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Neal Bruce B The George Institute for Global Health, University of Sydney, Royal Prince Alfred Hospital, Sydney, Australia. Electronic address: - - 2014
High blood pressure is the leading cause of premature mortality worldwide. Reducing salt intake lowers blood pressure and blood pressure-lowering reduces vascular disease. There is a very high likelihood that reducing dietary salt intake will prevent vascular disease and no evidence to suggest it will cause harm. With average population ...
Reeve Adam M - - 2014
Vascularized biological tissue has been shown to increase in stiffness with increased perfusion pressure. The interaction between blood in the vasculature and other tissue components can be modeled with a poroelastic, biphasic approach. The ability of this model to reproduce the pressure-driven stiffening behavior exhibited by some tissues depends on ...
Moulana Mohadetheh M Department of Psychiatry, University of Mississippi Medical Center, Jackson, - - 2014
The mechanisms responsible for the gender difference in blood pressure (BP) in humans are not clear. Over the past several years we have studied the spontaneously hypertensive rat (SHR) as a model of sex differences in BP control. In the present study, we tested the hypothesis that renal vascular and ...
Vinturache Angela E AE The Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada The Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, - - 2014
This study aimed to elucidate the roles of both angiotensin II (ANG II) receptors - type 1 (AT1Rs) and type 2 (AT2Rs) - separately and together in influencing hemodynamic effects of endogenously produced nitric oxide (NO) during postnatal development. In conscious, chronically instrumented lambs aged ~1 week (8 ± 1 ...
Ormseth Michelle J MJ Division of Rheumatology, Department of Medicine, Vanderbilt University, Nashville, - - 2014
Objective: To examine the hypothesis that improving insulin sensitivity would improve vascular function in rheumatoid arthritis (RA). Methods: We performed a 20-week, single center, randomized, double-blind, placebo-controlled, cross-over study. Patients with RA (n=34) and moderate disease activity on stable disease modifying anti-rheumatic drug therapy were randomized to drug sequence, receiving ...
Durand Matthew J MJ Medical College of - - 2014
Increased intraluminal pressure can reduce endothelial function in resistance arteries; however the mechanism of this impairment is unknown. The purpose of this study was to determine the effect of local renin-angiotensin system inhibition on the pressure-induced blunting of endothelium-dependent vasodilation in human adipose arterioles. Arterioles (100-200 µm) were dissected from ...
Caligiuri Stephanie P B SP Canadian Centre for Agri-food Research in Health and Medicine, Institute of Cardiovascular Sciences, Asper Clinical Research Institute, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada; and Departments of Physiology, Human Nutritional Sciences, and Internal Medicine, University of Manitoba, Winnipeg, Manitoba, - - 2014
In a randomized, double-blinded, controlled clinical trial, participants with peripheral arterial disease (75% hypertensive) consumed 30 g of milled flaxseed/d for 6 months. The flaxseed group exhibited significant reductions in systolic (-10 mm Hg) and diastolic (-7 mm Hg) blood pressure. Flaxseed contains the n3 fatty acid α-linolenic acid. Plasma ...
Triantafyllou Areti A 3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address: - - 2014
Early identification of hypertensive target organ damage (TOD) emerges as important for global cardiovascular risk assessment. Retinal vascular alterations, capillary rarefaction, and microalbuminuria represent different forms of microvascular TOD. However, data regarding their concomitant presence in the early stages of hypertension, the association of the number of affected organs with ...
Khoffi Foued F 2 European Research Group on Grafts Used in Vascular Surgery (ERGGVS), Faculty of Medicine, Strasbourg - - - 2014
Background: Compliance mismatch between native artery and a prosthetic graft used for infrainguinal bypass is said to be a factor for graft failure. The aim of this study was to develop a technique for measuring the compliance of collagen-coated polyethylene terephthalate (PET) vascular prostheses and to analyze the influence of ...
Jovanovski Elena E Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, - - 2014
Ginsenoside Rg3, present in steamed ginseng (Panax Ginseng C.A. Meyer), is thought to be a potent modulator of vascular function. Our objective was to clinically evaluate acute effects of ginsenoside Rg3-enriched Korean red ginseng (Rg3-KRG) on measures of arterial stiffness and peripheral and central blood pressure (BP) parameters in healthy ...
Fonda Borut B S2P, Science to Practice Ltd., Laboratory for Motor Control and Motor Behaviour, Tehnološki Park 19, 1000 Ljubljana, Slovenia; University of Birmingham, School of Sport, Exercise and Rehabilitation Sciences, Birmingham, United Kingdom. Electronic address: - - 2014
Whole-body cryotherapy (WBC) is the exposure of minimally dressed participants to very cold air, either in a specially designed chamber (cryo-chamber) or cabin (cryo-cabin), for a short period of time. Practitioners are vague when it comes to recommendations on the duration of a single session. Recommended exposure for cryo-chamber is ...
Parisotto Maria Teresa MT NephroCare Coordination, Fresenius Medical Care, Bad Homburg, - - 2014
Hemodialysis patient survival is dependent on the availability of a reliable vascular access. In clinical practice, procedures for vascular access cannulation vary from clinic to clinic. We investigated the impact of cannulation technique on arteriovenous fistula and graft survival. Based on an April 2009 cross-sectional survey of vascular access cannulation ...
Khan Md Abdul Hye - - 2014
Epoxyeicosatrienoic acids (EETs) contribute to hemodynamics, electrolyte homeostasis, and blood pressure regulation leading to the concept that EETs can be therapeutically targeted for hypertension. In this study, multiple structural EET analogs were synthesized based on the EET pharmacophore and vasodilator structure-activity studies. Four EET analogs with 91-119% vasodilatory activity in ...
Tomiyama Hirofumi H Second Department of Internal Medicine, Tokyo Medical - - 2014
Background: We examined which pathophysiological abnormalities of vascular function might be closely associated with abnormal baroreflex regulation in subjects with hypertension. Methods and Results: In the cross-sectional assessment, 280 subjects with hypertension were enrolled for measurement of brachial-ankle pulse wave velocity (baPWV), radial augmentation index (rAI), flow-mediated vasodilatation (FMD) of the brachial ...
Kopriva David D From the Department of Surgery, University of Saskatchewan, Regina Qu'Appelle Health Region, Regina, - - 2014
Distal revascularization and interval ligation (DRIL) is commonly used to treat ischemic steal syndrome caused by arteriovenous hemodialysis access and has been associated with good outcomes. However, the literature lacks technical details of a successful intervention. We tested the hypothesis that a brachial-level arteriovenous fistula (AVF) generates a zone of ...
Li Liu-Dong - - 2014
Background & objectives: a0 ngiotensin II receptor type 1 (AT1) is known to be involved in the pathogenesis of hypertension. t0 his study was undertaken to explore the effect of active immunization against AT1 receptor on blood pressure and small artery remodelling in spontaneously hypertensive rat (SHR). Methods: Male SHR ...
Sachse Gregor G University of Oxford, United - - 2014
The large conductance voltage and Ca2+-activated K+ (BK) channel is an important determinant of vascular tone and contributes to blood pressure regulation. Both activities depend on the ancillary BKβ1 subunit. To determine the significance of smooth muscle BK channel activity for blood pressure regulation, we investigated the potential link between ...
Guarido Karla L KL 1Department of Pharmacology, Laboratory of Cardiovascular Pharmacology, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil. 2Institute of Biological Sciences, Medical and Health, Universidade Paranaense, Umuarama, Parana, - - 2014
We evaluated the role of the renal vascular system and the Rho-A/Rho-kinase pathway in the maintenance of the pressor effects of vasopressin in endotoxemic rats. In vitro and in vivo animal study. University research laboratory. Male Wistar rats (200-300 g). Rats received either saline or lipopolysaccharide (10 mg/kg, intraperitoneal) 6 ...
Towfighi Amytis A From the Department of Neurology, University of Southern California, Los Angeles, CA (A.T.); Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Biomathematics, University of California, Los Angeles (D.M.); and Department of Neurosciences, Medical University of South Carolina, Charleston, SC - - 2014
Blood pressure (BP) reduction lowers vascular risk after stroke; however, little is known about the relationship between consistency of BP control and risk of subsequent vascular events. In this post hoc analysis of the Vitamin Intervention for Stroke Prevention trial (n=3680), individuals with recent (<120 days) stroke, followed up for ...
Chan Elsa C EC aCentre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia bKey Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong, - - 2014
Heme oxygenases, namely heme oxygenase-1 and heme oxygenase-2, have important biological functions in vascular homeostasis. Heme oxygenase and its catabolic products, including bilirubin and carbon monoxide, have been implicated in blood pressure regulation. Increased expression of heme oxygenase exerts multiple protective actions against hypertension-induced vascular injuries. However, the underlining mechanisms ...
Rajab Taufiek Konrad TK Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: - - 2014
Intraoperative hypotension is associated with adverse outcomes. The preferred treatment for intraoperative hypotension is to address its cause. In the interim the blood pressure can be supported by the anesthesia team with volume resuscitation and vasopressors. Additionally, preferential perfusion of vital organs, such as the myocardium and cerebrum, at the ...
Kitamura Kei-Ichiro KI Department of Clinical Laboratory Science, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920-0942, Japan. Electronic address: - - 2014
The aim of this study is to develop a painless system of measuring the brachial-ankle arterial pulse wave velocity (baPWV) without compression cuffs. The PWV reflects the compliance of the artery and is measured for the early diagnosis of arteriosclerotic vascular diseases. However, the conventional baPWV system, which measures four ...
Chang Thashi - - 2014
Intravenous immunoglobulin is considered generally safe and is used widely as proven, and sometimes empiric, treatment for an expanding list of autoimmune diseases. Thromboembolic complications following intravenous immunoglobulin therapy are rare and there have been only five previous reports of stroke occurring within 2 to 10 days of infusion. This ...
Okon-Singer Hadas H Department of Psychology, University of Haifa, 3498838 Haifa, Israel, Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany, Mind Brain Institute at Berlin School of Mind and Brain, Humboldt-University, 10099 Berlin, Germany, Charité University Hospital, 10117 Berlin, Germany, Machine Learning Group, Berlin Institute of Technology, 10587 Berlin, Germany, Laboratoire de Recherche en Neuroimagerie, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, 1011 Lausanne, Switzerland, and F. Hoffmann-La Roche, pRED, Pharma Research and Early Development, DTA Neuroscience, 4070 Basel, - - 2014
This study investigated the neural regions involved in blood pressure reactions to negative stimuli and their possible modulation by attention. Twenty-four healthy human subjects (11 females; age = 24.75 ± 2.49 years) participated in an affective perceptual load task that manipulated attention to negative/neutral distractor pictures. fMRI data were collected ...
Magyar Klara K 1(st) Department of Medicine, University of Pecs, Medical School, Pecs, - - 2014
Oxidative stress and neurohumoral factors play important role in the development of hypertension-induced vascular remodeling, likely by disregulating kinase cascades and transcription factors. Oxidative stress activates poly(ADP-ribose)-polymerase (PARP-1), which promotes inflammation and cell death. We assumed that inhibition of PARP-1 reduces the hypertension-induced adverse vascular changes. This hypothesis was tested ...
Sun Jing J Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, - - 2014
Environmental cold is a nonmodifiable hypertension risk factor. Transient receptor potential melastatin subtype 8 (TRPM8) is a cold-sensing cation channel that can be activated by menthol, a compound with a naturally cold sensation in mint. Little is known about the effect of TRPM8 activation on vascular function and blood pressure. ...
Kim Sang-Hyun SH From the Department of Anesthesiology and Perioperative Care, University of California Irvine, Orange, California (S.-H.K., M.L., K.S.S., J.R., M.C.); Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea (S.-H.K., C.C.); Department of Anesthesiology and Critical Care, Louis Pradel Hospital, Lyon, France (M.L.); and Department of Statistics, University of California Irvine, Orange, California - - 2014
Continuous noninvasive arterial pressure monitoring devices are available for bedside use, but the accuracy and precision of these devices have not been evaluated in a systematic review and meta-analysis. The authors performed a systematic review and meta-analysis of studies comparing continuous noninvasive arterial pressure monitoring with invasive arterial pressure monitoring. ...
Svenningsen Per P Department of Cardiovascular and Renal Research, University of Southern Denmark, Winsløwparken 21, 3, Odense, DK-5000, - - 2014
Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type channels in depolarization-dependent dilatation of mesenteric arteries and blood pressure regulation in ...
Sgouralis Ioannis I 1Duke - - 2014
A mathematical model of renal hemodynamics is used to assess the individual contributions of the tubuloglomerular feedback (TGF) mechanism and the myogenic response to glomerular filtration rate regulation in the rat kidney. The model represents an afferent arteriole segment, glomerular filtration, and a short loop of Henle. The afferent arteriole ...
Brook Robert D RD Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, - - 2014
Fine particulate matter (PM) air pollution is associated with numerous adverse health effects including increased blood pressure (BP) and vascular dysfunction. However, the cardiovascular (CV) impacts of coarse PM exposure remain largely unknown. Since it substantially contributes to global air pollution (yet differs in characteristics from fine particles and is ...
Vlahandonis Anna A The Ritchie Centre, Monash Institute of Medical Research, Monash University, Melbourne, Vic., - - 2014
Pulse transit time has been proposed as a surrogate measure of systolic arterial pressure, as it is dependent upon arterial stiffness. Past research has shown that pulse transit time has a significant inverse relationship to systolic arterial pressure in adults; however, studies in children are limited. This study aimed to ...
Chen Roland K - - 2014
Bipolar electrosurgical vessel sealing is commonly used in surgery to perform hemostasis. The electrode compressive force is demonstrably an important factor an important factor affecting the vessel seal burst pressure, an index of the seal quality. Using a piezoresistive force sensor attached to the handle of a laparoscopic surgical device, ...
Delgado Guillermo G Laboratory of Clinical Neurophysiology, Department of Neurology and Psychiatry, National Institute of Medical Sciences and Nutrition Salvador - - 2014
While the circulatory response to orthostatic stress has been already evaluated in Parkinson's disease patients without typical orthostatic hypotension (PD-TOH), there is an initial response to the upright position which is uniquely associated with active standing (AS). We sought to assess this response and to compare it to that seen ...
Kathem Sarmed H SH Center for Hypertension and Personalized Medicine, University of Toledo, Health Science Building, Room 312, 3000 Arlington Ave., Toledo, OH 43614, USA ; Department of Pharmacology, University of Toledo, Health Education Building, Room 274, 3000 Arlington Ave., Toledo, OH 43614, USA ; College of Pharmacy, University of Baghdad, Bab-Almoadhum 14026, Baghdad, - - 2014
Ciliopathies are a group of diseases associated with abnormal structure or function of primary cilia. Ciliopathies include polycystic kidney disease (PKD), a pathology associated with vascular hypertension. We previously showed that cilia length regulates cilia function, and cilia function is required for nitric oxide (NO) biosynthesis in endothelial cells. Because ...
Negishi Jun J Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062, - - 2014
A high hydrostatic pressure method, which can apply over 600 MPa pressure was employed for preparing a hydrogel of poly(vinyl alcohol) (PVA) loaded with heparin. The aim of this study was to fabricate a heparin-PVA hydrogel conduit and evaluate its potential for vascular access. Heparin-PVA complex hydrogel showed suppressed heparin ...
Rafiq Adnan A Gastroenterology Division, ASCOMS & Hospital, Jammu, Jammu and Kashmir 190011, - - 2014
Vascular oxidative stress is an important factor in hypertension‚ÄĎassociated vascular damage and is mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation. The C242T polymorphism at the p22PHOX gene affects binding of p22PHOX to heme, leading to variants of NADPH oxidase that produce different levels of reactive oxygen species (ROS). ...
Houston Mark M Mark Houston, Hypertension Institute, Saint Thomas Medical Plaza, Nashville, TN 37205, United - - 2014
Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrient-gene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, ...
Hatch Harold Wickes - - 2014
Although hot, cold and high pressure denaturation are well characterized, the possibility of negative pressure unfolding has received much less attention. Proteins under negative pressure, however, are important in applications such medical ultrasound, and the survival of biopoloymers in the xylem and adjacent parenchyma cells of vascular plants. In addition, ...
Laterreur Véronique V Centre LOEX de l◊≥Université Laval, Centre de recherche FRQS du CHU de Québec, Québec, QC, Canada; Department of Mechanical Engineering, Faculty of Science and Engineering, Université Laval, Québec, QC, Canada. Electronic address: - - 2014
Tissue engineering provides a promising alternative for small diameter vascular grafts, especially with the self-assembly method. It is crucial that these grafts possess mechanical properties that allow them to withstand physiological flow and pressure without being damaged. Therefore, an accurate assessment of their mechanical properties, especially the burst pressure, is ...
Sun Dong D Department of Physiology, New York Medical College, Valhalla, New - - 2014
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenases. EETs possess cardioprotective properties and are catalyzed by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs) that lack vasoactive property. To date, the role of sEH in the regulation of myogenic response of resistant arteries, a key player ...
Farsang Csaba C St. Imre University Teaching Hospital, Tétényi u. 12-16, Budapest, 1115, Hungary, - - 2014
Hypertension and type 2 diabetes mellitus (T2DM) synergistically deteriorate the vascular environment, making blood pressure reduction challenging, and substantially increasing cardiovascular risk. In the real-life, open-label, observational, PICASSO study, 9,257 hypertensive patients unsuccessfully treated with antihypertensives were switched to fixed-dose combination of perindopril 10 mg/indapamide 2.5 mg. In this subgroup analysis, we ...
Lopez Rosana R Anatomía, Fisiología y Genética vegetal, ETSI Montes, Universidad Politécnica de Madrid, - - 2014
When tree stems are mechanically stimulated, a rapid long-distance signal is induced that slows down primary growth. An investigation was carried out to determine whether the signal might be borne by a mechanically induced pressure pulse in the xylem. Coupling xylem flow meters and pressure sensors with a mechanical testing ...
Seçilmis Ma M 1Department of Pharmacology, Çukurova University, Medical School, Adana, - - 2014
In the presence of nitric oxide synthase (NOS) inhibitors, the contribution of residual NO to endothelium-dependent relaxation induced by chemical agonists acetylcholine and bradykinin has been documented in resistance vessels. However, the contribution of residual NO to the vasodilatation in response to pressure and fluid shear stress is not well ...
Nosova Emily V EV Department of Surgery, University of California, San Francisco, California; VIPERx Laboratory, San Francisco, - - 2014
Sedentarism, also termed physical inactivity, is an independent risk factor for cardiovascular diseases. Mechanisms thought to be involved include insulin resistance, dyslipidemia, hypertension, and increased inflammation. It is unknown whether changes in vascular and endothelial function also contribute to this excess risk. We hypothesized that short-term exposure to inactivity would ...
Shafi Tariq T Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, - - 2014
Hypertension is highly prevalent in hemodialysis patients but its management remains a matter of debate. In this review, we discuss the observational studies on the association of blood pressure with outcomes, measurement of blood pressure in hemodialysis patients and present an opinion-based approach to treating hypertension.
Gul Ambreen A Department of Medicine (AG, AH, BH, EB, PZ), University of New Mexico, Albuquerque, New Mexico; Department of Medicine (DM), Tufts University, Boston, Massachusetts; Department of Quantitative Health Sciences (JG), Cleveland Clinic Foundation, Cleveland, Ohio; Department of Medicine (JC), Boston University, Boston, Massachusetts; Dialysis Clinic, Inc (SP, PZ), Quality Management, Albuquerque, New Mexico; National Institutes of Health (JWK), NIDDK, Bethesda, Maryland; and Department of Medicine (MU), University of Pittsburgh, Pittsburgh, - - 2014
Cardiovascular disease (CVD) is markedly increased among hemodialysis (HD) patients. Optimizing blood pressure (BP) among HD patients may present an important opportunity to reduce the disparity in CVD rates between HD patients and the general population. The optimal target predialysis systolic BP (SBP) among HD patients is unknown. Current international ...
Byun Dae Sup DS Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, 761-1 Sanggye 7-dong, Nowon-gu, 139-707 Seoul, Republic of - - 2014
The aim of the present study was to explore the relationship between augmentation index (AIx) and vascular risk factors according to stroke subtypes. Patients were eligible for this study if they experienced their first ischemic stroke within the preceding 7days and were 45years of age or older. AIx was measured ...
Wagner Julia Y - - 2014
Monitoring cardiovascular function in acutely ill patients in the emergency department (ED) is of paramount importance. Arterial pressure (AP) is usually monitored using intermittent oscillometric measurements with an upper arm cuff. The vascular unloading technique (VUT) allows continuous noninvasive AP monitoring. In this study, we compare continuous AP measurements obtained ...
Dores Hélder H Serviço de Cardiologia, Hospital de Santa Cruz, CHLO, Lisboa, Portugal. Electronic address: - - 2014
The increase of activation of sympathetic nervous system has a central role in the pathophysiology of hypertension (HT). Catheter-based renal denervation (RDN) was recently developed for the treatment of resistant HT. To evaluate the safety and efficacy of RDN in HT reduction at 6-months in patients with resistant HT. Prospective ...
Willaert W W Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, - - 2014
Purpose: The objective of this experiment is to establish a continuous postmortem circulation in the vascular system of porcine lungs and to evaluate the pulmonary distribution of the perfusate. This research is performed in the bigger scope of a revascularization project of Thiel embalmed specimens. This technique enables teaching anatomy, ...
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