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Mizutani Yasuaki Y Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, - - 2014
Olfactory dysfunction is considered to precede motor symptoms and early markers of Parkinson's disease (PD), while the relative time at which cardiovascular dysautonomia appears in PD is not well understood. To assess the appearance of cardiovascular dysautonomia in PD, we evaluated its relation to olfactory dysfunction in early-stage PD patients. ...
Katare Charu C Department of Food & Nutrition, Kamla Raja Girls (PG), Autonomous College, Gwalior, Madhya Pradesh, - - 2014
The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < ...
Milan Alberto A Department of Medical Sciences, Division of Internal Medicine, Hypertension Unit, University Hospital 'S. Giovanni Battista', Turin, Italy, - - 2014
Volume overload is typical of haemodialysis patients; correct volume status evaluation is crucial in achieving blood pressure homeostasis, hypertension management and good treatment planning. This study evaluates the effect of acute volume depletion on ultrasonographic parameters and suggests two of them as able to predict patients volume overload. 27 patients ...
Lozo Mislav M Department of Integrative Physiology, University of Split School of Medicine, Split, - - 2014
Self-contained underwater breathing apparatus (SCUBA) diving is regularly associated with numerous asymptomatic changes in cardiovascular function. Freshwater SCUBA diving presents unique challenges compared with open sea diving related to differences in water density and the potential for dive locations at altitude. The aim of this study was to evaluate the ...
Burger Dylan - - 2014
The somatic isozyme of angiotensin I-converting enzyme (ACE) is comprised of two distinct, zinc-dependent catalytic domains with different substrate specificities for angiotensin I (cleaved selectively by the C- domain) and bradykinin (cleaved equally efficiently by both the N and C- domains). Classical ACE inhibitors (ACEI) target both domains, with side ...
Oliveira-Sales Elizabeth B EB School of Physiology & Pharmacology, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK; Department of Physiology, Federal University of Sao Paulo, UNIFESP, SP 04023-062, - - 2014
Despite extensive use of the renovascular/Goldblatt model of hypertension-2K-1C, and the use of renal denervation to treat drug resistant hypertensive patients, autonomic mechanisms that underpin the maintenance of this hypertension are important yet remain unclear. Our aim was to analyse cardiovascular autonomic function by power spectral density analysis of both ...
Schroeder Christoph C Institute of Clinical Pharmacology, Hannover Medical School, Hannover, - - 2014
Hyperpolarization-activated cyclic nucleotide-gated 4 channels (HCN4) comprise the final pathway for autonomic heart rate (HR) regulation. We hypothesized that HCN4 inhibition could reverse autonomic imbalance in a human model of cardiac sympathetic activation. Nineteen healthy men ingested oral metoprolol+reboxetine, ivabradine+reboxetine, or placebo+reboxetine in a double-blind, randomized, crossover fashion. We assessed ...
Chalyan David A DA From the Department of Radiological Sciences, University of California-Irvine, Irvine, CA (D.A.C., Z.Z., S.M.); Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA (D.A.C.); Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Z.Z.); Division of Cardiology, University of California-Irvine, Orange, CA - - 2014
Diastolic fractional flow reserve (dFFR) has been shown to be highly sensitive for detection of inducible myocardial ischemia. However, its reliance on measurement of left-ventricular pressure for zero-flow pressure correction, as well as manual extraction of the diastolic interval, has been its major limitation. Given previous reports of minimal zero-flow ...
Garisto Cristiana C Pediatric Cardiac Intensive Care Unit, Department of Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital, IRCCS, Rome, - - 2014
It is currently uncertain which hemodynamic monitoring device reliably measures stroke volume and tracks cardiac output changes in pediatric cardiac surgery patients. To evaluate the difference between stroke volume index (SVI) measured by pressure recording analytical method (PRAM) and bioreactance and their ability to track changes after a therapeutic intervention. ...
Hofhuizen Charlotte - - 2014
Nexfin (Edwards Lifesciences, Irvine, CA) allows for noninvasive continuous monitoring of blood pressure (ABPNI) and cardiac output (CONI) by measuring finger arterial pressure (FAP). To evaluate the accuracy of FAP in measuring ABPNI and CONI as well as the adequacy of detecting changes in ABP and CO, we compared FAP ...
Orbegozo Cortes D D Intensive Care Department,Hôpital Erasme,Université Libre de Bruxelles, Brussels, Belgium - - - 2014
Excessive adrenergic stimulation may be associated with several adverse events and contribute to increase mortality in critically ill septic patients. Few clinical data exist on the effects of adrenergic blockade in this setting. The objective of this study was to investigate the effect of a short acting b-blocker (esmolol) in ...
Hahn Robert G RG Södertälje Hospital, Research Unit, Södertälje, Sweden, Södertälje Hospital, Research Unit, Södertälje, - - 2014
To evaluate whether the pathophysiology of shock syndromes can be better understood by comparing central hemodynamics with kinetic data on fluid and electrolyte shifts. We studied the dilutional hyponatremic shock that developed in response to overhydration with electrolyte-free irrigating fluid - the so-called 'transurethral resection syndrome' - by comparing cardiac ...
Yin Wenpeng W Department of Emergency Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, - - 2014
Epinephrine has been used as a first-choice vasopressor drug for cardiac arrest (CA) since 1974. However, the administration of epinephrine is controversial. This study aims to compare the effects of Shen-Fu injection (SFI) and epinephrine on resuscitation outcomes in a porcine model of prolonged CA. Ventricular fibrillation (VF) was electrically ...
Camarço João Paulo Figueiredo JP Federal University of Goias, GoianiaGO, Brazil, Fellow Master degree, Postgraduate Program in Health Sciences, Federal University of Goias (UFG), Goiania-GO, Brazil. Intellectual and scientific contents of the study, technical procedures, manuscript - - 2014
To evaluate the feasibility of an experimental model of donors after cardiac death in remote ischemic preconditioning studies. Twelve Landrace pigs were used as organ donors. They underwent cardiac arrest by coronary en block suture and interruption of ventilatory support. Haemodynamic data regarding the donor surgical protocol were evaluated. Studies ...
Jennings Brett L BL Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN, 38163, - - 2014
We investigated the contribution of cytochrome P450 (CYP) 1B1 to hypertension and its pathogenesis by examining the effect of its selective inhibitor, 2,4,3',5'-tetramethoxystilbene (TMS), in spontaneously hypertensive rats (SHR). Blood pressure (BP) was measured bi-weekly. Starting at 8 weeks, TMS (600 μg/kg, i.p.) or its vehicle was injected daily. At 14 ...
Severo Mateus Dornelles MD Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, - - 2014
This study was conducted among individuals with diabetes and hypertension in order to assess the prevalence of erectile dysfunction (ED) and the association between ED and cardiovascular risk variables such as echocardiographic changes. We evaluated 114 men with type 2 diabetes mellitus and hypertension. ED was assessed by IIEF-5 score. ...
Paunović Katarina K Institute of Hygiene and Medical Ecology, Faculty of Medicine, University of Belgrade, Dr Subotića 8, 11000 Belgrade, Serbia. Electronic address: - - 2014
Noise exposure increases blood pressure in both experimental and field studies. The underlying mechanisms may be evaluated by thoracic bioelectrical impedance. The aim of this experimental study was to assess changes in blood pressure, cardiac and hemodynamic parameters provoked by recorded traffic noise in young adults. The study included 130 ...
Gammon Cheryl S CS Institute of Food, Nutrition and Human Health, Massey University, Auckland, New - - 2014
Increasing fruit and vegetable consumption is a key lifestyle modification in the prevention and treatment of hypertension. Kiwifruit has previously been shown to have favorable effects on blood pressure (BP), likely through inhibiting angiotensin I-converting enzyme activity. We hypothesized that the replacement of 2 fruit servings in a healthy diet ...
Tamargo Juan J Universidad Complutense, School of Medicine, Department of Pharmacology , Madrid , - - 2014
Introduction: Diuretics enhance the renal excretion of Na(+) and water due to a direct action at different tubular sites of the nephron where solute re-absorption occurs. Areas covered: This paper focuses on the mechanism of action, pharmacodynamics, antihypertensive effects, adverse effects, interactions and contraindications of loop diuretics and potassium-sparing agents ...
Fedecostante Massimiliano M Internal Medicine and Geriatrics and "Hypertension Excellence Centre" of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University "Politecnica delle Marche", Italian National Research Centre on Aging "U. Sestilli", IRCCS-INRCA, Ancona, - - 2014
Hypertension plays a key role in chronic kidney disease (CKD), but CKD itself affects the blood pressure (BP) profile. The aim of this study was to assess the association of BP profile with CKD and the presence of cardiac organ damage. We studied 1805 patients, referred to our Hypertension Centre, ...
Xu Jiefeng J Weil Institute of Critical Care Medicine, Rancho Mirage, CA, United States; Department of Emergency Medicine, Yuyao People's Hospital, Medical School of Ningbo University, Ningbo, China. Electronic address: - - 2014
One of the major goals of cardiopulmonary resuscitation (CPR) is to provide adequate oxygen delivery to the brain for minimizing cerebral injury resulted from cardiac arrest. The optimal chest compression during CPR should effectively improve brain perfusion without compromising intracranial pressure (ICP). Our previous study has demonstrated that the miniaturized ...
Chen Zhidan Z Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, - - 2014
Cardiac side population cells (CSPs) are promising cell resource for the regeneration in diseased heart as intrinsic cardiac stem cells. However, the relative low ratio of CSPs in the heart limited the ability of CSPs to repair heart and improve cardiac function effectively under pathophysiological condition. Which factors limiting the ...
- - 2014
Data on cardiovascular disease (CVD) risk in adolescents with type 2 diabetes (T2D) are limited. Echocardiography was performed in the last year of the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial (median 4½ yr from diagnosis of T2D, average age 18 yr), including MMode and 2D ...
Ocaranza Maria Paz MP aDivision de Enfermedades Cardiovasculares, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago bMillennium Institute on Immunology and Immunotherapy cInstituto de Ciencias Biomedicas, Facultad de Medicina, Santiago dAdvanced Center for Chronic Diseases & Centro Estudios Moleculares de la Celula, Facultad Ciencias Quimicas y Farmaceuticas & Facultad Medicina, Universidad de Chile, Santiago, Chile eDepartment of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas, Texas, - - 2014
Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. In this study, we evaluated whether angiotensin-(1-9) decreases hypertension and reverses experimental cardiovascular damage in the rat. Angiotensin-(1-9) (600 ng/kg per min for 2 weeks) reduced already-established hypertension in ...
Schmidt Matthieu M The Australian & New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Level 6, The Alfred Centre, Commercial Road, Melbourne, Victoria 3004, Australia. - - 2014
The timing of extracorporeal membrane oxygenation (ECMO) initiation and its outcome in the management of respiratory and cardiac failure have received considerable attention, but very little attention has been given to mechanical ventilation during ECMO. Mechanical ventilation settings in non-ECMO studies have been shown to have an effect on survival ...
Amat Nurmuhammat - - 2014
Dioscorea opposita Thunb. (Huai Shan Yao, DOT), a common staple food in China, has been used for more than 2000 years in traditional Chinese medicine (TCM) to treat different systemic diseases including hypertension. The objective of this study was to investigate the possible antihypertensive effects of the aqueous extract of ...
Eschalier Romain R INSERM, Center d'Investigation Clinique CIC-P 9501, Nancy, - - 2014
Incidence and prevalence of abdominal obesity (AO) are growing exponentially. Subjects with AO are at higher risk of developing heart failure. The purpose of the study was to investigate early changes in cardiac and arterial structure and function and extracellular matrix biomarkers in normotensive healthy subjects with AO. Subjects with ...
Bjerregaard Jens J Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, - - 2014
Continuing renin-angiotensin-aldosterone system antagonist therapy on the day of surgery is controversial, and appears to contribute to intraoperative hypotension. A patient presenting for cerebral aneurysm clipping continued her angiotensin-converting enzyme inhibitor on the morning of surgery, and subsequently experienced significant postinduction hypotension that culminated in cardiac arrest. Following successful resuscitation, ...
Kocyigit Ismail - - 2014
Introduction: Arterial stiffness is a risk marker for cardiovascular events in peritoneal dialysis (PD) patients. Strict volume control strategy has been shown to result in better cardiac functions and control of hypertension in these patients. The aim of the study was to identify the determinants of arterial stiffness and evaluate ...
Baban Babak B Department of Oral Biology, College of Dental Medicine, Georgia Regents University, Augusta, Georgia, - - 2014
Systemic hypertension and the associated increased myocardial load/mechanical stress are common in patients with coronary heart disease. Thus, unraveling of mechanosensitive molecular mechanisms that determine cell fate in the setting of cardiac tissue injury is of scientific and clinical relevance. We tested the hypothesis that the prosurvival, mechanosensitive, serum glucocorticoid-regulated ...
Stuckey Daniel J DJ 1British Heart Foundation Centre of Research Excellence, National Heart and Lung Institute, Imperial College London, London, United Kingdom; Centre for Advanced Biomedical Imaging, University College London, London, United - - 2014
-Diffuse interstitial fibrosis is present in diverse cardiomyopathies and associated with poor prognosis. We investigated whether MRI-based T1 mapping could quantify the induction and pharmacological suppression of diffuse cardiac fibrosis in murine pressure-overload hypertrophy. -Mice were subjected to transverse aortic constriction (TAC) or sham surgery. The angiotensin receptor blocker Losartan ...
Slagt C C Department of Anaesthesiology and Intensive Care, Zaans Medical Centre, Koningin Julianaplein 58, 1502 DV Zaandam, The - - 2014
The FloTrac/Vigileo™, introduced in 2005, uses arterial pressure waveform analysis to calculate cardiac output (CO) and stroke volume variation (SVV) without external calibration. The aim of this systematic review is to evaluate the performance of the system. Sixty-five full manuscripts on validation of CO measurements in humans, published in English, ...
Zhang Congcong C Beijing AnZhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, - - 2014
Inflammatory responses mediate the development of perivascular fibrosis and heart dysfunction induced by hypertension. Complement is an important inflammatory system, and we aimed to evaluate the effect of a specific C5a receptor antagonist (C5aRA), PMX53, on inflammation and perivascular fibrosis in the hypertensive heart of the mouse. Hypertension was induced ...
Nisenbaum Marcelo Gil MG Gynecology Department, Clinics Hospital, University of São Paulo Medical School, São Paulo 05403-000, Brazil. Electronic address: - - 2014
The use of combined oral contraceptives has been associated with an increased risk of adverse cardiovascular events. Whether these drugs alter cardiac autonomic nervous system control is not completely determined. To evaluate the effect of a contraceptive containing 20mcg of ethinyl estradiol and 3mg of drospirenone on the heart rate ...
Zhang Yan Y Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, - - 2014
Dickkopf-3 (DKK3), a secreted protein in the Dickkopf family, is expressed in various tissues, including the heart, and has been shown to play an important role in tissue development. However, the biological function of DKK3 in the heart remains largely unexplored. This study aimed to examine the role of DKK3 ...
Sandroni C C Department of Anesthesiology and Intensive Care, Catholic University School of Medicine, Rome, Italy - - - 2014
Experimental evidence shows that derangements of arterial partial pressures of either oxygen (PaO2) and carbon dioxide (PaCO2) immediately after resuscitation from cardiac arrest may increase the severity of organ dysfunction due to whole body ischemia and subsequent reperfusion. Hyperoxia is believed to increase reperfusion injury, especially to mitochondrial membrane due ...
Aprea Francesco F Dick White Referrals, Station Farm, Cambridgeshire, CB8 0UH, - - 2014
To describe bispectral index (BIS) findings and compare them with cardiovascular and respiratory trends during cardiac arrest and successful CPR in a propofol-anesthetized calf. A 3-month-old calf was anesthetized as part of a research project. A thromboxane analog drug (U46619) was administered IV to induce pulmonary hypertension. Within 10 minutes ...
Gkaliagkousi Eugenia E 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, - - 2014
Cardiotrophin 1 (CT-1) is an interleukin 6-related cytokine recently implicated in cardiac hypertrophy and vascular damage in essential hypertension (EH). We aimed first to determine CT-1 levels in naive, untreated patients with grade I EH (UH) as compared with normotensive (NT) individuals and, second, to investigate a possible association of ...
Singh Vikas V King George's Medical University, Lucknow, - - 2014
The present study was undertaken to assess the effect of volume expansion on cardiac haemodynamics in patients with cardiac tamponade and to ascertain an optimum amount of fluid that can produce the maximum benefit in tamponade patients. In patients of tamponade, interim measures may occasionally be needed when facilities for ...
Echavarría-Pinto Mauro M From the Cardiovascular Institute, Hospital Clínico San Carlos and Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (M.E.-P., B.I., A.Q., A.F.-O., J.E.); Cardiovascular Institute, Hospital Clínico San Carlos, Madrid, Spain (N.G., P.J.-Q., F.A., I.J.N.-G., C.B., C.M.); International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (R.P., S.S., S.N., J.T., J.D.); and Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea - - 2014
Intravenous adenosine infusion produces coronary and systemic vasodilatation, generally leading to systemic hypotension. However, adenosine-induced hypotension during stable hyperemia is heterogeneous, and its relevance to coronary stenoses assessment with fractional flow reserve (FFR) remains largely unknown. FFR, coronary flow reserve, and index of microcirculatory resistance were measured in 93 stenosed ...
Niewinski Piotr P 4th Military Hospital, - - 2014
Low-dose dopamine inhibits peripheral chemoreceptors and attenuates the hypoxic ventilatory response (HVR) in humans. However, it is unknown whether it also modulates: (1) the hemodynamic reactions to acute hypoxia, (2) cardiac baroreflex sensitivity (BRS) and (3) if there is any effect of dopamine withdrawal. We performed a double-blinded, placebo controlled ...
Smart C M CM Ayr Hospital, Ayr, - - 2014
To maximise the effect of a small fluid load, it is occasionally desirable to bolus manually with multiple depressions of a large-capacity syringe. This is usually achieved by placing the syringe on the side port of a three-way tap. We modified this technique by placing two-one-way valves in line with ...
Cinel Ismail I Department of Medicine, Cooper University Hospital , Camden, NJ 08103 , USA - - 2014
Abstract Preservation of cardiac output (CO) and pulmonary artery pressure (PAP) is vital to maintaining tissue oxygenation in sepsis. This feasibility study tested the hypothesis that therapeutic intra-thoracic pressure regulation (tIPR), delivered with a novel device, was designed to non-invasively enhance venous return by creating sub-atmospheric intra-thoracic pressure during the ...
Ingaramo Oscar A OA 1Department of Pediatric Critical Care, Sunrise Children's Hospital, Las Vegas, NV. 2Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, - - 2014
To evaluate the impact of different levels of positive end-expiratory pressure on cardiac index in children receiving mechanical ventilation. To explore the effect of lung recruitment on the relationship between positive end-expiratory pressure and cardiac output. Prospective, single center, and interventional. PICU in a tertiary care children's hospital. Fifty mechanically ...
Cassu Renata Navarro RN Oeste Paulista University, Scholl of Veterinary Medicine, Department of Veterinary Surgery and Anestesiology, Presidente PrudenteSP, - - 2014
To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group ...
Cheng Hui-Wen HW Cardiac Muscle Research Labratory, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical - - 2014
Emerging clinical data support the notion that RV dysfunction is critical to the pathogenesis of cardiovascular disease and heart failure(1-3). Moreover, the RV is significantly affected in pulmonary diseases such as pulmonary artery hypertension (PAH). In addition, the RV is remarkably sensitive to cardiac pathologies, including left ventricular (LV) dysfunction, ...
Weldy Chad S CS Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America ; Department of Pathology, University of Washington School of Medicine, Seattle, Washington, United States of - - 2014
Exposure to fine particulate air pollution (PM2.5) is strongly associated with cardiovascular morbidity and mortality. Exposure to PM2.5 during pregnancy promotes reduced birthweight, and the associated adverse intrauterine conditions may also promote adult risk of cardiovascular disease. Here, we investigated the potential for in utero exposure to diesel exhaust (DE) ...
Zhang Xiakun X School of Atmospheric Sciences, Nanjing University of Information Sciences and Technology, 219 Ningliu Road, Nanjing 210044, China. - - 2014
The effects of cold air on cardiovascular and cerebrovascular diseases were investigated in an experimental study examining blood pressure and biochemical indicators. Zhangye, a city in Gansu Province, China, was selected as the experimental site. Health screening and blood tests were conducted, and finally, 30 cardiovascular disease patients and 40 ...
Nekooeian Ali Akbar AA Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; ; Cardiovascular Pharmacology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, - - 2014
Background: The cardiac effects simultaneously occurring during experimental hypertension and diabetes have rarely been investigated. This study aimed at examining the effects of short-term renovascular hypertension and type 2 diabetes on cardiac functions. Methods: Five groups (7 each) of male Sprague-Dawley rats, including a control group, a diabetes (induced by ...
Rokamp Kim Z KZ Departments of Anesthesia, Rigshospitalet, University of Copenhagen Copenhagen, - - 2014
This study addresses three questions for securing tissue oxygenation in brain (rScO2) and muscle (SmO2) for 100 patients (age 71 ± 6 years; mean ± SD) undergoing vascular surgery: (i) Does preoxygenation (inhaling 100% oxygen before anesthesia) increase tissue oxygenation, (ii) Does inhalation of 70% oxygen during surgery prevent a ...
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