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You Beian B Department of Geriatrics, Qilu Hospital of Shandong University; Shandong Provincial Key Laboratory of Cardiovascular Proteomics, Jinan, Shandong 250012, - - 2014
Ouabain is a mammalian adrenocortical hormone that is involved in the pathogenesis of hypertension by inhibiting Na-K ATPase activity. It also participates in a variety of kinase-mediated signaling pathways associated with Na-K ATPase. Previous studies have shown that ouabain can cause cardiac remodeling independent of elevated blood pressure and that ...
Sahmeddini Mohammad Ali MA Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, - - 2014
Context-Attenuating postreperfusion syndrome during orthotopic liver transplant is very important for transplant anesthesiologists because of the syndrome's complications. Oxygen-derived free radicals play an important role in the genesis of postreperfusion syndrome, but the effect of mannitol (a free radical scavenger) on attenuating the syndrome is unclear.Objectives-To investigate the effectiveness of ...
Lee Eveline E University Hospital of - - 2014
Preload reduction during haemodialysis causes change in cardiac filling and contractility. This can be accurately assessed using standard echocardiography. We hypothesise that simple ECG parameters approximate Echo derived measurements and can be used as an initial tool. Thirty subjects (Age 59 ± 18 years, 35% female, LVEF 64 ± 6%, ...
Finegold Judith J International Centre for Circulatory Health, National Heart and Lung - - 2014
Acute haemodynamic measurements can be used for AV delay (AVD) optimisation of cardiac resynchronisation therapy (CRT). It is uncertain whether non-invasive measurements are as reliable as those measured invasively. 37 patients with CRT-P or CRT-D device (86% male, mean age 64 years) had AVD optimisation performed using both invasive and ...
Hammad Sally S The University of - - 2014
Heart failure is the common and final end point of cardiovascular disease. Seventy four percent of congestive heart failure patients also suffer from hypertension. Genome wide association studies (GWAS) have recently identified mutations in the ATP2B1 gene as having a strong association with hypertension risk. The ATP2B1 gene encodes the ...
Perry Blake G BG School of Sport and Exercise, Massey University, Palmerston North, New - - 2014
Hypercapnia impairs cerebrovascular control during rapid changes in blood pressure (BP); however, data concerning the effect of hypercapnia on steady state, nonpharmacological increases in BP is scarce. We recruited fifteen healthy volunteers (mean ± SD: age, 28 ± 6 years; body mass, 77 ± 12 kg) to assess the effect ...
Bae Joon-Ho JH Department of Emergency Medicine and Institute of Clinical Science, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, - - 2014
Defibrillation is no longer universally recommended as initial intervention for the reversal of ventricular fibrillation (VF) after a prolonged and untreated cardiac arrest. We sought to examine this issue in an animal model where a prolonged untreated VF was induced. The aim of this study was to investigate the potential ...
Bianchi Giorgia G Division of Internal Medicine and Nephrology, Ospedale la Carità, Locarno, - - 2014
Clinical experience and experimental data suggest that intradialytic hemodynamic profiles could be influenced by the characteristics of the dialysis membranes. Even within the worldwide used polysulfone family, intolerance to specific membranes was occasionally evoked. The aim of this study was to compare hemodynamically some of the commonly used polysulfone dialyzers ...
Samuel Chrishan S CS From the Department of Pharmacology, Monash University, Melbourne, Victoria, Australia (C.S.S., H.B., J.Y.C., R.E.W., S.G.R.); Neuropeptides Division, Florey Institute of Neuroscience and Mental Health (C.S.S.) and Department of Biochemistry and Molecular Biology (C.S.S.), University of Melbourne, Melbourne, Victoria, Australia; Department of Nephrology, Royal Melbourne Hospital, Melbourne, Victoria, Australia (T.D.H.); and Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australia (T.D.H.). chrishan.samuel@monash.edu - - 2014
Relaxin is a naturally occurring peptide hormone that mediates systemic hemodynamic and renal adaptive changes during pregnancy and abrogates aberrant scar tissue formation (fibrosis) in diverse pathogeneses. However, its efficacy relative to renin-angiotensin system blockade, the most effective antifibrotic strategy currently available, is not known. We compared the individual versus ...
Moret Enrique E Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain - - 2014
Maintaining vascular barrier competence, preventing interstitial edema, and keeping microcirculation intact is crucial to achieve an optimal outcome in cardiopulmonary bypass surgery (CPB). Blood contact with roller pumps and foreign surfaces during CPB induces shear stress and a pressure drop across the pump boot that leads to transient systemic activation ...
Brar Somjot S SS Department of Cardiology, Kaiser Permanente, Los Angeles, CA, USA; Regional Cardiac Cath Lab, Kaiser Permanente, Los Angeles, CA, USA; Department of Research and Evaluations, Kaiser Permanente, Pasadena, CA, USA. Electronic address: - - 2014
The administration of intravenous fluid remains the cornerstone treatment for the prevention of contrast-induced acute kidney injury. However, no well-defined protocols exist to guide fluid administration in this treatment. We aimed to establish the efficacy of a new fluid protocol to prevent contrast-induced acute kidney injury. In this randomised, parallel-group, ...
Mancia Giuseppe G From the IRCCS Istituto Auxologico Italiano, Milano, Italy (G.M.); Clinica Medica, Dipartimento di Scienze della Salute, Università Milano-Bicocca, Monza (Monza e Brianza), Italy (G.M., G.G.); and IRCCS Multimedica, Sesto San Giovanni, Milano, Italy (G.G.). - - 2014
Physiological studies have long documented the key role played by the autonomic nervous system in modulating cardiovascular functions and in controlling blood pressure values, both at rest and in response to environmental stimuli. Experimental and clinical investigations have tested the hypothesis that the origin, progression, and outcome of human hypertension ...
Dyson A A Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, - - 2014
In clinical practice, global oxygen delivery (DO2) is often considered as a whole; however pathological and adaptive responses after a decrease in individual constituents of the DO2 equation (cardiac output, haemoglobin, oxyhaemoglobin saturation) are likely to be diverse. We hypothesized that an equivalent decrease in DO2 after reductions in each ...
Teman Nicholas R NR Department of Surgery, University of Michigan Health System, Extracorporeal Life Support Laboratory, Ann Arbor, - - 2014
Centrifugal pumps are used increasingly for temporary mechanical support for the treatment of cardiogenic shock. However, centrifugal pumps can generate excessive negative pressure and are afterload sensitive. A previously developed modified roller pump mitigates these limitations both in vitro and in preliminary animal experiments. We report the results of intermediate-term testing ...
Vitacca Michele M Respiratory Rehabilitation Division, Salvatore Maugeri Foundation IRCCS, Lumezzane, (BS), Italy. Electronic address: - - 2014
To evaluate heart rate variability (HRV), hemodynamics, mechanics, dyspnea and blood gases following different mechanical ventilation (MV) settings. No study has evaluated physiological changes during T-piece trials following different MV settings. In 8 COPD patients on prolonged MV we applied in random order two MV settings: i) pressure support (PS) ...
Zgoła Katarzyna - - 2014
Anaesthetic drugs and internal electrical shock may alter haemodynamic status of patients undergoing implantable cardioverter-defibrillator (ICD) testing. Comparative data on the mechanisms of etomidate and propofol-induced changes in haemodynamic parameters are inconsistent. Also the effects of ICD shock on haemodynamics have not been extensively studied. To compare haemodynamic effects of ...
Fine Leon G LG Department of Biomedical Sciences, Cedars-Sinai Medical Center and University of California Los Angeles, Los Angeles, Calif., - - 2014
Ernest Henry Starling laid the groundwork for our modern understanding of how the interstitial fluid, which he referred to as 'lymph', is regulated. Together with his colleague, William Bayliss, he provided the crucial insight into how fluid is driven out of the capillary to form interstitial fluid. That was to ...
Pereira Dos Santos Marcos Antonio MA 1Departamento de Biofísica e Fisiologia, Campus Universitário Ministro Petrônio Portella, Universidade Federal do Piauí , Teresina-PI , - - 2014
This review evaluates the documented cardiovascular functioning among anabolic-androgenic steroid (AAS) users. AAS users manifest a reduction in HDL cholesterol, increased inflammatory markers, and oxidative stress. Strong evidence associating AAS use with blood pressure at hypertensive levels, as well as hypertrophy and cardiac dysfunction has also been reported. Both epidemiological ...
Reniguntala M S J MS Department of Pharmaceutical Sciences, Midwestern University Chicago College of Pharmacy, Downers Grove, IL, - - 2014
Centhaquin is a compound that produces hypotension and bradycardia in higher doses and resuscitation in lower doses. It is water insoluble, and is unsuitable for intravenous use. We prepared the citrate salt of centhaquin and evaluated its cardiovascular efficacy vs. centhaquin. Centhaquin citrate was prepared and characterized; its purity was ...
Tracy Richard E RE Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. Electronic address: - - 2014
Evidence is sparse concerning hypertrophy of cardiomyocytes in left and right ventricles (LV, RV). LV and RV from 105 forensic autopsies were weighed. Cross sectioned cardiac myocyte thicknesses were measured in hematoxylin and eosin-stained paraffin sections. Overweight (OW) is body weight >104.3 kg and hypertension (HT) is mean arterial pressure >106.7 mm Hg assessed from ...
Davies Justin E JE International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS - - 2014
Excess pressure integral (XSPI), a new index of surplus work performed by the left ventricle, can be calculated from blood pressure waveforms and may indicate circulatory dysfunction. We investigated whether XSPI predicted future cardiovascular events and target organ damage in treated hypertensive individuals. Radial blood pressure waveforms were acquired by ...
Parati Gianfranco G 1] Division of Cardiovascular Medicine, Department of Health Sciences, University of Milano-Bicocca, Milan, Italy [2] Department of Cardiology, S.Luca Hospital, IRCCS Istituto Auxologico Italiano and University of Milan-Bicocca, Piazza Brescia 20, Milan, - - 2014
Evidence has consistently supported the association of obstructive sleep apnea syndrome (OSAS) with an increased prevalence of hypertension. It has also been shown that the severity of OSAS is directly correlated with the degree of blood pressure (BP) elevation and that hypertension occurring in subjects with OSAS is more likely ...
Sinski Maciej M Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, - - 2014
Previous studies have shown that hyperoxia-induced deactivation of carotid body chemoreceptors reduces sympathetic activity in hypertensive patients but it does not affect blood pressure. The maintenance of blood pressure can be explained by the direct, vasoconstrictive effect of hyperoxia, which offsets diminished sympathetic activity. This study compares the effect of ...
Kolli Kranthi K KK Department of Mechanical and Materials Engineering, University of Cincinnati, 598 Rhodes Hall, PO Box 210072, Cincinnati, OH, 45221-0072, - - 2014
The assessment of functional coronary lesion severity using intracoronary hemodynamic parameters like the pressure-derived fractional flow reserve and the flow-derived coronary flow reserve are known to rely critically on the establishment of maximal hyperemia. We evaluated a hyperemia-free index, basal pressure drop coefficient (bCDP), that combines pressure and velocity for ...
Loirand Gervaise G INSERM; U1087; l'institut du thorax; Nantes, France; CNRS; U6291; Nantes, France; Université de Nantes; Nantes, France; CHU Nantes; l'institut du thorax; Nantes, - - 2014
Proper regulation of arterial blood pressure is essential to allow permanent adjustment of nutrient and oxygen supply to organs and tissues according to their need. This is achieved through highly coordinated regulation processes controlling vascular resistance through modulation of arterial smooth muscle contraction, cardiac output, and kidney function. Members of ...
Dhanani Sonny S 1Division of Pediatric Critical Care, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. 2Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. 3Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. 4Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada. 5McGill University Health Centre Research Institute, Montreal, QC, Canada. 6Department of Critical Care, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada. 7Faculty of Medicine, Interdepartmental Division of Critical Care, University of Toronto, ON, Canada. 8Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, BC, Canada. 9Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. 10Ingram School of Nursing McGill University, McGill University Health Centre, Montreal, QC, Canada. 11Faculty of Medicine Biomedical Ethics Unit, McGill University, Montreal, QC, Canada. 12Department of Critical Care Medicine and Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 13Pediatric Cardiology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. 14Neurosciences Intensive Care Unit, University of Alberta Hospital, Edmonton, AB, Canada. 15Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. 16Critical Care, The Ottawa Hospital, Ottawa, ON, Canada. 17Department of Medicine, University of Ottawa, Ottawa, ON, Canada. 18The Ottawa Health Research Institute, Ottawa, ON, Canada. 19The Clinical Epidemiology Program Methods Centre, University of Ottawa, Ottawa, ON, Canada. 20Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada. 21National GE3LS Program, Genome Canada, Ottawa, ON, Canada. 22Information Systems, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. 23Department of Clinical Neurological Sciences, London Health Sciences Centre, London, ON, Canada. 24Faculty of Medicine, University of Western Ontario, London, ON, Canada. 25Pediatric Critical Care, Montreal Children's Hospital, Montreal, QC, Canada. 26Faculty of Pediatrics, McGill University, Montreal, QC, - - 2014
Controversies regarding the process and timing of the determination of death for controlled organ donation after circulatory death persist. This study assessed the feasibility of conducting a prospective, observational study of continuous monitoring of vital signs for 30 minutes after the clinical determination of death in five Canadian ICUs. Waveform ...
Pikkemaat Robert R From the *Institute for Medical Information Technology, RWTH Aachen University, Aachen, Germany; †Department of Anesthesia and Intensive Care, Sahlgrenska University Hospital Gothenburg, Gothenburg, Sweden; and ‡Department of Medical Statistics, RWTH Aachen University, Aachen, - - 2014
Currently, the monitoring of cardiac output (CO) and stroke volume (SV) is mainly performed using invasive techniques. Therefore, performing CO monitoring noninvasively by means of electrical impedance tomography (EIT) would be advantageous for intensive care. Our hypothesis was that, by means of EIT, it is possible to assess heart rate ...
Charles Christopher J CJ Christchurch School of - - 2014
The reported effects of atrial natriuretic peptide (ANP) on sympathetic nerve activity (SNA) are variable, dependent on concomitant hemodynamic actions and likely to be regionally differentiated. There are few reports of the effect of B-type natriuretic peptide (BNP) on SNA and none have measured cardiac SNA (CSNA) by direct microneurography. ...
Santos Mário M Department of Physiology and Cardiothoracic Surgery, Cardiovascular R&D Unit, Faculty of Medicine, University of Porto, Porto, - - 2014
Hypertension is a powerful risk factor for cardiovascular mortality and morbidity, including heart failure with both preserved and reduced ejection fraction. Hypertensive heart disease (HHD) defines the complex and diverse perturbations of cardiac structure and function occurring secondary to hypertension. Left ventricular hypertrophy (LVH) is one of the most recognized ...
Sonneveld Milan J MJ Department of Clinical Neurophysiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Obstetrics and Gynecology, Division of Obstetrics and Perinatal Medicine, Erasmus MC, University Medical Center, Rotterdam, the - - 2014
Cerebral perfusion pressure (CPP) is elevated in preeclampsia, and may predispose to cerebrovascular complications and progression to eclampsia. We estimated zero flow pressure (ZFP) and CPP using simultaneously obtained arterial blood pressure and middle cerebral artery blood flow velocity in 10 women with preeclampsia, all treated with methyldopa with or ...
Lakshmikanthan Sribalaji S From the Blood Research Institute, BloodCenter of Wisconsin, Milwaukee (S.L., M.C.W.); Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville (B.J.Z., K.M., M.V.A., A.V.S.); and Department of Pharmacology and Toxicology (Z.-D.G., J.A.A.), Cardiovascular Center (Z.-D.G., X.Z., J.E.M., D.X.Z., J.A.A.), Department of Medicine (X.Z., J.E.M., D.X.Z.), Department of Physiology (H.L., D.L.M.), and Division of Biostatistics (A.S.), Medical College of Wisconsin, - - 2014
Small GTPase Ras-related protein 1 (Rap1b) controls several basic cellular phenomena, and its deletion in mice leads to several cardiovascular defects, including impaired adhesion of blood cells and defective angiogenesis. We found that Rap1b(-/-) mice develop cardiac hypertrophy and hypertension. Therefore, we examined the function of Rap1b in regulation of ...
Kolli Kranthi K KK Department of Mechanical and Materials Engineering, 598 Rhodes Hall, PO Box 210072, Cincinnati, OH 45221-0072 USA. - - 2014
Functional assessment of coronary lesion severity during cardiac catheterization is conducted using diagnostic parameters like fractional flow reserve (FFR; pressure derived) and coronary flow reserve (CFR; flow derived). However, the complex hemodynamics of stenosis might not be sufficiently explained by either pressure or flow alone, particularly in the case of ...
Liu Meiyan M Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, - - 2014
Ouabain and digoxin are important cardiac glycoside and related to many cardiovascular diseases. The purpose of this study was to investigate the changes of sodium pump α-subunit expression in rats and compare the effects of ouabain (OUA) and digoxin (DIG) on the development of hypertension. In situ hybridization was performed. ...
Stevenson Alec T - - 2014
Cardiovascular reflexes that regulate blood pressure (BP) adapt during repeated exposure to +Gz acceleration separated by short (< 20 s) breaks, but whether this effect is preserved with longer intervals remains unknown. There were 17 subjects who completed 5 repeated gradual onset (0.1 G x s(-1)) runs (GOR1-5) to 60 ...
Kang Woon-Seok WS Department of Anesthesiology and Pain Medicine, Konkuk University Hospital, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. ; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, - - 2014
The usefulness of dynamic parameters derived by heart-lung interaction for fluid responsiveness in pediatric patients has been revealed. However, the effects of peak inspiratory pressure (PIP) that could affect the absolute values and the accuracy in pediatric patients have not been well established. Participants were 30 pediatric patients who underwent ...
Khan Munasib M Natural Products Research Unit, Department of Biological and Biomedical, Sciences, Aga Khan University Medical College , Karachi , Pakistan - - 2014
Abstract In current study, we describe blood pressure (BP)-lowering, endothelium-dependent, and independent vasodilator and cardio-modulatory actions of Carum roxburghianum seed. The crude extract of C. roxburghianum seed (Cr.Cr) induced dose-dependent (10-100 mg/kg) fall in arterial BP of anaesthetized rats. In isolated rabbit aorta, Cr.Cr (0.3-10 mg/mL) inhibited high K(+) (80 mM) and phenylephrine ...
Noack Cornelia C Department of Neurology, Charité - University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, - - 2014
Levodopa is one of the most effective symptomatic treatment options for Parkinsonism with a favorable safety and tolerability profile. In some patients, particularly those suffering from orthostatic intolerance, the hypotensive effect of levodopa limits its therapeutic use. We used continuous noninvasive cardiovascular and ventilatory monitoring in 17 patients suffering from ...
Pereira Renata O RO *Fraternal Order of Eagles Diabetes Research Center, Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, - - 2014
During pathological hypertrophy, peroxisome proliferator-activated receptor coactivator 1α (PGC-1α) is repressed in concert with reduced mitochondrial oxidative capacity and fatty acid oxidation (FAO). We therefore sought to determine if maintaining or increasing PGC-1α levels in the context of pressure overload hypertrophy (POH) would preserve mitochondrial function and prevent contractile dysfunction. ...
Su Shaoyong S Georgia Prevention - - 2014
Growing evidence suggests that adverse childhood experiences (ACEs) increase the risks for coronary heart disease and hypertension in mid and late adulthood. We previously reported that early life stress induces a hyperreactive endothelin-dependent cardiovascular phenotype in a rat model. In the present study, we evaluated whether exposure to ACEs is ...
Vasileiou Panagiotis V S PV National and Kapodistrian University of Athens, Medical School, MSc "Cardiopulmonary Resuscitation", Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece. Electronic address: - - 2014
In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. However, its role in the cardiac arrest (CA) setting has not yet been adequately investigated. The aim of this study is to examine ...
Pinsky Michael R MR Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA, - - 2014
In 1992, we published a report on the effect of positive end-expiratory pressure (PEEP) on right ventricular (RV) function in humans. We measured RV volumes and pressures and pericardial pressure (Ppc) as PEEP was increased from zero to 15 cm H20 in 12 patients after thoracotomy, using a pulmonary arterial ...
Hartmann Silvia M SM Pediatric Critical Care Medicine, Seattle Children's Hospital, Seattle, WA, - - 2014
End-tidal carbon dioxide (ETCO2) measurements during cardiopulmonary resuscitation (CPR) reflect variable cardiac output over time, and low values have been associated with decreased survival. The goals of this review are to confirm and quantify this relationship and to determine the mean ETCO2 value among patients with return of spontaneous circulation ...
Lee Candice Y CY From the *University of Rochester Medical Center, Rochester, NY USA; and †LSI SOLUTIONS, Victor, NY - - 2014
This study compared the strength, consistency, and speed of prosthetic attachment sutures secured with automated fasteners with those of manual knots using an ex vivo porcine mitral valve annuloplasty model. A novel miniature pressure transducer system was developed to quantify pressures between sutured prosthetic rings and underlying cardiac tissue. Sixteen ...
Kato Daiki D Department of Cardiology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, - - 2014
Fractional flow reserve (FFR) is a useful modality to assess the functional significance of coronary stenoses. Although adenosine triphosphate (ATP) is generally used as the hyperemic stimulus, we sometimes encounter adverse events like hypotension during FFR measurement. Nicorandil, an ATP-sensitive potassium channel opener, recognized as an epicardial and resistance vessel ...
May Ross W RW Family Institute, Department of Family and Child Sciences, Florida State University, Tallahassee, Florida. Electronic address: - - 2014
High trait anger is linked to adverse cardiovascular outcomes. A potential antidote to the cardiotoxic influence of anger is trait forgiveness (TF), as it has shown associations with improved blood pressure (BP) and cardiovagal tone regulation in cardiac patients. However, it has yet to be determined if anger and forgiveness ...
Perel Azriel A Department of Anesthesiology and Intensive Care, Sheba Medical Center, Tel Aviv University, Tel Hashomer, 52621, Tel Aviv, Israel, - - 2014
Optimal fluid management is one of the main challenges in the care of the critically ill. However, the physiological parameters that are commonly monitored and used to guide fluid management are often inadequate and even misleading. From 1987 to 1989 we published four experimental studies which described a method for ...
Bebarta Vikhyat S VS Medical Toxicology, San Antonio Military Medical Center, San Antonio, TX. Electronic address: - - 2014
Hydroxocobalamin is a Food and Drug Administration-approved antidote for cyanide poisoning. Cobinamide is a potential antidote that contains 2 cyanide-binding sites. To our knowledge, no study has directly compared hydroxocobalamin with cobinamide in a severe, cyanide-toxic large-animal model. Our objective is to compare the time to return of spontaneous breathing ...
Redfors Bjorn B Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address: - - 2014
Takotsubo cardiomyopathy (TCM) is characterized by regional left ventricular dysfunction that cannot be explained by an occlusive lesion in a coronary artery. Catecholamines are implicated in the pathogenesis of TCM but the mechanisms involved are unknown. Because the endogenous and the most commonly used exogenous catecholamines have well defined adrenoceptor ...
Nikolaou Panayiotis - - 2014
We present a systematic, multi-parameter study of Rb/(129)Xe spin-exchange optical pumping (SEOP) in the regimes of high xenon pressure and photon flux using a 3D-printed, clinical-scale stopped-flow hyperpolarizer. In situ NMR detection was used to study the dynamics of (129)Xe polarization as a function of SEOP-cell operating temperature, photon flux, ...
Armstrong David W J DW Department of Biomedical and Molecular Sciences, Queen's University, Room 850 Botterell Hall, Kingston, ON, K7L 3N6, - - 2014
The developmental origins of health and disease refer to the theory that adverse maternal environments influence fetal development and the risk of cardiovascular disease in adulthood. We used the chronically hypertensive atrial natriuretic peptide knockout (ANP-/-) mouse as a model of gestational hypertension, and attempted to determine the effect of ...
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