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Results 251 - 300 of 1598
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Patel Jayesh - - 2011
Spinal deformity, a common problem in children with myelodysplasia, is associated with alterations in pulmonary function and sitting balance. Sitting imbalance causes areas of high pressure in patients already at high risk for developing pressure ulcers due to insensate skin. We asked: Does spinal deformity affect pulmonary function tests in ...
Dorfman Jon D - - 2011
BACKGROUND: Intracranial hypertension is a crucial modifiable risk factor for poor outcome after traumatic brain injury (TBI). Limited evidence suggests that decompressive laparotomy may be an effective treatment for refractory ICH in patients who have elevated intra-abdominal pressure. METHODS: Case report. RESULTS: We present a multi-trauma patient who sustained severe ...
Zafar Syed Nabeel - - 2011
BACKGROUND:: Recent research explores the relationship between vital signs on arrival to the emergency department and early outcomes. This work has not included traumatic brain injury (TBI). We aimed to evaluate the relationship of the initial emergency department systolic blood pressure (EDSBP) with outcome. METHODS:: By using the National Trauma ...
Yokobori Shoji - - 2011
BACKGROUND:: The aim of this study was to evaluate the time course of recovery from cerebral vulnerability, using microdialysis (MD) technique and cerebral vascular autoregulation measurement, to clarify the appropriate timing of subsequent major surgical procedures, and to minimize the possibility of secondary brain injury in patients with severe traumatic ...
Shahsavari S - - 2011
Myogenic autoregulation of cerebral blood ow is one of the mechanisms affecting cerebral hemodynamics. Short or long-lasting changes in intracranial pressure are believed to reveal the responses of the cerebral system to myogenic stimuli. Through the incorporation of a theoretical model into the experimental measurements of cerebrovascular distensibility and compliance ...
Fedorowski Artur - - 2011
Orthostatic hypotension (OH) is associated with increased total mortality but contribution of specific death causes has not been thoroughly explored. In this prospective study, authors followed up 32,068 individuals without baseline history of cancer or cardiovascular disease (69% men; mean age, 46 years; range, 26-61 years) over a period of ...
Carrera Emmanuel E Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom. - - 2011
The benefit of induced hyperventilation for intracranial pressure (ICP) control after severe traumatic brain injury (TBI) is controversial. In this study, we investigated the impact of early and sustained hyperventilation on compliances of the cerebral arteries and of the cerebrospinal (CSF) compartment during mild hyperventilation in severe TBI patients. We ...
Polly Derek M - - 2011
Severe hypertension is a frequent condition among patients presenting to emergency departments. Historically, this has been referred to as a hypertensive crisis. In addition, these hypertensive crises have been further divided into either hypertensive emergencies or urgencies depending on the presence or absence of target organ damage, respectively. The management ...
Esparza F - - 2011
Background Lower extremities injuries caused by non-body contact are highly prevalent in sports. Repetitive high loads on the foot could cause these injuries. Plantar pressure refers to the pressure measured on the plantar surface of the foot. Objective To measure the plantar pressure in soccer and basketball players. Design Descriptive ...
Harbeck-Seu Anja - - 2011
Traumatic brain injury is the leading cause of death in young patients and stroke is the leading cause of major disability in elderly patients. Both injuries are often followed by cerebral plasticity changes and increased intracerebral pressure (ICP). Aim of the review is to present current knowledge about amphetamines and ...
Lawson Lauren - - 2011
High blood pressure is one of the most common chronic medical conditions in this country, occurring in about 1 of every 3 adults. It is not uncommon for nurses to see individuals in the emergency room, hospital, home, or other settings who have severely elevated blood pressure readings. Extremely elevated ...
Johnson Ulf - - 2011
: Cerebral pressure autoregulation (CPA) is defined as the ability of the brain vasculature to maintain a constant blood flow over a range of different systemic blood pressures by means of contraction and dilatation. : To study CPA in relation to physiological parameters, treatment, and outcome in a series of ...
Shellington David K - - 2011
Resuscitation of hemorrhagic hypotension after traumatic brain injury is challenging. A hemoglobin-based oxygen carrier may offer advantages. The novel therapeutic hemoglobin-based oxygen carrier, polynitroxylated pegylated hemoglobin (PNPH), may represent a neuroprotective hemoglobin-based oxygen carrier for traumatic brain injury resuscitation. 1) PNPH is a unique non-neurotoxic hemoglobin-based oxygen carrier in neuronal ...
Citak Mustafa - - 2011
Study Design: Retrospective chart reviewObjective: The aim of this study was to analyze the correlation between necrotizing fasciitis and pressure ulcers, as well as the mortality and complication rate, in patients with spinal cord injury (SCI).Summary of Background Data: Pressure ulcers represent a challenging problem, especially in immobilized patients. Necrotizing ...
Bourdeaux Chris P - - 2011
BACKGROUND: Hypertonic sodium chloride solutions are routinely used to control raised intracranial pressure (ICP) after traumatic brain injury but have the potential to cause a hyperchloremic metabolic acidosis. Sodium bicarbonate 8.4% has previously been shown to reduce ICP and we have therefore conducted a randomized controlled trial to compare these ...
Chavanne Albert - - 2011
ABSTRACT: Study Design. In vitro cadaveric study of cervical spinal cord intramedullary pressure (IMP) in kyphotic deformity.Objective: To define the relationship between cervical spinal kyphotic deformity and spinal cord intramedullary pressure.Summary of Background Data. Previous studies of asymptomatic volunteers have revealed that the greatest variation in regional sagittal neutral upright ...
Jiang Li-Ping - - 2011
Pressure ulcers (PU) are caused by the interplay of multiple factors including skin microcirculation. Ischemia-reperfusion (I/R) injury is considered a significant mechanism in the early stages of pressure ulcer development. The objective of this controlled, single-blinded in vivo study was to create a pressure-induced injury rat animal model and explore ...
Kirkman E - - 2011
Blast injuries are an increasing problem in both military and civilian practice. Primary blast injury to the lungs (blast lung) is found in a clinically significant proportion of casualties from explosions even in an open environment, and in a high proportion of severely injured casualties following explosions in confined spaces. ...
Hutchison James S - - 2011
Hypotension and low cerebral perfusion pressure are known to be associated with unfavorable outcome in children and adults with traumatic brain injury. Using the database from a previously published, randomized controlled trial of 24 h of hypothermia therapy in children with severe traumatic brain injury, we compared the number of ...
Batchelor Peter Egerton - - 2011
Most cases of human spinal cord injury (SCI) are accompanied by continuing cord compression. Experimentally, compression results in rapid neurological decline over hours, suggesting a rise in intracanal pressure local to the site of injury. The aim of this study was to measure the rise in local intracanal pressure accompanying ...
Giesbrecht E M - - 2011
Study design:This study was a repeated measures study.Objectives:The objective was to systematically measure the relative reduction in interface pressure (IP) at the ischial tuberosities (IT) and sacrum through 10° increments of tilt in a manual wheelchair among individuals with motor complete spinal cord injury (SCI).Setting:This study was carried out in ...
Timofeev Ivan I Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke’s Hospital, Cambridge, - - 2011
Secondary insults can adversely influence outcome following severe traumatic brain injury. Monitoring of cerebral extracellular chemistry with microdialysis has the potential for early detection of metabolic derangements associated with such events. The objective of this study was to determine the relationship between the fundamental biochemical markers and neurological outcome in ...
Agbeko Rachel S - - 2011
OBJECTIVES:: To determine the effect of and dynamic interaction between head elevation on intracranial pressure and cerebral perfusion pressure in severe pediatric traumatic head injury. DESIGN:: Prospective, randomized, interventional cohort study. SETTING:: Two tertiary pediatric critical care referral units. PATIENTS:: Ten children admitted with severe traumatic brain injury defined as ...
Idowu O K - - 2011
Study design:Pressure ulceration and other complications constitute an encumbrance in the management of spinal cord injury in many services with limited resources in developing countries. These services undertake patients' care without adequate prehospital care, limited modern infrastructure and limited number of trained staff.Objectives:To evaluate the associated risk factors for pressure ...
Melo José Roberto Tude - - 2011
PURPOSE: The purpose of this study is to evaluate the accuracy of emergency Transcranial Doppler (TCD) to predict intracranial hypertension and abnormal cerebral perfusion pressure in children with severe traumatic brain injury (TBI). PATIENTS AND METHODS: A descriptive and retrospective cross-sectional study was designed through data collected from medical records ...
Leonardi Alessandra Dal Cengio - - 2011
Traumatic brain injuries (TBI) caused by improvised explosive devices (IEDs) affect a significant percentage of surviving soldiers wounded in Iraq and Afghanistan. The extent of a blast TBI, especially initially, is difficult to diagnose, as internal injuries are frequently unrecognized and therefore underestimated, yet problems develop over time. Therefore it ...
Utrobicić I - - 2011
High-pressure injection injuries to the hand are work-related injuries that can take a devastating toll on the functionality of the affected extremity. We present two cases of high-pressure injection hand injuries due to paint and sand. The patients were managed operatively and switch to intensive physiotherapeutic training, with excellent outcome.
Gura Melek - - 2011
In traumatic brain injury (TBI) patients, it is desired to monitor the intracranial pressure (ICP) to assess the cerebral haemodynamics and guide the therapy. The study was designed to see if the pulsatility index (PI) measured by transcranial Doppler ultrasonography (TCD) predicts information about ICP values. In 52 TBI patients ...
Haavind Anniken - - 2011
Pneumonia, severe sepsis, and acute respiratory distress syndrome (ARDS) are frequent complications after head trauma. Recombinant human activated protein C (APC) reportedly improves circulation and respiration in severe sepsis, but is contraindicated after head injury because of increased risk of intracranial bleeding. A 21-year-old man with severe head injury after ...
Rabadi Meheroz Hoshang - - 2011
The overall goal of this observational study was to determine whether modifiable vascular risk factors contribute to the prevalence of pressure ulcers (PrU) in veterans with traumatic spinal cord injury (SCI). Given the increasingly limited financial resources in hospitals and clinics, identifying risk factors associated with the development of PrU ...
Rice Todd W - - 2011
Conservative fluid management in patients with acute lung injury (ALI) increases time alive and free from mechanical ventilation. Vascular pedicle width (VPW) is a non-invasive measurement of intravascular volume status. The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW ...
Nelson David W - - 2011
Cerebral microdialysis (MD) is used to monitor local brain chemistry of patients with traumatic brain injury (TBI). Despite an extensive literature on cerebral MD in the clinical setting, it remains unclear how individual levels of real-time MD data are to be interpreted. Intracranial pressure (ICP) and cerebral perfusion pressure (CPP) ...
Peace Kaitlin - - 2010
Object Follow-up head CT scans are important in neurocritical care but involve intrahospital transport that may be associated with potential hazards including a deleterious effect on brain tissue oxygen pressure (PbtO(2)). Portable head CT (pHCT) scans offer an alternative imaging technique without a need for patient transport. In this study, ...
Sonenblum Sharon E - - 2011
The overall goal of this research was to improve the use of seated tilt to increase function, health and quality of life for people using power wheelchairs. Specifically, the objective of this study was to evaluate the biomechanical responses to seated full body tilt in persons with spinal cord injury ...
Etz Christian D - - 2010
To minimize paraplegia during thoracoabdominal aortic aneurysm repair, the concept of the collateral network was developed. That is, spinal cord perfusion is provided by an interconnecting complex of vessels in the intraspinal, paraspinous, and epidural space and in the paravertebral muscles, including intercostal and lumbar segmental as well as subclavian ...
Groothuis Jan T - - 2010
To compare the effect of different sympathetic stimuli, that is, exaggerated sympathetic activity and orthostatic challenges, on the increase in leg vascular resistance in persons with spinal cord injury (SCI) without and controls with supraspinal sympathetic control. Case-control intervention study. Physiology research laboratory. Persons with SCI (N=9; motor and sensory ...
Chavko Mikulas - - 2011
Exposure to a blast wave generated during an explosion may result in brain damage and related neurological impairments. Several mechanisms by which the primary blast wave can damage the brain have been proposed, including: (1) a direct effect of the shock wave on the brain causing tissue damage by skull ...
Sakellaridis Nikolaos - - 2011
The purpose of this study was to compare the effects of mannitol and hypertonic saline in doses of similar osmotic burden for the treatment of intracranial hypertension in patients with severe traumatic brain injury. The authors used an alternating treatment protocol to compare the effect of hypertonic saline with that ...
Ko Sang-Bae - - 2010
Paroxysmal sympathetic storm (PSS) is a rare complication of severe traumatic brain injury or cerebrovascular disease. Various medications have been tried in patients with PSS, but the clinical responses of the patients were variable. We report a classic case of PSS after spontaneous pontine hemorrhage in which the patient's fluctuating ...
Delgado Esmeralda - - 2010
This study characterizes the effects of endothelin-1 (ET-1) on the perfusion pressure of the choroidal vasculature using in situ perfused isolated rabbit eyes. Rabbit external ophthalmic arteries (n = 12) in a head-mounted preparation were cannulated and perfused with warmed tyrode. The three-way polypropylene catheter was further connected to a ...
Boerma E Christiaan - - 2010
The clinical use of vasoactive drugs is not only intended to improve systemic hemodynamic variables, but ultimately to attenuate derangements in organ perfusion and oxygenation during shock. This review aims (1) to discuss basic physiology with respect to manipulating vascular tone and its effect on the microcirculation, and (2) to ...
Elbers Paul W G - - 2011
Possible benefits of pulsatile perfusion during cardiopulmonary bypass often are attributed to enhanced microvascular flow. However, there is no evidence to support this in humans. Therefore, the authors assessed whether pulsatile perfusion alters human microvascular flow. A prospective, randomized observational crossover study. A tertiary cardiothoracic surgery referral center. Sixteen patients ...
Javadi Hamid - - 2010
Dipyridamole has extensively been administered as a substitute for physical activity in cardiovascular assessment. The aim of this study was to evaluate the association of dipyridamole side effects with hemodynamic oscillations, scanning results, and electrocardiography (ECG) findings. Overall, 590 patients referred to the nuclear medicine center for myocardial perfusion imaging ...
Krzemiński Tadeusz F - - 2010
The aim of our study was to find the most effective xylidine derivative, which reduced mortality, reduced incidence and duration of severe arrhythmias and had a beneficial influence on hemodynamic parameters in an in vivo setting. We compared the action of lidocaine, articaine, ropivacaine and mepivacaine in a dose 2.5 ...
- - 2010
Variations in ventilator designs may result in different inspiratory pressures being delivered at seemingly identical settings during delivery of pressure-controlled breaths. Because a lack of familiarity with these design variations may lead to the setting of excessive pressures that could result in lung injuries, staff need to be trained to ...
Jan Y-K - - 2011
Two-way factorial mixed design, the between-subjects factor as the spinal cord injury (SCI) status (SCI and non-SCI) and the within-subjects factor as the pressure pattern (alternating and constant pressures). To compare the effects of alternating and constant pressures on weight-bearing tissue perfusion in people with SCI, with application for improving ...
McNamee David A - - 2011
Recent research by the authors on the effects of extremely low-frequency (ELF) magnetic field (MF) exposure on human heart rate (HR), heart rate variability (HRV), and skin blood perfusion found no cardiovascular effects of exposure to an 1,800-μT, 60-Hz MF. Research from our group using rats, however, has suggested a ...
Jaeger Matthias M Department of Neurosurgery, University of Leipzig, Leipzig, Germany. - - 2010
To evaluate the concept of a cerebrovascular pressure reactivity-guided optimal cerebral perfusion pressure after traumatic brain injury by analyzing the relationship between optimal cerebral perfusion pressure and brain tissue oxygen. Prospective observational cohort study. Neurosurgical intensive care unit of a university hospital. Thirty-eight patients after head injury. Continuous computerized monitoring ...
Aylin Arici Mualla - - 2010
P-glycoprotein (P-gp) is expressed in tumour cells as well as normal tissues including heart. Modulation of P-gp transport in vivo may lead to increased drug penetrance to tissues with resulting increases in toxicity. We aimed to investigate the effects of P-gp on the isolated heart by digoxin infusion in the ...
Jakob Stephan M - - 2010
Mechanical ventilation is a cornerstone of ICU treatment. Because of its interaction with blood flow and intra-abdominal pressure, mechanical ventilation has the potential to alter hepato-splanchnic perfusion, abdominal organ function and thereby outcome of the most critically ill patients. Mechanical ventilation can alter hepato-splanchnic perfusion, but the effects are minimal ...
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