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Ku Elaine E 1] Division of Nephrology, Department of Medicine, University of California, San Francisco, California, USA [2] Division of Pediatric Nephrology, Department of Pediatrics, University of California, San Francisco, California, - - 2014
There is controversy regarding whether strict blood pressure control is indicated in chronic kidney disease (CKD) since the primary results of randomized controlled trials failed to show any impact on progression of kidney disease with this strategy. However, strict blood pressure control may have other beneficial effects beyond reducing the ...
Daemen Joost J Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The - - 2014
Aims: Renal denervation is a potential new treatment therapy for resistant hypertension. However, anatomic vascular variations might complicate the procedure and increase complications. A radial approach offers easier renal artery access and is associated with a decreased risk of vascular access complications. Methods and results: We describe the first-in-man use ...
Fotheringham James J From the Sheffield Kidney Institute, Northern General Hospital, Sheffield, UK (J.F., W.M., T.E.); Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK (A.O.); and Department of Cardiovascular Science, University of Sheffield, Sheffield, UK - - 2014
In animal models, reduced nephron mass impairs renal arteriolar autoregulation, increasing vulnerability of the remaining nephrons to elevated systemic blood pressure (BP). A feature of the resulting glomerular capillary hypertension is an increase in glomerular permeability. We sought evidence of a similar remnant nephron effect in human chronic kidney disease. ...
Schneider Antoine G - - 2014
IntroductionWe used contrast-enhanced ultrasound (CEUS) to estimate the effect of an increase in mean arterial pressure (MAP) induced by noradrenaline infusion on renal microvascular cortical perfusion in critically ill patients.MethodsTwelve patients requiring a noradrenaline infusion to maintain a MAP more than 60 mmHg within 48 hours of intensive care unit admission were ...
Nathan Sandeep S Department of Medicine, Section of Cardiology and ASH Comprehensive Hypertension Center, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago Medicine, 5841 South Maryland Avenue, MC 1027, Chicago, IL, 60637, - - 2014
Resistant hypertension, defined as inadequate blood pressure control despite three or more antihypertensive medications at maximally tolerated doses, is strongly linked to increased cardiovascular morbidity and mortality. Increased renal afferent and efferent sympathetic activity carried by nerves which arborize the adventitia of the renal arteries, appears to be central to ...
Persu Alexandre A aPole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain bDivision of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium cAssistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou and Université Paris Descartes, Paris, France dStudies Coordinating Center, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, Leuven, Belgium eDepartment of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden fThird Department of Internal Medicine, General Faculty Hospital, Prague, Czech Republic gDepartment of Cardiology, Ullevaal University Hospital, University of Oslo, Oslo, Norway hDepartment of Cardiology, Geneva University Hospitals, Geneva iDepartment of Nephrology, Lausanne University Hospital, Lausanne, Switzerland jBHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom kDepartment of Cardiology, Isala Klinieken, Zwolle, the Netherlands lKarolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Stockholm, Sweden mDepartment of Epidemiology, Maastricht University, Maastricht, the - - 2014
Blood pressure (BP) response after renal denervation (RDN) is highly variable. Besides baseline BP, no reliable predictors of response have been consistently identified. The differences between patients showing a major BP decrease after RDN vs. nonresponders have not been studied so far. We identified extreme BP responders (first quintile) and ...
Peng Meng M Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , - - 2014
Abstract Objective: To investigate the renal-protective effect of lercanidipine in patients undergoing renal artery intervention. Methods: A prospective, single-center, cohort study was conducted and patients, 30-75 years of age, with atherosclerotic renal artery stenosis were consecutively enrolled between September 2011 and October 2012. Lercanidipine (10-20 mg/day) was regularly taken after the ...
Rosa Ján J From the 3rd Department of Medicine, Centre for Hypertension, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic (J.R., O.P., T.Z., R.H., B.Š., Z.Š., J.W.); Cardiocentre, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic (J.R., P.W., P.T., K.Č., F.B.); Department of Anesthesiology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W.); Department of Internal Medicine I, University Hospital Olomouc, Czech Republic (M.T., J.V., E.K.); and Cardiocentre, Nemocnice Podlesí, Třinec, Czech Republic (M.B., I.N., O.J.). - - 2014
This prospective, randomized, open-label multicenter trial evaluated the efficacy of catheter-based renal denervation (Symplicity, Medtronic) versus intensified pharmacological treatment including spironolactone (if tolerated) in patients with true-resistant hypertension. This was confirmed by 24-hour ambulatory blood pressure monitoring after excluding secondary hypertension and confirmation of adherence to therapy by measurement of ...
Abdel-Sayed S S Cardiovascular Research, Department of Cardio-Vascular Surgery, University Hospital-CHUV, Lausanne, Switzerland - - 2014
Venous cannula orifice obstruction is an underestimated problem during augmented cardiopulmonary bypass (CPB), which can potentially be reduced with redesigned, virtually wall-less cannula designs versus traditional percutaneous control venous cannulas. A bench model, allowing for simulation of the vena cava with various affluent orifices, venous collapse and a worst case ...
Yatabe Midori Sasaki MS Department of Pharmacology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan, - - 2014
Na(+)/Ca(2+) exchanger 1 (NCX1) controls intracellular Ca(2+) concentration in various cell types. In the kidney, NCX1 is expressed mainly in the distal tubular basolateral membrane as well as in vascular smooth muscle. Tubular NCX1 is involved in Ca(2+) reabsorption, and NCX1 in renal arterioles may control intraglomerular pressure. However, the ...
Jeong J J Department of Emergency Medicine, College of Medicine, Dong-A University , Seo-Gu, Busan , Republic of - - 2014
A 73-year-old man was transferred to the emergency department (ED). He was found unconscious in his house along with an empty 200-mL bottle of Basta(™), a herbicide containing 18% glufosinate. He was comatose with a Glasgow Coma Scale score of 3. As his blood pressure dropped to 60/30 mmHg despite ...
Shi Zhi-Min ZM Medical College of Hebei University of Engineering, - - 2014
[Purpose] To assess the effects of Tai Chi on the renal and cardiac functions of patients with chronic kidney disease (CKD) and cardiovascular disease (CVD). [Subjects and Methods] Twenty-one patients with CKD and CVD were randomly divided into control and exercise groups. The exercise group performed Tai Chi training for ...
Park Eui Ju EJ Institute for Digestive Research, Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, - - 2014
We used high-resolution impedance manometry (HRIM) to determine the length of breaks on the isobaric contour which would predict incomplete bolus clearance in patients in the sitting position. In total, 651 swallows in 71 patients with esophageal symptoms were studied using a solid-state HRIM system in the sitting position. Each ...
Menzies Robert I RI British Heart Foundation Centre for Cardiovascular Science; Institute for Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, - - 2014
The regulation of extracellular fluid volume is a key component of blood pressure homeostasis. Long-term blood pressure is stabilized by the acute pressure natriuresis response by which changes in renal perfusion pressure evoke corresponding changes in renal sodium excretion. A wealth of experimental evidence suggests that a defect in the ...
Modesti Pietro Amedeo PA Department of Clinical and Experimental Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy, - - 2014
Daily sessions of slow-breathing (6 breaths/min) significantly reduced 24-h ambulatory blood pressure (ABP) in patients with mild hypertension and this effect persisted at least 6 months after the interruption of sessions. The sequence of changes induced by slow-breathing (SB) daily sessions on the modulation of ambulatory blood pressure, renal resistive index, ...
Gal P P Department of Cardiology, Isala Klinieken, Zwolle, The - - 2014
During renal sympathetic denervation (RDN), no mapping of renal nerves is performed and there is no clear end point of RDN. We hypothesized high-frequency renal nerve stimulation (RNS) may increase blood pressure (BP), and this increase is significantly blunted after RDN. The aim of this study was to determine the ...
Mahfoud Felix F From the Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany (F.M., B.C., D.L., M.B.); Medtronic Cardiovascular, Santa Rosa, CA (S.T., J.R., D.S.-J., R.J.M.); Klinik für Kardiologie & Angiologie II, Universitäts-Herzzentrum Freiburg-Bad Krozingen, Bad Krozingen, Germany (T.Z.); Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA (D.L.B.); and Prairie Heart Institute at St. John's Hospital, Springfield, IL (K.R.-S.). - - 2014
In selected patients with hypertension, renal artery (RA) stenting is used to treat significant atherosclerotic stenoses. However, blood pressure often remains uncontrolled after the procedure. Although catheter-based renal denervation (RDN) can reduce blood pressure in certain patients with resistant hypertension, there are no data on the feasibility and safety of ...
Sarafidis Pantelis A PA Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, - - 2014
Background/Aims: Elevated wave reflections and arterial stiffness, as well as ambulatory blood pressure (BP) are independent predictors of cardiovascular risk in end-stage-renal-disease. This study is the first to evaluate in hemodialysis patients the validity of a new ambulatory oscillometric device (Mobil-O-Graph, IEM, Germany), which estimates aortic BP, augmentation index (AIx) ...
Brasen Jens Christian JC Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark; and - - 2014
The proximal tubule Na(+)/H(+) exchanger 3 (NHE3), located in the apical dense microvilli (brush border), plays a major role in the reabsorption of NaCl and water in the renal proximal tubule. In response to a rise in blood pressure NHE3 redistributes in the plane of the plasma membrane to the ...
Hye Khan Md Abdul MA *Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, - - 2014
Epoxyeicosatrienoic acids (EETs) contribute to haemodynamics, electrolyte homoeostasis and blood pressure regulation, leading to the concept that EETs can be therapeutically targeted for hypertension. In the present study, multiple structural EET analogues were synthesized based on the EET pharmacophore and vasodilator structure-activity studies. Four EET analogues with 91-119% vasodilatory activity ...
Mansoori A A Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. - - 2014
Sexual differences in blood pressure are associated with angiotensin 1-7 (Ang1-7) and its receptor and enzyme function targeting. Blockade of angiotensin II (AngII) receptors type 1 and 2 (AT1R and AT2R) inhibits some actions of Ang1-7. We described the role of Ang1-7 receptor (MasR) antagonist (A779) on kidney hemodynamics when ...
Prochnau Dirk D Department of Internal Medicine I, Jena University Hospital, Jena, - - 2014
Renal denervation (RDN) with radiofrequency (RF) is being used to treat resistant hypertension (rHTN). As 15-30% of treated patients are non-responders to RDN, we investigated whether RDN with cryoenergy can serve as a second-line option. Ten non-responder patients (mean age 55 years, six male) with rHTN were treated with cryoenergy ...
Kuznetsova Tatiana T The Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; - - 2014
The cardio-renal interaction occurs via hemodynamic and humoral factors. Noninvasive assessment of renal hemodynamics is currently possible by assessment of renal resistive index (RRI) derived from intrarenal Doppler arterial waveforms as ((peak systolic velocity - end-diastolic velocity)/peak systolic velocity). Limited information is available regarding the relationship between RRI and cardiac ...
Safavi-Naeini Payam P Department of Cardiology, Texas Heart Institute, Houston, - - 2014
Cryoballoon ablation of pulmonary veins (PVs) is widely used to treat atrial fibrillation (AF). Successful ablation requires occluding the PVs by cryoballoon. Angiography is a standard method of assessing PV occlusion. To decrease contrast doses and overcome potential contraindications (e.g., allergy to contrast, renal disease), alternative methods have been tested, ...
Haruhara Kotaro K Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, - - 2014
Recent studies have demonstrated that ambulatory blood pressure monitoring is useful for predicting the long-term renal prognosis and future cardiovascular events in chronic kidney disease patients. Currently, however, information is limited regarding the relationships between individual renal histopathological findings and abnormalities in ambulatory blood pressure. This retrospective cross-sectional study included ...
Wang Xinquan X Department of Cardiology, Daping Hospital, The Third Military Medical University, P. R. China; Chongqing Institute of Cardiology, Chongqing, P. R. - - 2014
Adverse environment in early life can modulate the adult phenotype, including blood pressure. Lipopolysaccharide (LPS) exposure in utero results in increased blood pressure in the offspring, but the exact mechanisms are not clear. Studies have shown that the renal dopamine D1 receptor (D1R) plays an important role in maintaining sodium ...
Compton Friederike F Department of Nephrology, Charité University Medicine Berlin, Berlin, - - 2014
Management of volume status is difficult in critically ill patients with renal failure. Volumetric hemodynamic indices are increasingly being used to guide fluid therapy in the intensive care unit (ICU), but are not established to monitor hemodialysis-induced fluid removal in critically ill patients. Using volumetric hemodynamic monitoring, changes in extravascular ...
Cui H-X HX Department of General Surgery, Xuzhou Center Hospital, Xuzhou, Jiangsu, China. - - 2014
To investigate the efficacy of the treatment of severe acute pancreatitis (SAP) complicated by acute respiratory distress syndrome (ARDS) using continuous renal replacement therapy (CRRT) by evaluating the effect of CRRT on respiratory and circulatory function as well as serum cytokines level. Fifty four randomly selected patients with confirmed SAP ...
Gong Yongfeng Y Department of Internal Medicine-Renal Division, Center for Investigation of Membrane Excitability Diseases, and Department of Physiology, Binzhou Medical College, Yantai 264003, - - 2014
The paracellular pathway through the tight junction provides an important route for transepithelial chloride reabsorption in the kidney, which regulates extracellular salt content and blood pressure. Defects in paracellular chloride reabsorption may in theory cause deregulation of blood pressure. However, there is no evidence to prove this theory or to ...
Endres Bradley T BT Departments of Physiology andHuman and Molecular Genetics Center, - - 2014
PLEKHA7 (pleckstrin homology domain containing family A member 7) has been found in multiple studies as a candidate gene for human hypertension, yet functional data supporting this association are lacking. We investigated the contribution of this gene to the pathogenesis of salt-sensitive hypertension by mutating Plekha7 in the Dahl salt-sensitive ...
Jelani Qurat-Ul-Ain QU Leon H. Charney Division of Cardiology, New York University School of Medicine, New York University Langone Medical Center, New York, New - - 2014
Familial dysautonomia (FD) is a rare hereditary disease characterized by loss of afferent autonomic neural fiber signaling and consequent profound impairment of arterial baroreflex function and blood pressure regulation. Whether vascular endothelial dysfunction contributes to defective vasomotor control in this form of afferent autonomic failure is not known. We assessed ...
Borghi Claudio C Unit of Internal Medicine, Policlinico S.Orsola, University of Bologna, Via Massarenti 9, 40138 Bologna, - - 2014
The fixed combination of zofenopril 30 mg plus hydrochlorothiazide 12.5 mg is indicated for the management of hypertensive patients whose blood pressure (BP) is not adequately controlled on zofenopril alone. In clinical trials, this combination therapy proved to be superior to monotherapy in reducing office and ambulatory BP. In this ...
Al-Magableh Mohammad R MR Department of Pharmacology, Monash University, Clayton, Victoria, - - 2014
Hydrogen sulfide (H2S) is increasingly recognized as a gasotransmitter with protective effects in the cardiovascular system. The aim of the study was to examine the effects of chronic NaHS treatment on blood pressure, vascular function and oxidative stress in an in vivo model of hypertension and oxidative stress. Male C57Bl6/J ...
Martin-StPaul N K NK CEFE UMR 5175, CNRS-Université de Montpellier-Université Paul-Valéry Montpellier-EPHE-IRD, 1919 route de Mende 34293 Montpellier Cedex 5, France Laboratoire Ecologie Systématique et Evolution CNRS, Orsay F-91405, France nico09.martin@gmail.com - - 2014
Three methods are in widespread use to build vulnerability curves (VCs) to cavitation. The bench drying (BD) method is considered as a reference because embolism and xylem pressure are measured on large branches dehydrating in the air, in conditions similar to what happens in nature. Two other methods of embolism ...
Fajemiroye James Oluwagbamigbe JO Department of Physiological Sciences, Federal University of Goiás, Campus Samambaia, 74001-970 Goiâania, GO, Brazil. Electronic address: - - 2014
Clinical complaints on the first-line of cardiovascular medications make continuous search for new drugs a necessity. This study evaluated the cardiovascular effects and mechanism of 4-[(1-phenyl-1H-pyrazol-4-yl)methyl]1-piperazine carboxylic acid ethyl ester (LQFM008). Normotensive male Wistar or spontaneously hypertensive rats (anesthetized or conscious) were used to evaluate the effect of LQFM008 on ...
Feldman Ross D RD Robarts Research Institute, London, ON, - - 2014
Activation of vascular GPER has been linked to vasodepressor effects in animals. However, the significance of GPER regulation on chronic blood pressure control in humans is unknown. To examine this question we determined the functional significance of expression of a common missense single nucleotide variant of GPER, P16L in vascular ...
Asmussen Sven S aDepartments of Anesthesiology, The University of Texas Medical Branch, Galveston, TX bDepartment of Clinical Science and Education, Karolinska Institutet, Section of Anaesthesiology and Intensive Care, Södersjukhuset, Stockholm, Sweden cDepartment of Internal Medicine, The University of Texas Medical Branch, Galveston, - - 2014
The primary goal of fluid therapy is to maintain fluid homeostasis. Commonly used isotonic crystalloids are only marginally effective and contribute to fluid excess syndrome. In patients with decreased cardiovascular reserve, fluid therapy alone is not sufficient to maintain end-organ perfusion. Therefore, inotropes or vasoactive drugs are used to supplement ...
Ruhhammer Johannes J Department of Microsystems Engineering, University of Freiburg, Georges-Koehler-Allee 102, 79110, Freiburg, Germany, - - 2014
A novel sensor for measuring arterial distension, pulse and pressure waveform is developed and evaluated. The system consists of a magnetic sensor which is applied and fixed to arterial vessels without any blood vessel constriction, hence avoiding stenosis. The measurement principle could be validated by in vitro experiments on silicone ...
Lee Ji-Hyun JH Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, #101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of - - 2014
The aim of this study was to compare tissue oxygen saturation as measured by INVOS(®) and InSpectra™ during a vascular occlusion test (VOT) in the same subject. Twenty healthy adults were investigated. The INVOS(®) and InSpectra™ probes were placed randomly on the right and left thenar eminence in the same ...
Pozzobon Cesar Romaro CR Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
Background: Antihypertensive drugs are used to control blood pressure (BP) and reduce macro- and microvascular complications in hypertensive patients with diabetes. Objectives: The present study aimed to compare the functional vascular changes in hypertensive patients with type 2 diabetes mellitus after 6 weeks of treatment with amlodipine or losartan. Methods: ...
Raptis Athanasios E AE 2nd Department of Medicine-Propaedeutic Clinic, Research Institute, and Diabetes Centre, Athens University Medical School, Attikon University General Hospital, Haidari, Athens, Greece - - 2014
The aim of this study was to investigate the effects of aliskiren on vascular function and endothelial progenitor cells (EPCs) in patients with type 2 diabetes and essential hypertension. The study enrolled type 2 diabetic patients aged >50 years under stable glycemic control and first diagnosed mild essential hypertension. In ...
Wu Di D Institute of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, - - 2014
Apelin is a recently described endogenous peptide and its receptor APJ, is a member of the G protein-coupled receptors family. Apelin and APJ are widely distributed in central and peripheral tissues exert important biological effects on cardiovascular system. Recent studies have suggested that apelin/APJ system involves in decreasing the blood ...
Bibi Shahida S 1 Division of Colon and Rectal Surgery, Advocate Lutheran General Hospital , Park Ridge, - - 2014
Abstract Background: Mesenteric vascular ligation is a critical step in minimally invasive colorectal surgery. This study assessed the quality of in vivo and ex vivo sealing of the human inferior mesenteric artery (IMA), as well as the relation of IMA stump and bursting pressure. Patients and Methods: This was a ...
Dolinsky Brad M - - 2014
To determine if continuous infusion of taurocholic acid into the fetoplacental and intervillous circulation of a placental cotyledon affects the fetal arterial pressure response after injection of the thromboxane mimetic U44619. Taurine conjugated bile acid is one bile acid putatively mediating intrahepatic cholestasis of pregnancy (ICP). We selected 5 placentas ...
Durand Matthew J - - 2014
Increased intraluminal pressure can reduce endothelial function in resistance arterioles; however, the mechanism of this impairment is unknown. The purpose of this study was to determine the effect of local renin-angiotensin system inhibition on the pressure-induced blunting of endothelium-dependent vasodilation in human adipose arterioles. Arterioles (100-200 μm) were dissected from ...
Diaz-Abad Montserrat M School of Medicine, University of Maryland, Baltimore, MD, - - 2014
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which most patients die of respiratory failure. Although volume-targeted non-invasive bilevel positive airway pressure (BPAP) ventilation has been studied in patients with chronic respiratory failure of various etiologies, its use in ALS has not been reported. We present the case ...
Pollock Jonathan P JP Penn State Hershey Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, - - 2014
In response to hypoxia, a net vasodilation occurs in the limb vasculature in young healthy humans and this is referred to as "hypoxia-induced vasodilation". We performed two separate experiments to determine (1) if hypoxia-induced forearm vasodilation is impaired in older men (n = 8) compared to young men (n = ...
Momin A A Cardiothoracic Department, St George's Hospital, London, UK - - 2014
Hypertension is a risk factor for accelerated saphenous vein (SV) graft disease and endothelial dysfunction in a number of vascular territories. We examined the relationship between blood pressure (BP) and vascular function in SV from 94 male patients undergoing coronary artery bypass grafting (CABG). Patients were pretreated with respect to ...
Houston Mark M Hypertension Institute, Nashville, - - 2014
This blinded placebo-controlled crossover study evaluated the acute effects of an orally disintegrating lozenge that generates nitric oxide (NO) in the oral cavity on blood pressure (BP) response, endothelial function, and vascular compliance in unmedicated hypertensive patients. Thirty patients with clinical hypertension were recruited and enrolled in a blinded placebo-controlled ...
Kim Yong-Hoon YH Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon, South - - 2014
Endothelial nitric oxide synthase (eNOS) is involved in blood pressure (BP) regulation through the production of nitric oxide. Sirtuin I (SIRT1), an NAD-dependent protein deacetylase, promotes vascular relaxation through deacetylation and activation of eNOS. β-Lapachone (βL) increases the cellular NAD(+)/NADH ratio by activating NAD(P)H:quinone oxidoreductase 1 (NQO1). In this study, ...
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