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Francis Richard R Neurosurgical Trials Unit, 3-4 Claremont Terrace, Newcastle University , Newcastle upon Tyne , - - 2014
Introduction. Recent research has been equivocal regarding the usefulness of intracranial pressure (ICP) monitoring for traumatic intracerebral haemorrhage (ICH). We aimed to investigate attitudes of clinicians from as wide an international audience as possible. Materials and methods. A SurveyMonkey(®) questionnaire was distributed to individuals, including members of the Society of ...
Eide Per Kristian - - 2014
Monitoring of intracranial pressure (ICP) is a cornerstone in the surveillance of neurosurgical patients. The ICP is measured against a baseline pressure (i.e. zero - or reference pressure). We have previously reported that baseline pressure errors (BPEs), manifested as spontaneous shift or drifts in baseline pressure, cause erroneous readings of ...
Blankstein Michael M AO Research Institute Davos, Davos, - - 2014
The benefits of cement augmentation with fixation of osteoporotic pertrochanteric fractures have been previously demonstrated. The objective of this study was threefold: 1. Quantify the intra-osseous pressure produced during cement augmentation of the perforated PFNA blades. 2. Assess whether the pressure generated is influenced by the injection rate. 3. Assess ...
Lauerman Margaret H MH Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, - - 2014
Intracranial pressure (ICP) control is a mainstay of traumatic brain injury (TBI) management. However, development of intracranial hypertension (ICH) may be affected by factors outside of the cranial vault in addition to the local effects of the TBI. This review will examine the pathophysiology of multiple compartment syndrome (MCS) and ...
Karamanos Efstathios E Division of Acute Care Surgery (Trauma, Emergency Surgery, and Surgical Critical Care), University of Southern California-Keck School of Medicine, Los Angeles County General Hospital (LAC + USC), 2051 Marengo Street, C5L100, Los Angeles, CA 90033-4525, USA. Electronic address: - - 2014
Intracranial pressure (ICP) monitoring is a standard of care in severe traumatic brain injury when clinical features are unreliable. It remains unclear, however, whether elevated ICP or decreased cerebral perfusion pressure (CPP) predicts outcome. This is a prospective observational study of patients sustaining severe blunt head injury, admitted to the ...
Fujita Yasuki Y Departments of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, - - 2014
Data on intraoperative secondary insults in pediatric traumatic brain injury (TBI) are limited. We examined intraoperative secondary insults during extracranial surgery in children with moderate-severe TBI and polytrauma and their association with postoperative head computed tomography (CT) scans, intracranial pressure (ICP), and therapeutic intensity level (TIL) scores 24 h after surgery. ...
Ragauskas Arminas - - 2014
Objectives: To compare the diagnostic reliability of optic nerve sheath diameter (ONSD) ultrasonography with a transcranial Doppler (TCD)-based absolute intracranial pressure (ICP) value measurement method for detection of elevated ICP in neurological patients. The ONSD method has been only tested previously on neurosurgical patients. Methods: A prospective clinical study of ...
Kranz P G PG Department of Radiology, Duke University Medical Center, Durham, North Carolina; and Department Radiology and Radiological Science, Medical University of South Carolina, Charleston, South - - 2014
SUMMARY:Rebound intracranial hypertension is a complication of epidural blood patching for treatment of intracranial hypotension characterized by increased intracranial pressure, resulting in potentially severe headache, nausea, and vomiting. Because the symptoms of rebound intracranial hypertension may bear some similarity to those of intracranial hypotension and literature reports of rebound intracranial ...
Lizy Christelle C Christelle Lizy is a registered nurse, Dirk Vogelaers, Koenraad Vandewoude, and Stijn Blot are professors in the Department of Internal Medicine, Faculty of Medicine and Healthcare, Ghent University, Ghent, Belgium. Walter Swinnen is an intensivist and director of the intensive care unit, General Hospital Sint Blasius, Dendermonde, Belgium, Sonia Labeau is a lecturer in the Faculty of Education, Health and Social Work, University College Ghent, Ghent, Belgium, and Jan Poelaert is director of the Department of Anesthesiology, Free University Brussels, Brussels, Belgium. Joel Dulhunty is an intensivist in the Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, and the Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, - - 2014
Background In order to avoid microaspiration and tracheal injury, the target for endotracheal tube cuff pressure is 20 to 30 cm H2O. Objective To assess the effect of changes in body position on cuff pressure in adult patients. Methods Twelve orally intubated and sedated patients received neuromuscular blockers and were ...
Kasapas Konstantinos K Department of Neurosurgery, Athens General Hospital "G. Gennimatas", 11527 Athens, - - 2014
Introduction. An experimental epidural hematoma model was used to study the relation of ultrasound indices, namely, transcranial color-coded-Doppler (TCCD) derived pulsatility index (PI), optic nerve sheath diameter (ONSD), and pupil constriction velocity (V) which was derived from a consensual sonographic pupillary light reflex (PLR) test with invasive intracranial pressure (ICP) ...
Atsumi Hideki - - 2014
Objective: To assess a newly proposed noninvasive technique for evaluating intracranial pressure (ICP) index and brain compliance (BC) index based on an inverse analysis of a brain-circulation-equivalent electrical circuit (EC) model, in which cerebrospinal fluid (CSF) flow and arterial flow rates measured by using the phase contrast method are used ...
Lang Georgina E GE Mathematical Institute, University of Oxford, , Oxford, - - 2014
Brain tissue swelling is a dangerous consequence of traumatic injury and is associated with raised intracranial pressure and restricted blood flow. We consider the mechanical effects that drive swelling of brain tissue slices in an ionic solution bath, motivated by recent experimental results that showed that the volume change of ...
Erbabacan Emre E Istanbul University Cerrahpasa Medical Faculty, Department of Anaesthesiology and Reanimation, Fatih, - - 2014
Right internal jugular vein (RIJV) catheterisation is a common procedure in patients undergoing surgery. We aimed to compare diameters and the cross-sectional area (CSA) of the RIJV when the head is in a neutral or 30-degree rotated position during mechanical ventilation in various modes and spontaneous ventilation. Thirty patients undergoing ...
Song Zhiming Z Department of Cardiac Surgery, Peking University Third Hospital, Beijing, China - - 2014
Background The aim of this study was to determine the hemodynamic effects of various support modes of continuous flow left ventricular assist devices (CF-LVADs) on the cardiovascular system using a numerical cardiovascular system model. Material and Methods Three support modes were selected for controlling the CF-LVAD: constant flow mode, constant ...
Toksvang Linea Natalie LN Centre of Inflammation and Metabolism, University Hospital of Copenhagen, Copenhagen Ø, - - 2014
Summary We report a case of cerebral aspergilloma in a 25-year-old immunoincompetent man admitted to a general intensive care unit. Monitoring of intracranial pressure was instigated and revealed hour-long epochs of severe intracranial hypertension, despite a normal opening pressure, with decreases in cerebral perfusion pressure. We documented that this was ...
Reisner Andrew A Massachusetts General Hospital, Department of Emergency Medicine, Boston, Massachusetts, United States ; - - 2013
We hypothesized that vital signs could be used to improve the association between a trauma patient's prehospital Glasgow coma scale (GCS) score and his or her clinical condition. Previously, abnormally low and high blood pressures have both been associated with higher mortality for patients with traumatic brain injury (TBI). We ...
Launey Yoann Y CHU de Rennes, Anesthesiology & Critical Care, 2, rue Henri Le Guilloux, Rennes, France, 35033, +33 299 285 485, +33 299 282 559, Inserm, UMR991 - team2, Rennes, France ; - - 2013
The measurement of ocular nerve sheath diameter (ONSD) via ocular ultrasound scanning is a recent non-invasive method for intracranial pressure (ICP) assessment. Few clinical studies have assessed ONSD variations during osmotherapy for the treatment of sustained increased ICP episodes. The aim of our study was to determine the rate of ...
Andersen Johnny Dohn Holmgren JD From the Department of Anaesthesiology, University of Copenhagen, Glostrup Hospital, Glostrup, - - 2013
Near-infrared spectroscopy (NIRS) has been used to study regional cerebral blood oxygen saturation (rScO2) in patients in the prone position. We aimed to test the hypothesis that head rotation more than 45° would affect the rScO2. A prospective, controlled, single cohort study. University Hospital specialising in spinal surgery. Fifty-two patients ...
Imam Ayesha M - - 2013
Combination of traumatic brain injury (TBI) and hemorrhagic shock (HS) can result in significant morbidity and mortality. We have previously shown that early administration of fresh frozen plasma (FFP) in a large animal model of TBI and HS reduces the size of the brain lesion as well as the associated ...
Böhm Matthias M CIML Group, Department of Biophysics, University of Regensburg, 93040 Regensburg, Germany and Department of Neurosurgery, University Hospital Regensburg, 93042 Regensburg, - - 2013
Recently, a mathematical model of the basic physiological processes regulating the cerebral perfusion and oxygen supply was introduced [Jung et al., J. Math. Biol. 51, 491 (2005)]. Although this model correctly describes the interdependence of arterial blood pressure (ABP) and intracranial pressure (ICP), it fails badly when it comes to ...
Kirkman M A - - 2013
Measurement of intracranial pressure (ICP) and mean arterial pressure (MAP) is used to derive cerebral perfusion pressure (CPP) and to guide targeted therapy of acute brain injury (ABI) during neurointensive care. Here we provide a narrative review of the evidence for ICP monitoring, CPP estimation, and ICP/CPP-guided therapy after ABI. ...
Rao Vidar - - 2013
Cerebral perfusion pressure (CPP) is defined as the difference between the mean arterial pressure (MAP) and the intracranial pressure (ICP). However, since patients with traumatic brain injury (TBI) are usually treated with head elevation, the recorded CPP values depends on the zero level used for calibration of the arterial blood ...
Deng Wenjun - - 2013
Postural orthostatic tachycardia syndrome (POTS) is common, and has a serious impact on children's quality of life. Midodrine hydrochloride, an α1-adrenoreceptor agonist, is an effective treatment. The study was designed to examine the therapeutic efficacy of midodrine hydrochloride by quantifying changes in blood pressure during the head-up test (HUT), in ...
Varsos Georgios V - - 2013
Reducing cerebral perfusion pressure (CPP) below the lower limit of autoregulation (LLA) causes cerebral blood flow (CBF) to become pressure passive. Further reductions in CPP can cause cessation of CBF during diastole. We hypothesized that zero diastolic flow velocity (FV) occurs when diastolic blood pressure becomes less than the critical ...
Kako Hiromi - - 2013
Over the past few years, there has been a change in clinical practice with a transition to the use of cuffed instead of uncuffed endotracheal tubes (ETTs) in pediatric patients. These changes have led to concerns regarding unsafe intracuff pressures in pediatric patients, which may result in postoperative morbidity. To ...
Caricato Anselmo - - 2013
Endotracheal suctioning (ETS) is essential for patient care in an ICU but may represent a cause of cerebral secondary injury. Ketamine has been historically contraindicated for its use in head injury patients, since an increase of intracranial pressure (ICP) was reported; nevertheless its use was recently suggested in neurosurgical patients. ...
Freimann Florian Baptist - - 2013
The Neurovent-P-tel sensor is a promising device for telemetric intracranial pressure (ICP) measurements in cases of complex hydrocephalus. Data on its accuracy within a broad ICP range are missing. We applied a porcine model for large-scale manipulation of the ICP values. The telemetric ICP sensor was referenced against ICP values ...
de Andrade Ozahyr - - 2013
The autonomic nervous system is importantly involved in the maintenance of arterial pressure during orthostatic challenges. However, little is known about the specific central areas involved in these cardiovascular compensations. It has been proposed that the paraventricular nucleus of the hypothalamus (PVN) is involved in cardiovascular reflex responses related to ...
Nguyen Tammy T - - 2013
To report a case of sustained hypotension associated with the use of intravenous metoclopramide. A 50-year-old woman developed a hypotensive episode lasting approximately 90 minutes after the administration intravenous metoclopramide for the treatment of a migraine. The patient presented to the emergency department after she woke up with a severe ...
Stiebel-Kalish H - - 2013
Idiopathic intracranial hypertension is a common disorder affecting mainly healthy, young, overweight women. The pathogenesis of this condition is unknown, but it has been shown to follow treatment with several compounds including corticosteroids and vitamin A derivatives. This paper will offer a novel hypothesis and insight on the pathogenesis of ...
Zhang Minmin - - 2013
Pressure retarded osmosis (PRO) is an osmotically-driven membrane process that can be used to harvest salinity-gradient power. The PRO performance (both water flux and power density) can be severely limited by membrane fouling. The current study, for the first time, investigates PRO scaling in a bench-scale pressurized system using calcium ...
Lancioni Giulio E - - 2013
Objective: To assess whether a man with amyotrophic lateral sclerosis could benefit from using (a) a mouth pressure microswitch instead of an optic microswitch activated via head movement and (b) a special word prediction function within a text messaging system. Method: Initially, both microswitches were used for operating the text ...
Siebenmann Christoph C Center for Integrative Human Physiology, Institute of Physiology, University of Zurich Zurich, - - 2013
During acute altitude exposure tachycardia increases cardiac output (Q) thus preserving systemic O2 delivery. Within days of acclimatization, however, Q normalizes following an unexplained reduction in stroke volume (SV). To investigate whether the altitude-mediated reduction in plasma volume (PV) and hence central blood volume (CBV) is the underlying mechanism we ...
Ferreira Lucas Lima - - 2013
Objective: To analyze the outcomes of increased or decreased intracranial pressure and/or the decrease in cerebral perfusion pressure resulting from respiratory physiotherapy on critically ill patients admitted to the intensive care unit. Methods: Through a systematic review of the literature, clinical trials published between 2002 and 2012 were selected. The ...
Tang Sung-Chun - - 2013
Mannitol is commonly used in patients with increased intracranial pressure (ICP), but its effect on cerebrovascular pressure reactivity (CVPR) is uncertain. We analyzed the changes of pressure reactivity index (PRx) during the course of mannitol treatment. Twenty-one patients who received mannitol treatment for increased ICP were recruited prospectively. Continuous waveforms ...
Dias Celeste - - 2013
Plateau waves are common in traumatic brain injury. They constitute abrupt increases of intracranial pressure (ICP) above 40 mmHg associated with a decrease in cerebral perfusion pressure (CPP). The aim of this study was to describe plateau waves characteristics with multimodal brain monitoring in head injured patients admitted in neurocritical care. ...
Larsen Rikke Hebo - - 2013
To investigate the neuroprotective potential of ciclosporin during acute liver failure. We evaluated the effect of intrathecally administered ciclosporin on intracranial pressure, brain water content and aquaporin-4 expression in a rat model with acute hyperammonaemia. Twenty-four male Wistar rats with portacaval anastomosis were randomised into four groups receiving ciclosporin or ...
Ogawa Yuki - - 2013
Abstract Purpose: To develop a new structure and function of alternating pressure air mattress (APAM) which reduces discomfort during head-of-bed (HOB) elevation and evaluate the effectiveness. Method: An observational study (Study 1) and randomized crossover experiment (Study 2) were conducted in healthy adult volunteers. External force (interface pressure and shear ...
Wang Sheng-Hao - - 2013
The study was conducted to achieve early detection of increased compartment pressure by comparing the changes between the thickness and pressure within the musculofascial compartments after lower leg injury. We included cases of a lower-leg fracture between January and December 2007. Bilateral lower leg compartment pressure and thickness were measured ...
Cremer Antoine - - 2013
We validated against invasive measurements a measure of central SBP based on the QKD interval. The present objective is a comparison to the SphygmoCor device. A first cohort was used to redefine an algorithm for estimating ascending aorta SBP (cSBP) with respect to SphygmoCor. This algorithm was then tested in ...
Xia Huijing - - 2013
Rationale: Over-activity of the brain Renin Angiotensin System (RAS) is a major contributor to neurogenic hypertension. While over-expression of Angiotensin-Converting Enzyme type 2 (ACE2) has been shown to be beneficial in reducing hypertension by transforming Angiotensin (Ang)-II into Ang-(1-7), several groups have reported decreased brain ACE2 expression and activity during ...
Rostami Elham - - 2013
Modulation in ventilatory settings is one of the approaches and interventions used to treat and prevent secondary brain damage after traumatic brain injury (TBI). Here we investigate the effect of hyperoxia in combination with hypoventilation on brain oxygenation, metabolism and intracranial pressure. Twelve pigs were divided into three groups; group1-100% ...
Marchi Andrea - - 2013
It is unknown whether modified head-up tilt (MTILT) with inclination of the back rest, thigh rest and shank rest of 60, 0 and 15° respectively challenges autonomic control as assessed from beat-to-beat variability of heart period (HP) and systolic arterial pressure (SAP). In 15 healthy adult humans we found that ...
Olson Daiwai M - - 2013
Background Intracranial pressure is a frequent target for goal-directed therapy to prevent secondary brain injury. In critical care settings, nurses deliver many interventions to patients having intracranial pressure monitored, yet few data documenting the immediate effect of these interventions on intracranial pressure are available. Objective To examine the relationship between ...
Andresen Morten - - 2013
Object Intracranial pressure (ICP) monitoring is used extensively in clinical practice, and as such, the accuracy of registered ICP values is paramount. Clinical observations of nonphysiological changes in ICP have called into question the accuracy of registered ICP values. Subsequently, the authors have tried to determine if the ICP monitors ...
Schaeffer Anne Marie J - - 2013
We studied the pressure-induced superconductivity of BaLi4 up to 53 GPa by means of electrical resistivity in a diamond anvil cell. Superconductivity in BaLi4 is first observed at a pressure of 5.4 GPa with a superconducting critical temperature (Tc) of 4.5 K. Below 2 GPa, superconductivity is not observed above the minimum temperature achievable ...
Nwachuku Enyinna L - - 2013
There is clinical equipoise regarding whether neurointensive care unit management of external ventricular drains (EVD) in severe traumatic brain injury (TBI) should involve an open EVD, with continuous drainage of cerebrospinal fluid (CSF), versus a closed EVD, with intermittent opening as necessary to drain CSF. In a matched cohort design, ...
Skoglund Karin - - 2013
The neurological wake-up test (NWT) is used to monitor the level of consciousness in patients with traumatic brain injury (TBI). However, it requires interruption of sedation and may elicit a stress response. We evaluated the effects of the NWT using cerebral microdialysis (MD), brain tissue oxygenation (PbtiO2), jugular venous oxygen ...
Boltz Agnes - - 2013
In the choroid, there is evidence that blood flow does not only depend on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). The present study included 40 healthy subjects to investigate whether such behavior is also found in the optic nerve head ...
Younan Youliana - - 2013
Purpose: Low-intensity focused ultrasound has been shown to stimulate the brain noninvasively and without noticeable tissue damage. Such a noninvasive and localized neurostimulation is expected to have a major impact in neuroscience in the coming years. This emerging field will require many animal experiments to fully understand the link between ...
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