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Haruhara Kotaro K Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, - - 2014
Recent studies have demonstrated that ambulatory blood pressure monitoring is useful for predicting the long-term renal prognosis and future cardiovascular events in chronic kidney disease patients. Currently, however, information is limited regarding the relationships between individual renal histopathological findings and abnormalities in ambulatory blood pressure. This retrospective cross-sectional study included ...
Compton Friederike F Department of Nephrology, Charité University Medicine Berlin, Berlin, - - 2014
Management of volume status is difficult in critically ill patients with renal failure. Volumetric hemodynamic indices are increasingly being used to guide fluid therapy in the intensive care unit (ICU), but are not established to monitor hemodialysis-induced fluid removal in critically ill patients. Using volumetric hemodynamic monitoring, changes in extravascular ...
Gong Yongfeng Y Department of Internal Medicine-Renal Division, Center for Investigation of Membrane Excitability Diseases, and Department of Physiology, Binzhou Medical College, Yantai 264003, - - 2014
The paracellular pathway through the tight junction provides an important route for transepithelial chloride reabsorption in the kidney, which regulates extracellular salt content and blood pressure. Defects in paracellular chloride reabsorption may in theory cause deregulation of blood pressure. However, there is no evidence to prove this theory or to ...
Endres Bradley T BT Departments of Physiology andHuman and Molecular Genetics Center, - - 2014
PLEKHA7 (pleckstrin homology domain containing family A member 7) has been found in multiple studies as a candidate gene for human hypertension, yet functional data supporting this association are lacking. We investigated the contribution of this gene to the pathogenesis of salt-sensitive hypertension by mutating Plekha7 in the Dahl salt-sensitive ...
Jelani Qurat-Ul-Ain QU Leon H. Charney Division of Cardiology, New York University School of Medicine, New York University Langone Medical Center, New York, New - - 2014
Familial dysautonomia (FD) is a rare hereditary disease characterized by loss of afferent autonomic neural fiber signaling and consequent profound impairment of arterial baroreflex function and blood pressure regulation. Whether vascular endothelial dysfunction contributes to defective vasomotor control in this form of afferent autonomic failure is not known. We assessed ...
Borghi Claudio C Unit of Internal Medicine, Policlinico S.Orsola, University of Bologna, Via Massarenti 9, 40138 Bologna, - - 2014
The fixed combination of zofenopril 30 mg plus hydrochlorothiazide 12.5 mg is indicated for the management of hypertensive patients whose blood pressure (BP) is not adequately controlled on zofenopril alone. In clinical trials, this combination therapy proved to be superior to monotherapy in reducing office and ambulatory BP. In this ...
Al-Magableh Mohammad R MR Department of Pharmacology, Monash University, Clayton, Victoria, - - 2014
Hydrogen sulfide (H2S) is increasingly recognized as a gasotransmitter with protective effects in the cardiovascular system. The aim of the study was to examine the effects of chronic NaHS treatment on blood pressure, vascular function and oxidative stress in an in vivo model of hypertension and oxidative stress. Male C57Bl6/J ...
Martin-StPaul N K NK CEFE UMR 5175, CNRS-Université de Montpellier-Université Paul-Valéry Montpellier-EPHE-IRD, 1919 route de Mende 34293 Montpellier Cedex 5, France Laboratoire Ecologie Systématique et Evolution CNRS, Orsay F-91405, France nico09.martin@gmail.com - - 2014
Three methods are in widespread use to build vulnerability curves (VCs) to cavitation. The bench drying (BD) method is considered as a reference because embolism and xylem pressure are measured on large branches dehydrating in the air, in conditions similar to what happens in nature. Two other methods of embolism ...
Fajemiroye James Oluwagbamigbe JO Department of Physiological Sciences, Federal University of Goiás, Campus Samambaia, 74001-970 Goiâania, GO, Brazil. Electronic address: - - 2014
Clinical complaints on the first-line of cardiovascular medications make continuous search for new drugs a necessity. This study evaluated the cardiovascular effects and mechanism of 4-[(1-phenyl-1H-pyrazol-4-yl)methyl]1-piperazine carboxylic acid ethyl ester (LQFM008). Normotensive male Wistar or spontaneously hypertensive rats (anesthetized or conscious) were used to evaluate the effect of LQFM008 on ...
Feldman Ross D RD Robarts Research Institute, London, ON, - - 2014
Activation of vascular GPER has been linked to vasodepressor effects in animals. However, the significance of GPER regulation on chronic blood pressure control in humans is unknown. To examine this question we determined the functional significance of expression of a common missense single nucleotide variant of GPER, P16L in vascular ...
Asmussen Sven S aDepartments of Anesthesiology, The University of Texas Medical Branch, Galveston, TX bDepartment of Clinical Science and Education, Karolinska Institutet, Section of Anaesthesiology and Intensive Care, Södersjukhuset, Stockholm, Sweden cDepartment of Internal Medicine, The University of Texas Medical Branch, Galveston, - - 2014
The primary goal of fluid therapy is to maintain fluid homeostasis. Commonly used isotonic crystalloids are only marginally effective and contribute to fluid excess syndrome. In patients with decreased cardiovascular reserve, fluid therapy alone is not sufficient to maintain end-organ perfusion. Therefore, inotropes or vasoactive drugs are used to supplement ...
Ruhhammer Johannes J Department of Microsystems Engineering, University of Freiburg, Georges-Koehler-Allee 102, 79110, Freiburg, Germany, - - 2014
A novel sensor for measuring arterial distension, pulse and pressure waveform is developed and evaluated. The system consists of a magnetic sensor which is applied and fixed to arterial vessels without any blood vessel constriction, hence avoiding stenosis. The measurement principle could be validated by in vitro experiments on silicone ...
Lee Ji-Hyun JH Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, #101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of - - 2014
The aim of this study was to compare tissue oxygen saturation as measured by INVOS(®) and InSpectra™ during a vascular occlusion test (VOT) in the same subject. Twenty healthy adults were investigated. The INVOS(®) and InSpectra™ probes were placed randomly on the right and left thenar eminence in the same ...
Pozzobon Cesar Romaro CR Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
Background: Antihypertensive drugs are used to control blood pressure (BP) and reduce macro- and microvascular complications in hypertensive patients with diabetes. Objectives: The present study aimed to compare the functional vascular changes in hypertensive patients with type 2 diabetes mellitus after 6 weeks of treatment with amlodipine or losartan. Methods: ...
Raptis Athanasios E AE 2nd Department of Medicine-Propaedeutic Clinic, Research Institute, and Diabetes Centre, Athens University Medical School, Attikon University General Hospital, Haidari, Athens, Greece - - 2014
The aim of this study was to investigate the effects of aliskiren on vascular function and endothelial progenitor cells (EPCs) in patients with type 2 diabetes and essential hypertension. The study enrolled type 2 diabetic patients aged >50 years under stable glycemic control and first diagnosed mild essential hypertension. In ...
Wu Di D Institute of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, - - 2014
Apelin is a recently described endogenous peptide and its receptor APJ, is a member of the G protein-coupled receptors family. Apelin and APJ are widely distributed in central and peripheral tissues exert important biological effects on cardiovascular system. Recent studies have suggested that apelin/APJ system involves in decreasing the blood ...
Bibi Shahida S 1 Division of Colon and Rectal Surgery, Advocate Lutheran General Hospital , Park Ridge, - - 2014
Abstract Background: Mesenteric vascular ligation is a critical step in minimally invasive colorectal surgery. This study assessed the quality of in vivo and ex vivo sealing of the human inferior mesenteric artery (IMA), as well as the relation of IMA stump and bursting pressure. Patients and Methods: This was a ...
Pollock Jonathan P JP Penn State Hershey Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, - - 2014
In response to hypoxia, a net vasodilation occurs in the limb vasculature in young healthy humans and this is referred to as "hypoxia-induced vasodilation". We performed two separate experiments to determine (1) if hypoxia-induced forearm vasodilation is impaired in older men (n = 8) compared to young men (n = ...
Dolinsky Brad M - - 2014
To determine if continuous infusion of taurocholic acid into the fetoplacental and intervillous circulation of a placental cotyledon affects the fetal arterial pressure response after injection of the thromboxane mimetic U44619. Taurine conjugated bile acid is one bile acid putatively mediating intrahepatic cholestasis of pregnancy (ICP). We selected 5 placentas ...
Diaz-Abad Montserrat M School of Medicine, University of Maryland, Baltimore, MD, - - 2014
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which most patients die of respiratory failure. Although volume-targeted non-invasive bilevel positive airway pressure (BPAP) ventilation has been studied in patients with chronic respiratory failure of various etiologies, its use in ALS has not been reported. We present the case ...
Momin A A Cardiothoracic Department, St George's Hospital, London, UK - - 2014
Hypertension is a risk factor for accelerated saphenous vein (SV) graft disease and endothelial dysfunction in a number of vascular territories. We examined the relationship between blood pressure (BP) and vascular function in SV from 94 male patients undergoing coronary artery bypass grafting (CABG). Patients were pretreated with respect to ...
Houston Mark M Hypertension Institute, Nashville, - - 2014
This blinded placebo-controlled crossover study evaluated the acute effects of an orally disintegrating lozenge that generates nitric oxide (NO) in the oral cavity on blood pressure (BP) response, endothelial function, and vascular compliance in unmedicated hypertensive patients. Thirty patients with clinical hypertension were recruited and enrolled in a blinded placebo-controlled ...
Kim Yong-Hoon YH Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon, South - - 2014
Endothelial nitric oxide synthase (eNOS) is involved in blood pressure (BP) regulation through the production of nitric oxide. Sirtuin I (SIRT1), an NAD-dependent protein deacetylase, promotes vascular relaxation through deacetylation and activation of eNOS. β-Lapachone (βL) increases the cellular NAD(+)/NADH ratio by activating NAD(P)H:quinone oxidoreductase 1 (NQO1). In this study, ...
Weber Franz F St Walburga Hospital, Meschede, Private Practice at the Medical Care Center, Dialysis Center, - - 2014
The introduction of invasive treatments, some of which are irreversible, for the entity called treatment-resistant hypertension (TRH) creates the need for a comprehensive discussion of the diagnostic evaluation that TRH requires and the available options for its conservative treatment. The pertinent literature is selectively reviewed in the light of the ...
Barman Scott A SA From the Department of Forensic Medicine, Nanjing Medical University, Jiangsu, China (F.C.); Department of Pharmacology and Toxicology (S.A.B., Y.S., W.H., D.J.R.F.) and Vascular Biology Center (F.C., C.D., Y.W., J.D.S., N.B., O.R., R.R., S.M.B., D.W.S., G.R., D.J.R.F.), Georgia Regents University, Augusta; Vichem Chemie, Ltd, Budapest, Hungary (L.O., C.S.-K., G.K., I.S.); University of Leipzig, Leipzig, Germany (A.G.); Hannover Medical School, Hannover, Germany (D.J.); University of Texas Health Science Center at San Antonio (R.A.); and Pathobiochemical Research Group of Hungarian Academy of Sciences (G.K.) and Department of Pharmaceutical Chemistry (L.O.), Semmelweis University, Budapest, Hungary. sbarman@gru.edu dfulton@gru.edu - - 2014
Pulmonary hypertension (PH) is a progressive disease arising from remodeling and narrowing of pulmonary arteries (PAs) resulting in high pulmonary blood pressure and ultimately right ventricular failure. Elevated production of reactive oxygen species by NADPH oxidase 4 (Nox4) is associated with increased pressure in PH. However, the cellular location of ...
Deda Livia L 1Department of Endocrinology,Hospital for Sick Children,University of - - 2014
Reactive hyperemia index is a measure of endothelial function used to assess subclinical atherosclerosis. When evaluated in healthy adolescents, significant changes in endothelial function were correlated with advancing age, pubertal status, and blood pressure. Blood pressure was the principal contributor to reactive hyperemia index variability independent of age, lipid profile, ...
Hildebrandt Drew A DA From the Department of Physiology and Biophysics (D.A.H., T.E.L.) and Department of Surgery (D.A.H.), University of Mississippi Medical Center, Jackson; North Memorial Medical Center, Trauma Services, Robbinsdale, MN (E.D.I.); and CVRx, Inc, Minneapolis, MN - - 2014
Chronic electric activation of the carotid baroreflex produces sustained reductions in sympathetic activity and arterial pressure and is currently being evaluated as antihypertensive therapy for patients with resistant hypertension. However, the influence of variations in salt intake on blood pressure lowering during baroreflex activation (BA) has not yet been determined. ...
Yamashita Sumiyo S Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences , Nagoya , - - 2014
Objectives. The present study investigated whether brachial and central blood pressures have differential impact on the cardiovascular system in the general population. Methods. The study included 706 subjects (59 ± 10 years) who visited our hospital for a physical check-up. Brachial blood pressure and radial artery pressure waveforms were recorded ...
Calbet Jose Al JA Copenhagen Muscle Research Center, Rigshospitalet, section, 7652, Copenhagen, Denmark; Department of Physical Education, University of Las Palmas de Gran Canaria, Canary Islands, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), Las Palmas de Gran Canaria, Canary Islands, - - 2014
To determine the role played by adenosine, ATP and chemoreflex activation on the regulation of vascular conductance in chronic hypoxia. The vascular conductance response to low and high doses of adenosine and ATP was assessed in ten healthy men. Vasodilators were infused into the femoral artery at sea level and ...
Patwardhan V R VR Beth Israel Deaconess Medical Center, Boston, MA, - - 2014
Portal hypertensive gastropathy (PHG) and gastric antral vascular ectasia (GAVE) are important causes of both acute and chronic gastrointestinal bleeding in patients with cirrhosis. To review the current management of PHG and GAVE. PubMed was searched for English language articles using the key words 'GAVE', 'gastric antral vascular ectasia', 'cirrhosis', ...
Matz Brad M BM Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, - - 2014
To determine the effectiveness of a vascular sealing technology on canine carotid arteries using various seal configurations to achieve maximal vessel security. Ex-vivo study. Dogs (n = 20). Carotid arteries (n = 40) were removed from the mid-cervical region of recently euthanatized dogs. Harvested vessels were closed with 2 circumferential ligatures (Group 1) or ...
Harsanji-Drenjancevic Ines I University of Osijek Department of Physiology and Immunology, Faculty of Medicine J. Huttlera 4 31000 Osijek Croatia University of Pécs Pécs - - 2014
The control of arterial pressure is a complex interaction of the long- and short-term influences of hormones, local vascular factors, and neural mechanisms. The autonomic nervous system and its sympathetic arm play important roles in the regulation of blood pressure, and overactivity of sympathetic nerves may have an important role ...
Lee Joshua F - - 2014
A high degree of interindividual variability exists in the magnitude of heat stress (HS)-induced reductions in orthostatic tolerance relative to normothermia (NT). This variability may be associated with HS-mediated reductions in cerebral perfusion (indexed as middle cerebral artery blood velocity; MCAV(mean)) and altered cerebrovascular regulation. We tested the hypothesis that ...
Rigatelli Gianluca G Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, - - 2014
To assess the impact on stent implantation rate and mid-term outcomes of prolonged high pressure angioplasty of femoropopliteal lesions. We retrospectively enrolled 620 consecutive patients from January 2011 to December 2011 (75.6 ± 12.3 years, 355 males, 76.5% in Rutherford class 5-6), referred for critical limb ischemia and submitted to ...
Akal Ali A Department of Ophthalmology, Harran University, Sanlıurfa, - - 2014
Background and Aim: Resistive index (RI) is an indirect measurement of blood flow resistance that can be used to evaluate vascular damage in ophthalmologic disease. The purpose of this study was to evaluate the association between RI values of orbital arteries using the color Doppler imaging (CDI) in geriatric hypertensive ...
Lee HaNa H Division of Neonatology IS, Hauner Dr. von Hauner Children's Hospital, University of Munich, Munich, - - 2014
Increased carotid intima-media thickness (cIMT) and loss of capillary density are antecedents of cardiovascular disease in adults. Former preterm infants are at risk for metabolic precursors of vascular disease, but vascular changes have not yet been studied in this population. In 54 former preterm (birth weigh (BW) 753±152 g) and 12 ...
Guyette Jacques P JP 1] Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. - - 2014
The native extracellular matrix (ECM) outlines the architecture of organs and tissues. It provides a unique niche of composition and form, which serves as a foundational scaffold that supports organ-specific cell types and enables normal organ function. Here we describe a standard process for pressure-controlled perfusion decellularization of whole organs ...
Wang Hongyu H Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China. Electronic address: - - 2014
Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong prognostic marker in advanced stage of coronary heart disease (CHD). In the present study, we investigated the relationship between CAVI and NT-proBNP ...
Barbour Jayne A JA Nutrition Physiology Research Centre, Sansom Institute for Health Research, University of South Australia,GPO Box - - 2014
Nuts are rich in many nutrients that can benefit multiple cardiometabolic functions, including arterial compliance, blood pressure, inflammation, glucoregulation and endothelial vasodilatation. Impaired vasodilatation may contribute to impaired cognitive performance due to poor cerebral perfusion. The present narrative review examines associations between nut consumption, vascular health and cognitive function. It ...
Marchi Katia Colombo KC Katia Colombo Marchi, Programa de pós-graduação em Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, CEP 14040-900, - - 2014
The influences of life habits on the cardiovascular system may have important implications for public health, as cardiovascular diseases are among the leading causes of shorter life expectancy worldwide. A link between excessive ethyl alcohol (ethanol) consumption and arterial hypertension was first suggested early last century. Since then, this proposition ...
Edwards Martin O MO Department of Child Health, School of Medicine, Cardiff University, Cardiff, - - 2014
Preterm birth, low birth weight and poor fetal nutrition have been linked to cardiovascular disease, but the underlying mechanisms remain unclear. We explored prematurity and vascular function by studying a UK cohort of 14,049 children and conducting a systematic review. Systolic blood pressure was higher in subjects born preterm than ...
Yin Anlin A College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, - - 2014
In the vascular prosthetic field, the prevailing thought is that for clinical, long-term success, especially bioresorbable grafts, cellular migration and penetration into the prosthetic structure is required to promote neointima formation and vascular wall development. In this study, we fabricated poly (l-lactic acid-co-ɛ-caprolactone) P(LLA-CL)/silk fibroin (SF) vascular scaffolds through electrospinning ...
Tempark Therdpong T Department of Pediatrics, Chulalongkorn University, Bangkok, - - 2014
The clinical presentation of arborizing vascular dilatation can resemble Lichtenberg figures from lightning. Both have a feather-like or ferning pattern. We report an interesting case of pressure-induced vasodilatation (PIV) caused by temporary vascular occlusion from jeans buttons.
Endo Masako Y - - 2014
Recently, it was reported in healthy young subjects that fructose containing drinks increased blood pressure acutely, without any apparent change in total vascular conductance (TVC). However, because it is well known that the splanchnic vasculature is dilated by oral fructose ingestion, it is assumed to be the concomitant vasoconstriction in ...
Fajemiroye James O JO Department of Physiological Sciences, Federal University of Goiás, Campus Samambaia, 74001-970, Goiânia-GO, Brazil. Electronic address: - - 2014
Application of naturally occurring (E) - methyl isoeugenol (MIE) as food flavour has been widely accepted despite the growing concerns over cardiovascular issue. Hence, we sought to investigate hypotensive property of MIE and the involvement of central and/or peripheral mechanism (s). Variation in mean arterial pressure (MAP), heart rate (HR), ...
Kotliar Carol C Centre of Hypertension, Cardiology Service, Hospital Universitario Austral, Argentina - - 2014
The relationship between salt intake, blood pressure and RAAS activation is still controversial, being that both high- and low-salt intakes are associated with cardiovascular events in a J-shaped curve pattern. We hypothesized that different patterns of RAAS response to dietary salt intake among hypertensives could be identified, while vascular damage ...
Wang H H Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, - - 2014
An increasing of arterial stiffness is the path physiological characteristic of hypertension. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. In the present study, we investigated the relationship between CAVI and plasma lipids in hypertension subjects. A total of 542 subjects (male/female 336/206) from the Department of ...
Gavalas M V MV Stony Brook University Hospital, Department of Surgery, Division of Vascular Surgery, Stony Brook, NY, USA - - - 2014
Evaluate the short and longterm outcomes of percutaneous transluminal angioplasty in patients with hypertension and renal artery fibromuscular dysplasia (FMD) and identify specific patient factors that may affect outcomes. 29 patients with uncontrolled hypertension and renal artery FMD diagnosed by duplex ultrasound and angiography were prospectively enrolled. All patients underwent ...
de Raaf Michiel Alexander MA VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The - - 2014
The SU5416 combined with hypoxia (SuHx) rat model features angio-obliterative pulmonary hypertension resembling human pulmonary arterial hypertension. Despite increasing use of this model, a comprehensive haemodynamic characterisation in conscious rats has not been reported.We used telemetry to characterise haemodynamic responses in SuHx rats and associated these with serial histology.Right ventricular ...
Magder Sheldon A SA Department of Critical Care, McGill University Health Centre, Montreal, QC, - - 2014
Measurement of blood pressure is fundamental for the management of patients in shock, yet the physiological basis and meaning of blood pressure measurements are complex and often not well understood. This article is in two parts: part 1 deals with the mechanical and physiological aspects of blood pressure and its ...
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