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Results 151 - 200 of 2734
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Feng Wei - - 2009
BACKGROUND: Although cardiovascular magnetic resonance (CMR) is frequently performed to measure accurate LV volumes and ejection fractions, LV volume-time curves (VTC) derived ejection and filling rates are not routinely calculated due to lack of robust LV segmentation techniques. VTC derived peak filling rates can be used to accurately assess LV ...
Gedikli Omer - - 2009
BACKGROUND: The role of endogenous relaxin on hypertensive cardiovascular damage remains unknown. We investigated the relaxin level and its relation to cardiovascular function in patients with never treated hypertension (HT). METHODS: We studied 42 (47.8+/-10 years) never treated patients with HT and 40 age-matched (47+/-8.6 years) normotensive individuals. Serum relaxin ...
Elgeti Thomas - - 2009
PURPOSE OF STUDY: To compare magnetic resonance elastography (MRE) with ventricular pressure changes in an animal model. METHODS: Three pigs of different cardiac physiology (weight, 25 to 53 kg; heart rate, 61 to 93 bpm; left ventricular [LV] end-diastolic volume, 35 to 70 ml) were subjected to invasive LV pressure ...
Patel Dhaval R - - 2009
BACKGROUND: The aim of this study was to determine the accuracy, sensitivity, specificity, predictive values, and likelihood ratios of the left ventricular (LV) Tei index (TX) and the ratio of systolic duration to diastolic duration (S/D) to detect ventricular dysfunction. METHODS: LV systolic and diastolic function were studied in a ...
Scott Jessica M - - 2009
PURPOSES: To comprehensively investigate the cardiovascular consequences of a 160-km ultramarathon using traditional echocardiography, speckle tracking imaging, cardiac biomarkers, and heart rate variability (HRV) and to examine the relationship between the changes in these variables. METHODS: We examined athletes before an ultramarathon and reassessed all finishers immediately after the race. ...
Rudominer Rebecca L - - 2009
Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with premature atherosclerosis, vascular stiffening, and heart failure. This study was undertaken to investigate whether RA is associated with underlying structural and functional abnormalities of the left ventricle (LV). Eighty-nine RA patients without clinical cardiovascular disease and 89 healthy matched controls ...
Hettrick Douglas A DA Cardiac Rhythm and Disease Management Medtronic, Inc., Mounds View, MN 55112, USA. - - 2009
The ultimate hemodynamic sensor for an implantable device would provide information about cardiovascular performance including systolic function, diastolic function, preload, and afterload. We examined the potential clinical utility of simultaneous measurement of left ventricular pressure and continuous intrathoracic impedance in a group of 20 patients undergoing acute intravenous ablation for ...
Zhang Wei W Department of Physics, Washington University, USA. - - 2009
Using a simple harmonic oscillator model (PDF formalism), every early filling E-wave can be uniquely described by a set of parameters, (x(0), c, and k). Parameter c in the PDF formalism is a damping or relaxation parameter that measures the energy loss during the filling process. Based on Bernoulli's equation ...
Pavlopoulos Harry - - 2009
AIMS: Pulse pressure/stroke volume (PP/SV) is regarded as a surrogate index of arterial stiffness (AS). Strain echocardiography is a novel method to evaluate systolic and diastolic left ventricular (LV) function. The aim of this study was to investigate the effect of AS on segmental relaxation and systolic deformation in hypertensive ...
Malfatto Gabriella - - 2009
BACKGROUND: Diastolic dysfunction in long-term heart failure is accompanied by abnormal neurohormonal control and ventricular stiffness. The diastolic phase is determined by a balance between pressure gradients and intrinsic ventricular wall properties: according to a mathematical model, the latter (ie, left ventricular [LV] elastance, K(LV)) may be calculated by the ...
Shimizu Juichiro - - 2009
The external work (EW) efficiency of individual arrhythmic beats of the left ventricle (LV) cannot directly be obtained since LV O(2) consumption (VO(2)) of each beat cannot directly be measured under beat-to-beat varying contractile and loading conditions. We, however, have recently reported that VO(2) of each arrhythmic beat can reasonably ...
Palatini Paolo - - 2009
AIMS: The longitudinal relationship between aerobic exercise and left ventricular (LV) mass in hypertension is not well known. We did a prospective study to investigate the long-term effect of regular physical activity on development of LV hypertrophy (LVH) in a cohort of young subjects screened for Stage 1 hypertension. METHODS ...
Ihm Sang-Hyun - - 2009
BACKGROUND: Myocardial fibrosis is a feature of diastolic dysfunction and target organ damage, which was compared among subjects with normotension (NT), white-coat hypertension (WCH) and essential hypertension (EH). Serum procollagen type I propeptide (PIP) level was assessed as a marker of diastolic dysfunction in WCH. METHODS AND RESULTS: Of 90 ...
Ramani Gautam V - - 2009
BACKGROUND: Chronic pulmonary hypertension (PH) results in right ventricular (RV) mechanical dyssynchrony. However, its effects on left ventricular (LV) mechanics have not been examined. OBJECTIVE: Since speckle-tracking echocardiography (STE) is a novel approach to quantify LV dyssynchrony; we decided to use STE to assess the effect of PH on LV ...
Uemura Kazunori - - 2009
In acute heart failure, systemic arterial pressure (AP), cardiac output (CO), and left atrial pressure (P (LA)) have to be controlled within acceptable ranges. Under this condition, cardiac energetic efficiency should also be improved. Theoretically, if heart rate (HR) is reduced while AP, CO, and P (LA) are maintained by ...
Muranaka Atsuko - - 2009
BACKGROUND: Impaired left ventricular (LV) function is shown by strain rate (SR) imaging in patients with diabetes mellitus (DM). Left atrium (LA) function in patients with DM, however, has not been assessed by this method and the effect of hypertension (HT) on LV and LA functions in diabetic patients has ...
Sun Ying Y Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, Mich 48202-2689, - - 2009
Inducible NO synthase (iNOS) has been implicated in the pathogenesis of hypertension and target organ damage. We hypothesized that induction of iNOS contributes to left ventricular (LV) hypertrophy and dysfunction in mice with 2-kidney, 1-clip hypertension. Deletion of iNOS diminishes oxidative stress, thereby attenuating LV hypertrophy and enhancing cardiac performance. ...
Movahed Mohammad Reza - - 2009
BACKGROUND: Previous studies have demonstrated that obesity is one of the risk factors for congestive heart failure (CHF). By analyzing a large database, we investigated any association between body mass index (BMI) and left ventricular (LV) systolic dysfunction. METHODS: We retrospectively analyzed 24,265 echocardiograms performed between 1984 and 1998. Fractional ...
Elgeti Thomas - - 2008
OBJECTIVES: To develop cardiac magnetic resonance elastography (MRE) for noninvasively measuring left ventricular (LV) pressure-volume (P-V) work. MATERIAL AND METHODS: The anterior chest wall of 8 healthy volunteers was vibrated by 24.3-Hz acoustic waves for stimulating oscillating shear deformation in myocardium and adjacent blood. The induced motion was recorded by ...
Qie Liangyi - - 2008
BACKGROUND: Several studies have shown regional left ventricular (LV) systolic and diastolic changes associated with coronary artery disease (CAD). Statins may have beneficial pleiotropic effects in addition to their lipid-lowering properties. HYPOTHESIS: We hypothesized that atorvastatin can improve regional LV systolic and diastolic functions in CAD patients using tissue Doppler ...
Westermann Dirk - - 2008
Pharmacological renin inhibition with aliskiren is an effective antihypertensive drug treatment, but it is currently unknown whether aliskiren is able to attenuate cardiac failure independent of its blood pressure-lowering effects. We investigated the effect of aliskiren on cardiac remodeling, apoptosis, and left ventricular (LV) function after experimental myocardial infarction (MI). ...
Monreal Gretel - - 2008
AIMS: Fibrosis and myocyte hypertrophy are classical remodeling parameters in heart failure (HF); however, an intriguing possibility is that myocytes undergo intracellular remodeling which decrease compliance, contributing to diastolic dysfunction. The most obvious candidates are cytoskeletal proteins. The cytoskeletal protein desmin reinforces the sarcomeres, enabling force generation. As a contributor ...
Weytjens C - - 2009
In small animals studies, sick animals often have a significant reduction in heart rate while under anesthesia. The influence of heart rate reduction on Doppler myocardial imaging (DMI) parameters is not known. The aim of the present study was to assess the effect of heart rate reduction on DMI parameters ...
Nenadic Ivan - - 2008
Diastolic dysfunction is the impaired ability of the left ventricle (LV) to passively fill during diastole and maintain its stroke volume at physiologic filling pressures and is associated with impaired relaxation and reduced compliance of LV. Knowledge of the quantitative values of the myocardial viscoelastic properties would improve the clinician's ...
Ikonomidis I - - 2008
Systemic arterial stiffness is an indicator of cardiovascular disease and an independent marker of morbidity and cardiovascular mortality. We investigated the association of arterial wave reflections with left ventricular (LV) diastolic dysfunction and their incremental value to other determinants of LV diastolic dysfunction in patients with essential hypertension. In total ...
Padeletti Luigi - - 2008
Simultaneous stimulation of 2 left ventricular (LV) sites could enhance the effectiveness of cardiac resynchronization therapy (CRT). The aim of this study was to evaluate the acute hemodynamic response to dual-site LV CRT. Two LV pacing leads were successfully implanted in 12 CRT candidates (New York Heart Association classes III ...
Chinali Marcello M Department of Clinical and Experimental Medicine, Federico II University Hospital School of Medicine, Naples, Italy. - - 2008
Our aim was to evaluate the impact of metabolic syndrome (MetS) on cardiac phenotype in adolescents. A high prevalence of MetS has been reported in adolescents. Four hundred forty-six nondiabetic American Indian adolescents (age 14 to 20 years, 238 girls) underwent clinical evaluation, laboratory testing, and Doppler echocardiography. Age- and ...
Lim Young-Jae - - 2008
Clinical features of diastolic heart failure (DHF) have not been well characterized, leading to an inaccuracy in the diagnosis of DHF. Recently, the ratio of transmitral E velocity to early diastolic mitral annular velocity (E/E') has been shown to be useful to assess LV filling pressure. We tested the hypothesis ...
Sürücü Hüseyin - - 2008
OBJECTIVE: We investigated how velocity of isovolumetric relaxation period on pulsed-wave tissue Doppler trace (IVRa and IVRb) is affected by the left ventricular (LV) geometry changes. METHODS: Two hundred cases without exclusion criteria were included in the study. Normal LV mass index (LVMI) and normal relative wall thickness (RWT) was ...
Weeks Sarah G - - 2008
BACKGROUND: To evaluate the usefulness of currently accepted echocardiographic parameters of diastolic function to assess the acute change in left ventricular end-diastolic pressure (LVEDP) following the administration of nesiritide in a heart failure population. METHODS: In 25 heart failure patients (15 with systolic dysfunction, 10 with preserved ejection fraction [EF]), ...
Fujimoto Naoki - - 2008
Diastolic heart failure (DHF) has different underlying pathophysiologic mechanisms. We sought to compare hemodynamic characteristics in DHF patients with or without hypertension. A conductance catheter with microtip-manometer was used to measure left ventricular (LV) function and hemodynamics in 28 DHF patients. After baseline measurements, nitroglycerin was infused to alter the ...
Peters Dana C DC Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. - - 2008
To develop and validate a free-breathing cardiac cine acquisition, with potential to simplify cardiac MR studies, provide registered slices, and increase spatial resolution. A 2D free-breathing (FB) navigator-gated cine radial acquisition for cardiac function was developed that used two navigators (one placed prior to the QRS, and another 500 msec ...
Woodiwiss Angela J - - 2008
BACKGROUND: As it is uncertain whether excess adiposity promotes primarily concentric or eccentric left ventricular hypertrophy (LVH), we aimed to determine at a population level, the independent relationship between waist circumference (WC) and LV geometric changes and the potential hemodynamic mechanisms thereof. METHODS: We assessed the relations between WC and ...
Steine Kjetil - - 2008
Tissue Doppler imaging (TDI) has improved the ability to detect subclinical changes in left ventricular (LV) function. The aim of this study was to investigate if asymptomatic patients with moderate aortic stenosis (AS) had impaired LV systolic and diastolic function. Fifty patients (mean age 65 +/- 12 years) recruited into ...
Yano Naohiro - - 2008
The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates multiple cellular processes including cell survival/apoptosis and growth. In the cardiac context, PI3Kalpha plays important roles in cardiac growth. We have shown that cardiac PI3K activity is highly regulated during development, with the highest levels found during the fetal-neonatal transition period and the ...
Shapiro Brian P BP Cardiorenal Research Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN 55905, - - 2008
Advanced glycation end products (AGEs) are believed to increase left ventricular (LV) and vascular stiffness, in part via cross-linking proteins. We determined whether and where AGEs were increased in elderly hypertensive nondiabetic dogs and whether an AGE cross-link breaker (ALT-711) improved vascular or ventricular function. Elderly dogs with experimental hypertension ...
Ng Arnold C T - - 2008
Assessment of left ventricular (LV) dyssynchrony after myocardial infarction has prognostic value. There were no reference ranges for 2-dimensional (2D) speckle tracking synchrony, and it was unclear whether color tissue Doppler imaging and 2D speckle tracking synchrony indexes were comparable. One hundred twenty-two healthy volunteers and 40 patients with non-ST-elevation ...
Madias Christopher - - 2008
INTRODUCTION: Commotio cordis, sudden cardiac death secondary to blunt nonpenetrating chest blows in sports, is reported with increasing frequency. In a swine model, ventricular fibrillation (VF) is induced by a baseball blow to the chest, and the initiation of VF is related to the peak left ventricular (LV) pressure produced ...
Wakatsuki Yu - - 2009
PURPOSE: To evaluate left atrial (LA) function in subjects with early stage primary hypertension (HT) and without enlargement of LA, we used transthoracic echocardiogram and measured LA volumetric emptying fraction and compared the results with those in healthy volunteers. MATERIALS AND METHODS: 42 subjects with early stage primary HT (21 ...
Ghio Stefano - - 2008
AIM: We sought to verify which changes in right ventricular pressures occur before acute heart failure (HF) in patients with advanced systolic left ventricular (LV) dysfunction. In patients with chronic HF, continuous hemodynamic monitoring by implantable devices may detect increases in pulmonary pressures before the onset of symptoms. METHODS: A ...
Fornwalt Brandon K - - 2008
PURPOSE: To develop a method for quantifying left ventricular (LV) internal flow as a measure of dyssynchrony using standard cine cardiac magnetic resonance (CMR) images. MATERIALS AND METHODS: CMR images were obtained from 10 healthy controls and 10 patients with dyssynchronous heart failure (class III/IV, LV ejection fraction <35%, pattern ...
Hedhli Nadia N Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, - - 2008
We tested the possibility that proteasome inhibition may reverse preexisting cardiac hypertrophy and improve remodeling upon pressure overload. Mice were submitted to aortic banding and followed up for 3 wk. The proteasome inhibitor epoxomicin (0.5 mg/kg) or the vehicle was injected daily, starting 2 wk after banding. At the end ...
Zhang R - - 2008
Aim of this retrospective analysis was to evaluate the effects of ivabradine given primarily as a heart rate-lowering agent on allograft function and cardiopulmonary performance in heart transplant recipients with permanent sinus tachycardia. Starting May 2006, 26 heart transplant recipients with permanent sinus tachycardia received ivabradine (5 mg bid). It ...
Mornos Cristian - - 2009
BACKGROUND: Early diastolic transmitral velocity (E)/early mitral annular diastolic velocity (Ea) ratio has been proposed as the best Doppler predictor for evaluating left ventricular (LV) filling pressure. PURPOSE: To evaluate the relationship between a novel echocardiographic index, E/(EaxSa), and left ventricular end-diastolic pressure (LVEDP); Sa is the peak systolic mitral ...
Soliman Osama I I - - 2008
The aim of this study was to investigate the accuracy and reproducibility of the quantification of left ventricular (LV) function by real-time 3-dimensional echocardiography (RT3DE) using current state-of-the-art hardware and software. Compared with cardiac magnetic resonance (CMR), previous generations of hardware and software for RT3DE significantly underestimated LV volumes partly ...
Biederman Robert W W RW Division of Cardiology, Department of Cardiovascular MRI, Gerald McGuiness Center, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA. - - 2008
Concentric hypertensive left ventricular (LV) hypertrophy is presumed to be a symmetrical process. Using MRI-derived intramyocardial strain, we sought to determine whether segmental deformation was also symmetrical, as suggested by echocardiography. High echocardiographic LV relative wall thickness in hypertensive LV hypertrophy allows preserved endocardial excursion despite depressed LV midwall shortening ...
Galderisi Maurizio - - 2008
BACKGROUND: It has been recognized that "cross-talk" occurs between coronary flow and left ventricular (LV) function. This study tested the hypothesis that impairment of coronary flow reserve (CFR) in arterial hypertension is associated with LV systolic and diastolic dysfunction, independent of abnormalities in LV geometry. METHODS: We studied 59 newly ...
Su Ho-Ming - - 2008
Various patterns of mid-diastolic mitral annular motion may imply different left ventricular (LV) diastolic function and filling pressure. To be a reliable marker in the evaluation of LV diastolic function and filling pressure, these findings must be validated by invasive method. Hence, this study was designed to compare the LV ...
Kim Hyungseop - - 2008
Hypertension is an important contributor to different left ventricular (LV) geometric patterns with resultant myocardial dysfunction. Strain rate image (SRI) has been suggested as a useful tool for the evaluation of myocardial function. The aim of this study was to assess whether SRI correlates with LV geometric patterns in hypertensive ...
Lalande Sophie S Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, - - 2008
Diastolic heart failure is characterized by the symptoms and signs of heart failure, a preserved ejection fraction and abnormal left ventricular (LV) diastolic function caused by a decreased LV compliance and relaxation. The signs and symptoms of diastolic heart failure are indistinguishable from those of heart failure related to systolic ...
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