Natick, - - 2014
The sympathetic nervous system is a ubiquitous, integrating controller of myriad physiological functions. In the present article, we review the physiology of sympathetic neural control of cardiovascular function with a focus on integrative mechanisms in humans. Direct measurement of sympathetic neural activity (SNA) in humans can be accomplished using microneurography, ...
Kostas Vladimir I - - 2014
In this study we compare two models [head-up tilt (HUT) vs. body unweighting using lower body positive pressure (LBPP)] to simulate Moon, Mars, and Earth gravities. A literature search did not reveal any comparisons of this type performed previously. We hypothesized that segmental fluid volume shifts (thorax, abdomen, upper and ...
Lin T-W TW Department of Anesthesiology, Chang Gung Memorial Hospital-Linkou, Taoyuan, - - 2014
Fluid restriction has been used to decrease central venous pressure as a strategy of fluid management during living donor liver donation (LDLD). However, potential risks such as hemodynamic instability are also involved during the procedure. Monitoring of preload or preload responsiveness is therefore crucial during LDLD. The aim of this ...
Enekvist Bruno - - 2014
Atelectasis formation can be reduced by positive end-expiratory pressure (PEEP), but resulting increases in intrathoracic pressure could affect circulation. We have earlier demonstrated that increased tidal volumes with larger apparatus dead space improves oxygenation and sevoflurane uptake. In the present study, we hypothesize that isocapnic ventilation with increased tidal volumes ...
Arora Shubhangi S Department of Anaesthesia, All India Institute of Medical Sciences, Delhi, - - 2014
Hemodynamic monitoring in the form of invasive arterial, central venous pressure and pulmonary capillary wedge pressure monitoring may be required in seriously ill Intensive care unit patients, in patients undergoing surgeries involving gross hemodynamic changes and in patients undergoing cardiac surgeries. These techniques are considered the gold standards of hemodynamic ...
Cornelis Tom T Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address: - - 2014
Intensive hemodialysis (HD) may have significant benefits. Recently, the role of extended hemodiafiltration (HDF) has gained interest. The aim of this study was to evaluate the acute effects of extended HD and HDF on hemodynamic response and solute removal. Randomized crossover trial. Stable patients with end-stage renal disease undergoing conventional ...
Tran Linda T LT Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, V6T 1Z3, - - 2014
The purpose of this study was to investigate the effect of chronic treatment with prazosin, a selective α1-adrenoceptor antagonist, on the development of hypertension in fructose-fed rats (FFR). High-fructose feeding and treatment with prazosin (1 mg/kg/day via drinking water) were initiated simultaneously in male Wistar rats. Systolic blood pressure, fasted plasma ...
Bergström-Isacsson Märith M Rett Center Jämtland County Council, Östersund, Sweden. Electronic address: - - 2014
People with Rett syndrome (RTT) have severe communicative difficulties. They have as well an immature brainstem that implies dysfunction of the autonomic nervous system. Music plays an important role in their life, is often used as a motivating tool in a variety of situations and activities, and caregivers are often ...
Salla Kati K Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, - - 2014
To compare the cardiopulmonary effects of intravenous (IV) and intramuscular (IM) medetomidine and butorphanol with or without MK-467. Prospective, randomized experimental cross-over. Eight purpose-bred beagles (two females, six males), 3-4 years old and weighing 14.5 ±1.6 kg (mean ± SD). All dogs received four different treatments as follows: medetomidine 20 μg kg(-1) and butorphanol tartrate 0.1 mg kg(-1) IV ...
Petrie Colin J CJ aDepartment of Cardiology, Monklands Hospital, Monkscourt Avenue Airdrie, Glasgow, Scotland, UK bDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands cBritish Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, - - 2014
A low pulse pressure (PP) may reflect poor cardiac output (CO), but has not been well characterized by invasive haemodynamic studies. We investigated the relationship between PP and cardiac index (CI) in patients with cardiovascular disease including those with normal and impaired cardiac function. Cardiac catheterization data from 1897 patients ...
Kooijman Marjolein N MN aThe Generation R Study Group bDepartment of Epidemiology cDepartment of Pediatrics dDepartment of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, the - - 2014
Low birth weight is associated with cardiovascular disease in adulthood. Hemodynamic adaptations related to fetal growth restriction may underlie these associations, through persistent influences on cardiovascular development. We examined the associations of third trimester fetal hemodynamics with cardiovascular outcomes in childhood. In a prospective cohort study among 917 pregnant women ...
Dange Rahul B RB Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, - - 2014
Understanding the novel signaling pathways involved in the pathogenesis of hypertension is vital for development of effective therapeutic strategies. Recent evidence suggest a role for toll-like receptor (TLR) 4 in the development of cardiovascular diseases. Although brain has been implicated in the pathogenesis of hypertension, role of brain TLR4 in ...
Wang Shigang S Pediatric Cardiovascular Research Center, Penn State Hershey Children's Hospital, Penn State Milton S. Hershey Medical Center, Department of Pediatrics, Penn State Hershey College of Medicine, Hershey, PA, - - 2014
The objective of this study is to evaluate two extracorporeal life support (ECLS) circuits and determine the effect of pulsatile flow on pressure drop, flow/pressure waveforms, and hemodynamic energy levels in a pediatric pseudopatient. One ECLS circuit consisted of a Medos Deltastream DP3 diagonal pump and Hilite 2400 LT oxygenator ...
Bigal Marcelo E ME Labrys Biologics Inc., San Mateo, CA, - - 2014
The vascular effects of acute calcitonin gene-related peptide (CGRP) inhibition are well described, but the effects of sustained inhibition warrant further exploration in humans. The objective of this article is to assess the effects of sustained CGRP inhibition on blood pressure, heart rate, and ECGs in healthy women ≥40 years ...
Antonini Lanfranco L Cardiovascular Department, San Filippo Neri Hospital, Rome, Italy, - - 2014
To propose a clinical prognostic index for death and heart failure in patients with ischemic cardiomyopathy implanted with an ICD. This prospective study included 192 consecutive patients (age 68 ± 10) recruited from 2004 to 2009 and implanted with an ICD for MADIT II criteria. All patients performed 24-h ambulatory blood pressure ...
Lazzeri Chiara C Intensive Cardiac Coronary Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi , Florence , - - 2014
Background: Data on the hemodynamic and cardiovascular effects of hypothermia in patients with cardiac arrest are scarce. The aim of this study was to evaluate the hemodynamic changes induced by hypothermia by means of Most Care(®) (pressure recording analytical method, PRAM methodology), a beat-to-beat hemodynamic monitoring method. Methods: We enrolled ...
Miao Na N Department of Extracorporeal Circulation, Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, - - 2014
Human albumin is the conventional cardiopulmonary bypass circuit primer. However, it has high manufacturing costs. Crystalloid and colloid solutions have been developed as alternatives, including a new generation of non-ionic hydroxyethyl starch (HES). The efficacy of hydroxyethyl starch with a 130 molecular weight and substitution degree of 0.4 (hydroxyethyl starch ...
Fine D M DM Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, - - 2014
Doxorubicin is a common antineoplastic agent with dose-dependent cardiotoxic adverse effects, and pre-existing myocardial dysfunction is a contraindication to its use. To systematically define the hemodynamic and biochemical alterations in dogs undergoing chemotherapy for newly diagnosed lymphoma and assess the reversibility of these alterations with fluid administration. Twenty-one client-owned dogs ...
Legrand Matthieu M 1AP-HP, Hôpital Lariboisière, Department of Anesthesiology and Critical Care and Burn unit, Hôpitaux universitaires St-Louis-Lariboisière, F-75475, Paris, France 2Univ Paris Diderot, EA-3509, F-75475, Paris, - - 2014
Dissolved oxygen (i.e. unbound to hemoglobin) is often neglected as a determinant of central venous oxygen saturation (ScvO2) in review articles and textbooks. These statements may lead to potential misinterpretation of SCvO2 value across FiO2 changes. With this study, we aimed to explore the influence of PaO2 and FiO2 on ...
Sutherasan Y Y Ramathibodi hospital, Mahidol University, Bangkok Thailand - - - 2014
The mortality of post cardiac arrest patients was gradually reduced with years but still as high as 50%, despite advancements in the diagnostic and therapeutic approaches i.e. revascularization and therapeutic moderate hypothermia. However, recent evidence suggests that other therapeutic interventions aimed to minimize progressive deterioration of the brain and other ...
Dubin Ruth F RF Department of Medicine/Nephrology, San Francisco VA Medical Center/University of California, San Francisco, - - 2014
Diastolic dysfunction is common and associated with higher mortality in the end-stage renal disease (ESRD) population. E/E', a measure derived from tissue Doppler imaging (TDI), is a correlate of left ventricular (LV) filling pressures. E/E' may be viewed as a confirmatory marker of diastolic dysfunction, but it is not routinely ...
Yue Wen-Wei WW The Fourth People's Hospital of Ji'nan, Ji'nan Institute of Cardiovascular Disease, Second Affiliated Hospital, Tai Shan Medical College, Jinan, 250031, - - 2014
To investigate heart rate variability (HRV) in patients with masked hypertension (MH), participants were classified based on clinic and 24-h ambulatory blood-pressure monitoring: essential hypertension (EH, n = 40; MH, n = 36) and normotension (NT, n = 48). The HRV parameters were observed using a 24-h Holter monitor. Compared with NT controls, the parameters of ...
Russell James A JA From the Center for Heart Lung Innovation and the Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, BC, - - 2014
As fundamental as the issue is, there is no clear, high-level evidence to determine the most effective mean arterial pressure (MAP) for resuscitation of patients with septic shock. During hypotension, three salient aspects of cardiovascular physiology are important. First, the autoregulation of cerebral blood flow maintains an adequate level over ...
Alraies M Chadi MC Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, - - 2014
The ratio of early transmitral flow velocity (E) to mitral annular velocity (E') is considered a predictor of pulmonary capillary wedge pressure (PCWP). In a previous small study, the paradoxical relation between PCWP and E/E' ratio has been described in patients with constrictive pericarditis (CP). We sought to test this ...
Hirashiki Akihiro A Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of - - 2014
Background: Pulmonary hypertension (PH) because of left-sided heart disease carries a poor prognosis. We investigated whether non-ischemic dilated cardiomyopathy (DCM) with PH is associated with poor prognosis. Methods and Results: A total of 256 consecutive DCM patients were enrolled. We measured the ratio of the maximum first derivative of left ventricular pressure ...
Hulkkonen Janne - - 2014
Novel parameters derived from peak maximal oxygen uptake (VO2) and exercise arterial blood pressure, such as peak circulatory power (CP) and exercise cardiac power (ECP), can be used in the risk assessment of cardiovascular disease and stroke. However, the determinants of these factors are poorly characterized in the general population. ...
Li Jun J Department of Cardiology, Qilu Hospital, Shandong University , Jinan , PR China - - 2014
Abstract Context: Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora alopecuroides Linn. (Kudouzi). Sophocarpine injection was found to have significant antiviral effects against coxsackievirus B3 and therapeutic effects for viral myocarditis in the clinic. Objective: This study assessed the effects of sophocapine on ...
Spencer Andrew G AG Ardelyx Inc., Fremont, CA 94555, - - 2014
The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. When administered orally to rats, tenapanor acted ...
Azau A A Department of Anesthesia and Surgical Intensive Care, LUNAM Université, Université d'Angers, Angers, Larrey, - - 2014
We hypothesized that the optimization of renal haemodynamics by maintaining a high level of mean arterial blood pressure (MAP) during cardiopulmonary bypass (CPB) could reduce the rate of acute kidney injury (AKI) in high-risk patients. In this randomized, controlled study, we enrolled 300 patients scheduled for elective cardiac surgery under ...
Gimelli Alessia A Fondazione Toscana G. Monasterio, Via Moruzzi, 1, 56124 Pisa, - - 2014
To evaluate the relationships between measures of left ventricular (LV) filling dynamics at cadmium-zinc-telluride (CZT) imaging and indexes of LV diastolic function at transthoracic echocardiography. Two hundred and forty-seven patients underwent myocardial perfusion imaging at rest and after stress with a low-dose CZT protocol and a baseline transthoracic echocardiography study. ...
Lang Sean M SM aYale University School of Medicine, New Haven bConnecticut Children's Medical Center, Hartford cUniversity of Connecticut School of Medicine, Farmington, Connecticut, - - 2014
Blood pressure monitoring is an essential vital sign when caring for critically ill children. Invasive monitoring is considered the gold standard, but is not always feasible. The following study compared the CAS model 740 noninvasive blood pressure monitor with the Orion/MaxIQ NIBP module with the reference (invasive arterial measurement). We ...
Perrodin Stéphanie F SF Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, - - 2014
Most ventricular assist devices (VADs) currently used in infants are extracorporeal. These VAD require long-term anticoagulation therapy and extensive surgery, and two devices are needed for biventricular support. We designed a biventricular assist device based on shape memory alloy that reproduces the hemodynamic effects of cardiomyoplasty, supporting the heart with ...
Killu Ammar M AM Division of Cardiovascular Diseases, Mayo Clinic, Rochester, - - 2014
Cardiac resynchronization therapy (CRT) has been shown to improve heart failure (HF) symptoms and survival. We hypothesized that a greater improvement in left-ventricular ejection fraction (LVEF) after CRT is associated with greater survival benefit. In 693 patients across two international centers, the improvement in LVEF post-CRT was determined. Patients were ...
Zhu Jiang J First Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, - - 2014
Retinoid X receptor (RXR) has been demonstrated to play an important role in cardiac development and has been implicated in cardiovascular diseases. This study aimed to examine the effects of RXRα agonist bexarotene on pathological left ventricular hypertrophy (LVH) in a spontaneously hypertensive rat (SHR) model and the underlying mechanism. ...
Chen Szu-Ying SY Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan; Division of Surgical Intensive Care, Department of Critical Care Medicine, E-Da Hospital, I-Shou University, Kaohsiung, - - 2014
Particulate matter with aerodynamic diameter of <2.5μm (PM2.5) is associated with blood pressure and hemodynamic changes. Blunted nocturnal blood pressure dipping is a major risk factor for cardiovascular events; limited information is available on whether PM2.5 exposure-related hemodynamic changes vary with day-night blood pressure circadian rhythms. In this study, we ...
Semenas E E Department of Surgical Sciences/Anaesthesiology and Intensive Care, Faculty of Medicine, Uppsala University, Uppsala, - - 2014
Adrenaline (ADR) and vasopressin (VAS) are used as vasopressors during cardiopulmonary resuscitation. Data regarding their effects on blood-brain barrier (BBB) integrity and neuronal damage are lacking. We hypothesised that VAS given during cardiopulmonary resuscitation (CPR) after haemorrhagic circulatory arrest will preserve BBB integrity better than ADR. Twenty-one anaesthetised sexually immature ...
Fu Mingqiang M *Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; †Department of Medicine, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden; and ‡Institutes of Biomedical Sciences, Fudan University, Shanghai, - - 2014
To test whether olmesartan ameliorates cardiac diastolic dysfunction in spontaneously hypertensive rats (SHRs) through calcineurin pathway. Twenty-four male SHRs of 6 months were divided into saline- (n = 12) and olmesartan-treated (n = 12) groups. Age-matched WKY (n = 12) rats served as controls. Saline (10 mL·kg·d) or the same ...
Wang Yanfei Y Department of Cardiovascular Disease, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, - - 2014
Balloon release pressure may increase the incidence of no reflow after direct percutaneous coronary intervention (PCI). This randomized controlled study was designed to analyze the correlation between balloon release pressure and no-reflow in patients with acute myocardial infarction (AMI) undergoing direct PCI. There were 156 AMI patients who underwent PCI ...
Chatpun Surapong S Institute of Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, - - 2014
Increased vascular wall shear stress by elevated plasma viscosity significantly enhances the endothelial nitric oxide synthase (eNOS) activity during an acute isovolemic hemodilution. Also the modulation of plasma viscosity has effects on the cardiac function that were revealed if a left ventricular (LV) pressure-volume (PV) measurement was used. The aim ...
Brguljan-Hitij Jana J Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, - - 2014
Guidelines propose classification of conventional blood pressure (CBP) into normotension (<120/<80mm Hg), prehypertension (120-139/80-89mm Hg), and hypertension (≥140/≥90mm Hg). To assess the potential differential contribution of ambulatory blood pressure (ABP) in predicting risk across CBP strata, we analyzed outcomes in 7,826 untreated people recruited from 11 populations. During an 11.3-year ...
Dong Jinghui J Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. - - 2014
Vitamin D is essential for maintaining calcium and phosphate homeostasis, and vitamin D analogues have been prescribed to treat osteoporosis and hyperparathyroidism. Emerging evidence suggests that cardiovascular and chronic kidney diseases are closely associated with vitamin D deficiency resulting from either decreased sunshine exposure or inadequate intake. Vitamin D is ...
Pereira Renata O RO Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, 84112; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City - - 2014
To determine whether endogenous GLUT1 induction and the increased glucose utilization that accompanies pressure overload hypertrophy (POH) are required to maintain cardiac function during hemodynamic stress, and to test the hypothesis that lack of GLUT1 will accelerate the transition to heart failure. To determine the contribution of endogenous GLUT1 to ...
1 2 3 4 5 6 7 8 9 10 >