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Gao Ji J *Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, CIRB, Collège de France, INSERM U1050, Paris, F-75231, - - 2014
Hypertension affects one-third of the adult population and is a growing problem due to the increasing incidence of obesity and diabetes. Brain RAS (renin-angiotensin system) hyperactivity has been implicated in the development and maintenance of hypertension in several types of experimental and genetic hypertension animal models. We have identified in the ...
Corry Jesse J JJ Department of Neurology, Marshfield Clinic, 1000 N. Oak Ave., Marshfield, WI, 54449-5777, USA, - - 2014
The use of hypothermia for treatment of intracranial hypertension is controversial, despite no other medical therapy demonstrating consistent improvements in morbidity or mortality. Much of this may be the result of negative results from randomized controlled trials. However, the patients selected for these trials may have obscured the results in ...
Enok Sanne S Aarhus University, - - 2014
Interspecific allometric analyses indicate that mean arterial blood pressure (MAP) increases with body mass of snakes and mammals. In snakes, MAP increases in proportion to the increased distance between the heart and the head, when the heart-head vertical distance is expressed a ρgh, and the rise in MAP is associated ...
Nikulin Vadim V VV Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité, University Medicine, Hindenburgdamm 30, 12203 Berlin, Germany; Bernstein Center for Computational Neuroscience, Philippstraße 12, 10115 Berlin, Germany. Electronic address: - - 2014
Previous studies demonstrated the presence of Monochromatic Ultra-Slow Oscillations (MUSO) in human EEG. In the present study we explored the biological origin of MUSO by simultaneous recordings of EEG, Near-Infrared Spectroscopy (NIRS), arterial blood pressure, respiration and laser Doppler flowmetry. We used a head-up tilt test in order to check ...
Zeiler F A FA Section of Neurosurgery, Department of Surgery, University of Manitoba, Winnipeg, Canada, - - 2014
Our goal was to perform a systematic review of the literature on the use of tromethamine (THAM) and its effects on intracranial pressure (ICP) in patients with neurological illness. All articles from MEDLINE, BIOSIS, EMBASE, Global Health, HealthStar, Scopus, Cochrane Library, the International Clinical Trials Registry Platform (inception to February ...
Zhu Feng F Bioengineering Center, Wayne State University, Detroit, MI, - - 2014
Traumatic brain injury due to primary blast loading has become a signature injury in recent military conflicts. Efforts have been made to study the stress wave propagation in the head. However, the relationship of incident pressure, reflected pressure and intracranial pressure is still not clear, and the experimental findings reported ...
Andresen Morten M Clinic of Neurosurgery, Copenhagen University Hospital, Copenhagen, - - 2014
Object Current published normal values for intracranial pressure (ICP) are extrapolated from lumbar CSF pressure measurements and ICP measurements in patients treated for CSF pressure disorders. There is an emerging agreement that true normal ICP values are needed for diagnostic and therapeutic purposes. This study documents normal ICP in humans. ...
Otvos Balint B Cleveland Clinic Lerner College of Medicine; - - 2014
In 1919, it was observed that intravascular osmolar shifts could collapse the thecal sac and diminish the ability to withdraw CSF from the lumbar cistern. This led to the notion that hyperosmolar compounds could ameliorate brain swelling. Since then, various therapeutic interventions have been used for the reduction of intracranial ...
Kumar Ramesh R Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, - - 2014
In children with acute CNS infection, management of raised intracranial pressure improves mortality and neuromorbidity. We compared cerebral perfusion pressure-targeted approach with the conventional intracranial pressure-targeted approach to treat raised intracranial pressure in these children. Prospective open-label randomized controlled trial. PICU in a tertiary care academic institute. Hundred ten children ...
Zweifel Christian C Academic Neurosurgical Unit, University of Cambridge Department of Clinical Neurosciences, Cambridge, United Kingdom; Department of Neurosurgery, University Hospital of Basel, Basel, Switzerland. Electronic address: - - 2014
Integration of various brain signals can be used to determine cerebral autoregulation in neurocritical care patients to guide clinical management and to predict outcome. In this review, we will discuss current methodology of multimodal brain monitoring focusing on secondary 'reactivity indices' derived from various brain signals which are based on ...
Babiker Mohamed O E MO Fraser of Allander Neurosciences Unit, Royal Hospital of Sick Children, Glasgow, - - 2014
Idiopathic intracranial hypertension (IIH) is a rare condition where intracranial hypertension is found in the context of normal brain parenchyma and no mass lesion, ventriculomegaly, underlying infection, or malignancy. Our understanding of this condition has greatly improved in the recent years with neuroimaging features and normal values for lumbar puncture ...
Murillo-Cabezas F F Servicio de Cuidados Críticos y Urgencias, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address: - - 2014
The present study outlines a series of questions and reflections upon the recent publication of Chesnut et al., who compared 2 approaches to the treatment of intracranial hypertension (ICH) in severe head injuries: one with and the other without intracranial pressure monitoring (ICP). The authors concluded that no improved outcome ...
Bouchoux Guillaume G Division of Cardiovascular Health and Disease, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, - - 2014
Ultrasound in the sub-megahertz range enhances thrombolysis and may be applied transcranially to ischemic stroke patients. The consistency of transcranial insonification needs to be evaluated. Acoustic and thermal simulations based on computed-tomography (CT) scans of 20 patients were performed. An unfocused 120-kHz transducer allowed homogeneous insonification of the thrombus, and ...
Bergmann Kelly R KR Departments of Pediatrics - - 2014
Hyperammonemic crises in ornithine transcarbamylase deficiency (OTC) can be associated with devastating cerebral edema resulting in severe long-term neurologic impairment and death. We present an 8-year-old boy who had late-onset OTC deficiency in which early and aggressive management of hyperammonemia and associated cerebral edema, including therapeutic hypothermia and barbiturate-induced coma, ...
Hiploylee Carmen C Department of Psychology, University of Alberta, Edmonton, Alberta, - - 2014
In some patients, intracerebral hemorrhage (ICH) causes life-threatening elevations in intracranial pressure (ICP) arising from mass effect of the hematoma and edema. Accordingly, edema is a common endpoint to gauge treatment efficacy in rodent ICH models. Despite widespread reliance on edema, its relationship with ICP and cerebral perfusion pressure (CPP) ...
Milani Gregorio Paolo GP Pediatric Emergency - - 2014
Posterior reversible cerebral edema syndrome is a generally reversible neurologic condition that is diagnosed based on distinctive clinical and radiologic findings. The condition, which is mostly associated with severe arterial hypertension, has also been reported to be induced by several medications. We made the diagnosis of hypertension with posterior reversible ...
Major E H EH Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland, UK, - - 2014
In recent years hypertonic saline has attracted increasing interest in the treatment of traumatic intracranial hypertension, and has a number of documented and theoretical advantages over other hyperosmolar agents. To date, no consensus has been achieved on the safest and most effective HTS concentration for administration. The purpose of this ...
Kamine Tovy Haber TH Department of Surgery, Beth Israel Deaconess Medical Center, Boston, - - 2014
IMPORTANCE Increased abdominal pressure may have a negative effect on intracranial pressure (ICP). Human data on the effects of laparoscopy on ICP are lacking. We retrospectively reviewed laparoscopic operations for ventriculoperitoneal shunt placement to determine the effect of insufflation on ICP. OBSERVATIONS Nine patients underwent insufflation with carbon dioxide (CO2) ...
Zeiler F A FA Section of Neurosurgery, Department of Surgery, University of Manitoba, Winnipeg, MB, Canada, - - 2014
Our goal was to perform a systematic review of the literature on the use of ketamine in traumatic brain injury (TBI) and its effects on intracranial pressure (ICP). All articles from MEDLINE, BIOSIS, EMBASE, Global Health, HealthStar, Scopus, Cochrane Library, the International Clinical Trials Registry Platform (inception to November 2013), ...
Uldall Maria M .Danish Headache Center, Building 24, Department of Neurology, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 69, 2600 Glostrup, Denmark; Research Institute, Danish Headache Center, Glostrup, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 69, 2600 Glostrup, - - 2014
In preclinical neurological studies, monitoring intracranial pressure (ICP) in animal models, especially rodents, is challenging. Further, the lack of methods for long-term ICP monitoring has limited the possibilities to conduct prolonged studies on ICP fluctuations in parallel to disease progression or therapeutic interventions. For these reasons we aimed to set ...
Lazaridis Christos C Academic Neurosurgical Unit, University of Cambridge Clinical School, - - 2014
Object Based on continuous monitoring of the pressure reactivity index (PRx), the authors defined individualized intracranial pressure (ICP) thresholds by graphing the relationship between ICP and PRx. These investigators hypothesized that an "ICP dose" based on individually assessed ICP thresholds would correlate more closely with the 6-month outcome when compared ...
Ropper Allan H - - 2014
The management of raised intracranial pressure is undergoing rapid change. The choice of medical treatments to reduce intracranial pressure varies between institutions and regions of the world. The mainstay of therapy, however, continues to be the infusion of a hyperosmolar solution to achieve an osmotic gradient to force the exit ...
Francis Richard R Neurosurgical Trials Unit, 3-4 Claremont Terrace, Newcastle University , Newcastle upon Tyne , - - 2014
Introduction. Recent research has been equivocal regarding the usefulness of intracranial pressure (ICP) monitoring for traumatic intracerebral haemorrhage (ICH). We aimed to investigate attitudes of clinicians from as wide an international audience as possible. Materials and methods. A SurveyMonkey(®) questionnaire was distributed to individuals, including members of the Society of ...
Eide Per Kristian - - 2014
Monitoring of intracranial pressure (ICP) is a cornerstone in the surveillance of neurosurgical patients. The ICP is measured against a baseline pressure (i.e. zero - or reference pressure). We have previously reported that baseline pressure errors (BPEs), manifested as spontaneous shift or drifts in baseline pressure, cause erroneous readings of ...
Blankstein Michael M AO Research Institute Davos, Davos, - - 2014
The benefits of cement augmentation with fixation of osteoporotic pertrochanteric fractures have been previously demonstrated. The objective of this study was threefold: 1. Quantify the intra-osseous pressure produced during cement augmentation of the perforated PFNA blades. 2. Assess whether the pressure generated is influenced by the injection rate. 3. Assess ...
Lauerman Margaret H MH Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, - - 2014
Intracranial pressure (ICP) control is a mainstay of traumatic brain injury (TBI) management. However, development of intracranial hypertension (ICH) may be affected by factors outside of the cranial vault in addition to the local effects of the TBI. This review will examine the pathophysiology of multiple compartment syndrome (MCS) and ...
Karamanos Efstathios E Division of Acute Care Surgery (Trauma, Emergency Surgery, and Surgical Critical Care), University of Southern California-Keck School of Medicine, Los Angeles County General Hospital (LAC + USC), 2051 Marengo Street, C5L100, Los Angeles, CA 90033-4525, USA. Electronic address: - - 2014
Intracranial pressure (ICP) monitoring is a standard of care in severe traumatic brain injury when clinical features are unreliable. It remains unclear, however, whether elevated ICP or decreased cerebral perfusion pressure (CPP) predicts outcome. This is a prospective observational study of patients sustaining severe blunt head injury, admitted to the ...
Fujita Yasuki Y Departments of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, - - 2014
Data on intraoperative secondary insults in pediatric traumatic brain injury (TBI) are limited. We examined intraoperative secondary insults during extracranial surgery in children with moderate-severe TBI and polytrauma and their association with postoperative head computed tomography (CT) scans, intracranial pressure (ICP), and therapeutic intensity level (TIL) scores 24 h after surgery. ...
Ragauskas Arminas - - 2014
Objectives: To compare the diagnostic reliability of optic nerve sheath diameter (ONSD) ultrasonography with a transcranial Doppler (TCD)-based absolute intracranial pressure (ICP) value measurement method for detection of elevated ICP in neurological patients. The ONSD method has been only tested previously on neurosurgical patients. Methods: A prospective clinical study of ...
Kranz P G PG Department of Radiology, Duke University Medical Center, Durham, North Carolina; and Department Radiology and Radiological Science, Medical University of South Carolina, Charleston, South - - 2014
SUMMARY:Rebound intracranial hypertension is a complication of epidural blood patching for treatment of intracranial hypotension characterized by increased intracranial pressure, resulting in potentially severe headache, nausea, and vomiting. Because the symptoms of rebound intracranial hypertension may bear some similarity to those of intracranial hypotension and literature reports of rebound intracranial ...
Lizy Christelle C Christelle Lizy is a registered nurse, Dirk Vogelaers, Koenraad Vandewoude, and Stijn Blot are professors in the Department of Internal Medicine, Faculty of Medicine and Healthcare, Ghent University, Ghent, Belgium. Walter Swinnen is an intensivist and director of the intensive care unit, General Hospital Sint Blasius, Dendermonde, Belgium, Sonia Labeau is a lecturer in the Faculty of Education, Health and Social Work, University College Ghent, Ghent, Belgium, and Jan Poelaert is director of the Department of Anesthesiology, Free University Brussels, Brussels, Belgium. Joel Dulhunty is an intensivist in the Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, and the Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, - - 2014
Background In order to avoid microaspiration and tracheal injury, the target for endotracheal tube cuff pressure is 20 to 30 cm H2O. Objective To assess the effect of changes in body position on cuff pressure in adult patients. Methods Twelve orally intubated and sedated patients received neuromuscular blockers and were ...
Kasapas Konstantinos K Department of Neurosurgery, Athens General Hospital "G. Gennimatas", 11527 Athens, - - 2014
Introduction. An experimental epidural hematoma model was used to study the relation of ultrasound indices, namely, transcranial color-coded-Doppler (TCCD) derived pulsatility index (PI), optic nerve sheath diameter (ONSD), and pupil constriction velocity (V) which was derived from a consensual sonographic pupillary light reflex (PLR) test with invasive intracranial pressure (ICP) ...
Atsumi Hideki - - 2014
Objective: To assess a newly proposed noninvasive technique for evaluating intracranial pressure (ICP) index and brain compliance (BC) index based on an inverse analysis of a brain-circulation-equivalent electrical circuit (EC) model, in which cerebrospinal fluid (CSF) flow and arterial flow rates measured by using the phase contrast method are used ...
Reisner Andrew A Massachusetts General Hospital, Department of Emergency Medicine, Boston, Massachusetts, United States ; - - 2013
We hypothesized that vital signs could be used to improve the association between a trauma patient's prehospital Glasgow coma scale (GCS) score and his or her clinical condition. Previously, abnormally low and high blood pressures have both been associated with higher mortality for patients with traumatic brain injury (TBI). We ...
Launey Yoann Y CHU de Rennes, Anesthesiology & Critical Care, 2, rue Henri Le Guilloux, Rennes, France, 35033, +33 299 285 485, +33 299 282 559, Inserm, UMR991 - team2, Rennes, France ; - - 2013
The measurement of ocular nerve sheath diameter (ONSD) via ocular ultrasound scanning is a recent non-invasive method for intracranial pressure (ICP) assessment. Few clinical studies have assessed ONSD variations during osmotherapy for the treatment of sustained increased ICP episodes. The aim of our study was to determine the rate of ...
Andersen Johnny Dohn Holmgren JD From the Department of Anaesthesiology, University of Copenhagen, Glostrup Hospital, Glostrup, - - 2013
Near-infrared spectroscopy (NIRS) has been used to study regional cerebral blood oxygen saturation (rScO2) in patients in the prone position. We aimed to test the hypothesis that head rotation more than 45° would affect the rScO2. A prospective, controlled, single cohort study. University Hospital specialising in spinal surgery. Fifty-two patients ...
Imam Ayesha M - - 2013
Combination of traumatic brain injury (TBI) and hemorrhagic shock (HS) can result in significant morbidity and mortality. We have previously shown that early administration of fresh frozen plasma (FFP) in a large animal model of TBI and HS reduces the size of the brain lesion as well as the associated ...
Böhm Matthias M CIML Group, Department of Biophysics, University of Regensburg, 93040 Regensburg, Germany and Department of Neurosurgery, University Hospital Regensburg, 93042 Regensburg, - - 2013
Recently, a mathematical model of the basic physiological processes regulating the cerebral perfusion and oxygen supply was introduced [Jung et al., J. Math. Biol. 51, 491 (2005)]. Although this model correctly describes the interdependence of arterial blood pressure (ABP) and intracranial pressure (ICP), it fails badly when it comes to ...
Kirkman M A - - 2013
Measurement of intracranial pressure (ICP) and mean arterial pressure (MAP) is used to derive cerebral perfusion pressure (CPP) and to guide targeted therapy of acute brain injury (ABI) during neurointensive care. Here we provide a narrative review of the evidence for ICP monitoring, CPP estimation, and ICP/CPP-guided therapy after ABI. ...
Rao Vidar - - 2013
Cerebral perfusion pressure (CPP) is defined as the difference between the mean arterial pressure (MAP) and the intracranial pressure (ICP). However, since patients with traumatic brain injury (TBI) are usually treated with head elevation, the recorded CPP values depends on the zero level used for calibration of the arterial blood ...
Deng Wenjun - - 2013
Postural orthostatic tachycardia syndrome (POTS) is common, and has a serious impact on children's quality of life. Midodrine hydrochloride, an α1-adrenoreceptor agonist, is an effective treatment. The study was designed to examine the therapeutic efficacy of midodrine hydrochloride by quantifying changes in blood pressure during the head-up test (HUT), in ...
Varsos Georgios V - - 2013
Reducing cerebral perfusion pressure (CPP) below the lower limit of autoregulation (LLA) causes cerebral blood flow (CBF) to become pressure passive. Further reductions in CPP can cause cessation of CBF during diastole. We hypothesized that zero diastolic flow velocity (FV) occurs when diastolic blood pressure becomes less than the critical ...
Kako Hiromi - - 2013
Over the past few years, there has been a change in clinical practice with a transition to the use of cuffed instead of uncuffed endotracheal tubes (ETTs) in pediatric patients. These changes have led to concerns regarding unsafe intracuff pressures in pediatric patients, which may result in postoperative morbidity. To ...
Caricato Anselmo - - 2013
Endotracheal suctioning (ETS) is essential for patient care in an ICU but may represent a cause of cerebral secondary injury. Ketamine has been historically contraindicated for its use in head injury patients, since an increase of intracranial pressure (ICP) was reported; nevertheless its use was recently suggested in neurosurgical patients. ...
Freimann Florian Baptist - - 2013
The Neurovent-P-tel sensor is a promising device for telemetric intracranial pressure (ICP) measurements in cases of complex hydrocephalus. Data on its accuracy within a broad ICP range are missing. We applied a porcine model for large-scale manipulation of the ICP values. The telemetric ICP sensor was referenced against ICP values ...
de Andrade Ozahyr - - 2013
The autonomic nervous system is importantly involved in the maintenance of arterial pressure during orthostatic challenges. However, little is known about the specific central areas involved in these cardiovascular compensations. It has been proposed that the paraventricular nucleus of the hypothalamus (PVN) is involved in cardiovascular reflex responses related to ...
Nguyen Tammy T - - 2013
To report a case of sustained hypotension associated with the use of intravenous metoclopramide. A 50-year-old woman developed a hypotensive episode lasting approximately 90 minutes after the administration intravenous metoclopramide for the treatment of a migraine. The patient presented to the emergency department after she woke up with a severe ...
Stiebel-Kalish H - - 2013
Idiopathic intracranial hypertension is a common disorder affecting mainly healthy, young, overweight women. The pathogenesis of this condition is unknown, but it has been shown to follow treatment with several compounds including corticosteroids and vitamin A derivatives. This paper will offer a novel hypothesis and insight on the pathogenesis of ...
Zhang Minmin - - 2013
Pressure retarded osmosis (PRO) is an osmotically-driven membrane process that can be used to harvest salinity-gradient power. The PRO performance (both water flux and power density) can be severely limited by membrane fouling. The current study, for the first time, investigates PRO scaling in a bench-scale pressurized system using calcium ...
Lancioni Giulio E - - 2013
Objective: To assess whether a man with amyotrophic lateral sclerosis could benefit from using (a) a mouth pressure microswitch instead of an optic microswitch activated via head movement and (b) a special word prediction function within a text messaging system. Method: Initially, both microswitches were used for operating the text ...
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