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Surgit Ozgur O Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology , Istanbul , - - 2014
Objective. Left ventricular (LV) hypertrophy (LVH) predicts increased mortality in part due to an elevated incidence of sudden cardiac death in hypertension. The aim of the present study was to investigate the relation of microvolt T-wave alternans (MTWA) with different LV geometric patterns in patient with sustained hypertension. Methods. This ...
Simons Ap A Deptartment of Cardiothoracic Surgery, Maastricht University Medical Centre and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands - - 2014
The aim of this study was to examine the hydrodynamic performance and gaseous microemboli (GME) activity of two centrifugal pumps for possible use in low-flow extracorporeal CO2 removal. The performance of a Rotassist 2.8 and a Rotaflow 32 centrifugal pump (Maquet Cardiopulmonary AG, Hirrlingen, Germany) was evaluated in a water-glycerine ...
Savalia Krupa K Department of Cellular and Integrative Physiology, University of Nebraska Medical - - 2014
Excessive production of superoxide (O2(●-)) in the central nervous system has been widely implicated in the pathogenesis of cardiovascular diseases, including chronic heart failure and hypertension. In an attempt to overcome the failed therapeutic impact of currently available antioxidants in cardiovascular disease, we developed a nanomedicine-based delivery system for the ...
Mosing Martina M Division of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland, - - 2014
The aim of this study was to test the effect of cardiac output (CO) and pulmonary artery hypertension (PHT) on volumetric capnography (VCap) derived-variables. Nine pigs were mechanically ventilated using fixed ventilatory settings. Two steps of PHT were induced by IV infusion of a thromboxane analogue: PHT25 [mean pulmonary arterial ...
Krishnaveni G V GV Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India; *Centre for Cardiovascular Imaging, UCL Institute of Child Health, London, UK; Diabetes Unit, KEM Hospital Research Centre, Pune, India;Department of Psychology, University of Trier, Germany; St. Johns Research Institute, Bangalore, India; and MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK. Correspondence to: Dr GV Krishnaveni, Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, PO Box 38, Mandi Mohalla, Mysore 570 021, India. - - 2014
To test the Trier Social Stress Test for children (TSST-C) in a cohort of Indian adolescents. Cohort study. Holdsworth Memorial Hospital, Mysore, India. Adolescent children (N=273, 134 males; mean age 13.6 yrs) selected from an ongoing birth cohort; 269 completed the test. Performance of 5-minutes each of public- speaking and ...
Zafar Haroon H Tissue Optics & Microcirculation Imaging Facility, National University of Ireland, - - 2014
Frequency domain optical coherence tomography (FD-OCT) provides cross-sectional images of coronary arteries and deployed stents with micron resolution and measures lumen dimensions with excellent reproducibility. FD-OCT combined with a blood flow resistances model can overcome many limitations of conventional measures of stenosis severity based on quantitative coronary angiography (QCA) and ...
Alian Aymen A AA Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, PO Box 208051, New Haven, CT 06520-8051, - - 2014
Lower body negative pressure (LBNP) creates a reversible hypovolemia by sequestrating blood volume in the lower extremities. This study sought to examine the impact of central hypovolemia on peripheral venous pressure (PVP) waveforms in spontaneously breathing subjects. With IRB approval, 11 healthy subjects underwent progressive LBNP (baseline, -30, -75, and -90 mmHg ...
Andersen L J LJ Department of Cardiology, Roskilde Hospital, Roskilde, Denmark; Department of Cardiology, Gentofte University Hospital, Hellerup, - - 2014
We investigated the effects of 3 and 6 months of regular football training on cardiac structure and function in hypertensive men. Thirty-one untrained males with mild-to-moderate hypertension were randomized 2:1 to a football training group (n = 20) and a control group receiving traditional recommendations on healthy lifestyle (n = 11). Cardiac measures were ...
Molcan L L Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University Bratislava, Bratislava, Slovak Republic. - - 2014
Disturbed circadian activity of the sympathetic system may be involved in negative consequences of chronodisruption on the cardiovascular system. We studied daily changes in pressure response to adrenergic stimulation in rats exposed to repeated phase advance shifts (PAS) of light/dark (LD) regimen. Blood pressure (BP), heart rate (HR) and locomotor ...
Kawashiri Masa-Aki MA Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, - - 2014
A line of epidemiological studies suggests that the accumulation of coronary risk factors promotes the progression of coronary atherosclerosis. Recent clinical studies showed that aggressive low-density lipoprotein (LDL) cholesterol-lowering therapy using statins could regress coronary atheroma and reduce major cardiovascular events. Additionally, therapy that controlled amlodipine-based blood pressure reduced major ...
Kilgannon J Hope JH 1Department of Emergency Medicine, Cooper University Hospital, Camden, NJ. 2Department of Emergency Medicine, The University of Mississippi Medical Center, Jackson, MS. 3Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, Camden, - - 2014
Guidelines for post-cardiac arrest care recommend blood pressure optimization as one component of neuroprotection. Although some retrospective clinical studies suggest that postresuscitation hypotension may be harmful, and laboratory studies suggest that a postresuscitation hypertensive surge may be protective, empirical data are few. In this study, we prospectively measured blood pressure ...
Hillman Stan S SS Portland State University, United States; - - 2014
Amphibians have a single ventricle and common conus arteriosus that produces an equal pressure to the parallel pulmocutaneous and systemic vascular circuits. The distribution of blood flows between the pulmocutaneous (Qpul) and systemic (Qsys) circuits (net cardiac shunt) vary with a number of environmental conditions and behaviours; although autonomic regulation ...
Goodwill Adam G AG Department of Cellular & Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, 462025111, - - 2014
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has been shown to have hemodynamic and cardioprotective capacity in addition to its better characterized glucoregulatory actions. Because of this, emerging research has focused on the ability of GLP-1 based therapies to drive myocardial substrate selection, enhance cardiac performance and regulate heart ...
Poole Aaron T AT Maternal-Fetal Medicine Division, Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, United States. Electronic address: - - 2014
Lactation is associated with reduction in maternal metabolic disease and hypertension later in life; however, findings in humans may be confounded by socioeconomic factors. We sought to determine the independent contribution of lactation on cardiovascular parameters and adiposity in a murine model. Following delivery, CD-1 female mice were randomly divided ...
Zoerner Frank F From the Department of Operative and Intensive Care Medicine (F.Z.), Hallands Hospital Halmstad, Halmstad; and Department of Surgical Sciences/Anaesthesiology and Intensive Care (E.S.), Faculty of Medicine, Uppsala University, Uppsala, - - 2014
Supplemental digital content is available in the text. The aim of this experimental study was to compare survival and hemodynamic effects of a low-dose amiodarone and vasopressin compared with vasopressin in hypovolemic cardiac arrest model in piglets. Eighteen anesthetized male piglets (with a weight of 25.3 [1.8] kg) were bled ...
You Beian B Department of Geriatrics, Qilu Hospital of Shandong University; Shandong Provincial Key Laboratory of Cardiovascular Proteomics, Jinan, Shandong 250012, - - 2014
Ouabain is a mammalian adrenocortical hormone that is involved in the pathogenesis of hypertension by inhibiting Na-K ATPase activity. It also participates in a variety of kinase-mediated signaling pathways associated with Na-K ATPase. Previous studies have shown that ouabain can cause cardiac remodeling independent of elevated blood pressure and that ...
Sahmeddini Mohammad Ali MA Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, - - 2014
Context-Attenuating postreperfusion syndrome during orthotopic liver transplant is very important for transplant anesthesiologists because of the syndrome's complications. Oxygen-derived free radicals play an important role in the genesis of postreperfusion syndrome, but the effect of mannitol (a free radical scavenger) on attenuating the syndrome is unclear.Objectives-To investigate the effectiveness of ...
Perry Blake G BG School of Sport and Exercise, Massey University, Palmerston North, New - - 2014
Hypercapnia impairs cerebrovascular control during rapid changes in blood pressure (BP); however, data concerning the effect of hypercapnia on steady state, nonpharmacological increases in BP is scarce. We recruited fifteen healthy volunteers (mean ± SD: age, 28 ± 6 years; body mass, 77 ± 12 kg) to assess the effect ...
Bae Joon-Ho JH Department of Emergency Medicine and Institute of Clinical Science, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, - - 2014
Defibrillation is no longer universally recommended as initial intervention for the reversal of ventricular fibrillation (VF) after a prolonged and untreated cardiac arrest. We sought to examine this issue in an animal model where a prolonged untreated VF was induced. The aim of this study was to investigate the potential ...
Bianchi Giorgia G Division of Internal Medicine and Nephrology, Ospedale la Carità, Locarno, - - 2014
Clinical experience and experimental data suggest that intradialytic hemodynamic profiles could be influenced by the characteristics of the dialysis membranes. Even within the worldwide used polysulfone family, intolerance to specific membranes was occasionally evoked. The aim of this study was to compare hemodynamically some of the commonly used polysulfone dialyzers ...
Samuel Chrishan S CS From the Department of Pharmacology, Monash University, Melbourne, Victoria, Australia (C.S.S., H.B., J.Y.C., R.E.W., S.G.R.); Neuropeptides Division, Florey Institute of Neuroscience and Mental Health (C.S.S.) and Department of Biochemistry and Molecular Biology (C.S.S.), University of Melbourne, Melbourne, Victoria, Australia; Department of Nephrology, Royal Melbourne Hospital, Melbourne, Victoria, Australia (T.D.H.); and Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australia (T.D.H.). chrishan.samuel@monash.edu - - 2014
Relaxin is a naturally occurring peptide hormone that mediates systemic hemodynamic and renal adaptive changes during pregnancy and abrogates aberrant scar tissue formation (fibrosis) in diverse pathogeneses. However, its efficacy relative to renin-angiotensin system blockade, the most effective antifibrotic strategy currently available, is not known. We compared the individual versus ...
Moret Enrique E Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain - - 2014
Maintaining vascular barrier competence, preventing interstitial edema, and keeping microcirculation intact is crucial to achieve an optimal outcome in cardiopulmonary bypass surgery (CPB). Blood contact with roller pumps and foreign surfaces during CPB induces shear stress and a pressure drop across the pump boot that leads to transient systemic activation ...
Brar Somjot S SS Department of Cardiology, Kaiser Permanente, Los Angeles, CA, USA; Regional Cardiac Cath Lab, Kaiser Permanente, Los Angeles, CA, USA; Department of Research and Evaluations, Kaiser Permanente, Pasadena, CA, USA. Electronic address: - - 2014
The administration of intravenous fluid remains the cornerstone treatment for the prevention of contrast-induced acute kidney injury. However, no well-defined protocols exist to guide fluid administration in this treatment. We aimed to establish the efficacy of a new fluid protocol to prevent contrast-induced acute kidney injury. In this randomised, parallel-group, ...
Mancia Giuseppe G From the IRCCS Istituto Auxologico Italiano, Milano, Italy (G.M.); Clinica Medica, Dipartimento di Scienze della Salute, Università Milano-Bicocca, Monza (Monza e Brianza), Italy (G.M., G.G.); and IRCCS Multimedica, Sesto San Giovanni, Milano, Italy (G.G.). - - 2014
Physiological studies have long documented the key role played by the autonomic nervous system in modulating cardiovascular functions and in controlling blood pressure values, both at rest and in response to environmental stimuli. Experimental and clinical investigations have tested the hypothesis that the origin, progression, and outcome of human hypertension ...
Dyson A A Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, - - 2014
In clinical practice, global oxygen delivery (DO2) is often considered as a whole; however pathological and adaptive responses after a decrease in individual constituents of the DO2 equation (cardiac output, haemoglobin, oxyhaemoglobin saturation) are likely to be diverse. We hypothesized that an equivalent decrease in DO2 after reductions in each ...
Teman Nicholas R NR Department of Surgery, University of Michigan Health System, Extracorporeal Life Support Laboratory, Ann Arbor, - - 2014
Centrifugal pumps are used increasingly for temporary mechanical support for the treatment of cardiogenic shock. However, centrifugal pumps can generate excessive negative pressure and are afterload sensitive. A previously developed modified roller pump mitigates these limitations both in vitro and in preliminary animal experiments. We report the results of intermediate-term testing ...
Vitacca Michele M Respiratory Rehabilitation Division, Salvatore Maugeri Foundation IRCCS, Lumezzane, (BS), Italy. Electronic address: - - 2014
To evaluate heart rate variability (HRV), hemodynamics, mechanics, dyspnea and blood gases following different mechanical ventilation (MV) settings. No study has evaluated physiological changes during T-piece trials following different MV settings. In 8 COPD patients on prolonged MV we applied in random order two MV settings: i) pressure support (PS) ...
Zgoła Katarzyna - - 2014
Anaesthetic drugs and internal electrical shock may alter haemodynamic status of patients undergoing implantable cardioverter-defibrillator (ICD) testing. Comparative data on the mechanisms of etomidate and propofol-induced changes in haemodynamic parameters are inconsistent. Also the effects of ICD shock on haemodynamics have not been extensively studied. To compare haemodynamic effects of ...
Fine Leon G LG Department of Biomedical Sciences, Cedars-Sinai Medical Center and University of California Los Angeles, Los Angeles, Calif., - - 2014
Ernest Henry Starling laid the groundwork for our modern understanding of how the interstitial fluid, which he referred to as 'lymph', is regulated. Together with his colleague, William Bayliss, he provided the crucial insight into how fluid is driven out of the capillary to form interstitial fluid. That was to ...
Pereira Dos Santos Marcos Antonio MA 1Departamento de Biofísica e Fisiologia, Campus Universitário Ministro Petrônio Portella, Universidade Federal do Piauí , Teresina-PI , - - 2014
This review evaluates the documented cardiovascular functioning among anabolic-androgenic steroid (AAS) users. AAS users manifest a reduction in HDL cholesterol, increased inflammatory markers, and oxidative stress. Strong evidence associating AAS use with blood pressure at hypertensive levels, as well as hypertrophy and cardiac dysfunction has also been reported. Both epidemiological ...
Reniguntala M S J MS Department of Pharmaceutical Sciences, Midwestern University Chicago College of Pharmacy, Downers Grove, IL, - - 2014
Centhaquin is a compound that produces hypotension and bradycardia in higher doses and resuscitation in lower doses. It is water insoluble, and is unsuitable for intravenous use. We prepared the citrate salt of centhaquin and evaluated its cardiovascular efficacy vs. centhaquin. Centhaquin citrate was prepared and characterized; its purity was ...
Tracy Richard E RE Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. Electronic address: - - 2014
Evidence is sparse concerning hypertrophy of cardiomyocytes in left and right ventricles (LV, RV). LV and RV from 105 forensic autopsies were weighed. Cross sectioned cardiac myocyte thicknesses were measured in hematoxylin and eosin-stained paraffin sections. Overweight (OW) is body weight >104.3 kg and hypertension (HT) is mean arterial pressure >106.7 mm Hg assessed from ...
Davies Justin E JE International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS - - 2014
Excess pressure integral (XSPI), a new index of surplus work performed by the left ventricle, can be calculated from blood pressure waveforms and may indicate circulatory dysfunction. We investigated whether XSPI predicted future cardiovascular events and target organ damage in treated hypertensive individuals. Radial blood pressure waveforms were acquired by ...
Parati Gianfranco G 1] Division of Cardiovascular Medicine, Department of Health Sciences, University of Milano-Bicocca, Milan, Italy [2] Department of Cardiology, S.Luca Hospital, IRCCS Istituto Auxologico Italiano and University of Milan-Bicocca, Piazza Brescia 20, Milan, - - 2014
Evidence has consistently supported the association of obstructive sleep apnea syndrome (OSAS) with an increased prevalence of hypertension. It has also been shown that the severity of OSAS is directly correlated with the degree of blood pressure (BP) elevation and that hypertension occurring in subjects with OSAS is more likely ...
Sinski Maciej M Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, - - 2014
Previous studies have shown that hyperoxia-induced deactivation of carotid body chemoreceptors reduces sympathetic activity in hypertensive patients but it does not affect blood pressure. The maintenance of blood pressure can be explained by the direct, vasoconstrictive effect of hyperoxia, which offsets diminished sympathetic activity. This study compares the effect of ...
Kolli Kranthi K KK Department of Mechanical and Materials Engineering, University of Cincinnati, 598 Rhodes Hall, PO Box 210072, Cincinnati, OH, 45221-0072, - - 2014
The assessment of functional coronary lesion severity using intracoronary hemodynamic parameters like the pressure-derived fractional flow reserve and the flow-derived coronary flow reserve are known to rely critically on the establishment of maximal hyperemia. We evaluated a hyperemia-free index, basal pressure drop coefficient (bCDP), that combines pressure and velocity for ...
Loirand Gervaise G INSERM; U1087; l'institut du thorax; Nantes, France; CNRS; U6291; Nantes, France; Université de Nantes; Nantes, France; CHU Nantes; l'institut du thorax; Nantes, - - 2014
Proper regulation of arterial blood pressure is essential to allow permanent adjustment of nutrient and oxygen supply to organs and tissues according to their need. This is achieved through highly coordinated regulation processes controlling vascular resistance through modulation of arterial smooth muscle contraction, cardiac output, and kidney function. Members of ...
Dhanani Sonny S 1Division of Pediatric Critical Care, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. 2Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. 3Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. 4Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada. 5McGill University Health Centre Research Institute, Montreal, QC, Canada. 6Department of Critical Care, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada. 7Faculty of Medicine, Interdepartmental Division of Critical Care, University of Toronto, ON, Canada. 8Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, BC, Canada. 9Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. 10Ingram School of Nursing McGill University, McGill University Health Centre, Montreal, QC, Canada. 11Faculty of Medicine Biomedical Ethics Unit, McGill University, Montreal, QC, Canada. 12Department of Critical Care Medicine and Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 13Pediatric Cardiology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. 14Neurosciences Intensive Care Unit, University of Alberta Hospital, Edmonton, AB, Canada. 15Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. 16Critical Care, The Ottawa Hospital, Ottawa, ON, Canada. 17Department of Medicine, University of Ottawa, Ottawa, ON, Canada. 18The Ottawa Health Research Institute, Ottawa, ON, Canada. 19The Clinical Epidemiology Program Methods Centre, University of Ottawa, Ottawa, ON, Canada. 20Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. 21National GE3LS Program, Genome Canada, Ottawa, ON, Canada. 22Information Systems, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. 23Department of Clinical Neurological Sciences, London Health Sciences Centre, London, ON, Canada. 24Faculty of Medicine, University of Western Ontario, London, ON, Canada. 25Pediatric Critical Care, Montreal Children's Hospital, Montreal, QC, Canada. 26Faculty of Pediatrics, McGill University, Montreal, QC, - - 2014
Controversies regarding the process and timing of the determination of death for controlled organ donation after circulatory death persist. This study assessed the feasibility of conducting a prospective, observational study of continuous monitoring of vital signs for 30 minutes after the clinical determination of death in five Canadian ICUs. Waveform ...
Pikkemaat Robert R From the *Institute for Medical Information Technology, RWTH Aachen University, Aachen, Germany; †Department of Anesthesia and Intensive Care, Sahlgrenska University Hospital Gothenburg, Gothenburg, Sweden; and ‡Department of Medical Statistics, RWTH Aachen University, Aachen, - - 2014
Currently, the monitoring of cardiac output (CO) and stroke volume (SV) is mainly performed using invasive techniques. Therefore, performing CO monitoring noninvasively by means of electrical impedance tomography (EIT) would be advantageous for intensive care. Our hypothesis was that, by means of EIT, it is possible to assess heart rate ...
Charles Christopher J CJ Christchurch School of - - 2014
The reported effects of atrial natriuretic peptide (ANP) on sympathetic nerve activity (SNA) are variable, dependent on concomitant hemodynamic actions and likely to be regionally differentiated. There are few reports of the effect of B-type natriuretic peptide (BNP) on SNA and none have measured cardiac SNA (CSNA) by direct microneurography. ...
Santos Mário M Department of Physiology and Cardiothoracic Surgery, Cardiovascular R&D Unit, Faculty of Medicine, University of Porto, Porto, - - 2014
Hypertension is a powerful risk factor for cardiovascular mortality and morbidity, including heart failure with both preserved and reduced ejection fraction. Hypertensive heart disease (HHD) defines the complex and diverse perturbations of cardiac structure and function occurring secondary to hypertension. Left ventricular hypertrophy (LVH) is one of the most recognized ...
Sonneveld Milan J MJ Department of Clinical Neurophysiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Obstetrics and Gynecology, Division of Obstetrics and Perinatal Medicine, Erasmus MC, University Medical Center, Rotterdam, the - - 2014
Cerebral perfusion pressure (CPP) is elevated in preeclampsia, and may predispose to cerebrovascular complications and progression to eclampsia. We estimated zero flow pressure (ZFP) and CPP using simultaneously obtained arterial blood pressure and middle cerebral artery blood flow velocity in 10 women with preeclampsia, all treated with methyldopa with or ...
Lakshmikanthan Sribalaji S From the Blood Research Institute, BloodCenter of Wisconsin, Milwaukee (S.L., M.C.W.); Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville (B.J.Z., K.M., M.V.A., A.V.S.); and Department of Pharmacology and Toxicology (Z.-D.G., J.A.A.), Cardiovascular Center (Z.-D.G., X.Z., J.E.M., D.X.Z., J.A.A.), Department of Medicine (X.Z., J.E.M., D.X.Z.), Department of Physiology (H.L., D.L.M.), and Division of Biostatistics (A.S.), Medical College of Wisconsin, - - 2014
Small GTPase Ras-related protein 1 (Rap1b) controls several basic cellular phenomena, and its deletion in mice leads to several cardiovascular defects, including impaired adhesion of blood cells and defective angiogenesis. We found that Rap1b(-/-) mice develop cardiac hypertrophy and hypertension. Therefore, we examined the function of Rap1b in regulation of ...
Kolli Kranthi K KK Department of Mechanical and Materials Engineering, 598 Rhodes Hall, PO Box 210072, Cincinnati, OH 45221-0072 USA. - - 2014
Functional assessment of coronary lesion severity during cardiac catheterization is conducted using diagnostic parameters like fractional flow reserve (FFR; pressure derived) and coronary flow reserve (CFR; flow derived). However, the complex hemodynamics of stenosis might not be sufficiently explained by either pressure or flow alone, particularly in the case of ...
Liu Meiyan M Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, - - 2014
Ouabain and digoxin are important cardiac glycoside and related to many cardiovascular diseases. The purpose of this study was to investigate the changes of sodium pump α-subunit expression in rats and compare the effects of ouabain (OUA) and digoxin (DIG) on the development of hypertension. In situ hybridization was performed. ...
Stevenson Alec T - - 2014
Cardiovascular reflexes that regulate blood pressure (BP) adapt during repeated exposure to +Gz acceleration separated by short (< 20 s) breaks, but whether this effect is preserved with longer intervals remains unknown. There were 17 subjects who completed 5 repeated gradual onset (0.1 G x s(-1)) runs (GOR1-5) to 60 ...
Kang Woon-Seok WS Department of Anesthesiology and Pain Medicine, Konkuk University Hospital, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. ; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, - - 2014
The usefulness of dynamic parameters derived by heart-lung interaction for fluid responsiveness in pediatric patients has been revealed. However, the effects of peak inspiratory pressure (PIP) that could affect the absolute values and the accuracy in pediatric patients have not been well established. Participants were 30 pediatric patients who underwent ...
Khan Munasib M Natural Products Research Unit, Department of Biological and Biomedical, Sciences, Aga Khan University Medical College , Karachi , Pakistan - - 2014
Abstract In current study, we describe blood pressure (BP)-lowering, endothelium-dependent, and independent vasodilator and cardio-modulatory actions of Carum roxburghianum seed. The crude extract of C. roxburghianum seed (Cr.Cr) induced dose-dependent (10-100 mg/kg) fall in arterial BP of anaesthetized rats. In isolated rabbit aorta, Cr.Cr (0.3-10 mg/mL) inhibited high K(+) (80 mM) and phenylephrine ...
Noack Cornelia C Department of Neurology, Charité - University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, - - 2014
Levodopa is one of the most effective symptomatic treatment options for Parkinsonism with a favorable safety and tolerability profile. In some patients, particularly those suffering from orthostatic intolerance, the hypotensive effect of levodopa limits its therapeutic use. We used continuous noninvasive cardiovascular and ventilatory monitoring in 17 patients suffering from ...
Pereira Renata O RO *Fraternal Order of Eagles Diabetes Research Center, Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, - - 2014
During pathological hypertrophy, peroxisome proliferator-activated receptor coactivator 1α (PGC-1α) is repressed in concert with reduced mitochondrial oxidative capacity and fatty acid oxidation (FAO). We therefore sought to determine if maintaining or increasing PGC-1α levels in the context of pressure overload hypertrophy (POH) would preserve mitochondrial function and prevent contractile dysfunction. ...
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