Search Results
Results 401 - 450 of 2726
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Choi Jin-Oh - - 2007
BACKGROUND: The novel parameter T(E-E'), which is the time interval between the onset of the early diastolic mitral inflow velocity (E) and the early diastolic mitral annular velocity (E'), is reported to be related to the constant of the left ventricular (LV) relaxation, and T(E-E') is also reported to be ...
Drager Luciano F - - 2007
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) and hypertension are independently associated with increased stiffness of large arteries that may contribute to left ventricular (LV) remodeling. We sought to investigate the impact of OSA, hypertension, and their association with arterial stiffness and heart structure. DESIGN: We studied 60 middle-aged subjects classified ...
Jansen Annemieke H M - - 2007
BACKGROUND: Variable results of cardiac resynchronization therapy (CRT) on diastolic function have been described. We investigated 3 and 12 months' effect of CRT on diastolic function and left ventricular (LV) filling pressures and their relation to LV reverse remodeling. METHODS: Fifty-two patients' (36 male, 69 +/- 8 years, QRS duration ...
Tsang Michael W - - 2007
Glucose-insulin-potassium (GIK) infusion improves clinical outcome after coronary artery bypass surgery (CABG). The mechanism of benefit is unclear, but GIK limits ischemia and reperfusion injury. This study was designed to assess whether the clinical benefit of perioperative GIK infusion is mediated through reduction in the severity of diastolic dysfunction that ...
Rovner Aleksandr A Cardiovascular Imaging and Clinical Research Core Laboratory, Washington University School of Medicine, Cardiovascular Division, St. Louis, Missouri 63110, - - 2007
Tissue Doppler imaging (TDI) and color M-mode (CMM) indices provide assessment of left ventricular (LV) relaxation when combined with pulse-wave Doppler (PWD)-derived transmitral inflow, allows for estimation of LV filling pressures. However, use of these indices in patients with LV systolic dysfunction (LVSD) has not been well characterized. The study ...
Hui Ling L Pediatric Cardiology, Oregon Health Science University, Portland, Oregon 97239-3098, - - 2007
Torsion is an essential component of left ventricular (LV) function. Systolic rotation, as a component of torsion, winds the heart muscle up like a spring, setting up recoil for early diastole. We used a new 2-dimensional speckle tracking strain method to study differences in twisting in subendocardial and subepicardial layers ...
Cheung Caroline T Y - - 2007
Coxsackievirus B3 (CVB3) is the most common causative agent of infectious myocarditis. Chronic inflammation, loss of contractile tissue, and maladaptive remodeling all contribute to dilated cardiomyopathy and heart failure. The 4-1BB receptor is a costimulatory molecule expressed by T cells and cardiomyocytes. We infected mice with CVB3 to examine if ...
Voon Wen-Chol - - 2007
To test the applicability of isovolumic relaxation flow propagation velocity (IRFPV) as an indicator of relaxation, 38 patients undergoing cardiac catheterization for chest pain were included. The time constant of isovolumic left ventricular (LV) pressure decline (tau) had a significant correlation with the LV end-diastolic pressure, the peak negative dp/dt, ...
Bermejo Javier - - 2008
BACKGROUND: Echocardiographic assessment of LV wall motion is still most frequently done visually. This study was designed to validate a new system for semi-automatic quantification of global and regional LV systolic function from contrast-enhanced cross-sectional echocardiograms. METHODS: Measurements of LV volumes were validated in 50 patients using magnetic resonance (MR) ...
Lam Yat-Yin - - 2007
The effect of pressure-overloading distance on left ventricular (LV) function in patients with congenital aortic coarctation and aortic stenosis (AS) was investigated. LV long-axis motions were recorded using M-mode and tissue Doppler imaging (TDI) techniques in 46 consecutive patients with severe LV outflow tract obstruction (23 coarctation and 23 AS), ...
Schmidt Christoph - - 2007
BACKGROUND: Cardiac resynchronization therapy has been shown to improve systolic function in patients with advanced chronic heart failure and electromechanical delay (QRS width > 120 ms). However, the effect of acute biventricular (BiV) pacing on perioperative haemodynamic changes is not well defined. In the present study, acute changes in regional ...
Jugdutt Bodh I - - 2007
To determine whether therapy with the angiotensin II type 1 receptor blocker (ARB) candesartan and the comparator angiotensin-converting-enzyme inhibitor (ACEI) enalapril during healing after reperfused ST-elevation myocardial infarction (RSTEMI) limit adverse remodeling of infarct zone (IZ) collagens and left ventricular (LV) diastolic dysfunction, we randomized 24 dogs surviving anterior RSTEMI ...
Buys Emmanuel S ES Cardiac Ultrasound Laboratory, 55 Fruit Street, Boston, MA 02115-2696, - - 2007
Although nitric oxide synthase (NOS)3 is implicated as an important modulator of left ventricular (LV) remodeling, its role in the cardiac response to chronic pressure overload is controversial. We examined whether selective restoration of NOS3 to the hearts of NOS3-deficient mice would modulate the LV remodeling response to transverse aortic ...
Lichodziejewska Barbara - - 2007
BACKGROUND: Left ventricular (LV) diastolic dysfunction has been observed in cigarette smokers with coronary artery disease. The aim of the study was to assess LV and right ventricular (RV) diastolic function in healthy, young, and slim smokers before and after smoking one cigarette. MATERIAL AND METHODS: The participants were 66 ...
Tavil Yusuf - - 2007
OBJECTIVE: We sought to evaluate aortic function and its relationship with left ventricular (LV) function in patients with obstructive sleep apnea syndrome (OSAS), with or without systemic hypertension. METHODS: A total of 29 patients with OSAS, 28 patients with systemic hypertension without OSAS, and 19 patients having both disorders were ...
Cottone S - - 2007
AIMS: Left ventricular hypertrophy (LVH) is a predictor for cardiovascular mortality, and it is considered to be a surrogate marker of preclinical cardiovascular disease. This study aimed at evaluating whether fetuin-A plasma levels are decreased in patients with moderate chronic kidney disease (CKD) and their linkage to plasma concentrations of ...
Chang Shu-Mei - - 2007
BACKGROUND: As a consequence of a leftward shift of the interventricular septum and of pericardial restraint, related to the degree RV dilatation, left heart function would be influenced after pulmonary hypertension and right heart failure. METHODS AND RESULTS: We enrolled 70 patients with pulmonary artery systolic pressure (PASP) more than ...
Mishra Rakesh K - - 2007
INTRODUCTION: The myocardial performance index (MPI) introduced by Tei, a Doppler-derived echocardiographic measure that reflects both left ventricular (LV) systolic and diastolic function, has been shown to have prognostic value in several clinical settings, including myocardial infarction and congestive heart failure. There are scant data on the correlates and prognostic ...
Poerner Tudor C - - 2007
The objective was to determine the influence of left ventricular (LV) inflow pattern on the accuracy of different echocardiographic indices for estimation of LV end-diastolic pressure (LVEDP). Echocardiography with color tissue Doppler imaging (TDI) and LVEDP measurements using fluid-filled catheters were performed in 176 consecutive patients on the same day. ...
Schmid Isabelle - - 2007
To compare the effects on heart rate (HR), on left ventricular (LV) or arterial pressures, and the general safety of a non-ionic low-osmolar contrast medium (CM) and a non-ionic iso-osmolar CM in patients undergoing cardiac angiography (CA) or peripheral intra-arterial digital subtraction angiography (IA-DSA). Two double-blind, randomized studies were conducted ...
Blendea D - - 2007
Increased blood pressure and left ventricular (LV) mass predict the onset of the clinically manifest hypertension, but little is known regarding the possible predictive value of LV function. The present study was designed to evaluate the association between echocardiographic LV long-axis systolic, and diastolic function and hypertension onset. We prospectively ...
Gurudevan Swaminatha V - - 2007
OBJECTIVES: The purpose of this study was to investigate the cause of abnormal left ventricular (LV) Doppler diastolic filling characteristics in chronic thromboembolic pulmonary hypertension (CTEPH). BACKGROUND: In CTEPH, LV diastolic function often appears abnormal. It is unclear whether this "impaired relaxation" (E<A) filling pattern is caused by septal hypertrophy, ...
Kjaergaard Jesper - - 2007
Pulmonary hypertension is a well-known complication in heart failure, but its prognostic importance is less well established. This study assessed the risk associated with pulmonary hypertension in patients with heart failure with preserved or reduced left ventricular (LV) ejection fractions. Patients with known or presumed heart failure (n = 388) ...
Valzania Cinzia - - 2007
Haemodynamic and functional effects of cardiac resynchronization therapy (CRT) have been studied mostly at rest. CRT effects on left ventricular (LV) dyssynchrony and function during stress have not been evaluated in detail. We studied the electromechanical effects of CRT at rest and during Dobutamine stress echocardiography (DSE), during active and ...
Wang Jianwen - - 2007
BACKGROUND: Diastolic strain rate (SR) measurements that comprise all left ventricular (LV) segments are advantageous over myocardial velocity for assessment of diastolic function. Mitral early diastolic velocity (E)/SR ratio during the isovolumetric relaxation (IVR) period can be used to estimate LV filling pressures. METHODS AND RESULTS: Simultaneous echocardiographic imaging and ...
Kozakova Michaela - - 2007
BACKGROUND: In the hypertensive heart, epicardial arteries are not enlarged, despite increased total coronary flow related to augmented cardiac workload, wall stress, and left ventricular (LV) mass. The aims of this study were to assess the impact of different hemodynamic factors and LV mass on baseline left main coronary artery ...
Ballo Piercarlo - - 2007
BACKGROUND: Depressed circumferential midwall performance and impaired left ventricular (LV) longitudinal function are both early markers of LV systolic dysfunction in patients with hypertension. The relation between midwall and longitudinal indices in these patients has never been analyzed. METHODS: In 126 patients with hypertension, midwall fractional shortening (mFS), stress-corrected mFS, ...
Hou Yuan-ping - - 2007
Recent studies suggest that cardiac myocyte apoptosis contributes to the progress of CHF (congestive heart failure). In the present study, we tested the hypothesis that metoprolol in conjunction with the standard treatment regime for CHF [an ACE (angiotensin-converting enzyme) inhibitor, diuretics and digoxin] may significantly reduce the plasma concentrations of ...
Kelly Dominic - - 2007
AIM: To describe temporal profiles of plasma matrix metalloproteinases (MMP-2 and MMP-9), and their relationship with echocardiographic (Echo) parameters of left ventricular (LV) function and remodelling, after acute myocardial infarction (AMI) in man. METHODS AND RESULTS: Plasma MMP-2 and MMP-9 were assayed at intervals (0-12, 12-24, 24-48, 48-72, 72-96, and ...
Palecek Tomas - - 2007
Early diastolic mitral annular velocity (Em) as measured by pulsed-wave tissue Doppler echocardiography (PW-TDE) has been described as a relatively load independent index of left ventricular (LV) relaxation allowing more precise assessment of LV diastolic function. Nevertheless, substantial regional differences in Em are encountered. A systematic study comparing accuracy of ...
Emilsson Kent - - 2007
Earlier studies have shown a +/-5% end-systolic decrease in the volume encompassed by the pericardial sack, manifesting as a radial diminution of the pericardial/epicardial contour of the left ventricle (LV). The aim of this study was to measure this radial displacement at different segmental levels of the LV and try ...
Duygu Hamza - - 2008
BACKGROUND: Levosimendan is a novel positive inotropic calcium sensitizer agent used in acute heart failure. In acute heart failure, it improves hemodynamic parameters more favorably than the conventional positive inotropes. In this study, the effect levosimendan on E/E' ratio as a non-invasive indicator of LV filling pressure was evaluated compared ...
Maurer Mathew S - - 2007
The purpose of this study was to evaluate left ventricular (LV) size and structure in elderly subjects with hypertension (HTN) and heart failure who have a normal ejection fraction (HFNEF) in a large population-based sample. The pathophysiology of HFNEF is incompletely understood but is generally attributed to LV diastolic dysfunction ...
Van de Veire Nico R - - 2007
Tissue synchronisation imaging (TSI) is a new technique to assess left ventricular (LV) dyssynchrony. The value of using TSI to automatically assess LV dyssynchrony compared with manual assessment of LV dyssynchrony from colour-coded tissue Doppler imaging (TDI), and to evaluate the value of TSI to predict response to cardiac resynchronisation ...
Becker Michael - - 2007
Definition of the optimal left ventricular (LV) lead position in cardiac resynchronisation therapy (CRT) is desirable. To define the optimal LV lead position in CRT and assess the effectiveness of CRT depending on the LV lead position using new myocardial deformation imaging. Myocardial deformation imaging based on tracking of acoustic ...
Riordan Matt M - - 2007
Although Doppler tissue imaging frequently indicates the presence of mitral annular oscillations (MAO) following the E' wave (E'' wave, etc.), only recently was it shown that annular "ringing" follows the rules of damped harmonic oscillatory motion. Oscillatory model-based analysis of E' and E'' waves provides longitudinal left ventricular (LV) stiffness ...
Henderson Brooke C - - 2007
Despite extensive strides in understanding pressure overload induced heart failure, there is very little known about oxidative stress induced matrix metalloproteinase (MMP) activation, collagen degradation and remodeling in pressure overload heart failure. We hypothesize that pressure overload leads to redox imbalance causing increased expression/activity of MMP-2/9 producing collagen degradation and ...
Ryan Thomas D - - 2007
OBJECTIVES: We hypothesized that left ventricular (LV) remodeling and matrix loss in volume overload (VO) are mediated by bradykinin (BK) and exacerbated by chronic angiotensin-converting enzyme (ACE) inhibition. BACKGROUND: Chronic ACE inhibition increases anti-fibrotic BK and does not attenuate LV remodeling in pure VO. The relative contribution of changes in ...
Flewitt Jacqueline A - - 2007
We extend our recently published windkessel-wave interpretation of vascular function to the wave intensity analysis (WIA) of left ventricular (LV) filling dynamics by separating the pressure changes due to the windkessel from those due to traveling waves. With the use of LV compliance, the change in pressure due solely to ...
Triposkiadis Filippos - - 2007
OBJECTIVE: We sought to determine left atrial (LA) volume and systolic function (LA remodeling) in younger (<70 years) patients with systolic and diastolic heart failure (HF). METHODS: In all, 32 patients with diastolic HF (left ventricular [LV] ejection fraction > or = 0.50), 26 patients with systolic HF (LV ejection ...
Chung T - - 2007
BACKGROUND: Androgens have striking effects on skeletal muscle, but the effects on human cardiac muscle function are not well defined, neither has the role of metabolic activation (aromatization, 5alpha reduction) of testosterone on cardiac muscle been directly studied. OBJECTIVE: To assess the effects of testosterone and nandrolone, a non-amplifiable and ...
Nishizawa Takao - - 2007
Both enhanced sympathetic drive and altered autonomic control are involved in the pathogenesis of heart failure. The goal of the present study was to determine the extent to which chronically enhanced sympathetic drive, in the absence of heart failure, alters reflex autonomic control in conscious, transgenic (TG) rabbits with overexpressed ...
Fox Ervin R - - 2007
BACKGROUND: The distribution and determinants of left ventricular (LV) geometric patterns and their relation to LV function in African Americans is not well described despite higher rates of LV hypertrophy and cardiovascular mortality reported in this group. PURPOSE: This study investigates the distribution and clinical correlates of LV geometric patterns ...
Aydin Mehmet - - 2007
PURPOSE: The purpose of this study was to assess left ventricular (LV) function by gated SPECT in acute hypothyroidism. METHODS: Thirty-eight acute hypothyroid patients without any cardiac disease and 40 healthy controls underwent gated SPECT at rest. Fourteen patients had a second examination during thyroxine replacement therapy. Gated SPECT was ...
Shapiro Mia - - 2007
BACKGROUND: The third heart sound (S3) and systolic time intervals (STIs) are validated clinical indicators of left ventricular (LV) dysfunction. We investigated the test characteristics of a combined score summarizing S3 and STI results for predicting LV dysfunction. METHODS AND RESULTS: A total of 81 adults underwent computerized phonelectrocardiography for ...
McConnell Patrick I - - 2007
BACKGROUND: In this study we evaluate load-independent ventricular function during left ventricular assist device (LVAD) support based solely on telemetered measurements of left ventricular (LV) pressure, which has not been reported previously. METHODS: Adult sheep underwent placement of an axial-flow LVAD, a telemetered LV pressure manometer and instruments for pressure-volume ...
Sohn Dae-Won - - 2007
BACKGROUND: Prevention of tachycardia is an important therapeutic strategy in patients with relaxation abnormality. METHODS: Eleven patients with stable relaxation abnormality (group 1) and 8 healthy individuals (group 2) were enrolled. Left ventricular (LV) mean diastolic pressure, LV dimensions, stroke volume (SV), and LV ejection, filling, and isovolumic times between ...
Freihage Jeffrey H JH Department of Medicine, Division of Cardiology, Loyola University Medical Center, Maywood, Illinois 60153, USA. - - 2007
We sought to analyze several new hemodynamic characteristics which address the interplay of left atrial (LA) and left ventricular (LV) pressures, as well as to re-analyze several other V wave characteristics employed in the determination of mitral regurgitation (MR) severity in order to determine which, if any, had adequate correlation ...
Sharman James E - - 2007
Left ventricular (LV) diastolic dysfunction and increased arterial stiffness are prevalent in patients with type 2 diabetes mellitus (DM). Because the systemic vasculature plays a pivotal role in myocardial loading, this study aimed to determine the effect of arterial characteristics on LV diastolic function in patients with type 2 DM. ...
Sakata Susumu - - 2007
The aim of this study was to examine how global cardiac gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) can influence left ventricular (LV) mechanical and energetic function, especially in terms of O(2) cost of LV contractility, in normal rats. Normal rats were randomized to receive an adenovirus carrying the SERCA2a ...
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