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Chang Thashi - - 2014
Intravenous immunoglobulin is considered generally safe and is used widely as proven, and sometimes empiric, treatment for an expanding list of autoimmune diseases. Thromboembolic complications following intravenous immunoglobulin therapy are rare and there have been only five previous reports of stroke occurring within 2 to 10 days of infusion. This ...
Okon-Singer Hadas H Department of Psychology, University of Haifa, 3498838 Haifa, Israel, Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany, Mind Brain Institute at Berlin School of Mind and Brain, Humboldt-University, 10099 Berlin, Germany, Charité University Hospital, 10117 Berlin, Germany, Machine Learning Group, Berlin Institute of Technology, 10587 Berlin, Germany, Laboratoire de Recherche en Neuroimagerie, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, 1011 Lausanne, Switzerland, and F. Hoffmann-La Roche, pRED, Pharma Research and Early Development, DTA Neuroscience, 4070 Basel, - - 2014
This study investigated the neural regions involved in blood pressure reactions to negative stimuli and their possible modulation by attention. Twenty-four healthy human subjects (11 females; age = 24.75 ± 2.49 years) participated in an affective perceptual load task that manipulated attention to negative/neutral distractor pictures. fMRI data were collected ...
Magyar Klara K 1(st) Department of Medicine, University of Pecs, Medical School, Pecs, - - 2014
Oxidative stress and neurohumoral factors play important role in the development of hypertension-induced vascular remodeling, likely by disregulating kinase cascades and transcription factors. Oxidative stress activates poly(ADP-ribose)-polymerase (PARP-1), which promotes inflammation and cell death. We assumed that inhibition of PARP-1 reduces the hypertension-induced adverse vascular changes. This hypothesis was tested ...
Sun Jing J Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, - - 2014
Environmental cold is a nonmodifiable hypertension risk factor. Transient receptor potential melastatin subtype 8 (TRPM8) is a cold-sensing cation channel that can be activated by menthol, a compound with a naturally cold sensation in mint. Little is known about the effect of TRPM8 activation on vascular function and blood pressure. ...
Svenningsen Per P Department of Cardiovascular and Renal Research, University of Southern Denmark, Winsløwparken 21, 3, Odense, DK-5000, - - 2014
Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type channels in depolarization-dependent dilatation of mesenteric arteries and blood pressure regulation in ...
Kim Sang-Hyun SH From the Department of Anesthesiology and Perioperative Care, University of California Irvine, Orange, California (S.-H.K., M.L., K.S.S., J.R., M.C.); Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea (S.-H.K., C.C.); Department of Anesthesiology and Critical Care, Louis Pradel Hospital, Lyon, France (M.L.); and Department of Statistics, University of California Irvine, Orange, California - - 2014
Continuous noninvasive arterial pressure monitoring devices are available for bedside use, but the accuracy and precision of these devices have not been evaluated in a systematic review and meta-analysis. The authors performed a systematic review and meta-analysis of studies comparing continuous noninvasive arterial pressure monitoring with invasive arterial pressure monitoring. ...
Sgouralis Ioannis I 1Duke - - 2014
A mathematical model of renal hemodynamics is used to assess the individual contributions of the tubuloglomerular feedback (TGF) mechanism and the myogenic response to glomerular filtration rate regulation in the rat kidney. The model represents an afferent arteriole segment, glomerular filtration, and a short loop of Henle. The afferent arteriole ...
Brook Robert D RD Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, - - 2014
Fine particulate matter (PM) air pollution is associated with numerous adverse health effects including increased blood pressure (BP) and vascular dysfunction. However, the cardiovascular (CV) impacts of coarse PM exposure remain largely unknown. Since it substantially contributes to global air pollution (yet differs in characteristics from fine particles and is ...
Vlahandonis Anna A The Ritchie Centre, Monash Institute of Medical Research, Monash University, Melbourne, Vic., - - 2014
Pulse transit time has been proposed as a surrogate measure of systolic arterial pressure, as it is dependent upon arterial stiffness. Past research has shown that pulse transit time has a significant inverse relationship to systolic arterial pressure in adults; however, studies in children are limited. This study aimed to ...
Oliveira Santos P P Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, - - 2014
Vitamin D is thought to protect the cardiovascular system, although its role is not completely clear. The beneficial effect may occur by vascular calcification inhibition through blockage of both inflammatory cytokines and adhesion molecules. Moreover, calcitriol is a renin negative regulator, interfering in renin-angiotensin-aldosterone system (RAAS) and limiting the production ...
Kathem Sarmed H SH Center for Hypertension and Personalized Medicine, University of Toledo, Health Science Building, Room 312, 3000 Arlington Ave., Toledo, OH 43614, USA ; Department of Pharmacology, University of Toledo, Health Education Building, Room 274, 3000 Arlington Ave., Toledo, OH 43614, USA ; College of Pharmacy, University of Baghdad, Bab-Almoadhum 14026, Baghdad, - - 2014
Ciliopathies are a group of diseases associated with abnormal structure or function of primary cilia. Ciliopathies include polycystic kidney disease (PKD), a pathology associated with vascular hypertension. We previously showed that cilia length regulates cilia function, and cilia function is required for nitric oxide (NO) biosynthesis in endothelial cells. Because ...
Delgado Guillermo G Laboratory of Clinical Neurophysiology, Department of Neurology and Psychiatry, National Institute of Medical Sciences and Nutrition Salvador - - 2014
While the circulatory response to orthostatic stress has been already evaluated in Parkinson's disease patients without typical orthostatic hypotension (PD-TOH), there is an initial response to the upright position which is uniquely associated with active standing (AS). We sought to assess this response and to compare it to that seen ...
Chen Roland K - - 2014
Bipolar electrosurgical vessel sealing is commonly used in surgery to perform hemostasis. The electrode compressive force is demonstrably an important factor an important factor affecting the vessel seal burst pressure, an index of the seal quality. Using a piezoresistive force sensor attached to the handle of a laparoscopic surgical device, ...
Negishi Jun J Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062, - - 2014
A high hydrostatic pressure method, which can apply over 600 MPa pressure was employed for preparing a hydrogel of poly(vinyl alcohol) (PVA) loaded with heparin. The aim of this study was to fabricate a heparin-PVA hydrogel conduit and evaluate its potential for vascular access. Heparin-PVA complex hydrogel showed suppressed heparin ...
Rafiq Adnan A Gastroenterology Division, ASCOMS & Hospital, Jammu, Jammu and Kashmir 190011, - - 2014
Vascular oxidative stress is an important factor in hypertension‑associated vascular damage and is mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation. The C242T polymorphism at the p22PHOX gene affects binding of p22PHOX to heme, leading to variants of NADPH oxidase that produce different levels of reactive oxygen species (ROS). ...
Houston Mark M Mark Houston, Hypertension Institute, Saint Thomas Medical Plaza, Nashville, TN 37205, United - - 2014
Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrient-gene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, ...
Laterreur Véronique V Centre LOEX de l׳Université Laval, Centre de recherche FRQS du CHU de Québec, Québec, QC, Canada; Department of Mechanical Engineering, Faculty of Science and Engineering, Université Laval, Québec, QC, Canada. Electronic address: - - 2014
Tissue engineering provides a promising alternative for small diameter vascular grafts, especially with the self-assembly method. It is crucial that these grafts possess mechanical properties that allow them to withstand physiological flow and pressure without being damaged. Therefore, an accurate assessment of their mechanical properties, especially the burst pressure, is ...
Hatch Harold Wickes - - 2014
Although hot, cold and high pressure denaturation are well characterized, the possibility of negative pressure unfolding has received much less attention. Proteins under negative pressure, however, are important in applications such medical ultrasound, and the survival of biopoloymers in the xylem and adjacent parenchyma cells of vascular plants. In addition, ...
Sun Dong D Department of Physiology, New York Medical College, Valhalla, New - - 2014
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenases. EETs possess cardioprotective properties and are catalyzed by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs) that lack vasoactive property. To date, the role of sEH in the regulation of myogenic response of resistant arteries, a key player ...
Farsang Csaba C St. Imre University Teaching Hospital, Tétényi u. 12-16, Budapest, 1115, Hungary, - - 2014
Hypertension and type 2 diabetes mellitus (T2DM) synergistically deteriorate the vascular environment, making blood pressure reduction challenging, and substantially increasing cardiovascular risk. In the real-life, open-label, observational, PICASSO study, 9,257 hypertensive patients unsuccessfully treated with antihypertensives were switched to fixed-dose combination of perindopril 10 mg/indapamide 2.5 mg. In this subgroup analysis, we ...
Lopez Rosana R Anatomía, Fisiología y Genética vegetal, ETSI Montes, Universidad Politécnica de Madrid, - - 2014
When tree stems are mechanically stimulated, a rapid long-distance signal is induced that slows down primary growth. An investigation was carried out to determine whether the signal might be borne by a mechanically induced pressure pulse in the xylem. Coupling xylem flow meters and pressure sensors with a mechanical testing ...
Seçilmis Ma M 1Department of Pharmacology, Çukurova University, Medical School, Adana, - - 2014
In the presence of nitric oxide synthase (NOS) inhibitors, the contribution of residual NO to endothelium-dependent relaxation induced by chemical agonists acetylcholine and bradykinin has been documented in resistance vessels. However, the contribution of residual NO to the vasodilatation in response to pressure and fluid shear stress is not well ...
Nosova Emily V EV Department of Surgery, University of California, San Francisco, California; VIPERx Laboratory, San Francisco, - - 2014
Sedentarism, also termed physical inactivity, is an independent risk factor for cardiovascular diseases. Mechanisms thought to be involved include insulin resistance, dyslipidemia, hypertension, and increased inflammation. It is unknown whether changes in vascular and endothelial function also contribute to this excess risk. We hypothesized that short-term exposure to inactivity would ...
Shafi Tariq T Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, - - 2014
Hypertension is highly prevalent in hemodialysis patients but its management remains a matter of debate. In this review, we discuss the observational studies on the association of blood pressure with outcomes, measurement of blood pressure in hemodialysis patients and present an opinion-based approach to treating hypertension.
Gul Ambreen A Department of Medicine (AG, AH, BH, EB, PZ), University of New Mexico, Albuquerque, New Mexico; Department of Medicine (DM), Tufts University, Boston, Massachusetts; Department of Quantitative Health Sciences (JG), Cleveland Clinic Foundation, Cleveland, Ohio; Department of Medicine (JC), Boston University, Boston, Massachusetts; Dialysis Clinic, Inc (SP, PZ), Quality Management, Albuquerque, New Mexico; National Institutes of Health (JWK), NIDDK, Bethesda, Maryland; and Department of Medicine (MU), University of Pittsburgh, Pittsburgh, - - 2014
Cardiovascular disease (CVD) is markedly increased among hemodialysis (HD) patients. Optimizing blood pressure (BP) among HD patients may present an important opportunity to reduce the disparity in CVD rates between HD patients and the general population. The optimal target predialysis systolic BP (SBP) among HD patients is unknown. Current international ...
Byun Dae Sup DS Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, 761-1 Sanggye 7-dong, Nowon-gu, 139-707 Seoul, Republic of - - 2014
The aim of the present study was to explore the relationship between augmentation index (AIx) and vascular risk factors according to stroke subtypes. Patients were eligible for this study if they experienced their first ischemic stroke within the preceding 7days and were 45years of age or older. AIx was measured ...
Wagner Julia Y - - 2014
Monitoring cardiovascular function in acutely ill patients in the emergency department (ED) is of paramount importance. Arterial pressure (AP) is usually monitored using intermittent oscillometric measurements with an upper arm cuff. The vascular unloading technique (VUT) allows continuous noninvasive AP monitoring. In this study, we compare continuous AP measurements obtained ...
Willaert W W Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, - - 2014
Purpose: The objective of this experiment is to establish a continuous postmortem circulation in the vascular system of porcine lungs and to evaluate the pulmonary distribution of the perfusate. This research is performed in the bigger scope of a revascularization project of Thiel embalmed specimens. This technique enables teaching anatomy, ...
Dores Hélder H Serviço de Cardiologia, Hospital de Santa Cruz, CHLO, Lisboa, Portugal. Electronic address: - - 2014
The increase of activation of sympathetic nervous system has a central role in the pathophysiology of hypertension (HT). Catheter-based renal denervation (RDN) was recently developed for the treatment of resistant HT. To evaluate the safety and efficacy of RDN in HT reduction at 6-months in patients with resistant HT. Prospective ...
Yeung Joyce J Academic Department of Critical Care, Anaesthesia and Pain, Heart of England NHS Foundation Trust, Birmingham, UK, B9 5SS; University of Birmingham, College of Medical and Dental Studies, UK, B15 - - 2014
AIM: : This study aims to compare the effect of three CPR prompt and feedback devices on quality of chest compressions amongst healthcare providers. A single blinded, randomised controlled trial compared a pressure sensor/metronome device (CPREzy™), an accelerometer device (Phillips Q-CPR) and simple metronome on the quality of chest compressions ...
Ufnal Marcin M Department of Experimental and Clinical Physiology, Medical University of Warsaw, Krakowskie Przedmieście 26/28, 00-927 Warsaw, Poland. Electronic address: - - 2014
Accumulating evidence suggests that blood borne hormones modulate brain mechanisms regulating blood pressure. This appears to be mediated by the circumventricular organs which are located in the walls of the brain ventricular system and lack the blood-brain barrier. Recent evidence shows that neurons of the circumventricular organs express receptors for ...
Hu Weitong W Research Institute of Cardiovascular Diseases and Department of Cardiology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of - - 2014
To evaluate whether inter-arm diastolic blood pressure difference (DBPl-r) induced by one arm ischemia correlates with flow-mediated dilatation (FMD). Bilateral arm BPs were simultaneously measured with two automatic devices and right brachial artery diameter (D) was measured by ultrasound technique in 108 subjects (56 hypertensives and 52 normotensives). Following baseline ...
Buys Emmanuel E aAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital bDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-dependent signaling mechanisms have a profound effect on the regulation of blood pressure (BP). In this review, we will discuss recent findings in the field that support the importance of sGC in the development of hypertension. The importance of sGC in BP regulation was highlighted ...
Osei-Owusu Patrick P Drexel University College of - - 2014
Elastin (Eln) insufficiency in mice and humans is associated with hypertension and altered structure and mechanical properties of large arteries. However, it is not known to what extent functional or structural changes in resistance arteries contribute to the elevated blood pressure characteristic of elastin insufficiency. Here we investigate how elastin ...
Heinze Christoph - - 2014
High blood pressure is the leading risk factor for death worldwide. One of the hallmarks is a rise of peripheral vascular resistance, which largely depends on arteriole tone. Ca2+-activated chloride currents (CaCCs) in vascular smooth muscle cells (VSMCs) are candidates for increasing vascular contractility. We analyzed the vascular tree and ...
Uys A S AS Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South - - 2014
Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite (NOx) responses, cardiovascular function and structural vascular disease in a cohort of African and Caucasian men. The study included 81 African and ...
Schutte A E AE Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa. Electronic address: - - 2014
Insulin-like growth factor-1 (IGF-1) has potent endothelial-protective, anti-platelet and anti-thrombotic activities, and also exerts mitogenic and proliferatory actions on vascular smooth muscle cells. Conflicting reports exist regarding the role of IGF-1 in vascular protection and atherogenesis. We therefore investigated the relationships of ambulatory blood pressure (BP) and carotid intima-media thickness ...
Hodgson Jonathan M JM School of Medicine and Pharmacology, University of Western Australia, GPO Box X2213 Perth, Western Australia 6847, Australia. Electronic address: - - 2014
Characteristics of short-term blood pressure (BP) variation may influence cardiovascular disease risk via effects on vascular function. In a cross-sectional study of a group of treated hypertensive and untreated largely normotensive subjects we investigated the relationships of measures of short-term BP variation with brachial artery vasodilator function. A total of ...
Paciaroni Maurizio M Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Sant'Andrea delle Fratte, 06126 - Perugia, Italy. - - 2014
Secondary prevention of atherosclerotic stroke and transient ischemic attack includes both conventional approaches to vascular risk factor management (blood pressure lowering, cholesterol reduction with statins and smoking cessation), antiplatelet therapy and more specific interventions, such as carotid revascularization. The objective of this review is to discuss effective interventions for optimal ...
Mahara Atsushi A 0000-0002-4075-6019 Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Fujishiro-dai, Suita, Osaka 565-8565, - - 2014
Pressure treatment has been developed in tissue engineering application. Although the tissue scaffold prepared by a ultrahydrostatic pressure treatment has been reported, an excessive pressure has a potential to disrupt a structure of extracellular matrix through protein denaturation. It is important to understand the suitable low-pressure condition and mechanisms for ...
André Gwennan G Inserm UMR_S1087, CNRS UMR_C6291, l'institut du thorax, Nantes, F-44000, France (G.A., J.E.S., G.T., M.R.D., G.L., V.S.) Université de Nantes, Nantes, F-44000, France (G.A., J.E.S., G.T., M.R.D., G.L., - - 2014
Increasing evidence implicates overactivation of RhoA as a critical component of the pathogenesis of hypertension. Although a substantial body of work has established that Rac1 functions antagonize RhoA in a broad range of physiological processes, the role of Rac1 in the regulation of vascular tone and blood pressure is not ...
Vanbavel Ed E Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The - - 2014
Organ perfusion is regulated by vasoactivity and structural adaptation of small arteries and arterioles. These resistance vessels are sensitive to pressure, flow and a range of vasoactive stimuli. Several strongly interacting control loops exist. As an example, the myogenic response to a change of pressure influences the endothelial shear stress, ...
Gomez-Marcos Manuel A MA Instituto de Investigación Biomédica de Salamanca (IBSAL). Primary Care Research Unit, La Alamedilla Health Center, Castilla and León Health Service-SACYL, Salamanca, - - 2014
Target organ damage (TOD) is associated with increased cardiovascular risk. The study objectives were to analyse the relationship of TOD to blood pressure, size of retinal arteries and veins, oxidative stress and different polymorphisms in the VAV-2 and VAV-3 genes in participants with hypertension. A case-control study to analyse the ...
Santos Priscila Portugal Dos PP Department of Internal Medicine, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, - - 2014
The aim of this study was to evaluate whether supplementation of high doses of cholecalciferol for two months in normotensive rats results in increased systolic arterial pressure and which are the mechanisms involved. Specifically, this study assesses the potential effect on cardiac output as well as the changes in aortic ...
Timm Richard W RW Ethicon Inc., Cincinnati, OH, - - 2014
Ultrasonic energy is a mainstay in the armamentarium of surgeons, providing multifunctionality, precision, and control when dissecting and sealing vessels up to 5 mm in diameter. Historically, the inability to seal vessels in the 5-7 mm range has been perceived as an inherent limitation of ultrasonic technology. The purpose of ...
Chattopadhyay Saurabh S Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of - - 2014
Angiotensin-converting enzyme (ACE) regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-system (RAS). Ace-/- mice are smaller in size, have low blood pressure and defective kidney structure and functions. All of these defects are cured by transgenic expression of somatic ACE (sACE) in vascular endothelial cells ...
Zhanatbekova A K - - 2014
Arterial hypertensionis an important worldwide health problem. Its relevance relatesboth to the high incidence and prevalence in all adult communities and to the high risk of serious and potentially fatal cardiovascular events dueto hypertension. Resistant hypertension is defined as a blood pressure (BP) remaining above goal (>140/90 mm Hg) despite ...
Karaca Mustafa M Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, - - 2014
Background Endothelial dysfunction, which is characterized by an imbalance between relaxing and contracting factors, procoagulant and anticoagulant substances, and between pro-inflammatory mediators, may play a particularly significant role in the pathogenesis of atherosclerosis. Numerous experimental and clinical reports suggest that a high von Willebrand factor (vWF) level reflects endothelial damage ...
Moreira Daniel Medeiros - - 2014
Cohort studies have demonstrated the association between blood pressure and increased cardiovascular events. There are different therapeutic strategies to achieve goals of systolic and diastolic blood pressure. For a long time, therapeutic targets were not well defined and the concept of "smaller is better" was used diffusely. However, clinical trials ...
Al-Qubati Yasin Y Dermatology, Taiz University School of Medicine, Taiz, Yemen and Dermatology and Pediatrics, Rutgers University New Jersey Medical School, Newark, New Jersey, - - 2014
Pyogenic granuloma (PG) is a benign vascular neoplasm most often evident as a rapidly developing solitary, sessile, or polypoid vascular nodule or tumor prone to ulceration or hemorrhage. Bleeding may be episodic, copious, and refractory to pressure, mandating treatment, particularly when on the lip. We describe a 14-year-old adolescent with ...
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