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Briasoulis Alexandros - - 2013
Nephropathy progression is slowed and cardiovascular events reduced in patients with stage 3 or higher chronic kidney disease when blood pressure is controlled using combinations of renin-angiotensin system (RAS) blockers with dihydropyridine calcium channel blockers or diuretics. We discuss a trial comparing high-dose RAS blockade with lower-dose RAS blockade combined ...
Lin Tsung-Hsien - - 2013
Fixed-dose combinations (FDCs) are one of the options for improving blood pressure (BP) goal attainment. We enrolled 141 patients and evaluated the efficacy and safety between a fixed dose of olmesartan/amlodipine (OA) and a double dose of amlodipine (DA) for treating mild to moderate hypertension after amlodipine monotherapy failure. After ...
Hanayama Yoshihisa - - 2012
Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood ...
Taller Daniel - - 2012
A planar surface acoustic wave on a solid substrate and its radiated sound into a static liquid drop produce time-averaged, exponentially decaying acoustic and electric Maxwell pressures near the contact line. These localized contact-line pressures are shown to generate two sequences of hemispherical satellite droplets at the tens of microns ...
Neutel Joel M - - 2012
AIMS: An estimated 25% of patients will require 3 antihypertensive agents to achieve blood pressure (BP) control; combination therapy is thus an important strategy in hypertension treatment. This review discusses the triple-therapy combination of an angiotensin receptor blocker (ARB) or direct renin antagonist (DRI) with a calcium channel blocker (CCB) ...
Servat J Javier - - 2012
A 49-year-old woman, who had previously undergone bilateral Jones tube placement, began nasal continuous positive airway pressure for obstructive sleep apnea. The patient's use of continuous positive airway pressure was limited by intolerance of the transfer of air through the Jones tube to her ocular surface resulting in irritation and ...
Huan Yonghong - - 2012
Hypertension is a leading cause of cardiovascular morbidity and mortality, and uncontrolled hypertension remains common despite the availability of several classes of effective antihypertensive medications. Combination therapy with antihypertensive agents of complementary actions has been advocated in the management of hypertension to maximize efficacy and minimize side effects. This review ...
Littlejohn T W TW - - 2012
Most patients with hypertension need more than one drug to achieve blood pressure (BP) control. This randomized, double-blind, multifactorial study evaluated whether combinations of aliskiren and amlodipine provided superior BP reductions to component monotherapies in patients with hypertension (mean sitting diastolic BP (msDBP) 95-<110 mm Hg). Overall, 1688 patients were randomized to ...
Funakoshi Ken-Ichi - - 2012
We describe a new method for the in situ measurement of the density of a liquid at high pressure and high temperature using the falling-sphere technique. Combining synchrotron radiation X-ray radiography with a large-volume press, the newly developed falling-sphere method enables the determination of the density of a liquid at ...
Kay Colin D - - 2012
SCOPE: Previous systematic reviews suggest beneficial effects of flavonoids on biomarkers of cardiovascular disease (CVD) risk, but have overlooked the impact of dose response or food complexity. The aim of the present study was to examine the relative impact of composition, flavonoid structure and dose. METHODS AND RESULTS: MEDLINE, EMBASE ...
Wang John - - 2012
Mechanical devices are modeled as single and double rotating dipoles in this study. The expressions for sound pressure, intensity and power are derived. Sound pressure and sound power level reduction is investigated. The reduction is quantified. The theory is compared with test data. The applications are discussed.
Murray Alexander V - - 2012
J Clin Hypertens (Greenwich). 2012; 14:821-827. ©2012 Wiley Periodicals, Inc. Combination antihypertensive therapies are recommended to attain blood pressure (BP) targets especially in high-risk patients in whom rapid and pronounced BP control is essential. This 28- to 54-week, open-label, multicenter study evaluated the safety and efficacy of a triple combination, ...
Blake E - - 2012
Methyl aminolevulinate photodynamic therapy (MAL-PDT) (a topical treatment used for a number of precancerous skin conditions) utilizes the combined interaction of a photosensitizer (protoporphyrin IX (PpIX)), light of the appropriate wavelength, and molecular oxygen to produce singlet oxygen and other reactive oxygen species which induce cell death. During treatment, localized ...
Erdine Serap - - 2012
Uncontrolled hypertension imposes a substantial global health burden, and poor patient compliance with prescribed antihypertensive medication makes a major contribution to the development of suboptimal blood pressure (BP) control. The asymptomatic nature of hypertension, side effects of medication, treatment complexity, and high pill burdens all have a negative impact on ...
Dave Mital H - - 2012
Background: The aim of the present study was to investigate the effect of the Lanz system on air sealing by self-inflation in high volume-low pressure (HVLP) tube cuffs. Methods: In vitro tracheal air sealing was studied in HVLP tracheal tube cuffs (internal diameter [ID] 8.0 mm) made from polyurethane ([PU] ...
Scurr J R H - - 2012
OBJECTIVES: To examine the longitudinal migratory force required to cause disconnection of the bifurcated distal body component from the tubular proximal body of a fenestrated stent-graft. METHODS: Using a previously reported mathematical model distal distraction forces were calculated prior to performing in vitro pullout testing. The top end of the proximal ...
Ward L C - - 2012
Abstract Background: Assessment of lymphedema is frequently based upon measuring the increase in volume of the affected region compared to that of a comparable unaffected region. This requires methods that can measure the volume of body regions that are not only accurate and sensitive but also suitable for use in ...
Briganti Angela - - 2012
Objective  To evaluate the endotracheal tube cuff pressure achieved by four different inflation methods. Study design  Prospective clinical study. Animals  Eighty client owned dogs. Methods  After anaesthesia induction, endotracheal intubation was performed using plastic or silicone tubes. A clinician unaware of tube type inflated the cuff by simple digital palpation ...
Valentini Ilaria - - 2012
PURPOSE: Determine the effects of different tracheotomy tube (TT) sizes on diaphragm effort and weanability indices Methods: 10 tracheotomized and difficult to wean patients were randomized to two T-piece trials, with different TT diameters (8mm ID and 6.5mm ID). Diaphragm pressure time product per min. (PTPdi/min), lung compliance and resistances ...
Teno Joan M - - 2012
The evidence regarding the use of feeding tubes in persons with advanced dementia to prevent or heal pressure ulcers is conflicting. Using national data, we set out to determine whether percutaneous endoscopic gastrostomy (PEG) tubes prevent or help heal pressure ulcers in nursing home (NH) residents with advanced cognitive impairment ...
Wang Zhentao - - 2012
Time response is an important performance characteristic for gas-pressurized ionization chambers. To study the time response, it is especially crucial to measure the ion drift time in high pressure ionization chambers. In this paper, a new approach is proposed to study the ion drift time in high pressure ionization chambers. ...
Phethean Jill - - 2012
The purpose of this study was to determine if plantar pressure data in 4-7 year old children with normal development: (1) required normalising by body mass and/or body mass index and (2) should be separated or pooled for boys and girls. The outcome will guide the management of plantar pressure ...
Slocum Alexander H AH - - 2012
Endotracheal intubation is a frequently performed procedure in the prehospital setting, intensive care unit, and for patients undergoing surgery. The endotracheal tube cuff must be inflated to a pressure that prevents air leaks without compromising tracheal mucosal blood flow. For simultaneous endotracheal tube cuff inflation and measurement, we designed and ...
Knoblauch Michael - - 2012
Long-distance assimilate distribution in higher plants takes place in the enucleate sieve-tube system of the phloem. It is generally accepted that flow of assimilates is driven by an osmotically generated pressure differential, as proposed by Ernst Münch more than 80 years ago. In the period between 1960 and 1980, the pressure ...
Kemerink Martijn - - 2012
This article will provide an assessment of the application of x-rays in the early days of radiology, which is an excellent way to come to value the convenience and safety of modern x-ray systems. The gas tubes that were originally applied for x-ray production were very unstable because of variations ...
Jagannathan N - - 2012
We conducted a randomised trial comparing the size-2 LMA Supreme™ with the LMA ProSeal™ in 60 children undergoing surgery. The outcomes measured were airway leak pressure, ease and time for insertion, fibreoptic examination, incidence of gastric insufflation, ease of gastric tube placement, quality of the airway during anaesthetic maintenance and ...
Abdel-Sayed Saad - - 2012
Objective: Bench evaluation of the hydrodynamic behavior of venous cannulas is a valuable technique for the analysis of their performance during cardiopulmonary bypass (CPB). The aim of this study was to investigate the effect of the internal diameter of the extracorporeal connecting tube of venous cannulas on flow rate (Q), ...
Ash Stephen R - - 2012
The StenTec™ Gauge provides a method to determine the static intra-access pressure ratio (P(Ia Ratio) ) within a fistula or graft. The StenTec Gauge estimates the peak systolic pressure within the fistula or graft by measurement of the distance that the blood-air interface progresses into the tubing of the fistula ...
Arvedsen Sine Kongsbak - - 2012
The hypothesis was tested that the cardiovascular changes during an upper body anti-orthostatic maneuver in humans are more pronounced in tall than in short individuals, because of the larger intravascular hydrostatic pressure gradients. In 34 males and 41 females (20 - 30 y, BH = 147 - 206 cm), inter-individual ...
Bluestone Charles D - - 2012
We recently encountered a 15-year-old female with bilateral tympanostomy tubes who manifested persistent severe vertigo, at ground level, secondary to a unilateral middle-ear pressure of +200 mm H(2)O elicited by an obstructed tympanostomy tube in the presence of chronic nasal obstruction. We believe this is a previously unreported scenario in ...
Babaei Arash A Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, - - 2012
Studies of the pressure response of the upper esophageal sphincter (UES) to simulated or spontaneous gastroesophageal reflux have shown conflicting results. These discrepancies could result from uncontrolled influence of variables such as posture, volume, and velocity of distension. We characterized in humans the effects of these variables on UES pressure ...
Heran Balraj S - - 2012
Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. thiazide diuretics) and much less commonly prescribed as monotherapy. Therefore, it is essential to determine the effects of ENaC blockers on blood pressure (BP), heart rate ...
Green Torrance T Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, - - 2012
Cyclooxygenase-2 (COX-2) plays a critical role in modulating deleterious actions of angiotensin II (Ang II) where there is an inappropriate activation of the renin-angiotensin system (RAS). This review discusses the recent developments regarding the complex interactions by which COX-2 modulates the impact of an activated RAS on kidney function and ...
Kapoor Shobhna - - 2012
Regulation of protein function is often linked to a conformational switch triggered by chemical or physical signals. To evaluate such conformational changes and to elucidate the underlying molecular mechanisms of subsequent protein function, experimental identification of conformational substates and characterization of conformational equilibria are mandatory. We apply pressure modulation in ...
West Christopher R - - 2011
We asked whether abdominal binding improves cardiorespiratory function in individuals with cervical spinal cord injury (SCI). 13 participants with chronic SCI (C(5)-C(7)) and 8 able-bodied controls were exposed to varying degrees of elastic abdominal compression (unbound [UB], loose-bound [LB], and tight-bound [TB]) whilst seated. In SCI, TB increased vital capacity ...
Versey H Shellae - - 2011
Hostility may be related to risk factors for cardiovascular disease (CVD), such as blood pressure. However, the process by which hostility affects blood pressure is not fully understood. The current study sought to evaluate abdominal obesity (waist-to-hip ratio [WHR]) as a potential mediator and modifier of the relationship between cynical ...
Chakkarapani Elavazhagan - - 2011
PURPOSE: To assess the effect of 18 hour (h) 50% xenon (Xe) inhalation at normothermia (NT, 38.5°C) or hypothermia (HT, 33.5°C) on mean arterial blood pressure (MABP), inotropic support and heart rate (HR) following an induced perinatal global hypoxic-ischaemic insult (HI) in newborn pigs. METHODS: Newborn pigs ventilated under inhalational anaesthesia, ...
Jiang Houli H Department of Pharmacology, New York Medical College, Valhalla, NY, - - 2012
Red blood cells (RBCs) have an important function in regulation of the circulation by producing and releasing epoxyeicosatrienoic acids (EETs) in response to a low O₂ environment such as encountered in the cardiac microcirculation during exercise. RBCs, in their role as sensors of low pO₂, release ATP and critical lipid ...
Tsai Emily J - - 2012
Soluble guanylyl cyclase (sGC) generates cyclic guanosine monophophate (cGMP) upon activation by nitric oxide (NO). Cardiac NO-sGC-cGMP signaling blunts cardiac stress responses, including pressure-overload-induced hypertrophy. The latter itself depresses signaling through this pathway by reducing NO generation and enhancing cGMP hydrolysis. We tested the hypothesis that the sGC response to ...
Nicholl David D M - - 2012
Increased levels of albuminuria and proteinuria, both linked to augmented renin-angiotensin system (RAS) activity, are associated with adverse kidney and cardiovascular events. However, the relationship between variations in urinary albumin excretion (UAE) and total protein excretion (UTPE) in the normal range and RAS activity is unclear. We examined the association ...
Graudal Niels A - - 2011
BackgroundThe question of whether reduced sodium intake is effective as a health prophylaxis initiative is unsolved. The purpose was to estimate the effects of low-sodium vs. high-sodium intake on blood pressure (BP), renin, aldosterone, catecholamines, and lipids.MethodsStudies randomizing persons to low-sodium and high-sodium diets evaluating at least one of the ...
Shishani Kawkab - - 2011
Hypertension is the most common cardiovascular disease. No data exists on the health status of the largest ethnic groups in Jordan. Seven hundred ninety two Chechens and Circassians participated in this study. Two readings of systolic and diastolic blood pressure were taken from the left arm with the subject seated ...
Lee Jiwon - - 2011
It has been suggested that an approach to hypertension based on the constitutional make-up of an individual may be effective. We conducted a retrospective chart review to explore the association of Sasang constitution with hypertension. The results show that the prevalence of hypertension was highest in the Taeeum (TE) constitutional ...
Hodgson Jonathan M - - 2011
Short-term randomised, controlled trials have found that dietary protein relative to carbohydrate can reduce blood pressure. Our objective was to investigate the effects on blood pressure of an increase in protein intake from whey over 2 years in women aged over 70 years. From the general population, 219 women aged ...
Bolay Hayrunnisa - - 2011
Although atmospheric weather changes are often listed among the common migraine triggers, studies to determine the specific weather component(s) responsible have yielded inconsistent results. Atmospheric pressure change produces air movement, and low pressure in particular is associated with warm weather, winds, clouds, dust, and precipitation, but how this effect might ...
Downey Christina C Department of Surgery, Michigan State University, 1200 East Michigan Ave., Suite 655, Lansing, MI 48912, - - 2011
Intratumoral pressure may stimulate cancer proliferation whereas intravascular pressure promotes metastatic adhesion. α-Actinin proteins facilitate focal adhesion formation and link focal adhesion complexes to the cytoskeleton. We hypothesized that α-actinin is the mechanotransducer that mediates the effects of pressure on cancer cell proliferation and adhesion. We treated SW620 colon cancer ...
Ares Gustavo R - - 2011
The kidney plays an essential role in blood pressure regulation by controlling short-term and long-term NaCl and water balance. The thick ascending limb of the loop of Henle (TAL) reabsorbs 25-30% of the NaCl filtered by the glomeruli in a process mediated by the apical Na(+)-K(+)-2Cl(-) cotransporter NKCC2, which allows ...
Tanaka Kunihiko - - 2011
The current U.S. extravehicular activity (EVA) suit is pressurized at 0.29 atm, which is much lower than the pressures of sea level and inside a space station. Higher pressure can reduce the risk of decompression sickness (DCS), but mobility would be sacrificed. We have demonstrated that a glove and sleeve ...
Aletti Federico - - 2011
The effect of mild lower body negative pressure (LBNP) on baroreflex control of arterial blood pressure (ABP) has long been thought to affect cardiopulmonary baroreflex only, although recent studies have pointed out that arterial baroreceptors may be transiently unloaded too after the rapid onset of mild LBNP. This paper presents ...
Bashir Saira - - 2011
The fixed-dose combination containing the antihypertensive agent amlodipine and the statin, atorvastatin, is the first combination of its kind designed to treat two risk factors for cardiovascular disease (CVD), i.e., hypertension and dyslipidemia. In this study, blood pressure and lipid lowering effects of combination of amlodipine and atorvastatin were evaluated ...
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