Search Results
Results 451 - 500 of 2735
< 5 6 7 8 9 10 11 12 13 14 15 >
Shapiro Mia - - 2007
BACKGROUND: The third heart sound (S3) and systolic time intervals (STIs) are validated clinical indicators of left ventricular (LV) dysfunction. We investigated the test characteristics of a combined score summarizing S3 and STI results for predicting LV dysfunction. METHODS AND RESULTS: A total of 81 adults underwent computerized phonelectrocardiography for ...
McConnell Patrick I - - 2007
BACKGROUND: In this study we evaluate load-independent ventricular function during left ventricular assist device (LVAD) support based solely on telemetered measurements of left ventricular (LV) pressure, which has not been reported previously. METHODS: Adult sheep underwent placement of an axial-flow LVAD, a telemetered LV pressure manometer and instruments for pressure-volume ...
Nishizawa Takao - - 2007
Both enhanced sympathetic drive and altered autonomic control are involved in the pathogenesis of heart failure. The goal of the present study was to determine the extent to which chronically enhanced sympathetic drive, in the absence of heart failure, alters reflex autonomic control in conscious, transgenic (TG) rabbits with overexpressed ...
Chung T - - 2007
BACKGROUND: Androgens have striking effects on skeletal muscle, but the effects on human cardiac muscle function are not well defined, neither has the role of metabolic activation (aromatization, 5alpha reduction) of testosterone on cardiac muscle been directly studied. OBJECTIVE: To assess the effects of testosterone and nandrolone, a non-amplifiable and ...
Freihage Jeffrey H JH Department of Medicine, Division of Cardiology, Loyola University Medical Center, Maywood, Illinois 60153, USA. - - 2007
We sought to analyze several new hemodynamic characteristics which address the interplay of left atrial (LA) and left ventricular (LV) pressures, as well as to re-analyze several other V wave characteristics employed in the determination of mitral regurgitation (MR) severity in order to determine which, if any, had adequate correlation ...
Triposkiadis Filippos - - 2007
OBJECTIVE: We sought to determine left atrial (LA) volume and systolic function (LA remodeling) in younger (<70 years) patients with systolic and diastolic heart failure (HF). METHODS: In all, 32 patients with diastolic HF (left ventricular [LV] ejection fraction > or = 0.50), 26 patients with systolic HF (LV ejection ...
Aydin Mehmet - - 2007
PURPOSE: The purpose of this study was to assess left ventricular (LV) function by gated SPECT in acute hypothyroidism. METHODS: Thirty-eight acute hypothyroid patients without any cardiac disease and 40 healthy controls underwent gated SPECT at rest. Fourteen patients had a second examination during thyroxine replacement therapy. Gated SPECT was ...
Sharman James E - - 2007
Left ventricular (LV) diastolic dysfunction and increased arterial stiffness are prevalent in patients with type 2 diabetes mellitus (DM). Because the systemic vasculature plays a pivotal role in myocardial loading, this study aimed to determine the effect of arterial characteristics on LV diastolic function in patients with type 2 DM. ...
Nguyen Tom C TC Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305-5247, United - - 2007
Septal-lateral annular cinching ('SLAC') corrects both acute and chronic ischemic mitral regurgitation in animal experiments, which has led to the development of therapeutic surgical and interventional strategies incorporating this concept (e.g., Edwards GeoForm ring, Myocor Coapsys, Ample Medical PS3). Changes in left ventricular (LV) transmural cardiac and fiber-sheet strains after ...
Sakata Susumu - - 2007
The aim of this study was to examine how global cardiac gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) can influence left ventricular (LV) mechanical and energetic function, especially in terms of O(2) cost of LV contractility, in normal rats. Normal rats were randomized to receive an adenovirus carrying the SERCA2a ...
Sakata Susumu S Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, - - 2007
The aim of this study was to examine whether short- and long-term gene transfer of Ca(2+) handling proteins restore left ventricular (LV) mechanoenergetics in aortic banding-induced failing hearts. Aortic-banded rats received recombinant adenoviruses carrying sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) (Banding+SERCA), parvalbumin (Banding+Parv) or beta-galactosidase (Banding+betagal), or an adeno-associated virus carrying SERCA2a ...
Erdogan Dogan - - 2007
BACKGROUND: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (BP) provides guideline for the new category of BP levels as normal, prehypertension (PHT), and hypertension. Although PHT is associated with a markedly increased risk of developing hypertension within 4 years, ...
de Cock Carel C - - 2007
BACKGROUND: Cardiac resynchronization therapy (CRT) improves left ventricular (LV) systolic function and clinical status, and prolongs survival of patients suffering from heart failure. An optimal LV site selection is key with respect to improvements in systolic function, though whether a site-specific effect on diastolic function exists is unclear. This study ...
Henderson Brooke C - - 2007
Elevated oxidative stress has been characterized in numerous disorders including systemic hypertension, arterial stiffness, left ventricular hypertrophy (LVH) and heart failure. The peroxisome proliferator activated receptor gamma (PPARgamma) ameliorates oxidative stress and LVH. To test the hypothesis that PPARgamma decreased LVH and cardiac fibrosis in chronic pressure overload, in part, ...
DuszaƄska Agata - - 2007
Incessant tachycardia may result in left ventricular (LV) systolic dysfunction. Little is known about the influence of atrioventricular tachycardia (AVRT) and atrioventricular nodal re-entrant tachycardia (AVNRT) on LV systolic and diastolic function. The aim of the study was to assess LV systolic and diastolic function and factors affecting LV systolic ...
Prefumo F - - 2007
OBJECTIVE: To compare the maternal cardiac function and serum concentration of cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in first-trimester patients, according to uterine artery Doppler velocimetry (UADV). METHODS: This cross-sectional study included singleton pregnancies with normal UADV (n=17) and abnormal UADV (n=19). Maternal echocardiography was performed ...
Zizek Bogomir - - 2007
OBJECTIVES: We aimed to investigate left ventricular (LV) morphology and function in normotensive offspring of subjects with essential hypertension (familial trait - FT), and to determine the association between LV mass and determinants of LV diastolic function and endothelium-dependent (NO-mediated) dilation of the brachial artery (BA). MATERIALS AND METHODS: The ...
Frenneaux Michael - - 2007
Chronic heart failure is a common clinical problem, and, until recently, attention has focused predominantly on those patients with reduced left ventricular (LV) systolic function, as evidenced by a reduced LV ejection fraction. However, nearly half of all patients thought clinically to have heart failure have a "preserved" LV ejection ...
Simko F - - 2007
Aldosterone receptor antagonist, spironolactone, has been shown to prevent remodeling of the heart in several models of left ventricular hypertrophy. The aim of the present study was to determine whether the treatment with spironolactone can prevent hypertension, reduction of tissue nitric oxide synthase activity and left ventricular (LV) and aortic ...
Liang Yuanhong - - 2007
Gene therapy has been applied to reduce blood pressure in rats. However, little is known about the effects of gene therapy on both blood pressure and left ventricular (LV) remodeling. This study was designed to compare the antihypertensive effect of ss(1) adrenergic receptor antisense oligodeoxynucleotides (ss(1)- AS-ODN) by delivery with ...
Sigfridsson Andreas - - 2007
PURPOSE: To develop a new volumetric imaging method resolved over both the cardiac and respiratory cycles, to enable future physiological and pathophysiological studies of respiratory-related cardiac motion. MATERIALS AND METHODS: An acquisition scheme is proposed whereby the k-space acquisition order is controlled in real-time by the current cardiac and respiratory ...
Ma Zhi-Yong - - 2007
Despite normal indices of left-ventricular (LV) chamber function, patients with hypertension are thought to have depressed LV midwall systolic shortening. This study was designed to investigate effects of short-term therapy with cilnidipine on LV midwall fractional shortening (mFS) in Chinese patients with hypertension. Thirty-seven patients with mild to moderate essential ...
Krenning Boudewijn J - - 2007
BACKGROUND: The effects of hemodialysis (HD) on left ventricular (LV) function have been studied by various echocardiographic techniques (M-mode, 2D echocardiography). These studies are hampered by a low accuracy of measurements because of geometric assumptions regarding LV shape. Three-dimensional echocardiography (3DE) overcomes this limitation. METHODS: We tested the feasibility of ...
Chiladakis John A - - 2007
BACKGROUND: Atrial synchronous right ventricular pacing (VP) may compromise ventricular function in patients undergoing pacemaker implantation for atrioventricular block. We assessed the usefulness of tissue Doppler imaging (TDI) and color M-mode echocardiography in evaluating patients with VP, and examined the long-term effects of VP on ventricular function by echocardiographic indices ...
Su Ho-Ming - - 2007
BACKGROUND: The T(Ea-E), which is defined as the time interval between the peak of the R-wave and the onset of early diastolic mitral annular waveform (T(Ea)) minus the time interval between the peak of the R-wave and the onset of early diastolic mitral inflow waveform (T(E)), is recently proposed as ...
Kirn Borut - - 2007
We studied the variation from the simultaneous contraction of the normal left ventricle (LV). The pattern of the contraction along the LV long axes was assessed on the LV free wall on seven guinea pig hearts in situ with ultra fast video system and epicardial markers by means of the ...
Bergman Marina R - - 2007
Although enhanced cardiac matrix metalloproteinase (MMP)-2 synthesis has been associated with ventricular remodeling and failure, whether MMP-2 expression is a direct mediator of this process is unknown. We generated transgenic mice expressing active MMP-2 driven by the alpha-myosin heavy chain promoter. At 4 mo MMP-2 transgenic hearts demonstrated expression of ...
Jegger David - - 2007
It has been suggested that the shape of the normalized time-varying elastance curve [E(n)(t(n))] is conserved in different cardiac pathologies. We hypothesize, however, that the E(n)(t(n)) differs quantitatively after myocardial infarction (MI). Sprague-Dawley rats (n = 9) were anesthetized, and the left anterior descending coronary artery was ligated to provoke ...
Fielitz Jens - - 2007
Pressure overload leads to myocardial remodelling with collagen accumulation, left ventricular hypertrophy (LVH), neurohormonal activation and myocardial dysfunction. Prolyl 4-hydroxylases (P4H) are involved in collagen maturation. Inhibition of P4H has been shown to prevent LV remodelling and improve survival post-myocardial infarction. To evaluate the role of P4H in pressure overload-induced ...
Jenkins Carly - - 2007
Echocardiographic follow-up of left ventricular (LV) volumes is difficult because of the test-retest variation of 2-dimensional echocardiography (2DE). We investigated whether the accuracy and reproducibility of real-time 3-dimensional echocardiography (RT3DE) would make this modality more feasible for serial follow-up of LV measurements. We performed 2DE and RT3DE and cardiac magnetic ...
Balakumar Pitchai - - 2006
The present study has been designed to investigate the effect of Ac-DEVD-CHO, a specific caspase-3 inhibitor in partial abdominal aortic constriction for 4 week-induced pathological and chronic swimming training for 8 week-induced physiological cardiac hypertrophy. Ac-DEVD-CHO (2 mg/kg intraperitoneally, day(-1)) treatment was started three days before partial abdominal aortic constriction ...
Lemmens Katrien - - 2007
Left ventricular (LV) hypertrophy (LVH) is an adaptive response to hemodynamic overload, but also contributes to the pathogenesis of heart failure. LVH can be concentric (cLVH) but subsequent dilatation and progression to eccentric hypertrophy (eLVH) may lead to global pump failure. Recently, several endogenous molecular inhibitors of hypertrophy have been ...
Avelar Erick - - 2007
Obese subjects have a high prevalence of left ventricular (LV) hypertrophy. It is unclear to what extent LV hypertrophy results directly from obesity or from associated conditions, such as hypertension, impaired glucose homeostasis, or obstructive sleep apnea. We tested the hypothesis that LV hypertrophy in severe obesity is associated with ...
Butler Javed - - 2007
Along with coronary evaluation, 64-slice multidetector computed tomography (MDCT) permits comprehensive assessment of left ventricular (LV) anatomy and function; however, how it compares with 2-dimensional transthoracic echocardiography (TTE) in patients with heart failure (HF) is not known. In this study, we compared 25 patients with ejection fractions of <45% who ...
Brickson S S Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53711, USA. - - 2007
Cardiac myosin binding protein-C (cMyBP-C) is a thick filament-associated protein that binds tightly to myosin and has a potential role for modulating myocardial contraction. We tested the hypothesis that cMyBP-C 1) contributes to the enhanced in vivo contractile state following beta-adrenergic stimulation and 2) is necessary for myocardial adaptation to ...
Moorjani Narain - - 2007
BACKGROUND: Cardiomyocyte apoptosis is implicated in the pathogenesis of heart failure and mitochondria play an important role in this mode of cell death. In this study, activity of the Bcl-2 family of mitochondrial apoptotic proteins and their regulator (p53) were assessed during the transition to heart failure. METHODS: Ten adult ...
Kim Hyung Kook - - 2007
OBJECTIVE: To compare estimates of left ventricular (LV) end-systolic elastance created by inferior vena caval (IVC) occlusion with those by apneic continuous positive airway pressure (CPAP). DESIGN AND SETTING: Prospective interventional study in a university large animal research laboratory. SUBJECTS: Sixteen intact, pentobarbital-anesthetized mongrel male dogs. INTERVENTIONS: Insertion of LV ...
Yu Cheuk-Man - - 2007
OBJECTIVES: The present study aimed to examine whether diastolic and systolic asynchrony exist in diastolic heart failure (DHF) and their prevalence and relationship to systolic heart failure (SHF) patients. BACKGROUND: Few data exist on mechanical asynchrony in DHF. METHODS: Tissue Doppler echocardiography was performed in 373 heart failure patients (281 ...
Bedi Maninder - - 2006
BACKGROUND: Wide QRS complexes are associated with left ventricular (LV) dyssynchrony, but an optimal site of LV pacing has not been established. HYPOTHESIS: We hypothesized that concordance between the sites of LV pacing and of latest LV mechanical activation during cardiac resynchronization therapy (CRT) is associated with more favorable acute ...
Govind Satish C - - 2006
BACKGROUND: The advent of colour-coded tissue velocity echocardiography (TVE) has now made it possible to quantify left ventricular (LV) functions in patients with systemic arterial hypertension (HTN). Hypothesis In this project, we have studied the cardiac effects of a single dose of orally administered valsartan in patients with known HTN. ...
Grandi Anna Maria - - 2006
In our retrospective study, we evaluated whether ACE inhibitors can influence left ventricular (LV) morphofunctional characteristics in essential hypertension independently of the antihypertensive effect. We studied 21 hypertensive patients (group 1) before and after at least 18 months of treatment with ACE inhibitors that did not induce any blood pressure ...
George Isaac - - 2007
OBJECTIVE: Passive restraint of the left ventricle (LV) has been shown to have beneficial effects on acute hemodynamics and reverse remodeling in both animal and human models. The goals of this study were to test whether a left ventricular support device (LVSD) improves LV synchrony and/or affects cardiac performance. METHODS: ...
Ogunyankin Kofo O - - 2006
BACKGROUND: Commonly used echocardiographic indices for grading diastolic function predicated on mitral inflow Doppler analysis have a poor diagnostic concordance and discriminatory value. Even when combined with other indices, significant overlap prevents a single group assignment for many subjects. We tested the relative validity of echocardiographic and clinical algorithms for ...
Lavine Steven J - - 2006
BACKGROUND: Decompensated heart failure with preserved left ventricular (LV) ejection fraction (EF) is often accompanied by hypertensive episodes. We hypothesized that acute increase in arterial pressure results in elevated early and late diastolic LV pressures as a result of further impaired LV relaxation. METHODS: To test this hypothesis, we used ...
Vaskelyte Jolanta - - 2006
BACKGROUND AND AIM OF THE STUDY: The issues regarding the appropriate management of patients with ischemic mitral regurgitation (MR) and advanced left ventricular (LV) dysfunction are controversial and limited. The present study was undertaken to evaluate the mid-term dynamics of MR, LV dimensions, function and NYHA functional class in patients ...
Muiesan M Lorenza - - 2006
BACKGROUND: The appropriateness of left ventricular (LV) mass to cardiac workload may be calculated by the ratio of observed LV mass to the value predicted for an individual's sex, height, and stroke work at rest. OBJECTIVE: To investigate test-retest reproducibility of observed/predicted LV mass in a single patient. DESIGN AND ...
Goland Sorel - - 2006
Nonalcoholic fatty liver disease (NAFLD) is linked to the metabolic syndrome. The aim of the present study is to determine the effect of the metabolic syndrome on left ventricular (LV) geometry and function using as a model patients with NAFLD. Thirty-eight patients with NAFLD, less than 55 years of age ...
Le Corvoisier Philippe - - 2007
CONTEXT: Experimental studies suggest that GH treatment may improve cardiovascular parameters in chronic heart failure (CHF). However, clinical trials involved small numbers of patients and did not allow a conclusion to be drawn on the effect of this treatment in humans. OBJECTIVE: We systematically reviewed and analyzed all randomized controlled ...
Thai Hoang - - 2006
This study was designed to determine the effects of pretreatment with an angiotensin receptor blocker on left ventricular (LV) function and remodeling during acute myocardial infarction (MI). Sprague-Dawley rats were pretreated with candesartan (10 mg x kg(-1) x d(-1)) for 2 weeks and studied at 1, 3, and 6 minutes ...
Innelli Pasquale - - 2006
OBJECTIVE: The aim of this study was to evaluate the incremental diagnostic role of tissue Doppler in primary cardiac amyloidosis (CA). METHODS: Eleven patients with CA at diagnosis and 11 healthy controls, matched for sex and age, underwent standard Doppler echocardiography and pulsed tissue Doppler of the left ventricular (LV) ...
< 5 6 7 8 9 10 11 12 13 14 15 >