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Magder Sheldon A SA Department of Critical Care, McGill University Health Centre, Montreal, QC, - - 2014
Measurement of blood pressure is fundamental for the management of patients in shock, yet the physiological basis and meaning of blood pressure measurements are complex and often not well understood. This article is in two parts: part 1 deals with the mechanical and physiological aspects of blood pressure and its ...
Parisotto Maria Teresa MT NephroCare Coordination, Fresenius Medical Care, Bad Homburg, - - 2014
Hemodialysis patient survival is dependent on the availability of a reliable vascular access. In clinical practice, procedures for vascular access cannulation vary from clinic to clinic. We investigated the impact of cannulation technique on arteriovenous fistula and graft survival. Based on an April 2009 cross-sectional survey of vascular access cannulation ...
Khan Md Abdul Hye - - 2014
Epoxyeicosatrienoic acids (EETs) contribute to hemodynamics, electrolyte homeostasis, and blood pressure regulation leading to the concept that EETs can be therapeutically targeted for hypertension. In this study, multiple structural EET analogs were synthesized based on the EET pharmacophore and vasodilator structure-activity studies. Four EET analogs with 91-119% vasodilatory activity in ...
Tomiyama Hirofumi H Second Department of Internal Medicine, Tokyo Medical - - 2014
Background: We examined which pathophysiological abnormalities of vascular function might be closely associated with abnormal baroreflex regulation in subjects with hypertension. Methods and Results: In the cross-sectional assessment, 280 subjects with hypertension were enrolled for measurement of brachial-ankle pulse wave velocity (baPWV), radial augmentation index (rAI), flow-mediated vasodilatation (FMD) of the brachial ...
Kopriva David D From the Department of Surgery, University of Saskatchewan, Regina Qu'Appelle Health Region, Regina, - - 2014
Distal revascularization and interval ligation (DRIL) is commonly used to treat ischemic steal syndrome caused by arteriovenous hemodialysis access and has been associated with good outcomes. However, the literature lacks technical details of a successful intervention. We tested the hypothesis that a brachial-level arteriovenous fistula (AVF) generates a zone of ...
Sachse Gregor G University of Oxford, United - - 2014
The large conductance voltage and Ca2+-activated K+ (BK) channel is an important determinant of vascular tone and contributes to blood pressure regulation. Both activities depend on the ancillary BKβ1 subunit. To determine the significance of smooth muscle BK channel activity for blood pressure regulation, we investigated the potential link between ...
Guarido Karla L KL 1Department of Pharmacology, Laboratory of Cardiovascular Pharmacology, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil. 2Institute of Biological Sciences, Medical and Health, Universidade Paranaense, Umuarama, Parana, - - 2014
We evaluated the role of the renal vascular system and the Rho-A/Rho-kinase pathway in the maintenance of the pressor effects of vasopressin in endotoxemic rats. In vitro and in vivo animal study. University research laboratory. Male Wistar rats (200-300 g). Rats received either saline or lipopolysaccharide (10 mg/kg, intraperitoneal) 6 ...
Towfighi Amytis A From the Department of Neurology, University of Southern California, Los Angeles, CA (A.T.); Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Biomathematics, University of California, Los Angeles (D.M.); and Department of Neurosciences, Medical University of South Carolina, Charleston, SC - - 2014
Blood pressure (BP) reduction lowers vascular risk after stroke; however, little is known about the relationship between consistency of BP control and risk of subsequent vascular events. In this post hoc analysis of the Vitamin Intervention for Stroke Prevention trial (n=3680), individuals with recent (<120 days) stroke, followed up for ...
Chan Elsa C EC aCentre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia bKey Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong, - - 2014
Heme oxygenases, namely heme oxygenase-1 and heme oxygenase-2, have important biological functions in vascular homeostasis. Heme oxygenase and its catabolic products, including bilirubin and carbon monoxide, have been implicated in blood pressure regulation. Increased expression of heme oxygenase exerts multiple protective actions against hypertension-induced vascular injuries. However, the underlining mechanisms ...
Chang Thashi - - 2014
Intravenous immunoglobulin is considered generally safe and is used widely as proven, and sometimes empiric, treatment for an expanding list of autoimmune diseases. Thromboembolic complications following intravenous immunoglobulin therapy are rare and there have been only five previous reports of stroke occurring within 2 to 10 days of infusion. This ...
Kitamura Kei-Ichiro KI Department of Clinical Laboratory Science, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920-0942, Japan. Electronic address: - - 2014
The aim of this study is to develop a painless system of measuring the brachial-ankle arterial pulse wave velocity (baPWV) without compression cuffs. The PWV reflects the compliance of the artery and is measured for the early diagnosis of arteriosclerotic vascular diseases. However, the conventional baPWV system, which measures four ...
Okon-Singer Hadas H Department of Psychology, University of Haifa, 3498838 Haifa, Israel, Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany, Mind Brain Institute at Berlin School of Mind and Brain, Humboldt-University, 10099 Berlin, Germany, Charité University Hospital, 10117 Berlin, Germany, Machine Learning Group, Berlin Institute of Technology, 10587 Berlin, Germany, Laboratoire de Recherche en Neuroimagerie, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, 1011 Lausanne, Switzerland, and F. Hoffmann-La Roche, pRED, Pharma Research and Early Development, DTA Neuroscience, 4070 Basel, - - 2014
This study investigated the neural regions involved in blood pressure reactions to negative stimuli and their possible modulation by attention. Twenty-four healthy human subjects (11 females; age = 24.75 ± 2.49 years) participated in an affective perceptual load task that manipulated attention to negative/neutral distractor pictures. fMRI data were collected ...
Magyar Klara K 1(st) Department of Medicine, University of Pecs, Medical School, Pecs, - - 2014
Oxidative stress and neurohumoral factors play important role in the development of hypertension-induced vascular remodeling, likely by disregulating kinase cascades and transcription factors. Oxidative stress activates poly(ADP-ribose)-polymerase (PARP-1), which promotes inflammation and cell death. We assumed that inhibition of PARP-1 reduces the hypertension-induced adverse vascular changes. This hypothesis was tested ...
Sun Jing J Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, - - 2014
Environmental cold is a nonmodifiable hypertension risk factor. Transient receptor potential melastatin subtype 8 (TRPM8) is a cold-sensing cation channel that can be activated by menthol, a compound with a naturally cold sensation in mint. Little is known about the effect of TRPM8 activation on vascular function and blood pressure. ...
Kim Sang-Hyun SH From the Department of Anesthesiology and Perioperative Care, University of California Irvine, Orange, California (S.-H.K., M.L., K.S.S., J.R., M.C.); Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea (S.-H.K., C.C.); Department of Anesthesiology and Critical Care, Louis Pradel Hospital, Lyon, France (M.L.); and Department of Statistics, University of California Irvine, Orange, California - - 2014
Continuous noninvasive arterial pressure monitoring devices are available for bedside use, but the accuracy and precision of these devices have not been evaluated in a systematic review and meta-analysis. The authors performed a systematic review and meta-analysis of studies comparing continuous noninvasive arterial pressure monitoring with invasive arterial pressure monitoring. ...
Svenningsen Per P Department of Cardiovascular and Renal Research, University of Southern Denmark, Winsløwparken 21, 3, Odense, DK-5000, - - 2014
Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type channels in depolarization-dependent dilatation of mesenteric arteries and blood pressure regulation in ...
Sgouralis Ioannis I 1Duke - - 2014
A mathematical model of renal hemodynamics is used to assess the individual contributions of the tubuloglomerular feedback (TGF) mechanism and the myogenic response to glomerular filtration rate regulation in the rat kidney. The model represents an afferent arteriole segment, glomerular filtration, and a short loop of Henle. The afferent arteriole ...
Brook Robert D RD Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, - - 2014
Fine particulate matter (PM) air pollution is associated with numerous adverse health effects including increased blood pressure (BP) and vascular dysfunction. However, the cardiovascular (CV) impacts of coarse PM exposure remain largely unknown. Since it substantially contributes to global air pollution (yet differs in characteristics from fine particles and is ...
Vlahandonis Anna A The Ritchie Centre, Monash Institute of Medical Research, Monash University, Melbourne, Vic., - - 2014
Pulse transit time has been proposed as a surrogate measure of systolic arterial pressure, as it is dependent upon arterial stiffness. Past research has shown that pulse transit time has a significant inverse relationship to systolic arterial pressure in adults; however, studies in children are limited. This study aimed to ...
Chen Roland K - - 2014
Bipolar electrosurgical vessel sealing is commonly used in surgery to perform hemostasis. The electrode compressive force is demonstrably an important factor an important factor affecting the vessel seal burst pressure, an index of the seal quality. Using a piezoresistive force sensor attached to the handle of a laparoscopic surgical device, ...
Delgado Guillermo G Laboratory of Clinical Neurophysiology, Department of Neurology and Psychiatry, National Institute of Medical Sciences and Nutrition Salvador - - 2014
While the circulatory response to orthostatic stress has been already evaluated in Parkinson's disease patients without typical orthostatic hypotension (PD-TOH), there is an initial response to the upright position which is uniquely associated with active standing (AS). We sought to assess this response and to compare it to that seen ...
Negishi Jun J Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062, - - 2014
A high hydrostatic pressure method, which can apply over 600 MPa pressure was employed for preparing a hydrogel of poly(vinyl alcohol) (PVA) loaded with heparin. The aim of this study was to fabricate a heparin-PVA hydrogel conduit and evaluate its potential for vascular access. Heparin-PVA complex hydrogel showed suppressed heparin ...
Houston Mark M Mark Houston, Hypertension Institute, Saint Thomas Medical Plaza, Nashville, TN 37205, United - - 2014
Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrient-gene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, ...
Rafiq Adnan A Gastroenterology Division, ASCOMS & Hospital, Jammu, Jammu and Kashmir 190011, - - 2014
Vascular oxidative stress is an important factor in hypertension‑associated vascular damage and is mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation. The C242T polymorphism at the p22PHOX gene affects binding of p22PHOX to heme, leading to variants of NADPH oxidase that produce different levels of reactive oxygen species (ROS). ...
Sun Dong D New York Medical - - 2014
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenases. EETs possess cardioprotective properties and are catalyzed by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs) that lack vasoactive property. To date, the role of sEH in the regulation of myogenic response of resistant arteries, a key player ...
Hatch Harold Wickes - - 2014
Although hot, cold and high pressure denaturation are well characterized, the possibility of negative pressure unfolding has received much less attention. Proteins under negative pressure, however, are important in applications such medical ultrasound, and the survival of biopoloymers in the xylem and adjacent parenchyma cells of vascular plants. In addition, ...
Laterreur Véronique V Centre LOEX de l׳Université Laval, Centre de recherche FRQS du CHU de Québec, Québec, QC, Canada; Department of Mechanical Engineering, Faculty of Science and Engineering, Université Laval, Québec, QC, Canada. Electronic address: - - 2014
Tissue engineering provides a promising alternative for small diameter vascular grafts, especially with the self-assembly method. It is crucial that these grafts possess mechanical properties that allow them to withstand physiological flow and pressure without being damaged. Therefore, an accurate assessment of their mechanical properties, especially the burst pressure, is ...
Lopez Rosana R Anatomía, Fisiología y Genética vegetal, ETSI Montes, Universidad Politécnica de Madrid, - - 2014
When tree stems are mechanically stimulated, a rapid long-distance signal is induced that slows down primary growth. An investigation was carried out to determine whether the signal might be borne by a mechanically induced pressure pulse in the xylem. Coupling xylem flow meters and pressure sensors with a mechanical testing ...
Farsang Csaba C St. Imre University Teaching Hospital, Tétényi u. 12-16, Budapest, 1115, Hungary, - - 2014
Hypertension and type 2 diabetes mellitus (T2DM) synergistically deteriorate the vascular environment, making blood pressure reduction challenging, and substantially increasing cardiovascular risk. In the real-life, open-label, observational, PICASSO study, 9,257 hypertensive patients unsuccessfully treated with antihypertensives were switched to fixed-dose combination of perindopril 10 mg/indapamide 2.5 mg. In this subgroup analysis, we ...
Seçilmis Ma M 1Department of Pharmacology, Çukurova University, Medical School, Adana, - - 2014
In the presence of nitric oxide synthase (NOS) inhibitors, the contribution of residual NO to endothelium-dependent relaxation induced by chemical agonists acetylcholine and bradykinin has been documented in resistance vessels. However, the contribution of residual NO to the vasodilatation in response to pressure and fluid shear stress is not well ...
Nosova Emily V EV Department of Surgery, University of California, San Francisco, California; VIPERx Laboratory, San Francisco, - - 2014
Sedentarism, also termed physical inactivity, is an independent risk factor for cardiovascular diseases. Mechanisms thought to be involved include insulin resistance, dyslipidemia, hypertension, and increased inflammation. It is unknown whether changes in vascular and endothelial function also contribute to this excess risk. We hypothesized that short-term exposure to inactivity would ...
Shafi Tariq T Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, - - 2014
Hypertension is highly prevalent in hemodialysis patients but its management remains a matter of debate. In this review, we discuss the observational studies on the association of blood pressure with outcomes, measurement of blood pressure in hemodialysis patients and present an opinion-based approach to treating hypertension.
Wagner Julia Y - - 2014
Monitoring cardiovascular function in acutely ill patients in the emergency department (ED) is of paramount importance. Arterial pressure (AP) is usually monitored using intermittent oscillometric measurements with an upper arm cuff. The vascular unloading technique (VUT) allows continuous noninvasive AP monitoring. In this study, we compare continuous AP measurements obtained ...
Dores Hélder H Serviço de Cardiologia, Hospital de Santa Cruz, CHLO, Lisboa, Portugal. Electronic address: - - 2014
The increase of activation of sympathetic nervous system has a central role in the pathophysiology of hypertension (HT). Catheter-based renal denervation (RDN) was recently developed for the treatment of resistant HT. To evaluate the safety and efficacy of RDN in HT reduction at 6-months in patients with resistant HT. Prospective ...
Willaert W W Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, - - 2014
Purpose: The objective of this experiment is to establish a continuous postmortem circulation in the vascular system of porcine lungs and to evaluate the pulmonary distribution of the perfusate. This research is performed in the bigger scope of a revascularization project of Thiel embalmed specimens. This technique enables teaching anatomy, ...
Yeung Joyce J Academic Department of Critical Care, Anaesthesia and Pain, Heart of England NHS Foundation Trust, Birmingham, UK, B9 5SS; University of Birmingham, College of Medical and Dental Studies, UK, B15 - - 2014
AIM: : This study aims to compare the effect of three CPR prompt and feedback devices on quality of chest compressions amongst healthcare providers. A single blinded, randomised controlled trial compared a pressure sensor/metronome device (CPREzy™), an accelerometer device (Phillips Q-CPR) and simple metronome on the quality of chest compressions ...
Ufnal Marcin M Department of Experimental and Clinical Physiology, Medical University of Warsaw, Krakowskie Przedmieście 26/28, 00-927 Warsaw, Poland. Electronic address: - - 2014
Accumulating evidence suggests that blood borne hormones modulate brain mechanisms regulating blood pressure. This appears to be mediated by the circumventricular organs which are located in the walls of the brain ventricular system and lack the blood-brain barrier. Recent evidence shows that neurons of the circumventricular organs express receptors for ...
Buys Emmanuel E aAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital bDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-dependent signaling mechanisms have a profound effect on the regulation of blood pressure (BP). In this review, we will discuss recent findings in the field that support the importance of sGC in the development of hypertension. The importance of sGC in BP regulation was highlighted ...
Hu Weitong W Research Institute of Cardiovascular Diseases and Department of Cardiology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of - - 2014
To evaluate whether inter-arm diastolic blood pressure difference (DBPl-r) induced by one arm ischemia correlates with flow-mediated dilatation (FMD). Bilateral arm BPs were simultaneously measured with two automatic devices and right brachial artery diameter (D) was measured by ultrasound technique in 108 subjects (56 hypertensives and 52 normotensives). Following baseline ...
Osei-Owusu Patrick P Drexel University College of - - 2014
Elastin (Eln) insufficiency in mice and humans is associated with hypertension and altered structure and mechanical properties of large arteries. However, it is not known to what extent functional or structural changes in resistance arteries contribute to the elevated blood pressure characteristic of elastin insufficiency. Here we investigate how elastin ...
Heinze Christoph - - 2014
High blood pressure is the leading risk factor for death worldwide. One of the hallmarks is a rise of peripheral vascular resistance, which largely depends on arteriole tone. Ca2+-activated chloride currents (CaCCs) in vascular smooth muscle cells (VSMCs) are candidates for increasing vascular contractility. We analyzed the vascular tree and ...
Uys A S AS Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South - - 2014
Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite (NOx) responses, cardiovascular function and structural vascular disease in a cohort of African and Caucasian men. The study included 81 African and ...
Hodgson Jonathan M JM School of Medicine and Pharmacology, University of Western Australia, GPO Box X2213 Perth, Western Australia 6847, Australia. Electronic address: - - 2014
Characteristics of short-term blood pressure (BP) variation may influence cardiovascular disease risk via effects on vascular function. In a cross-sectional study of a group of treated hypertensive and untreated largely normotensive subjects we investigated the relationships of measures of short-term BP variation with brachial artery vasodilator function. A total of ...
Schutte A E AE Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa. Electronic address: - - 2014
Insulin-like growth factor-1 (IGF-1) has potent endothelial-protective, anti-platelet and anti-thrombotic activities, and also exerts mitogenic and proliferatory actions on vascular smooth muscle cells. Conflicting reports exist regarding the role of IGF-1 in vascular protection and atherogenesis. We therefore investigated the relationships of ambulatory blood pressure (BP) and carotid intima-media thickness ...
Hernanz Raquel - - 2014
Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-oxygenases has been involved in the alterations in vascular function, structure and mechanical properties observed in cardiovascular diseases, including hypertension. In addition, it is well known that production of ROS (reactive oxygen species) plays an important role in the ...
Chattopadhyay Saurabh S Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of - - 2014
Angiotensin-converting enzyme (ACE) regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-system (RAS). Ace-/- mice are smaller in size, have low blood pressure and defective kidney structure and functions. All of these defects are cured by transgenic expression of somatic ACE (sACE) in vascular endothelial cells ...
Karaca Mustafa M Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, - - 2014
Background Endothelial dysfunction, which is characterized by an imbalance between relaxing and contracting factors, procoagulant and anticoagulant substances, and between pro-inflammatory mediators, may play a particularly significant role in the pathogenesis of atherosclerosis. Numerous experimental and clinical reports suggest that a high von Willebrand factor (vWF) level reflects endothelial damage ...
Vanbavel Ed E Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The - - 2014
Organ perfusion is regulated by vasoactivity and structural adaptation of small arteries and arterioles. These resistance vessels are sensitive to pressure, flow and a range of vasoactive stimuli. Several strongly interacting control loops exist. As an example, the myogenic response to a change of pressure influences the endothelial shear stress, ...
Al-Qubati Yasin Y Dermatology, Taiz University School of Medicine, Taiz, Yemen and Dermatology and Pediatrics, Rutgers University New Jersey Medical School, Newark, New Jersey, - - 2014
Pyogenic granuloma (PG) is a benign vascular neoplasm most often evident as a rapidly developing solitary, sessile, or polypoid vascular nodule or tumor prone to ulceration or hemorrhage. Bleeding may be episodic, copious, and refractory to pressure, mandating treatment, particularly when on the lip. We describe a 14-year-old adolescent with ...
Mehlsen Jesper J Coordinating Research Centre, Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark ; Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, - - 2014
The present study aimed at examining the interarm difference in blood pressure and its use as an indicator of peripheral arterial disease (PAD). Data were included from consecutive patients referred from their general practitioner to our vascular laboratory for possible PAD aged 50 years or older without known cardiac disease, ...
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