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Wajima Zen'ichiro - - 2012
STUDY OBJECTIVE: To investigate changes in stroke volume variation (SVV) by both induced hypertension (pressor test) and hypotension (depressor test), and also by induced hypotensive anesthesia in patients with good cardiac function. DESIGN: Prospective, controlled clinical study. SETTING: University hospital. PATIENTS: 31 ASA physical status 1 and 2 patients, aged ...
Lao Hsuan-Chih - - 2012
BACKGROUND: Activation of sympathetic nervous system has a crucial role in mediating the pneumatic tourniquet inflation induced hyperdynamic response. Dexmedetomidine, a selective α(2)-adrenergic receptor agonist, has potent sympatholytic effects. We conducted this prospective, randomized, placebo-controlled, double-blinded study to elucidate the effects of dexmedetomidine on attenuating the tourniquet-induced hyperdynamic response during ...
Capone Carmen C Department of Neurology and Neuroscience, Division of Neurobiology, Weill Cornell Medical College, New York, New York 10021, - - 2012
Hypertension, a powerful risk factor for stroke and dementia, has damaging effects on the brain and its vessels. In particular, hypertension alters vital cerebrovascular control mechanisms linking neural activity to cerebral perfusion. In experimental models of slow-developing hypertension, free radical signaling in the subfornical organ (SFO), one of the forebrain ...
Nan Zhang - - 2012
In industrial practice, the cavity-type oscillation is undesirable from the perspective of inducement of structure vibration and fatigue, generation of noise and drastic increase in drag on the body. A numerical work for the prediction of wall pressure fluctuations and flow-induced noise of cavity is performed in the paper. Firstly, ...
Yan Yu X - - 2012
Suboptimal health status (SHS) has become a new public health challenge in urban China. Despite indications that SHS may be associated with progression or development of chronic diseases such as cardiovascular and metabolic diseases, there are few reports on SHS investigations. To explore the relationship between SHS and traditional cardiovascular ...
Shim Jongmin - - 2012
We introduce a class of continuum shell structures, the Buckliball, which undergoes a structural transformation induced by buckling under pressure loading. The geometry of the Buckliball comprises a spherical shell patterned with a regular array of circular voids. In order for the pattern transformation to be induced by buckling, the ...
Hu Hanbo - - 2012
Pulmonary vascular endothelial nitric oxide (NO) synthase (eNOS)-derived NO is the major stimulant of cyclic guanosine 5'-monophosphate (cGMP) production and NO/cGMP-dependent vasorelaxation in the pulmonary circulation. We recently synthesized multiple peptides and reported that an eleven amino acid (SSWRRKRKESS) peptide (P1) but not scrambled P1 stimulated the catalytic activity but ...
Takano Yuri - - 2012
BACKGROUND: We have reported that α and β adrenergic blockers could protect against emotional stress-induced cardiac dysfunction. Azelnidipine is a unique calcium blocker which does not increase heart rate. The purpose of this study is to evaluate the effect of azelnidipine to prevent stress-induced cardiac dysfunction. METHODS AND RESULTS: Rats ...
Iwasaki Yu-Ki - - 2012
OBJECTIVES: To assess mechanisms underlying atrial fibrillation (AF)-promotion by obesity and obstructive sleep apnea (OSA) in rat models. BACKGROUND: Obesity and OSA are risk factors for AF, but the underlying mechanisms are poorly understood. METHODS: Zucker obese (ORs) and lean rats (LRs) were intubated and ventilated with air and 2%-isoflurane. ...
Kiss Péter T - - 2012
We present a short overview of pressure calculation in molecular dynamics or Monte Carlo simulations. The emphasis is given to polarizable models in order to resolve the controversy caused by the paper of M. J. Louwerse and E. J. Baerends [Chem. Phys. Lett. 421, 138 (2006)] about pressure calculation in ...
Pankey Edward A - - 2012
Pulmonary hypertension (PH) is a rare disorder that without treatment is progressive and often fatal within 3 years. The treatment of PH involves the use of a diverse group of drugs and lung transplantation. Although nitrite was once thought to be an inactive metabolite of endothelial-derived nitric oxide (NO), there ...
Shepherd Helena J - - 2012
The effect of pressure on the dinuclear spin crossover material [{Fe(bpp)(NCS)(2)}(2)(4,4'-bipy)]·2MeOH (where bpp = 2,6-bis(pyrazol-3-yl)pyridine and 4,4'-bipy = 4,4'-bipyridine, 1) has been investigated with single crystal X-ray diffraction and Raman spectroscopy using diamond anvil cell techniques. The very gradual pressure-induced spin crossover occurs between 7 and 25 kbar, and shows ...
Rautureau Yohann - - 2012
The purpose of this review of the vascular biology of endothelin-1 (ET-1) is the presentation of recent data including the use of endothelin-receptor antagonists for the treatment of hypertension. Recent discoveries regarding the pharmacology of ET-1 in the vascular wall and its effect on signalling transduction and gene expression in ...
Stamer W Daniel - - 2012
Regulation of intraocular pressure by the conventional (trabecular) outflow pathway is complicated, involving a myriad of mechanical and chemical signals. In most, intraocular pressure is maintained within a tight range over a lifetime. Unfortunately in some, dysfunction results in ocular hypertension and open-angle glaucoma. In the context of established knowledge, ...
Pandolfino J E JE Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-2951, USA. - - 2012
High-resolution manometry and esophageal pressure topography have enhanced our ability to analyze esophageal motor disturbances by improving the detail and accuracy of measurements of peristaltic activity.This has been extremely helpful in the evaluation of disorders of rapid propagation as the technique is able to define important time points and physiologic ...
Lazarowska A - - 2012
The luminescence and luminescence kinetics of LiLuF(4) doped with 1.5 at.% of Pr(3+) obtained at high hydrostatic pressure changing from ambient to 220 kbar applied in a diamond anvil cell are presented. It has been shown that pressure causes shift of the emission lines toward the red with rates of the order ...
Singh Vineet Kumar - - 2012
Effect of high pressure on as prepared 20mM CTAB capped CdS nanoparticles (size ∼4nm) has been analyzed in this paper. Raman scattering has been used to observe the phase transition pressure. X-ray diffraction pattern is used for structural characterization. Raman scattering predicts the phase transition occur from mixed cubical phase ...
Nagae Takayuki - - 2012
Hydrostatic pressure induces structural changes in proteins, including denaturation, the mechanism of which has been attributed to water penetration into the protein interior. In this study, structures of 3-isopropylmalate dehydrogenase (IPMDH) from Shewanella oneidensis MR-1 were determined at about 2 Å resolution under pressures ranging from 0.1 to 650 MPa using a ...
Sun Hong-Qiang - - 2012
BACKGROUND: Alcohol cues can precipitate the desire to drink and cause relapse in recovering alcohol-dependent patients. Serotonin and dopamine may play a role in alcohol cue-induced craving. Acute combined tryptophan (Trp), tyrosine (Tyr), and phenylalanine (Phe) depletion (CMD) in the diet attenuates the synthesis of serotonin and dopamine in the ...
Leite-Moreira Adelino F - - 2012
In animal experiments, elevating systolic pressures induces diastolic dysfunction and may contribute to congestion, a finding not yet translated to humans. Coronary surgery patients (63 ± 8 years) were studied with left ventricular (LV) pressure (n = 17) or pressure-volume (n = 3) catheters, immediately before cardiopulmonary bypass. Single-beat graded pressure elevations were induced by clamping the ...
Castro Michele M - - 2012
Vascular dysfunction associated with two-kidney, one-clip (2K-1C) hypertension may result from both altered matrix metalloproteinase (MMP) activity and higher concentrations of reactive oxygen species (ROS). Doxycycline is considering the most potent MMP inhibitor of tetracyclines and attenuates 2K-1C hypertension-induced high blood pressure and chronic vascular remodeling. Doxycycline might also act ...
Yu Hong - - 2012
The present study was designed to investigate the underlying molecular mechanism for Angiotensin II type 1 receptor blockers (ARBs) mediated cardio-protection against pressure overload-induced cardiac remodeling with a focus on Smad7. ROCK-1, Smad3 and fibronectin expressions were increased in male C57BL/6 mice underwent transverse aortic constriction (TAC) for 2weeks. Treatment ...
Lazaridis Christos - - 2012
Advanced hemodynamic monitoring is necessary for many patients with acute brain and/or spinal cord injury. Optimizing cerebral and systemic physiology requires multi-organ system function monitoring. Hemodynamic manipulations are cardinal among interventions to regulate cerebral perfusion pressure and cerebral blood flow. The pulmonary artery catheter is not any more the sole ...
Susic Dinko - - 2012
This review will discuss some relevant and novel studies on the relationship between sodium intake and cardiovascular structure and function, focusing on blood pressure independent effects of salt on the heart, arteries, and kidneys. Several new reports clearly demonstrate the role of high dietary salt in mediating cardiovascular and renal ...
Currie Gemma G Department of Endocrinology, Western Infirmary, Glasgow G11 6NT, - - 2012
Catecholamines (epinephrine and norepinephrine) are synthesised and produced by the adrenal medulla and postganglionic nerve fibres of the sympathetic nervous system. It is known that essential hypertension has a significant neurogenic component, with the rise in blood pressure mediated at least in part by overactivity of the sympathetic nervous system. ...
Yamawaki Hideyuki - - 2012
Nesfatin-1 is a novel adipocytokine which exerts not only anorexigenic but also hypertensive roles through acting on hypothalamus melanocortin-3/4 receptors. Although it is logical to hypothesize that nesfatin-1 could also affect the contractile reactivity of peripheral blood vessels, it still remains to be examined. The present study was performed to ...
Jolly Sabrina - - 2012
In freshwater ecosystems, a large number of chemical substances are able to disturb homeostasis of fish by modulating one or more physiological functions including the immune system. The aim of this study was to assess multi-biomarker responses including immunotoxicity induced by urban and agricultural pressure in European bullheads living in ...
Ferdinand Keith C - - 2012
PURPOSE: The identification of specific factors that contribute to hypertension development and progression among blacks in the US is the focus of much ongoing research. The purpose of this paper is to review these factors and discuss how they present unique opportunities for improving the management of hypertension in this ...
Gattinoni Luciano - - 2012
PURPOSE OF REVIEW: To survey the causes of ventilator-induced lung injury focusing on its mechanical determinants, lung stress and strain. RECENT FINDINGS: Tidal volume per ideal body weight (tidal volume/IBW) and airway pressure (PAW) are poor surrogates of strain and stress, which are respectively defined as the ratio of volume ...
Alicandri-Ciufelli Matteo - - 2012
At the present time, the function of the mastoid remains unknown. One of the main hypotheses accredited in the literature interprets the mastoid as a pressure buffer. Other theories underline the role of the mastoid mucosa in pressure regulation by transmucosal gas exchanges. The question is what advantage does air ...
Rockwood Michael R H - - 2012
Systolic hypertension and OH, as with many other deficits, accumulate with age. This deficit accumulation results in frailty: enhanced vulnerability to adverse outcomes. This study evaluated OH in relation to age, frailty, systolic hypertension, and mortality. In the population-based Canadian Study of Health and Aging second clinical examination, complete data ...
Glass Graeme E - - 2012
BACKGROUND: Negative pressure wound therapy (NPWT) is a technique that has gained such rapid acceptance for such a diversity of wound management problems that the evidence for optimal use has struggled to keep up. While clinical studies have sought to evaluate its effectiveness for a variety of acute and chronic ...
Hogan Michael J - - 2012
Although aging is associated with progressive increases in blood pressure level, previous research has been inconsistent at to whether older adults show greater or lesser cardiovascular reactivity (CVR) to emotion than do younger adults. There is reason to believe that these inconsistencies could be clarified by examining age-related differences in ...
Tomiyama Hirofumi - - 2012
The pathophysiological abnormalities associated with increased arterial stiffness and/or abnormal pressure wave reflection may play crucial roles in increasing the risk of development of cardiovascular events. On the other hand, prehypertension, defined as a systolic blood pressure of 120-139 and/or a diastolic blood pressure of 80-89 mmHg, is a "danger zone" ...
Hawkes Colin Patrick - - 2012
AIM: : To review the literature surrounding various aspects of T-piece resuscitator use, with particular emphasis on the evidence comparing the device to other manual ventilation devices in neonatal resuscitation. DATA SOURCES: : The Medline, EMBASE, Cochrane databases were searched in April 2011. Ongoing trials were identified using www.clinicaltrials.gov, www.controlled-trials.com. ...
Sanchez-Soria Pablo - - 2012
Cardiovascular disease is the leading cause of death in the United States and worldwide. High incidence of cardiovascular diseases has been linked to populations with elevated arsenic content in their drinking water. Although this correlation has been established in many epidemiological studies, a lack of experimental models to study mechanisms ...
Partsch Hugo - - 2012
Aim: A review is given on the different tools of compression therapy and their mode of action. Methods: Interface pressure and stiffness of compression devices, alone or in combination can be measured in vivo. Hemodynamic effects have been demonstrated by measuring venous volume and flow velocity using MRI, Duplex and ...
Patel Bhavin C - - 2012
Elevated peripheral (brachial) blood pressure (PBP) is related to hard cardiovascular outcomes and remains the main target for antihypertensive therapy. However, central aortic blood pressure (CABP) can be measured noninvasively and could potentially prove to be a more important marker of cardiovascular diseases in future. Several studies have shown association ...
Sadighi-Bonabi Rasoul - - 2012
The luminescence parameters of laser-induced bubble in the presence of an acoustic field in water are studied. A comparison is made between parameters such as bubble radius, interior temperature, and pressure of the bubble induced by laser and an acoustic field influenced by different driving pressure amplitudes. It is found ...
Suehiro Kotaro - - 2012
Objectives: To evaluate the interface pressures (IP) obtained by double compression stockings. Methods: Ten healthy volunteers with legs fitting size S stockings wore single and double class I stockings, sizes S to 4L. We measured IPs with the patient wearing each stocking standing and supine. Results: IPs obtained wearing double ...
Krassioukov Andrei - - 2012
To present the complex issues of the impact of spinal cord injury (SCI) in sport, with a specific focus on autonomic dysreflexia (AD) and the potential debilitating effects of unstable blood pressure control among athletes. A literature review based on a key word electronic literature search of articles, practice guidelines, ...
Suzuki Hitoshi - - 2012
Although acute atrial dilation facilitates the induction of atrial fibrillation (AF) in the normal heart, little is known about whether the induction of AF due to acute atrial dilation increases in the diseased heart. To clarify this, we compared the inducibility of AF by an acute increase of atrial pressure ...
Gura Melek - - 2012
Hypertension, hypervolemia and hemodilution therapy is a common approach to cerebral vasospasm after subarachnoid haemorrhage. This study is designed to see the difference of moderate or aggressive hypervolemia supported with induced hypertension in symptomatic vasospasm detected with transcranial Doppler ultrasonography (TCD) measurements. MATERIAL and Fifty eight patients who had aneurysm ...
Monge García Manuel Ignacio - - 2012
The passive leg-raising (PLR) maneuver provides a dynamic assessment of fluid responsiveness inducing a reversible increase in cardiac preload. Since its effects are sudden and transitory, a continuous cardiac output (CO) monitoring is required to appropriately assess the hemodynamic response of PLR. On the other hand, changes in partial end-tidal ...
Lim Mihwa - - 2012
The goal of the current study was to determine whether the sphingosine kinase 1 (SK1)/sphingosine-1-phosphate (S1P) pathway is involved in myogenic vasoconstriction under normal physiological conditions. In the present study, we assessed whether endogenous S1P generated by pressure participates in myogenic vasoconstriction and which signaling pathways are involved in SK1/S1P-induced ...
Frydrychowski Andrzej F - - 2012
The aim of this study was to assess the effect of acute bilateral jugular vein compression on: (1) pial artery pulsation (cc-TQ); (2) cerebral blood flow velocity (CBFV); (3) peripheral blood pressure; and (4) possible relations between mentioned parameters. Experiments were performed on a group of 32 healthy 19-30 years ...
Ryan Kathy L - - 2012
Hemorrhage remains a major cause of mortality following traumatic injury in both military and civilian settings. Lower body negative pressure (LBNP) has been used as an experimental model to study the compensatory phase of hemorrhage in conscious humans, as it elicits central hypovolemia like that induced by hemorrhage. One physiological ...
Pham Isabelle I Paris 13, University, laboratory: "Cellular and functional responses to hypoxia", Bobigny, - - 2012
Hypoxia-induced pulmonary vasoconstriction in patients with a medical history of high-altitude pulmonary edema (HAPE) may involve activation of the endothelin-1 (ET-1) pathway. We, therefore, compared the effect of the ETA/ETB receptor antagonist, bosentan, on pulmonary artery systolic pressure (PASP) in healthy subjects with (HS: HAPE subjects, n=5) or without a ...
Djasim U M - - 2011
Facilities for hyperbaric oxygen therapy that are suitable for animal experimental research are scarce. In this paper, the authors introduce a hyperbaric oxygen chamber that was developed specifically for animal experimental purposes. The hyperbaric oxygen chamber was designed to meet a number of criteria regarding safety and ease of use. ...
Pozzi Ambra - - 2012
Glomerulosclerosis is a general term for scarring of the kidney glomerulus. It cannot be reversed. As glomerulosclerosis accumulates, the diseased kidney progresses to end-stage renal disease. Treatment with inhibitors of the renin-angiotensin system often decreases the rate of progression of glomerulosclerosis in chronic kidney diseases. Although the mechanisms by which ...
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