Search Results
Results 151 - 200 of 1561
1 2 3 4 5 6 7 8 9 10 >
Soehle Martin - - 2013
Physiological parameters, such as intracranial pressure (ICP), are regulated by interconnected feedback loops, resulting in a complex time course. According to the decomplexification theory, disease is characterised by a loss of feedback loops resulting in a reduced complexity of the time course of physiological parameters. We hypothesized that complexity of ...
Griesdale Donald Eg - - 2013
ABSTRACT: The observational literature suggests that hypernatremia is associated with worse outcomes in patients with traumatic brain injury. In a previous issue of Critical Care, Wells and colleagues add to this literature by failing to show an association between hypernatremia and reduced intracranial pressure. However, we must bear in mind ...
Kocan Mary Jo - - 2013
Patients with neurologic illness or injury benefit from early interventions to increase physical activity and mobility, but they also have special needs related to hemodynamic stability and intracranial pressure dynamics. After brain injury, moving paralyzed limbs-even passively-helps promote neural plasticity, "rerouting" signals around the injured area and forming new connections, ...
Akutsu Nobuyuki - - 2013
In cases of severe uncontrollable brain swelling, simple skin closure often increases intracranial pressure. This study examined the efficacy of a new technique of decompressive skinplasty to decrease intracranial pressure following decompressive craniectomy in cases of severe traumatic brain injury with uncontrollable brain swelling. In our technique, we use artificial ...
Zhang Yin-Gang - - 2013
Because negative pressure can stimulate vascular proliferation, improve blood circulation and promote osteogenic differentiation of bone marrow stromal cells, we investigated the therapeutic effect of negative pressure on femoral head necrosis (FHN) in a rabbit model. Animals were divided into four groups (n = 60/group): [1] model control, [2] core decompression, [3] ...
Harrigan T P - - 2013
The skull-brain complex is typically modeled as an integrated structure, similar to a fluid-filled shell. Under dynamic loads, the interaction of the skull and the underlying brain, cerebrospinal fluid, and other tissue produces the pressure and strain histories that are the basis for many theories meant to describe the genesis ...
Hamlyn John M - - 2013
Endogenous cardiotonic steroids (CTS) exert long-term effects on salt and blood pressure homeostasis. Here we discuss recent observations on mechanisms of salt sensitivity that involve endogenous ouabain and novel pathways in the brain and discuss their possible relationship to arterial and renal function in hypertension. Chronic elevation of brain sodium ...
Aung Thein - - 2013
The baroreceptors in the neck and aortic arch are important regulators of sudden blood pressure changes. They are innervated by CN IX and X and synapse in the brainstem. Baroreceptor failure is an under-recognized cause of recurrent syncope, orthostatic hypotension, and volatile hypertension, which is refractory to and may in ...
Stuebner Eva - - 2013
Non-motor symptoms are now commonly recognized in Parkinson's disease (PD) and can include dysautonomia. Impairment of cardiovascular autonomic function can occur at any stage of PD but is typically prevalent in advanced stages or related to (anti-Parkinsonian) drugs and can result in atypical blood pressure (BP) readings and related symptoms ...
Hocker Sara E - - 2013
Background: Although the effects of opioids on intracranial pressure (ICP) have long been a subject of controversy, they are frequently administered to patients with severe head trauma. We present a patient with an uncommon paradoxical response to opioids.Case Report: A patient with refractory intracranial hypertension after closed head injury was ...
Schoon Yvonne - - 2013
Carotid sinus hypersensitivity has a high prevalence in the elderly and is a possible cause of falls. In carotid sinus hypersensitivity, external triggers cause sudden reductions in blood pressure, leading to dizziness or syncope, resulting in falls. Turning of the head is considered an important example of such an external ...
Rangamani Padmini - - 2013
We present here a procedure for growing lipid tubules in vitro. This method allows us to grow tubules of consistent shape and structure, and thus can be a useful tool for nano-engineering applications. There are three stages during the tubule growth process: initiation, elongation and termination. Balancing the forces that ...
Aleksandrowicz M - - 2013
Hyponatremia is a common disorder of water-electrolyte balance characterized by the decrease of plasma sodium ions concentration below 135 mM. Although water-electrolyte balance is regulated by a kidney, symptoms of hyponatremia are related to the disturbances of intracranial homeostasis and are attributed to brain swelling. Despite the importance of blood ...
Krbila S - - 2013
 Objective: The aim of the study was to assess (i) a group of patients with established intracranial pressure (ICP) sensor in severe brain injuries scoring 3 points of Glasgow Coma Scale, (ii) mortality and survival of the patients within periods of 7, 30, 180 and 270 days; and (iii) predictive value ...
Roy Chowdhury Uttio U Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of - - 2013
Reduced intracranial pressure is considered a risk factor for glaucomatous optic neuropathies. All current data supporting intracranial pressure as a glaucoma risk factor comes from retrospective and prospective studies. Unfortunately, there are no relevant animal models for investigating this link experimentally. Here we report a novel rat model that can ...
Güiza Fabian - - 2012
OBJECTIVE:: Intracranial pressure monitoring is standard of care after severe traumatic brain injury. Episodes of increased intracranial pressure are secondary injuries associated with poor outcome. We developed a model to predict increased intracranial pressure episodes 30 mins in advance, by using the dynamic characteristics of continuous intracranial pressure and mean ...
Rodríguez-Boto G - - 2012
INTRODUCTION: Many brain processes that cause death are mediated by intracranial hypertension (ICH). The natural course of this condition inevitably leads to brain death. The objective of this study is to carry out a systematic review of cerebral pathophysiology and intracranial pressure (ICP) monitoring. DEVELOPMENT: Studying, monitoring, and recording ICP ...
Ropper Allan H - - 2012
The brain, despite its sophistication, resides in a rudimentary container. The rigid cranium restricts enlargement of its contents, so that intracranial pressure rises rapidly as brain volume expands. When pressure becomes greatly elevated, cerebral blood flow is impeded, and the result is brain death. For this reason, the reduction of ...
Chesnut Randall M RM Department of Neurological Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA. - - 2012
Intracranial-pressure monitoring is considered the standard of care for severe traumatic brain injury and is used frequently, but the efficacy of treatment based on monitoring in improving the outcome has not been rigorously assessed. We conducted a multicenter, controlled trial in which 324 patients 13 years of age or older ...
Roth Christian - - 2012
BACKGROUND: Physiotherapy plays an important role in the therapy of patients with acute cerebral diseases. Studies concerning the effects of physiotherapy on intracerebral pressure (ICP) and cerebral perfusion pressure (CPP) are, however, rare. METHODS: An observational study was performed on critically ill patients who were receiving ICP measurements and who ...
Uğraş Gülay Altun - - 2012
ABSTRACT: Although endotracheal suctioning is a routine nursing intervention, this procedure can lead to an increase in intracranial pressure (ICP). This study was planned to determine the appropriate suctioning technique (open system suctioning [OS] and closed system suctioning [CS]) to minimize variability of ICP and cerebral perfusion pressure (CPP) in ...
Linsler Stefan - - 2012
INTRODUCTION: LiquoGuard is a new device for intracranial pressure (ICP)-controlled drainage of cerebrospinal fluid (CSF). This present study evaluates the accuracy of ICP measurement via the LiquoGuard device in comparison with Spiegelberg. Thus, we compared data ascertained from simultaneous measurement of ICP using tip-transducer and tip-sensor devices. MATERIAL AND METHODS: ...
Varsos Georgios V GV Neurosurgical Unit, Department of Clinical Neurosciences, Division of Neurosurgery, Addenbrooke's Hospital, Cambridge, UK. - - 2013
Critical closing pressure (CCP) is the arterial blood pressure (ABP) at which brain vessels collapse and cerebral blood flow (CBF) ceases. Using the concept of impedance to CBF, CCP can be expressed with brain-monitoring parameters: cerebral perfusion pressure (CPP), ABP, blood flow velocity (FV), and heart rate. The novel multiparameter ...
Villar Rodrigo - - 2013
This study hypothesized that central and local reflex mechanisms affecting vascular conductance (VC) through the popliteal artery compensated for the reduction in muscle perfusion pressure (MPP) to maintain popliteal blood flow (PBF) during head-down tilt (35˚ HDT), but not in head-up tilt (45˚ HUT). Resting measurements were made on 15 ...
Weenink Robert P - - 2012
Cerebral arterial gas embolism (CAGE) is well known as a complication of invasive medical procedures and as a risk in diving and submarine escape. In the underwater environment, CAGE is caused by trapped air, which expands and leads to lung vessel rupture when ambient pressure decreases during ascent. Pressure decrease ...
Eley Karen A - - 2012
: In a small number of children with unicoronal synostosis, the phenotype is mild and the aesthetic benefit of surgical correction is potentially outweighed by surgical risk. Raised intracranial pressure, however, would necessitate intervention. The authors documented the incidence of raised intracranial pressure in children with mild features and/or parental ...
Park Jin Suk - - 2012
This study was designed to assess the effects of pneumoperitoneal pressure (PP) and positional changes on the respiratory mechanics during laparoscopy assisted colectomy. Peak inspiratory pressure, plateau pressure, lung compliance, and airway resistance were recorded in PP of 10 mmHg and 15 mmHg, with the position change in 5 steps: ...
Porta A A Department of Biomedical Sciences for Health, Galeazzi Orthopedic Institute, University of Milan, Milan, Italy. - - 2012
It is unclear whether the complexity of the variability of the systolic arterial pressure (SAP) provides complementary information to that of the heart period (HP). The complexity of HP and SAP variabilities was assessed from short beat-to-beat recordings (i.e., 256 cardiac beats). The evaluation was made during a pharmacological protocol ...
Somkuti Judit - - 2012
Contrary to the classical view, according to which all proteins adopt a specific folded conformation necessary for their function, intrinsically unstructured proteins (IUPs) display random-coil-like conformation under physiological conditions. We compared the structured and unstructured domains from titin, a giant protein responsible for striated-muscle elasticity. A 171-residue-long fragment (polyE) of ...
Sheth Kevin N - - 2012
OBJECTIVE: Detecting and treating elevated intracranial pressure (ICP) is a cornerstone of management in patients with severe traumatic brain injury. The aim of this study was to determine the association between area under the curve measurement of elevated ICP and clinical outcome. METHODS: Single center observational study using prospectively collected ...
Al-Jehani Hosam M - - 2012
Management of intracranial hypertension is a major cornerstone of neurocritical care. Apart from traumatic brain injury, there are no clear guidelines for intracranial pressure (ICP) monitoring. The insertion of ICP monitors is an invasive procedure with inherent risks and could be contraindicated in case of severe coagulopathy. The transcranial Doppler ...
Xia Wang - - 2012
Objective To explore the effects of different liquid therapies on the intracranial pressure, brain water content, and expressions of aquaporin-4 and N-methyl-D-aspartate-1 in the brain tissue. Methods Two intervention factors including the colloids (two levels: 4% gelofusine; 6% hydroxyethyl starch and sodium chloride injection) and the crystal/gel ratios (two levels: ...
Md Sina Grape - - 2012
Persisting severe brain edema causes intracranial hypertension and is associated with poor patient outcome. The treatment of acute intracranial hypertension is complex and multimodal. The most important options for medical treatment include controlled ventilation and osmotherapy, maintenance of brain and body homeostasis, and sedation. Osmotherapy is recommended in all relevant ...
Hamilton Robert R Neural Systems and Dynamics Laboratory, Department of Neurosurgery, the David Geffen School of Medicine, University of California-Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095, - - 2012
This study identifies a novel relationship between cerebrospinal fluid (CSF) stroke volume through the cerebral aqueduct and the characteristic peaks of the intracranial pulse (ICP) waveform. ICP waveform analysis has become much more advanced in recent years; however, clinical practice remains restricted to mean ICP, mainly due to the lack ...
Mathieu Antoine - - 2012
BACKGROUND:: In patients with severe brain injury, endotracheal suctioning (ETS) can increase intracranial pressure (ICP) and reduce cerebral perfusion pressure (CPP). The aim of this prospective, blinded clinical trial was to assess the effectiveness of aerosolized lidocaine to prevent increase of ICP induced by ETS in mechanically ventilated head-injured patients. ...
Goldstein David S - - 2012
A cardinal manifestation of chronic autonomic failure is neurogenic orthostatic hypotension (OH), which often is associated with supine hypertension, posing a therapeutic dilemma. We report here success in a first step toward development of a "prosthetic baroreceptor system" to maintain blood pressure during orthostasis without worsening supine hypertension. In all ...
Brady Ken M - - 2012
The pressure reactivity index (PRx) identifies optimal cerebral perfusion pressure after traumatic brain injury. We describe a method to improve PRx precision by induced variations in arterial blood pressure (ABP) using positive end-expiratory pressure (PEEP) modulation (iPRx). Neonatal swine (n = 10) were ventilated with static PEEP and then with ...
Tang Peter - - 2012
We compare scaphoid excision and 4-bone arthrodesis (FBA) with proximal row carpectomy (PRC) in terms of contact pressure, area, and location. Six cadaveric forearms underwent simulated FBA with K-wires. We measured pressures in the radiocarpal joint with Fuji contact film after we applied a 200-N load via the wrist tendons ...
Piacsek Andrew A - - 2012
A possible method for noninvasively monitoring changes in intracranial pressure is to measure changes in skull resonance frequencies. Recent measurements of the vibrational response of a spherical aluminum shell clearly demonstrate that resonance frequencies shift higher as the internal pressure is increased [Piacsek et al, J. Acous. Soc. Am, 131, ...
Dal Cengio Leonardi Alessandra - - 2012
Since an increasing number of returning military personnel are presenting with neurological manifestations of traumatic brain injury (TBI), there has been a great focus on the effects resulting from blast exposure. It is paramount to resolve the physical mechanism by which the critical stress is being inflicted on brain tissue ...
Muehlsteff Jens - - 2012
Blood pressure regulation failures cause neurally mediated syncope often resulting in a fall. A warning device might help to make patients aware of an impending critical event or even trigger the patient to perform countermeasures such as lying down or isometric exercises. We previously demonstrated that the Pulse Arrival Time ...
Kim Mi Ok - - 2012
The pulsatile energy transmission between arterial blood pressure (BP) and intracranial pressure (ICP) is affected by cerebrospinal fluid (CSF) and brain tissue. Studies in dogs have shown that the transfer function (TF) between BP and ICP shows damping of pulsatile energy around heart rate frequency (1-3Hz) with notch filter characteristics, ...
Nazirizadeh Yousef - - 2012
We propose and demonstrate a visual, all-optical pressure-measuring device composed of a flexible membrane dilating toward a photonic crystal slab. Due to its transparency and capability to be miniaturized, it may be integrated on the inner side of an artificial lens and directly measure the eye's intraocular pressure. Using crossed ...
Volpe Massimo M Department of Clinical and Molecular Science, Division of Cardiology, Faculty of Medicine, University of Rome Sapienza, Sant'Andrea Hospital, Rome, Italy. - - 2012
Angiotensin II receptor blockers (ARBs) inhibit the renin-angiotensin system. As a result, these agents provide beneficial effects in terms of cardiovascular (CV) and renal protection, independent of their blood pressure-lowering effects. Telmisartan and valsartan are the most intensively studied ARBs for the effects on CV outcomes. Randomized clinical trials assessing ...
Gutbrod Andreas - - 2012
OBJECTIVE: To evaluate the effect of 15° external rotational humeral osteotomy (ERHO) on canine elbow joint contact mechanics. STUDY DESIGN: Ex vivo biomechanical study. SAMPLE POPULATION: Unpaired cadaveric canine thoracic limbs (n = 8) METHODS: Digital pressure sensors placed in a subchondral osteotomy distal to the elbow joint were used ...
Ode Gabriella E - - 2012
BACKGROUND:Radial transection of the peripheral fibers of the meniscus could render it nonfunctional; however, the biomechanical consequences of a complete lateral meniscal radial tear and repair in human specimens have not been elucidated. HYPOTHESIS:A complete radial tear will exhibit knee contact mechanics approaching those of total meniscectomy. Repair of complete ...
Matityahu A M - - 2012
Open reduction and internal fixation of a distal radius fracture can leave a volar plate in close proximity or touching the tendons of the wrist. This cadaveric study examines the how volar plate position changes contact pressure and force against the flexor pollicis longus (FPL) tendon in multiple wrist extension ...
Schimpf Melissa M - - 2012
Increased intracranial pressure (ICP) is a challenging complication to treat within a critical care setting. It is imperative that clinicians use a stepwise approach in developing a diagnosis, as to be comprehensive and decrease morbidity and mortality related to increased ICP. This article provides an algorithm that can be used ...
Posthuma Leo - - 2012
Species sensitivity distributions (SSDs) quantify fractions of species potentially affected in contaminated environmental compartments using test species sensitivity data. The present study quantitatively describes associations between predicted and observed ecological impacts of contaminant mixtures, based on monitoring data of benthic macroinvertebrates. Local mixture toxic pressures (multi-substance potentially affected fraction of ...
Martinelli N - - 2012
Previous studies reported the effect of flatfoot deformity on tibiotalar joint contact characteristics. The lateral shift of the load which occurred in flatfeet may be responsible for degenerative changes in the ankle joint. The purpose was to assess the pattern of joint contact stress of the tibiotalar joint in intact, ...
1 2 3 4 5 6 7 8 9 10 >