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Utrobicić I - - 2011
High-pressure injection injuries to the hand are work-related injuries that can take a devastating toll on the functionality of the affected extremity. We present two cases of high-pressure injection hand injuries due to paint and sand. The patients were managed operatively and switch to intensive physiotherapeutic training, with excellent outcome.
Gura Melek - - 2011
In traumatic brain injury (TBI) patients, it is desired to monitor the intracranial pressure (ICP) to assess the cerebral haemodynamics and guide the therapy. The study was designed to see if the pulsatility index (PI) measured by transcranial Doppler ultrasonography (TCD) predicts information about ICP values. In 52 TBI patients ...
Haavind Anniken - - 2011
Pneumonia, severe sepsis, and acute respiratory distress syndrome (ARDS) are frequent complications after head trauma. Recombinant human activated protein C (APC) reportedly improves circulation and respiration in severe sepsis, but is contraindicated after head injury because of increased risk of intracranial bleeding. A 21-year-old man with severe head injury after ...
Rabadi Meheroz Hoshang - - 2011
The overall goal of this observational study was to determine whether modifiable vascular risk factors contribute to the prevalence of pressure ulcers (PrU) in veterans with traumatic spinal cord injury (SCI). Given the increasingly limited financial resources in hospitals and clinics, identifying risk factors associated with the development of PrU ...
Rice Todd W - - 2011
Conservative fluid management in patients with acute lung injury (ALI) increases time alive and free from mechanical ventilation. Vascular pedicle width (VPW) is a non-invasive measurement of intravascular volume status. The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW ...
Nelson David W - - 2011
Cerebral microdialysis (MD) is used to monitor local brain chemistry of patients with traumatic brain injury (TBI). Despite an extensive literature on cerebral MD in the clinical setting, it remains unclear how individual levels of real-time MD data are to be interpreted. Intracranial pressure (ICP) and cerebral perfusion pressure (CPP) ...
Peace Kaitlin - - 2010
Object Follow-up head CT scans are important in neurocritical care but involve intrahospital transport that may be associated with potential hazards including a deleterious effect on brain tissue oxygen pressure (PbtO(2)). Portable head CT (pHCT) scans offer an alternative imaging technique without a need for patient transport. In this study, ...
Sonenblum Sharon E - - 2011
The overall goal of this research was to improve the use of seated tilt to increase function, health and quality of life for people using power wheelchairs. Specifically, the objective of this study was to evaluate the biomechanical responses to seated full body tilt in persons with spinal cord injury ...
Etz Christian D - - 2010
To minimize paraplegia during thoracoabdominal aortic aneurysm repair, the concept of the collateral network was developed. That is, spinal cord perfusion is provided by an interconnecting complex of vessels in the intraspinal, paraspinous, and epidural space and in the paravertebral muscles, including intercostal and lumbar segmental as well as subclavian ...
Groothuis Jan T - - 2010
To compare the effect of different sympathetic stimuli, that is, exaggerated sympathetic activity and orthostatic challenges, on the increase in leg vascular resistance in persons with spinal cord injury (SCI) without and controls with supraspinal sympathetic control. Case-control intervention study. Physiology research laboratory. Persons with SCI (N=9; motor and sensory ...
Chavko Mikulas - - 2011
Exposure to a blast wave generated during an explosion may result in brain damage and related neurological impairments. Several mechanisms by which the primary blast wave can damage the brain have been proposed, including: (1) a direct effect of the shock wave on the brain causing tissue damage by skull ...
Sakellaridis Nikolaos - - 2011
The purpose of this study was to compare the effects of mannitol and hypertonic saline in doses of similar osmotic burden for the treatment of intracranial hypertension in patients with severe traumatic brain injury. The authors used an alternating treatment protocol to compare the effect of hypertonic saline with that ...
Delgado Esmeralda - - 2010
This study characterizes the effects of endothelin-1 (ET-1) on the perfusion pressure of the choroidal vasculature using in situ perfused isolated rabbit eyes. Rabbit external ophthalmic arteries (n = 12) in a head-mounted preparation were cannulated and perfused with warmed tyrode. The three-way polypropylene catheter was further connected to a ...
Ko Sang-Bae SB Department of Neurology, Clinical Research Center for Stroke, Clinical Research Institute, College of Medicine, Seoul National University Hospital, Seoul. - - 2010
Paroxysmal sympathetic storm (PSS) is a rare complication of severe traumatic brain injury or cerebrovascular disease. Various medications have been tried in patients with PSS, but the clinical responses of the patients were variable. We report a classic case of PSS after spontaneous pontine hemorrhage in which the patient's fluctuating ...
Boerma E Christiaan - - 2010
The clinical use of vasoactive drugs is not only intended to improve systemic hemodynamic variables, but ultimately to attenuate derangements in organ perfusion and oxygenation during shock. This review aims (1) to discuss basic physiology with respect to manipulating vascular tone and its effect on the microcirculation, and (2) to ...
Elbers Paul W G - - 2011
Possible benefits of pulsatile perfusion during cardiopulmonary bypass often are attributed to enhanced microvascular flow. However, there is no evidence to support this in humans. Therefore, the authors assessed whether pulsatile perfusion alters human microvascular flow. A prospective, randomized observational crossover study. A tertiary cardiothoracic surgery referral center. Sixteen patients ...
Javadi Hamid - - 2010
Dipyridamole has extensively been administered as a substitute for physical activity in cardiovascular assessment. The aim of this study was to evaluate the association of dipyridamole side effects with hemodynamic oscillations, scanning results, and electrocardiography (ECG) findings. Overall, 590 patients referred to the nuclear medicine center for myocardial perfusion imaging ...
Krzemiński Tadeusz F - - 2010
The aim of our study was to find the most effective xylidine derivative, which reduced mortality, reduced incidence and duration of severe arrhythmias and had a beneficial influence on hemodynamic parameters in an in vivo setting. We compared the action of lidocaine, articaine, ropivacaine and mepivacaine in a dose 2.5 ...
- - 2010
Variations in ventilator designs may result in different inspiratory pressures being delivered at seemingly identical settings during delivery of pressure-controlled breaths. Because a lack of familiarity with these design variations may lead to the setting of excessive pressures that could result in lung injuries, staff need to be trained to ...
Jan Y-K - - 2011
Two-way factorial mixed design, the between-subjects factor as the spinal cord injury (SCI) status (SCI and non-SCI) and the within-subjects factor as the pressure pattern (alternating and constant pressures). To compare the effects of alternating and constant pressures on weight-bearing tissue perfusion in people with SCI, with application for improving ...
McNamee David A - - 2011
Recent research by the authors on the effects of extremely low-frequency (ELF) magnetic field (MF) exposure on human heart rate (HR), heart rate variability (HRV), and skin blood perfusion found no cardiovascular effects of exposure to an 1,800-μT, 60-Hz MF. Research from our group using rats, however, has suggested a ...
Jaeger Matthias M Department of Neurosurgery, University of Leipzig, Leipzig, Germany. - - 2010
To evaluate the concept of a cerebrovascular pressure reactivity-guided optimal cerebral perfusion pressure after traumatic brain injury by analyzing the relationship between optimal cerebral perfusion pressure and brain tissue oxygen. Prospective observational cohort study. Neurosurgical intensive care unit of a university hospital. Thirty-eight patients after head injury. Continuous computerized monitoring ...
Aylin Arici Mualla - - 2010
P-glycoprotein (P-gp) is expressed in tumour cells as well as normal tissues including heart. Modulation of P-gp transport in vivo may lead to increased drug penetrance to tissues with resulting increases in toxicity. We aimed to investigate the effects of P-gp on the isolated heart by digoxin infusion in the ...
Jakob Stephan M - - 2010
Mechanical ventilation is a cornerstone of ICU treatment. Because of its interaction with blood flow and intra-abdominal pressure, mechanical ventilation has the potential to alter hepato-splanchnic perfusion, abdominal organ function and thereby outcome of the most critically ill patients. Mechanical ventilation can alter hepato-splanchnic perfusion, but the effects are minimal ...
Ospina-Tascon Gustavo - - 2010
To evaluate the effects of fluid administration on microcirculatory alterations in sepsis. With a Sidestream Dark Field device, we evaluated the effects of fluids on the sublingual microcirculation in 60 patients with severe sepsis. These patients were investigated either within 24 h (early, n = 37) or more than 48 ...
Warwick Richard - - 2010
Organ ischemia, particularly mesenteric and renal, can occur despite a seemingly adequate perfusion flow and pressure during a period of cardiopulmonary bypass. The blood pressure to run bypass at remains a contentious issue. We present the concept that perfusion pressure during cardiopulmonary bypass should be patient specific, depending on an ...
Karcz Marcin M West London Renal and Transplant Centre, Imperial College Kidney and Transplant Institute, Middlesex, United Kingdom. - - 2010
Hypothermic machine perfusion is a well-established preservation method for kidneys that allows for better preservation over longer periods and pretransplant assessment of graft viability. This technique has only sporadically been used for pancreatic grafts. The aim of this study was to establish a hypothermic machine perfusion model for porcine pancreas ...
Van Bommel Jasper - - 2010
BACKGROUND: Esophagectomy with gastric tube reconstruction is the surgical treatment for cancer of the esophagus. Perfusion of the anastomotic site of the tube depends exclusively on microcirculation, making it susceptible to hypoperfusion. It is unknown whether vasodilatation is superior to increased perfusion pressure to improve gastric tissue perfusion of the ...
Haldenwang Peter L - - 2010
OBJECTIVE: The effect of perfusion pressure on cerebral hemodynamics and metabolism during selective cerebral perfusion in patients undergoing aortic surgery is still unknown. This study explored cerebral blood flow, metabolic rate, and intracranial pressure at different pressure rates. METHODS: Twenty-five pigs (32-38 kg) were cooled during cardiopulmonary bypass to 25 ...
Woo Hyun Jin - - 2010
Paroxysmal sympathetic storm (PSS), or diencephalic seizure, usually appears in patients with severe traumatic brain injury and is characterized by various sympathetic symptoms. The physiological effects of this syndrome are not well studied. The authors monitored intracranial pressure (ICP) in a patient with PSS and reviewed its impact on the ...
Marinis Athanasios - - 2010
The aims of our study were to evaluate the impact of increased intra-abdominal pressure (IAP) on central nervous system (CNS) cytokines (Interleukin 6 and tumor necrosis factor), lactate and perfusion pressures, testing the hypothesis that intra-abdominal hypertension (IAH) may possibly lead to CNS ischemia. Fifteen pigs were studied. Helium pneumoperitoneum ...
Kubota Hiroshi - - 2010
Kitahori, Kawata, Takamoto et al. described the effectiveness of a novel protocol for retrograde cerebral perfusion that included intermittent pressure augmentation for brain protection in a canine model. Based on their report, we applied this novel technique clinically. Although the duration of circulatory arrest with retrograde cerebral perfusion was long, ...
Di Gennaro Jane L - - 2010
Vasopressors are commonly used to increase mean arterial blood pressure (MAP) and cerebral perfusion pressure (CPP) after traumatic brain injury (TBI), but there are few data comparing vasopressor effectiveness after pediatric TBI. To determine which vasopressor is most effective at increasing MAP and CPP in children with moderate-to-severe TBI. After ...
Penna Guilherme Loures de Araújo GL Serviço de Terapia Intensiva, Casa de Saúde São José, Rio de Janeiro, RJ, - - 2009
Arterial pulse pressure respiratory variation is a good predictor of fluid response in ventilated patients. Recently, it was shown that respiratory variation in arterial pulse pressure correlates with variation in pulse oximetry plethysmographic waveform amplitude. We wanted to evaluate the correlation between respiratory variation in arterial pulse pressure and respiratory ...
P?rez-Torres Israel - - 2010
Influence of sex on arachidonic acid metabolism, a pathway involved in the link between metabolic syndrome (MS) and renal damage, was studied in isolated perfused kidney. Metabolic syndrome was induced by feeding 30% sucrose solution for 24 weeks to intact and gonadectomized female (Ovx) and male (Cas) rats. Systolic blood ...
Ko Yoshihiro - - 2009
This article has been removed at the request of the Editor-in-Chief. Please see Elsevier Policy on Article Withdrawal: (http://www.elsevier.com/locate/withdrawalpolicy).
Iatridis James C - - 2009
A literature review and new data are presented to evaluate the influence of intervertebral disc (IVD) injury on biomechanics, cellularity, inflammation, and biosynthesis. Literature and new experimental evidence support the hypothesis that localized injury in the disc can lead to immediate and long-term organ level changes in biomechanics and biology ...
Liu Xin - - 2009
This study compared the impact of two perfusates (A: 4.5% BSA-MOPS buffer and B: 4% dextran and 0.5% BSA-MOPS buffer) on the pharmacokinetics of the physiological markers [(3)H]-water, [(14)C]-sucrose, [(14)C]-antipyrine and Evans Blue-labelled albumin; and the drugs atenolol and propranolol using an in-situ single pass perfusion model in the rat ...
den Uil Corstiaan A - - 2009
INTRODUCTION: Microcirculatory abnormalities are frequently observed in patients with severe heart failure and correlate to worse outcomes. We tested the hypothesis that nitroglycerin dose-dependently improves perfusion in severe heart failure and that this could be monitored by measuring central-peripheral temperature gradient and with Sidestream Dark Field imaging of the sublingual ...
Kapapa Thomas - - 2010
To minimize the secondary brain damage, we analyzed the effect of cerebral perfusion pressure-orientated management and tried to find factors of clinical management and biochemical findings that influence clinical, cognitive, and psychosocial outcome. Management at intensive care unit was standardized. A standardized (short form 36 health survey) and nonstandardized split ...
Jakobsen J?rn S - - 2010
OBJECTIVE: To investigate the effects on the pressure-flow relation of renal pelvic pressure during semirigid ureterorenoscopy and endoluminal perfusion of isoproterenol (ISO) 0.1 microg/mL, with emphasis on local effects and cardiovascular side-effects, as topically administered ISO effectively and dose-dependently causes relaxation of the upper urinary tract in pigs with no ...
Garbade Jens - - 2009
Continuous blood perfusion of donor hearts for transplantation has been the focus of an increasing amount of research, but the optimal preparation and perfusion techniques have not been clearly defined. Therefore, we investigated the effectiveness of different preservation strategies using continuous, normothermic heart perfusion after donor heart harvesting. Hearts of ...
Schmidt Bernhard B Department of Neurology, Chemnitz Medical Center, Dresdner Strasse 178, 09131 Chemnitz, Germany. - - 2009
The purpose of cerebral autoregulation is to keep cerebral blood flow constant during variations of cerebral perfusion pressure (CPP). Recently, the autoregulatory response was reported to be greater during arterial blood pressure (ABP) increase than during decrease following repeated induced changes in ABP in 14 brain-injured subjects. The goal of ...
Blain Grégory M - - 2009
We used extracorporeal perfusion of the reversibly isolated carotid sinus region to determine the effects of specific carotid body (CB) chemoreceptor inhibition on eupneic ventilation (Vi) in the resting, awake, intact dog. Four female spayed dogs were studied during wakefulness when CB was perfused with 1) normoxic, normocapnic blood; and ...
den Uil Corstiaan A - - 2009
Impaired tissue perfusion is often observed in patients with acute heart failure. We tested whether low-dose nitroglycerin (NTG) improves microcirculatory perfusion in patients admitted for acute heart failure. In 20 acute heart failure patients, NTG was given as intravenous infusion at a fixed dose of 33 microg/min. Using Sidestream Dark ...
Sun Tzong-Bor - - 2009
Both hypotension and hypertension aggravate the damage of reperfusion injury after reconstructive microsurgery. The purpose of this study is to establish a theoretical guide for postoperative blood pressure control in optimizing the cutaneous perfusion and flap survival. Systemic arterial pressure was altered by the intravenous infusion of saline, sodium nitroprusside, ...
Murakami Masataka - - 2009
A part of the salivary components are shifted from the blood via a trans- and/or paracellular route. The isolated, arterially perfused, salivary glands (submandibular and parotid glands) were used to assess paracellular transport functionally and morphologically. In the present study, the hydrostatic pressure of the perfusion was changed and the ...
Lindstedt Isak - - 2009
In the present study, we hypothesized that changes in perfusion pressure result in altered expression of mRNA and protein encoding for the ETA-, ETB-, AT1- and AT2-receptors in rat mesenteric vessels. Segments of the rat mesenteric artery were cannulated with glass micropipettes, pressurized and luminally perfused in a perfusion chamber. ...
Garbade Jens - - 2008
Continuous blood perfusion of donor hearts for transplantation has been the focus of an increasing amount of research, but the optimal preparation and perfusion techniques have not been clearly defined. Therefore, we investigated the effectiveness of different preservation strategies using continuous, normothermic heart perfusion after donor heart harvesting. Hearts of ...
Trivedi Monica M Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, - - 2009
Head injury remains a major cause of preventable death and serious morbidity in young adults. Based on the available evidence, it appears that a cerebral perfusion pressure of 50 to 70 mm Hg is generally adequate to ensure cerebral oxygen delivery and prevent ischemia. However, evidence suggests that perfusion requirements ...
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