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Parra David D Section of Clinical Pharmacy, Veterans Affairs Medical Center West Palm Beach, 7305 North Military Trail, West Palm Beach, FL, 33410, USA, - - 2014
Targeting a specific blood pressure based upon patient risk has been the approach to reducing cardiovascular risk in patients with hypertension. Drug selection was based upon compelling indications with titration and the addition of other agents as needed until the blood pressure target was achieved. However, new information has emerged ...
Salamat Ashkan A Lyman Laboratory of Physics, Harvard University, Cambridge, MA 02138, USA. - - 2014
Combining metastable precursors with high pressure-temperature treatment is a powerful tool to make nitrogen-rich metal nitrides. Two new dense polymorphs of Ta3N5 have previously been theoretically predicted, with U3Se5 (Pnma) and U3Te5 (Pnma) structure types, and are now shown to exist. Amorphous Ta3N5 from thermal ammonolysis of an amorphous polymeric ...
Triggle Nick - - 2014
OVER THE past year, much of the national debate about the NHS has concerned pressures on emergency departments (EDs). In recent weeks, however, the focus has shifted to GP access.
Aronson Solomon S Department of Anesthesiology, Duke University School of Medicine, Box 3094, 102 Baker House, Durham, NC, 27710, USA, - - 2014
The concept of "perioperative hypertensive emergency" must be defined differently from that of ambulatory hypertensive emergency in view of its unique clinical considerations in an atypical setting. It should be noted that moderately high normal blood pressure (BP) values in the perioperative setting often trigger situations requiring immediate treatment in ...
Padilla Ramos Alan A Universidad Autonoma de Baja California, Mexicali Campus, Mexicali, - - 2014
Hypertension is an increasingly prevalent chronic illness. The condition may present as a hypertensive crisis, and this entity may be further categorized as either hypertensive emergency or urgency. As the presentation is quite variable and is dependent upon the specific end-organ injury, a thorough history and examination are necessary. Once ...
Manning Lisa L Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK, - - 2014
Neurological hypertensive emergencies cause significant morbidity and mortality. Most occur in the setting of ischaemic stroke, spontaneous intracerebral hemorrhage (ICH), or subarachnoid hemorrhage (SAH), but other causes relate to hypertensive encephalopathy and reversible cerebral vasoconstriction syndrome (RCVS). Prompt and controlled reduction of blood pressure (BP) is necessary, although there remains ...
Carbone Federico F Federico Carbone, Fabrizio Montecucco, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, - - 2014
Vitamin D deficiency has been indicated as a pandemic emerging public health problem. In addition to the well-known role on calcium-phosphorus homeostasis in the bone, vitamin D-mediated processes have been recently investigated on other diseases, such as infections, cancer and cardiovascular diseases. Recently, both the discovery of paracrine actions of ...
Mente Andrew A Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. Electronic address: - - 2014
Policy positions on salt consumption (based largely on the association of sodium and blood pressure [BP]) has remained unchanged since the 1970s, until recently. However, this is beginning to change as new evidence emerges. The evidence supports a strong association of sodium with BP and cardiovascular disease events in hypertensive ...
Pettersen Klas H KH Department of Mathematical and Technological Sciences, Norwegian University of Life Sciences, Ås, - - 2014
Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the ...
Camporesi Enrico M - - 2014
Exposure to hyperbaric oxygen (HBO2) before a crucial event, with the plan to create a preventing therapeutic situation, has been defined "preconditioning" and is emerging as a useful adjunct both in diving medicine as well before ischemic or inflammatory events. Oxygen pre-breathing before diving has been extensively documented in recreational, ...
Cappiello Jhaymie L JL Mr Cappiello is affiliated with Respiratory Care Services, Duke University Hospital, and Dr Hocker is affiliated with the Division of Emergency Medicine, Duke University Medical Center, Durham, North - - 2014
Noninvasive ventilation (NIV) in severe acute asthma is controversial but may benefit this population by preventing intubation. We report on a 35-year-old male asthma patient who presented to our emergency department via emergency medical services. The patient was responsive, diaphoretic, and breathing at 35 breaths/min on 100% oxygen with bag-mask ...
Park Ki-Tae KT School of Environmental Science and Engineering, Pohang University of Science and Technology , Pohang 790-784, - - 2014
Oceanic dimethyl sulfide (DMS) is the enzymatic cleavage product of the algal metabolite dimethylsulfoniopropionate (DMSP) and is the most abundant form of sulfur released into the atmosphere. To investigate the effects of two emerging environmental threats (ocean acidification and warming) on marine DMS production, we performed a large-scale perturbation experiment ...
Schimanski Karen K Emergency Department, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand. Electronic address: - - 2014
Forearm blood pressures have been suggested as an alternative site to measure blood pressures when the upper arm is unavailable. However there is little evidence utilising clinical populations to support this substitution. To determine agreement between blood pressures measured in the left upper arm and forearm using a singular oscillometric ...
Kontaraki Joanna E JE Molecular Cardiology Laboratory, School of Medicine, University of Crete, Greece. Electronic address: - - 2014
MicroRNAs (miRs), as essential gene expression regulators, modulate cardiovascular development and disease and thus they are emerging as potential biomarkers and therapeutic targets in cardiovascular disease, including hypertension. We assessed the expression levels of the microRNAs miR-9 and miR-126 in 60 patients with untreated essential hypertension and 29 healthy individuals. ...
Jin Sung Woong SW Department of Emergency Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of - - 2014
To examine the cooling effectiveness of a rapid infusion system (RIS) during induction of therapeutic hypothermia. This laboratory study simulated the effect of three fluid delivery methods: rapid dripping without any other equipment (control); RIS; pressure bag. Cold energy loss ( × min) was calculated as: (temperature of the proximal thermoprobe - ...
Derosa G G Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy; Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, - - 2014
There is considerable interest in pharmacogenetic and molecular biomarkers. Our aim was to evaluate the effects of enalapril/lercanidipine combination on some emerging biomarkers for cardiovascular risk stratification of hypertensive patients, such as lipoprotein(a) [Lp(a)], soluble advanced glycation end products (sRAGE), soluble CD40 ligand (sCD40L) and serum myeloperoxidase (MPO). Three hundred ...
Sontgerath Joseph S JS Department of Emergency Medicine, Fort Sam Houston, TX 78234. Electronic address: - - 2014
Intramedullary pressure changes during intraosseous (IO) procedures have been implicated in the intravasation of bone marrow fat and with pain in conscious patients. The objective of this study was to demonstrate inter-provider variability in pressures generated during initial flush procedures. IO cannulas were inserted into the proximal tibiae and humeri ...
Rao Akhilesh A Division of Nephrology, Department of Internal Medicine, University of Missouri-Columbia School of Medicine, 5 Hospital Drive, Columbia, MO, 65212, - - 2014
Incretin-based therapies are now well established for diabetes management and are among the frontline agents for control of hyperglycemia. In addition to their antihyperglycemic effects, evidence is emerging on the role of these agents on blood pressure regulation, cardioprotective and renoprotective properties. Because of the pleiotropic nature of these affects, ...
Anand Tanu T Department of Community Medicine, Maulana Azad Medical College and Associated L.N, G.N.E.C and G.B., Pant Hospitals, New Delhi, - - 2014
Hypertension is fast emerging as a major health problem amongst all school adolescents, particularly in urban areas. Regular screening of the students for this is required for preventing the emergence of complications later in life. Therefore, the present study was undertaken with the objective to determine the prevalence of hypertension ...
Wilson Kristin K Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children's Hospital, Columbus, OH, - - 2014
Two main hemodynamic overload mechanisms [i.e., volume and pressure overload (VO and PO, respectively] result in heart failure (HF), and these two mechanisms have divergent pathologic alterations and different pathophysiological mechanisms. Extensive evidence from animal models and human studies of PO demonstrate a clear association with alterations in Ca(2+) homeostasis. ...
Fang Yuan Y Department of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, 730000, - - 2014
Human opiorphin is recently identified endogenous pentapeptide, encoded by ProL1 multigenes family that contributes to cardiovascular modulation. The aim of the study was to evaluate the effect of opiorphin through intravenous injection (i.v.) on mean arterial pressure (MAP) regulation. To investigate the bioactivity of opiorphin, a rat cannulation model was ...
Arhami Dolatabadi Ali A Department of Emergency Medicine, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, IR - - 2014
Hypertension (HTN) is a serious health problem that threatens one fourth of the adult population in some countries. This study aimed to assess the prevalence and outcome of undiagnosed hypertensive patients admitted to the emergency department. This cross-sectional study was conducted from March 2009 to March 2010 at Imam Hossein ...
Seal David W DW Jacksonville Practice Division, College of Pharmacy & Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, - - 2014
Objective:To evaluate the provisions made by pharmacists when dispensing an emergency supply of an antihypertensive medication to patients in a community setting.Participants:Pharmacists and nonpharmacists (pharmacy technicians or interns) who were employed with community pharmacies and have witnessed or dispensed an emergency supply of an antihypertensive medication. Those who agreed to ...
Sun J J College of Biomedical Engineering and Medical Imaging, Third Military Medical University, Chongqing, China, College of Biomedical Engineering and Medical Imaging, Third Military Medical University, Chongqing, - - 2014
Acute cerebral hemorrhage (ACH) is an important clinical problem that is often monitored and studied with expensive devices such as computed tomography, magnetic resonance imaging, and positron emission tomography. These devices are not readily available in economically underdeveloped regions of the world, emergency departments, and emergency zones. We have developed ...
Price Raymond S RS Department of Neurology, University of Pennsylvania, Philadelphia, PA, - - 2014
The definition of hypertension has continuously evolved over the last 50 years. Hypertension is currently defined as a blood pressure greater than 140/90mmHg. One in every four people in the US has been diagnosed with hypertension. The prevalence of hypertension increases further with age, affecting 75% of people over the ...
Ronzaud Caroline C Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, - - 2014
Ubiquitylation is crucial for regulating numerous cellular functions. In the kidney, ubiquitylation regulates the epithelial Na(+) channel ENaC. The importance of this process is highlighted in Liddle's syndrome, where mutations interfere with ENaC ubiquitylation, resulting in constitutive Na(+) reabsorption and hypertension. There is emerging evidence that NCC, involved in hypertensive ...
Francis Joseph J 1 Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, - - 2014
Abstract Cellular redox balance is vital in health and disease. In this Forum, we highlight the importance of reactive oxygen species (ROS) in the regulation of redox balance in different organ systems of the body and ROS contribution to the development of hypertension. The Forum examines interactions between oxidative and ...
Zhu Zhiyong Z Physical Sciences and Engineering Division, KAUST, Thuwal 23955-6900, Kingdom of Saudi - - 2014
Ab-initio calculations show a pressure induced trivial-nontrivial-trivial topological phase transition in the normal state of 1T-TiSe2. The pressure range in which the nontrivial phase emerges overlaps with that of the superconducting ground state. Thus, topological superconductivity can be induced in protected surface states by the proximity effect of superconducting bulk ...
Pinna Giuliano G Department of Internal Medicine, Ospedale Cottolengo, Torino, - - 2014
Epidemiological data on the impact of hypertensive crises (emergencies and urgencies) on referral to the Emergency Departments (EDs) are lacking, in spite of the evidence that they may be life-threatening conditions. We performed a multicenter study to identify all patients aged 18 years and over who were admitted to 10 ...
Isaacson Stuart H SH Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, FL, - - 2014
Neurogenic orthostatic hypotension (nOH) is due to failure of the autonomic nervous system to regulate blood pressure in response to postural changes due to an inadequate release of norepinephrine, leading to orthostatic hypotension and supine hypertension. nOH is common in Parkinson's disease (PD). Prevalence varies throughout the course of PD, ...
Napoli Donna Jo DJ Department of Linguistics, Swarthmore College Swarthmore, PA, - - 2014
A survey of reports of sign order from 42 sign languages leads to a handful of generalizations. Two accounts emerge, one amodal and the other modal. We argue that universal pressures are at work with respect to some generalizations, but that pressure from the visual modality is at work with ...
Pater Krzysztof - - 2014
Increased intracranial pressure due to metastatic brain disease is one of the oncological emergencies. It may cause herniation or insufficient brain blood flow, thus it is a life-threatening condition. This article focuses on diagnostic and treatment options, which should be introduced immediately. The prognosis remains poor.
Irisawa Taro - - 2013
Stroke is difficult to diagnose when consciousness is disturbed. However few reports have discussed the clinical predictors of stroke in out-of-hospital emergency settings. This study aims to evaluate the association between initial systolic blood pressure (SBP) value measured by emergency medical service (EMS) and diagnosis of stroke among impaired consciousness ...
Ganguly Samrat - - 2013
We report a 12-year-old girl presenting with acute disseminated encephalomyelitis (ADEM) along with hypertensive emergency. Hypertension persisted for few weeks following recovery and subsided with oral clonidine. Although autonomic instability in ADEM has been reported before, hypertensive emergency was not previously documented as presenting feature of ADEM.
Harm Falko - - 2013
Inappropriately cuffed tracheal tubes can lead to inadequate ventilation or silent aspiration, or to serious tracheal damage. Cuff pressures are of particular importance during aeromedical transport as they increase due to decreased atmospheric pressure at flight level. We hypothesised, that cuff pressures are frequently too high in emergency and critically ...
Triggle Nick - - 2013
REDUCING EMERGENCY admissions, particularly among older patients, will be crucial in helping the NHS in England cope with winter pressures in the future, according to an audit of the system.
Meersman Filip - - 2013
High pressures extending up to several thousands of atmospheres provide extreme conditions for biological organisms to survive. Recent studies are investigating the survival mechanisms and biological function of microorganisms under natural and laboratory conditions extending into the GigaPascal range, with applications to understanding the Earth's deep biosphere and food technology. ...
Wilfond Benjamim S - - 2013
Every so often, a bioethics controversy emerges that galvanizes our views. The Surfactant, Positive Pressure, and Oxygenation Randomized Trial mushroomed into a controversy of this sort this past year. In 2007, the "Ashley case," involving the use of estrogen to attenuate the growth of a girl with profound disabilities, was ...
Berns Veronica M - - 2013
Even after significant advances in the structural characterization of quasicrystals-phases whose diffraction patterns combine the sharp peaks normally associated with lattice periodicity and rotational symmetries antithetical to such periodicity-this new form of long-range order remains enigmatic. Here, we present DFT-chemical pressure calculations on the Tsai-type quasicrystal approximant CaCd6, which reveal ...
Cancio Leopoldo C - - 2013
We found that heart rate (HR) complexity metrics such as sample entropy (SampEn) identified patients with trauma receiving lifesaving interventions (LSIs). We now aimed (1) to test a multiscale entropy (MSE) index, (2) to compare it to single-scale measures including SampEn, and (3) to assess different parameter values for calculation ...
Wu J J - - 2013
The recent discovery of iron ferropnictide superconductors has received intensive concern in connection with magnetically involved superconductors. Prominent features of ferropnictide superconductors are becoming apparent: the parent compounds exhibit an antiferromagnetic ordered spin density wave (SDW) state, the magnetic-phase transition is always accompanied by a crystal structural transition, and superconductivity ...
Shekhar Shashank - - 2013
To compare the effectiveness of orally administered nifedipine and intravenously administered labetalol for acute blood pressure control in hypertensive emergency of pregnancy. In this double-blind, randomized, controlled trial, pregnant women with sustained increase in systolic blood pressure of 160 mm Hg or higher or diastolic blood pressure of 110 mm ...
Blakemore Sophie - - 2013
A £500 million short-term government bailout to help emergency departments (EDs) cope with winter pressures should be translated into long-term investment, the RCN has warned.
Frei Steven P - - 2013
Hypertension is a common incidental finding in the emergency department (ED). However, the authors noticed a segment of patients who present to the ED specifically because their blood pressure is found to be elevated outside of the hospital. Emergency medicine physicians are often unsure of the level of intervention that ...
Guo Jing - - 2013
The emergence of superconductivity in the iron pnictide or cuprate high temperature superconductors usually accompanies the suppression of a long-ranged antiferromagnetic (AFM) order state in a corresponding parent compound by doping or pressurizing. A great deal of effort by doping has been made to find superconductivity in Mn-based compounds, which ...
Sprinks Jennifer - - 2013
Prime minister David Cameron has announced that struggling A&E departments across England will share an extra £500 million over the next two years to relieve winter pressures.
Too Gloria T - - 2013
Hypertension affects 10% of pregnancies, many with underlying chronic hypertension, and approximately 1-2% will undergo a hypertensive crisis at some point during their lives. Hypertensive crisis includes hypertensive urgency and emergency; the American College of Obstetricians and Gynecologists describes a hypertensive emergency in pregnancy as persistent (lasting 15min or more), ...
Mota Maria J - - 2013
Hydrostatic pressure is a well-known physical parameter which is now considered an important variable of life, since organisms have the ability to adapt to pressure changes, by the development of resistance against this variable. In the past decades a huge interest in high hydrostatic pressure (HHP) technology is increasingly emerging ...
Chauvet Cristina - - 2013
Hypertension, the most frequently-diagnosed clinical condition world-wide, predisposes individuals to morbidity and mortality, yet its underlying pathological etiologies are poorly understood. So far, a large number of quantitative trait loci (QTLs) have been identified in both humans and animal models, but how they function together in determining overall blood pressure ...
Fu Yinan - - 2013
High-pressure NMR spectroscopy has emerged as a complementary approach for investigating various structural and thermodynamic properties of macromolecules. Noticeably absent from the array of experimental restraints that have been employed to characterize protein structures at high hydrostatic pressure is the residual dipolar coupling, which requires the partial alignment of the ...
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