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Slusarz Katherine M KM Center for Neurofibromatosis and Allied Disorders, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, - - 2014
Bevacizumab treatment is associated with tumor shrinkage and hearing improvement in about 50 % of neurofibromatosis 2 (NF2) patients with progressive vestibular schwannomas. Hypertension and proteinuria are common side effects of treatment. However, the long-term toxicity of bevacizumab in this population has not been reported. We reviewed the medical records of ...
Karovic Sanja S Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois, - - 2014
Hypertension with vascular endothelial growth factor (VEGF) receptor inhibitors is associated with superior treatment outcomes for advanced cancer patients. To determine whether increased doses of sorafenib cause incremental increases in blood pressure (BP) we measured 12-hour ambulatory BP in 41 normotensive advanced solid tumor patients in a randomized dose escalation ...
Volpe Massimo M Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035-39, 00189, Rome, Italy, - - 2014
Hypertension is a major modifiable risk for the development of cardiovascular, cerebrovascular and renal diseases. Thus, effective treatment of high blood pressure is an important strategy for reducing disease burden; however, in spite of the availability of numerous effective therapies only 30-40 % of patients with hypertension achieve the recommended blood ...
Richards Tiffany R TR Division of Nephrology, Sunnybrook Health Sciences Centre, Toronto, Ontario, - - 2014
Combining multiple classes of antihypertensive drugs together is one of the most important factors for achieving blood pressure control in most hypertensive patients. The benefits of combination therapy in comparison with monotherapy include: a synergistic enhancement of each drug's hypertensive effects and a potential reduction of side effects if each ...
Mahmood Shahid S Mechanical Engineering Department, Chung-Ang University, Seoul 156-756, Republic of - - 2014
The velocity profile and radiation pressure field of a bubble cluster containing several thousand micro bubbles were obtained by solving the continuity and momentum equations for the bubbly mixture. In this study, the bubbles in the cluster are assumed to be generated and collapsed synchronously with an applied ultrasound. Numerical ...
Lawrence Gould A A Merck Research Laboratories, West Point, PA, - - 2014
This study compared blood pressure (BP) changes after 8 weeks of therapy between a fixed-dose combination (FDC) of amlodipine/losartan and amlodipine/valsartan using a network meta-analysis because no trials directly compared amlodipine/losartan with other FDCs. A systematic search identified six randomised controlled trials (amlodipine/losartan-3, amlodipine/valsartan-3) of FDCs and their component monotherapies. Conventional ...
Liu Donald D Department of Dermatology, University of Edinburgh, Edinburgh, - - 2014
The incidence of hypertension and cardiovascular disease correlates with latitude and rises in winter. The molecular basis for this remains obscure. As nitric oxide (NO) metabolites are abundant in human skin we hypothesised that exposure to UVA may mobilise NO bioactivity into the circulation to exert beneficial cardiovascular effects independently ...
Tamargo Juan J Universidad Complutense, School of Medicine, Department of Pharmacology , Madrid , - - 2014
Introduction: Thiazides and thiazide-like diuretics inhibit the electroneutral Na(+)-Cl(-) cotransporter located on the apical membrane of the early segment of the distal convoluted tubule. They have been widely prescribed over 60 years in the treatment of hypertension and various edematous states. Areas covered: Thiazide diuretics reduce blood pressure (BP), although ...
Xue Pengchong P State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, P. R. China. xuepengchong@jlu.edu.cn - - 2014
A triphenylamine-based benzoxazole derivative exhibits a low contrast piezofluorochromic behavior under external pressure, and a high-contrast fluorescence change induced by protonation can be observed.
Wong Gavin Wk GW Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada, V6T - - 2014
Beta-blockers are one of the classes of drugs frequently used to treat hypertension. Quantifying the blood pressure (BP) lowering effects of nonselective beta-blockers provides important information that aids clinical decision making. To quantify the dose-related effects of nonselective beta-adrenergic receptor blockers (beta-blockers) on systolic blood pressure (SBP) and diastolic blood ...
Wang Qiming Q Institute of Atomic and Molecular Physics, Sichuan University, Chengdu 610065, - - 2014
The x-ray diffraction study of 12 nm CeO2 was carried out up to ~40 GPa using an angle dispersive synchrotron-radiation in a diamond-anvil cell with different pressure transmitting medium (PTM) (4:1 methanol: ethanol mixture, silicone oil and none) at room temperature. While the cubic fluorite-type structure CeO2 was retained to the highest ...
- - 2013
The prevalence of resistant hypertension (ReHy) is not well established. Furthermore, diuretics, angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers, and calcium channel blockers are largely used as the first 3-drug combinations for treating ReHy. However, the fourth drug to be added to the triple regimen is still controversial and guided by ...
Yoshida Masahiro M Department of Physics, Tohoku University, Sendai 980-8578, - - 2014
A single-crystal momentum-resolved resonant inelastic X-ray scattering (RIXS) experiment under high pressure using an originally designed diamond anvil cell (DAC) is reported. The diamond-in/diamond-out geometry was adopted with both the incident and scattered beams passing through a 1 mm-thick diamond. This enabled us to cover wide momentum space keeping the scattering ...
Bakris George - - 2013
Despite the high prevalence of hypertension and documented benefits of blood pressure (BP) control, >40% of patients with hypertension are not controlled. A majority of uncontrolled hypertensive patients receive two or more antihypertensive drugs. The current review examined the relationship between antihypertensive combination drug therapy, achievement of goal BP, and ...
Potúcek P P Department Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. - - 2013
In the last decade, a number of clinical studies identified an additional improvement of blood pressure control if the single drug treatment is time-targeted in hypertensive individuals. On the other hand, only a few of them investigated whether any different antihypertensive effects with combination therapy can be confirmed between morning ...
Ram C Venkata S CV Texas Blood Pressure Institute, Dallas Nephrology Associates, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. - - 2013
Hypertension remains uncontrolled in approximately 50% of patients with hypertension, which increases the risk of cardiovascular morbidity and mortality in these individuals. A key factor contributing to poor blood pressure (BP) control is nonadherence to prescribed antihypertensive medications. Improving patient adherence to antihypertensive therapy is the key to improving BP ...
Kamal Sahar Mohamed SM Department of Pharmacology, Faculty of Medicine, University of Ain-Shams, - - 2013
Calcium channel blockers are increasingly used for the treatment of hypertension. Hypertension is an important risk factor for liver damage and several other circulatory abnormalities. The aim of this study was to determine the effects of lacidipine in a irradiation-induced hepatocellular damage model in Deoxyc Orticosterone Acetate (DOCA)-salt-induced hypertensive model ...
Chung M - - 2013
A major technological challenge in building a muon cooling channel is operating rf cavities in multitesla external magnetic fields. We report the first proof-of-principle experiment of a high pressure gas-filled rf cavity for use with intense ionizing beams and strong external magnetic fields. rf power consumption by beam-induced plasma is ...
von Paris P - - 2013
Abstract Ice-albedo feedback is a potentially important destabilizing effect for the climate of terrestrial planets. It is based on the positive feedback between decreasing surface temperatures, an increase of snow and ice cover, and an associated increase in planetary albedo, which then further decreases surface temperature. A recent study shows ...
Sergueev I - - 2013
Magnetic and elastic properties of Ni metal have been studied up to 260 GPa by nuclear forward scattering of synchrotron radiation with the 67.4 keV Mössbauer transition of ^{61}Ni. The observed magnetic hyperfine splitting confirms the ferromagnetic state of Ni up to 260 GPa, the highest pressure where magnetism in any material has ...
Neldam S - - 2013
Rapid and sustained blood pressure (BP) goal attainment is important to reduce cardiovascular risk. Initial use of combination therapy may improve BP goal attainment. The Boehringer Ingelheim trial database was searched for randomised, double-blind studies comparing telmisartan/amlodipine combination therapy with monotherapy. Eight studies were identified. Eight separate analyses were used ...
Kong P P - - 2013
The pressure-induced superconductivity and structural evolution of Bi2Se3 single crystals are studied. The emergence of superconductivity at an onset transition temperature (Tc) of about 4.4 K is observed at around 12 GPa. Tc increases rapidly to a maximum of 8.2 K at 17.2 GPa, decreases to around 6.5 K at 23 GPa, and then remains almost ...
Epstein Benjamin J - - 2013
The objective of this review is to evaluate the role of fixed-dose triple-combination therapy for the management of hypertension. An assessment of clinical trials showed that half the patients with hypertension have uncontrolled blood pressure (BP), with underlying factors including therapeutic inertia and poor patient adherence. Many patients will require ...
Hadi Hadil Al - - 2013
The cellular and molecular mechanism through which hyperbaric oxygen therapy (HBO) improves osteonecrosis (ON) is unclear. The present study therefore examined the effect of HBO, pressure and hyperoxia on RANKL-induced osteoclast formation in RAW 264.7 cells and human peripheral blood monocytes (PBMC). Daily exposure to HBO (2.4 ATA, 97% O2 ...
Maron Y - - 2013
Detailed spectroscopic diagnostics of the stagnating plasma in two disparate z pinches allow, for the first time, the examination of the plasma properties within a 1D shock wave picture, demonstrating a good agreement with this picture. The conclusion is that for a wide range of imploding-plasma masses and current amplitudes, ...
Chan Martin C W - - 2013
Rotavirus is a leading cause of severe infectious diarrhea in infants and young children aged <5 years. Rotavirus infections have minimal to strong seasonality depending on geographical locations. In this study, a comprehensive retrospective analysis was performed to evaluate the association between rotavirus admission and multiple key meteorological variables, including ...
Sosner Philippe - - 2013
The aim of this French observational study was to evaluate how the direct renin inhibitor aliskiren is being prescribed to treat hypertension by primary care providers (PCPs) and office-based cardiologists. Each participating physician included the first three consecutive hypertensive patients who had been prescribed aliskiren at least 4 weeks beforehand ...
Rao N Srinivasa NS Department of General Medicine, Osmania General Hospital and Medical College, Hyderabad, Andhra Pradesh, - - 2013
This open-labeled, post-marketing study was conducted to assess the efficacy and tolerability of fixed dose combination of amlodipine and metoprolol extended release capsules in mild to moderate hypertension in adult Indian patients. Of 101 enrolled patients, 64 drug naïve patients were treated with regimen A (amlodipine 5 mg + metoprolol ...
Quan Zewei - - 2013
Combining in-situ high-pressure X-ray scattering with transmission electron microscopy, we investigated the pressure-induced structural switches between the rock salt and amorphous phases as well as the associated mechanisms of their crystallization and growth in 6 nm PbTe nanoparticle. It was observed that rock salt PbTe nanoparticle started to become amorphous ...
Gee Kent L - - 2013
Spatial properties of noise statistics near unheated, laboratory-scale supersonic jets yield insights into source characteristics and near-field shock formation. Primary findings are (1) waveforms with positive pressure skewness radiate from the source with a directivity upstream of maximum overall level and (2) skewness of the time derivative of the pressure ...
Inoue Masafumi - - 2013
The structural colored balloons (SCBs) composed of poly(vinyl cinnamate) (PVCi) showed solvent responsiveness of structural color by the change of shell thickness along with the size change by osmotic pressure and the gradual color change could be controlled by UV irradiation. The rate of size change was decreased by the ...
Russell David J - - 2013
Abstract Purpose: To describe the effect of radiation therapy on intraocular pressure in patients who have had orbital radiation for Graves' orbitopathy, and to provide a descriptive analysis of these patients. Design: Retrospective case series. Participants: 24 consecutive patients referred for orbital radiation therapy for Graves' orbitopathy from December 1st, ...
Farah Raymond - - 2013
OBJECTIVE: Uncontrolled hypertension is present in most patients treated with only a single morning dose or fixed dose drug combination; usually a third of them have a high prevalence of a nondipper blood pressure pattern, especially patients with chronic illness. In most cases, nondipping is related partly to the absence ...
Gorostidi Manuel - - 2013
Hypertension is recognized as a major risk factor for cardiovascular and renal diseases and represents the leading cause of mortality worldwide. In spite of proven benefits of hypertension treatment, blood pressure control rates are poor, even in high-income countries with virtually full-access to therapies. Nearly 75% of hypertensive patients do ...
Facta Stefania - - 2013
ABSTRACT: Use of ultraviolet radiation-emitting tanning devices has been classified as "carcinogenic to humans" (group 1) by the International Agency for Research on Cancer. Following this classification, the knowledge of typical ultraviolet emission levels from tanning devices can be of interest for evaluating their impact on health. In this work, ...
Kulkarni Ranganath R - - 2013
Disulfiram (DSF) is one of the recommended aids in the management of alcohol dependence. Hypertension may be a clinically significant, dose-dependent, and usually reversible adverse event of DSF therapy. We report 6 month prospective study of normotensive case of comorbid alcohol and tobacco dependence that developed reversible stage-II hypertension within ...
Garnock-Jones Karly P - - 2013
Combination therapy is often required in patients with hypertension, and fixed-dose single-pill combinations have been shown to provide an easier regimen for patients, improving adherence. Irbesartan/amlodipine (Aprovasc(®)) is an angiotensin-receptor blocker/calcium-channel blocker fixed-dose single-pill combination, whose constituent drugs exert additive effects when coadministered. In two randomized, open-label, multicentre, phase III ...
Santoro Mario - - 2013
Meso/micro-porous solids, such as zeolites, are complex materials used in an impressive range of applications. Here we photo-polymerized ethylene using non-catalytic high-pressure techniques at 0.5-1.5 GPa under ultraviolet (351-364 nm) irradiation on a sub-nanometre scale in the channels of a pure SiO zeolite, silicalite, to obtain a unique nano-composite material with drastically ...
Salamat Ashkan - - 2013
There is interest in identifying novel materials for use in radioactive waste applications and studying their behavior under high pressure conditions. The mineral zirconolite (CaZrTi(2)O(7)) exists naturally in trace amounts in diamond-bearing deep-seated metamorphic/igneous environments, and it is also identified as a potential ceramic phase for radionuclide sequestration. However, it ...
Ceppatelli Matteo - - 2013
A high-pressure job: Under high-pressure conditions, within a diamond anvil cell, irradiation of red phosphorus (see scheme, orange) and water was found to lead to a reaction that gives H(2) , PH(3) , H(3) PO(2) , H(3) PO(4) , and H(3) PO(4) (H gray, O red, P orange). This reaction ...
Maxit Laurent - - 2013
Stiffened structures excited by the turbulent boundary layer (TBL) occur very frequently in engineering applications; for instance, in the wings of airplanes or the pressure hulls of submarines. To improve knowledge of the interaction between stiffened structures and TBL, this paper deals with the modeling of infinite periodically stiffened plates ...
Mallat Samir G - - 2013
Hypertension (HTN) is a worldwide health problem and a major preventable risk factor for cardiovascular (CV) events. Achieving an optimal blood pressure (BP) target for patients with HTN will often require more than one BP-lowering drug. Combination therapy is not only needed, but also confers many advantages such as better ...
Ogawa Rei - - 2013
Introduction: Many cases of severe keloid are associated with high blood pressure (hypertension). An analysis of 100 consecutive patients with keloid in our department in 2011 revealed that patients with multiple (>3) or large keloids (>10 cm(2)) were significantly more likely to have hypertension than patients with mild keloids (<2 ...
Briasoulis Alexandros - - 2013
Nephropathy progression is slowed and cardiovascular events reduced in patients with stage 3 or higher chronic kidney disease when blood pressure is controlled using combinations of renin-angiotensin system (RAS) blockers with dihydropyridine calcium channel blockers or diuretics. We discuss a trial comparing high-dose RAS blockade with lower-dose RAS blockade combined ...
Lin Tsung-Hsien - - 2013
Fixed-dose combinations (FDCs) are one of the options for improving blood pressure (BP) goal attainment. We enrolled 141 patients and evaluated the efficacy and safety between a fixed dose of olmesartan/amlodipine (OA) and a double dose of amlodipine (DA) for treating mild to moderate hypertension after amlodipine monotherapy failure. After ...
Hanayama Yoshihisa - - 2012
Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood ...
Taller Daniel - - 2012
A planar surface acoustic wave on a solid substrate and its radiated sound into a static liquid drop produce time-averaged, exponentially decaying acoustic and electric Maxwell pressures near the contact line. These localized contact-line pressures are shown to generate two sequences of hemispherical satellite droplets at the tens of microns ...
Neutel Joel M - - 2012
AIMS: An estimated 25% of patients will require 3 antihypertensive agents to achieve blood pressure (BP) control; combination therapy is thus an important strategy in hypertension treatment. This review discusses the triple-therapy combination of an angiotensin receptor blocker (ARB) or direct renin antagonist (DRI) with a calcium channel blocker (CCB) ...
Servat J Javier - - 2012
A 49-year-old woman, who had previously undergone bilateral Jones tube placement, began nasal continuous positive airway pressure for obstructive sleep apnea. The patient's use of continuous positive airway pressure was limited by intolerance of the transfer of air through the Jones tube to her ocular surface resulting in irritation and ...
Huan Yonghong - - 2012
Hypertension is a leading cause of cardiovascular morbidity and mortality, and uncontrolled hypertension remains common despite the availability of several classes of effective antihypertensive medications. Combination therapy with antihypertensive agents of complementary actions has been advocated in the management of hypertension to maximize efficacy and minimize side effects. This review ...
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