Search Results
Results 101 - 150 of 1027
1 2 3 4 5 6 7 8 9 10 >
Magyar Klara K 1(st) Department of Medicine, University of Pecs, Medical School, Pecs, - - 2014
Oxidative stress and neurohumoral factors play important role in the development of hypertension-induced vascular remodeling, likely by disregulating kinase cascades and transcription factors. Oxidative stress activates poly(ADP-ribose)-polymerase (PARP-1), which promotes inflammation and cell death. We assumed that inhibition of PARP-1 reduces the hypertension-induced adverse vascular changes. This hypothesis was tested ...
Sun Jing J Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, - - 2014
Environmental cold is a nonmodifiable hypertension risk factor. Transient receptor potential melastatin subtype 8 (TRPM8) is a cold-sensing cation channel that can be activated by menthol, a compound with a naturally cold sensation in mint. Little is known about the effect of TRPM8 activation on vascular function and blood pressure. ...
Kim Sang-Hyun SH From the Department of Anesthesiology and Perioperative Care, University of California Irvine, Orange, California (S.-H.K., M.L., K.S.S., J.R., M.C.); Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea (S.-H.K., C.C.); Department of Anesthesiology and Critical Care, Louis Pradel Hospital, Lyon, France (M.L.); and Department of Statistics, University of California Irvine, Orange, California - - 2014
Continuous noninvasive arterial pressure monitoring devices are available for bedside use, but the accuracy and precision of these devices have not been evaluated in a systematic review and meta-analysis. The authors performed a systematic review and meta-analysis of studies comparing continuous noninvasive arterial pressure monitoring with invasive arterial pressure monitoring. ...
Svenningsen Per P Department of Cardiovascular and Renal Research, University of Southern Denmark, Winsløwparken 21, 3, Odense, DK-5000, - - 2014
Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type channels in depolarization-dependent dilatation of mesenteric arteries and blood pressure regulation in ...
Sgouralis Ioannis I 1Duke - - 2014
A mathematical model of renal hemodynamics is used to assess the individual contributions of the tubuloglomerular feedback (TGF) mechanism and the myogenic response to glomerular filtration rate regulation in the rat kidney. The model represents an afferent arteriole segment, glomerular filtration, and a short loop of Henle. The afferent arteriole ...
Brook Robert D RD Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, - - 2014
Fine particulate matter (PM) air pollution is associated with numerous adverse health effects including increased blood pressure (BP) and vascular dysfunction. However, the cardiovascular (CV) impacts of coarse PM exposure remain largely unknown. Since it substantially contributes to global air pollution (yet differs in characteristics from fine particles and is ...
Vlahandonis Anna A The Ritchie Centre, Monash Institute of Medical Research, Monash University, Melbourne, Vic., - - 2014
Pulse transit time has been proposed as a surrogate measure of systolic arterial pressure, as it is dependent upon arterial stiffness. Past research has shown that pulse transit time has a significant inverse relationship to systolic arterial pressure in adults; however, studies in children are limited. This study aimed to ...
Chen Roland K - - 2014
Bipolar electrosurgical vessel sealing is commonly used in surgery to perform hemostasis. The electrode compressive force is demonstrably an important factor an important factor affecting the vessel seal burst pressure, an index of the seal quality. Using a piezoresistive force sensor attached to the handle of a laparoscopic surgical device, ...
Delgado Guillermo G Laboratory of Clinical Neurophysiology, Department of Neurology and Psychiatry, National Institute of Medical Sciences and Nutrition Salvador - - 2014
While the circulatory response to orthostatic stress has been already evaluated in Parkinson's disease patients without typical orthostatic hypotension (PD-TOH), there is an initial response to the upright position which is uniquely associated with active standing (AS). We sought to assess this response and to compare it to that seen ...
Kathem Sarmed H SH Center for Hypertension and Personalized Medicine, University of Toledo, Health Science Building, Room 312, 3000 Arlington Ave., Toledo, OH 43614, USA ; Department of Pharmacology, University of Toledo, Health Education Building, Room 274, 3000 Arlington Ave., Toledo, OH 43614, USA ; College of Pharmacy, University of Baghdad, Bab-Almoadhum 14026, Baghdad, - - 2014
Ciliopathies are a group of diseases associated with abnormal structure or function of primary cilia. Ciliopathies include polycystic kidney disease (PKD), a pathology associated with vascular hypertension. We previously showed that cilia length regulates cilia function, and cilia function is required for nitric oxide (NO) biosynthesis in endothelial cells. Because ...
Negishi Jun J Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062, - - 2014
A high hydrostatic pressure method, which can apply over 600 MPa pressure was employed for preparing a hydrogel of poly(vinyl alcohol) (PVA) loaded with heparin. The aim of this study was to fabricate a heparin-PVA hydrogel conduit and evaluate its potential for vascular access. Heparin-PVA complex hydrogel showed suppressed heparin ...
Rafiq Adnan A Gastroenterology Division, ASCOMS & Hospital, Jammu, Jammu and Kashmir 190011, - - 2014
Vascular oxidative stress is an important factor in hypertension‑associated vascular damage and is mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation. The C242T polymorphism at the p22PHOX gene affects binding of p22PHOX to heme, leading to variants of NADPH oxidase that produce different levels of reactive oxygen species (ROS). ...
Houston Mark M Mark Houston, Hypertension Institute, Saint Thomas Medical Plaza, Nashville, TN 37205, United - - 2014
Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrient-gene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, ...
Hatch Harold Wickes - - 2014
Although hot, cold and high pressure denaturation are well characterized, the possibility of negative pressure unfolding has received much less attention. Proteins under negative pressure, however, are important in applications such medical ultrasound, and the survival of biopoloymers in the xylem and adjacent parenchyma cells of vascular plants. In addition, ...
Laterreur Véronique V Centre LOEX de l׳Université Laval, Centre de recherche FRQS du CHU de Québec, Québec, QC, Canada; Department of Mechanical Engineering, Faculty of Science and Engineering, Université Laval, Québec, QC, Canada. Electronic address: - - 2014
Tissue engineering provides a promising alternative for small diameter vascular grafts, especially with the self-assembly method. It is crucial that these grafts possess mechanical properties that allow them to withstand physiological flow and pressure without being damaged. Therefore, an accurate assessment of their mechanical properties, especially the burst pressure, is ...
Sun Dong D Department of Physiology, New York Medical College, Valhalla, New - - 2014
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenases. EETs possess cardioprotective properties and are catalyzed by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs) that lack vasoactive property. To date, the role of sEH in the regulation of myogenic response of resistant arteries, a key player ...
Farsang Csaba C St. Imre University Teaching Hospital, Tétényi u. 12-16, Budapest, 1115, Hungary, - - 2014
Hypertension and type 2 diabetes mellitus (T2DM) synergistically deteriorate the vascular environment, making blood pressure reduction challenging, and substantially increasing cardiovascular risk. In the real-life, open-label, observational, PICASSO study, 9,257 hypertensive patients unsuccessfully treated with antihypertensives were switched to fixed-dose combination of perindopril 10 mg/indapamide 2.5 mg. In this subgroup analysis, we ...
Lopez Rosana R Anatomía, Fisiología y Genética vegetal, ETSI Montes, Universidad Politécnica de Madrid, - - 2014
When tree stems are mechanically stimulated, a rapid long-distance signal is induced that slows down primary growth. An investigation was carried out to determine whether the signal might be borne by a mechanically induced pressure pulse in the xylem. Coupling xylem flow meters and pressure sensors with a mechanical testing ...
Seçilmis Ma M 1Department of Pharmacology, Çukurova University, Medical School, Adana, - - 2014
In the presence of nitric oxide synthase (NOS) inhibitors, the contribution of residual NO to endothelium-dependent relaxation induced by chemical agonists acetylcholine and bradykinin has been documented in resistance vessels. However, the contribution of residual NO to the vasodilatation in response to pressure and fluid shear stress is not well ...
Nosova Emily V EV Department of Surgery, University of California, San Francisco, California; VIPERx Laboratory, San Francisco, - - 2014
Sedentarism, also termed physical inactivity, is an independent risk factor for cardiovascular diseases. Mechanisms thought to be involved include insulin resistance, dyslipidemia, hypertension, and increased inflammation. It is unknown whether changes in vascular and endothelial function also contribute to this excess risk. We hypothesized that short-term exposure to inactivity would ...
Shafi Tariq T Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, - - 2014
Hypertension is highly prevalent in hemodialysis patients but its management remains a matter of debate. In this review, we discuss the observational studies on the association of blood pressure with outcomes, measurement of blood pressure in hemodialysis patients and present an opinion-based approach to treating hypertension.
Gul Ambreen A Department of Medicine (AG, AH, BH, EB, PZ), University of New Mexico, Albuquerque, New Mexico; Department of Medicine (DM), Tufts University, Boston, Massachusetts; Department of Quantitative Health Sciences (JG), Cleveland Clinic Foundation, Cleveland, Ohio; Department of Medicine (JC), Boston University, Boston, Massachusetts; Dialysis Clinic, Inc (SP, PZ), Quality Management, Albuquerque, New Mexico; National Institutes of Health (JWK), NIDDK, Bethesda, Maryland; and Department of Medicine (MU), University of Pittsburgh, Pittsburgh, - - 2014
Cardiovascular disease (CVD) is markedly increased among hemodialysis (HD) patients. Optimizing blood pressure (BP) among HD patients may present an important opportunity to reduce the disparity in CVD rates between HD patients and the general population. The optimal target predialysis systolic BP (SBP) among HD patients is unknown. Current international ...
Byun Dae Sup DS Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, 761-1 Sanggye 7-dong, Nowon-gu, 139-707 Seoul, Republic of - - 2014
The aim of the present study was to explore the relationship between augmentation index (AIx) and vascular risk factors according to stroke subtypes. Patients were eligible for this study if they experienced their first ischemic stroke within the preceding 7days and were 45years of age or older. AIx was measured ...
Wagner Julia Y - - 2014
Monitoring cardiovascular function in acutely ill patients in the emergency department (ED) is of paramount importance. Arterial pressure (AP) is usually monitored using intermittent oscillometric measurements with an upper arm cuff. The vascular unloading technique (VUT) allows continuous noninvasive AP monitoring. In this study, we compare continuous AP measurements obtained ...
Dores Hélder H Serviço de Cardiologia, Hospital de Santa Cruz, CHLO, Lisboa, Portugal. Electronic address: - - 2014
The increase of activation of sympathetic nervous system has a central role in the pathophysiology of hypertension (HT). Catheter-based renal denervation (RDN) was recently developed for the treatment of resistant HT. To evaluate the safety and efficacy of RDN in HT reduction at 6-months in patients with resistant HT. Prospective ...
Willaert W W Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, - - 2014
Purpose: The objective of this experiment is to establish a continuous postmortem circulation in the vascular system of porcine lungs and to evaluate the pulmonary distribution of the perfusate. This research is performed in the bigger scope of a revascularization project of Thiel embalmed specimens. This technique enables teaching anatomy, ...
Yeung Joyce J Academic Department of Critical Care, Anaesthesia and Pain, Heart of England NHS Foundation Trust, Birmingham, UK, B9 5SS; University of Birmingham, College of Medical and Dental Studies, UK, B15 - - 2014
AIM: : This study aims to compare the effect of three CPR prompt and feedback devices on quality of chest compressions amongst healthcare providers. A single blinded, randomised controlled trial compared a pressure sensor/metronome device (CPREzy™), an accelerometer device (Phillips Q-CPR) and simple metronome on the quality of chest compressions ...
Ufnal Marcin M Department of Experimental and Clinical Physiology, Medical University of Warsaw, Krakowskie Przedmieście 26/28, 00-927 Warsaw, Poland. Electronic address: - - 2014
Accumulating evidence suggests that blood borne hormones modulate brain mechanisms regulating blood pressure. This appears to be mediated by the circumventricular organs which are located in the walls of the brain ventricular system and lack the blood-brain barrier. Recent evidence shows that neurons of the circumventricular organs express receptors for ...
Buys Emmanuel E aAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital bDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-dependent signaling mechanisms have a profound effect on the regulation of blood pressure (BP). In this review, we will discuss recent findings in the field that support the importance of sGC in the development of hypertension. The importance of sGC in BP regulation was highlighted ...
Hu Weitong W Research Institute of Cardiovascular Diseases and Department of Cardiology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of - - 2014
To evaluate whether inter-arm diastolic blood pressure difference (DBPl-r) induced by one arm ischemia correlates with flow-mediated dilatation (FMD). Bilateral arm BPs were simultaneously measured with two automatic devices and right brachial artery diameter (D) was measured by ultrasound technique in 108 subjects (56 hypertensives and 52 normotensives). Following baseline ...
Osei-Owusu Patrick P Drexel University College of - - 2014
Elastin (Eln) insufficiency in mice and humans is associated with hypertension and altered structure and mechanical properties of large arteries. However, it is not known to what extent functional or structural changes in resistance arteries contribute to the elevated blood pressure characteristic of elastin insufficiency. Here we investigate how elastin ...
Heinze Christoph - - 2014
High blood pressure is the leading risk factor for death worldwide. One of the hallmarks is a rise of peripheral vascular resistance, which largely depends on arteriole tone. Ca2+-activated chloride currents (CaCCs) in vascular smooth muscle cells (VSMCs) are candidates for increasing vascular contractility. We analyzed the vascular tree and ...
Uys A S AS Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South - - 2014
Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite (NOx) responses, cardiovascular function and structural vascular disease in a cohort of African and Caucasian men. The study included 81 African and ...
Hodgson Jonathan M JM School of Medicine and Pharmacology, University of Western Australia, GPO Box X2213 Perth, Western Australia 6847, Australia. Electronic address: - - 2014
Characteristics of short-term blood pressure (BP) variation may influence cardiovascular disease risk via effects on vascular function. In a cross-sectional study of a group of treated hypertensive and untreated largely normotensive subjects we investigated the relationships of measures of short-term BP variation with brachial artery vasodilator function. A total of ...
Schutte A E AE Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa. Electronic address: - - 2014
Insulin-like growth factor-1 (IGF-1) has potent endothelial-protective, anti-platelet and anti-thrombotic activities, and also exerts mitogenic and proliferatory actions on vascular smooth muscle cells. Conflicting reports exist regarding the role of IGF-1 in vascular protection and atherogenesis. We therefore investigated the relationships of ambulatory blood pressure (BP) and carotid intima-media thickness ...
Hernanz Raquel - - 2014
Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-oxygenases has been involved in the alterations in vascular function, structure and mechanical properties observed in cardiovascular diseases, including hypertension. In addition, it is well known that production of ROS (reactive oxygen species) plays an important role in the ...
Chattopadhyay Saurabh S Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of - - 2014
Angiotensin-converting enzyme (ACE) regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-system (RAS). Ace-/- mice are smaller in size, have low blood pressure and defective kidney structure and functions. All of these defects are cured by transgenic expression of somatic ACE (sACE) in vascular endothelial cells ...
Karaca Mustafa M Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, - - 2014
Background Endothelial dysfunction, which is characterized by an imbalance between relaxing and contracting factors, procoagulant and anticoagulant substances, and between pro-inflammatory mediators, may play a particularly significant role in the pathogenesis of atherosclerosis. Numerous experimental and clinical reports suggest that a high von Willebrand factor (vWF) level reflects endothelial damage ...
Vanbavel Ed E Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The - - 2014
Organ perfusion is regulated by vasoactivity and structural adaptation of small arteries and arterioles. These resistance vessels are sensitive to pressure, flow and a range of vasoactive stimuli. Several strongly interacting control loops exist. As an example, the myogenic response to a change of pressure influences the endothelial shear stress, ...
Al-Qubati Yasin Y Dermatology, Taiz University School of Medicine, Taiz, Yemen and Dermatology and Pediatrics, Rutgers University New Jersey Medical School, Newark, New Jersey, - - 2014
Pyogenic granuloma (PG) is a benign vascular neoplasm most often evident as a rapidly developing solitary, sessile, or polypoid vascular nodule or tumor prone to ulceration or hemorrhage. Bleeding may be episodic, copious, and refractory to pressure, mandating treatment, particularly when on the lip. We describe a 14-year-old adolescent with ...
Mehlsen Jesper J Coordinating Research Centre, Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark ; Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, - - 2014
The present study aimed at examining the interarm difference in blood pressure and its use as an indicator of peripheral arterial disease (PAD). Data were included from consecutive patients referred from their general practitioner to our vascular laboratory for possible PAD aged 50 years or older without known cardiac disease, ...
Gomez-Marcos Manuel A MA Instituto de Investigación Biomédica de Salamanca (IBSAL). Primary Care Research Unit, La Alamedilla Health Center, Castilla and León Health Service-SACYL, Salamanca, - - 2014
Target organ damage (TOD) is associated with increased cardiovascular risk. The study objectives were to analyse the relationship of TOD to blood pressure, size of retinal arteries and veins, oxidative stress and different polymorphisms in the VAV-2 and VAV-3 genes in participants with hypertension. A case-control study to analyse the ...
Azushima Kengo K Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, - - 2014
Both strict blood pressure (BP) control and improvements in BP profile such as BP variability are important for suppression of renal deterioration and cardiovascular complication in hypertension and chronic kidney disease (CKD). In the present study, we examined the beneficial effects of the single pill-based combination therapy of amlodipine and ...
Nishijima Yoshinori Y Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin ; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, - - 2014
Transient receptor potential vanilloid type 4 (TRPV4) is an endothelial Ca(2+) entry channel contributing to endothelium-mediated dilation in conduit and resistance arteries. We investigated the role of TRPV4 in the regulation of blood pressure and endothelial function under hypertensive conditions. TRPV4-deficient (TRPV4(-/-)) and wild-type (WT) control mice were given l-NAME ...
Zhanatbekova A K - - 2014
Arterial hypertensionis an important worldwide health problem. Its relevance relatesboth to the high incidence and prevalence in all adult communities and to the high risk of serious and potentially fatal cardiovascular events dueto hypertension. Resistant hypertension is defined as a blood pressure (BP) remaining above goal (>140/90 mm Hg) despite ...
Paciaroni Maurizio M Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Sant'Andrea delle Fratte, 06126 - Perugia, Italy. - - 2014
Secondary prevention of atherosclerotic stroke and transient ischemic attack includes both conventional approaches to vascular risk factor management (blood pressure lowering, cholesterol reduction with statins and smoking cessation), antiplatelet therapy and more specific interventions, such as carotid revascularization. The objective of this review is to discuss effective interventions for optimal ...
Cheng Jiu-Hua JH Department of Aerospace Physiology and Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, - - 2014
To elucidate further from the biomechanical aspect whether microgravity-induced cerebral vascular mal-adaptation might be a contributing factor to postflight orthostatic intolerance and the underlying mechanism accounting for the potential effectiveness of intermittent artificial gravity (IAG) in preventing this adverse effect. Middle cerebral arteries (MCAs) were isolated from 28-day SUS (tail-suspended, ...
Gonzales Albert L AL Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA. Department of Pharmacology, University of Vermont, Burlington, VT 05405, - - 2014
Maintaining constant blood flow in the face of fluctuations in blood pressure is a critical autoregulatory feature of cerebral arteries. An increase in pressure within the artery lumen causes the vessel to constrict through depolarization and contraction of the encircling smooth muscle cells. This pressure-sensing mechanism involves activation of two ...
Mahara Atsushi A 0000-0002-4075-6019 Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Fujishiro-dai, Suita, Osaka 565-8565, - - 2014
Pressure treatment has been developed in tissue engineering application. Although the tissue scaffold prepared by a ultrahydrostatic pressure treatment has been reported, an excessive pressure has a potential to disrupt a structure of extracellular matrix through protein denaturation. It is important to understand the suitable low-pressure condition and mechanisms for ...
Zimmerman Deborah L DL Associate Professor of Medicine, Division of Nephrology, Ottawa Hospital, Kidney Research Centre of the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, - - 2014
Treatment of end stage renal disease patients with short daily hemodialysis has been associated with an improvement in blood pressure. It is unclear from these studies if anti-hypertensive management had been optimized prior to starting short daily hemodialysis. Also, the potential mechanism(s) of blood pressure improvement remain to be fully ...
1 2 3 4 5 6 7 8 9 10 >