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Results 251 - 300 of 2928
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Henríquez-Hernández Luis A LA Toxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria (Spain), Instituto Canario de Investigación del Cáncer (ICIC), and Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERObn), Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain; Radiation Oncology Department, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, - - 2014
Epidemiological studies have reported significant associations between exposure to persistent organic pollutants (POPs) and increased blood pressure (BP). Environmental exposure to POPs, mainly organochlorine pesticides, is of concern to the population of the Canary Islands, who display a high prevalence of diseases associated with hypertension such as metabolic syndrome, obesity ...
Toth Peter P 1] Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [2] Department of Pathophysiology and Gerontology, Medical School and Szentagothai Research Center, University of Pecs, Pecs, - - 2014
Aging impairs autoregulatory protection in the brain, exacerbating hypertension-induced cerebromicrovascular injury, neuroinflammation, and development of vascular cognitive impairment. Despite the importance of the age-related decline in circulating insulin-like growth factor-1 (IGF-1) levels in cerebrovascular aging, the effects of IGF-1 deficiency on functional adaptation of cerebral arteries to high blood pressure ...
Thomopoulos Costas C aDepartment of Cardiology, Helena Venizelou Hospital, Athens, Greece bDepartment of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Istituto Auxologico Italiano IRCCS cDepartment of Health Sciences, University of Milan Bicocca dScientific Direction, Istituto Auxologico Italiano IRCCS eCentro Interuniversitario di Fisiologia Clinica e Ipertensione, University of Milan, Milan, - - 2014
Antihypertensive treatment is based on randomized controlled trials (RCTs) started since 1966. Meta-analyses comprehensive of all RCTs but limited to RCTs investigating blood pressure (BP) lowering in hypertensive patients are lacking. Two clinical questions were investigated: the extent of different outcome reductions by BP lowering in hypertensive patients, and the ...
Kakizaki Hirohiko H *Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan; and †Ide Eye Hospital, Kasumicho, Yamagata, - - 2014
Movement of the lacrimal canalicular wall has been speculated to occur during blinking. Movement of the common internal ostium has been observed under nasal endoscopy, and pressure changes in the lacrimal canalicular cavity have been observed with a pressure sensor; however, lacrimal canalicular wall movement under pressure changes has not ...
Lu Xiangfeng X State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, - - 2014
Hypertension is a common disorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWAS) in European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for blood pressure. The ...
Jou Judy J Division of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis, - - 2014
To determine whether patient-perceived pressure from clinicians for labor induction or cesarean delivery is significantly associated with having these procedures. Listening to Mothers III, a nationally representative survey of women 18-45 years who delivered a singleton infant in a U.S. hospital July 2011-June 2012 (N = 2,400). Multivariate logistic regression analysis of ...
Almeida Antonio Eduardo Monteiro de AE Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba, - - 2014
Background: The importance of measuring blood pressure before morning micturition and in the afternoon, while working, is yet to be established in relation to the accuracy of home blood pressure monitoring (HBPM). Objective: To compare two HBPM protocols, considering 24-hour ambulatory blood pressure monitoring (wakefulness ABPM) as gold-standard and measurements ...
Bondonno Catherine P CP School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia. Electronic address: - - 2014
Evidence for a beneficial effect of dietary nitrate, through the nitrate-nitrite-NO pathway, on measures of cardiovascular function in healthy individuals is accumulating. It is less clear whether increased dietary nitrate intake from green leafy vegetables would have similar beneficial vascular effects in those at increased risk of developing hypertension. Our ...
Almeida Antonio Eduardo Monteiro de AE Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba, - - 2014
The importance of measuring blood pressure before morning micturition and in the afternoon, while working, is yet to be established in relation to the accuracy of home blood pressure monitoring (HBPM). To compare two HBPM protocols, considering 24-hour ambulatory blood pressure monitoring (wakefulness ABPM) as gold-standard and measurements taken before ...
Pandit Lavannya M LM From the Departments of Internal Medicine (L.M.P., X.H.T.W., R.M.B.), Anesthesiology (E.E.L., R.M.B.), Cardiovascular Research Institute, Department of Molecular Physiology and Biophysics (J.O.R., C.R., X.H.T.W., R.M.B.), Baylor College of Medicine, and Department of Microbiology and Immunology (W.S.L.), The University of Texas Medical Branch - - 2014
TWIK-2 (KCNK6) is a member of the 2-pore domain (K2P) family of potassium channels, which are highly expressed in the vascular system. We tested the hypothesis that TWIK-2 deficiency leads to pulmonary hypertension. TWIK-2 knockout mice and their wildtype littermates at 8 weeks of age had similar mean right ventricular ...
Mancia Giuseppe G From the IRCCS Istituto Auxologico Italiano, Milano, Italy (G.M., G.P., A.Z.); Department of Health Sciences, University of Milano-Bicocca, Milano, Italy (G.M., R.F., G.P.); and Università degli Studi di Milano, Milano, Italy (A.Z.). - - 2014
Limited evidence is available on the extent and frequency by which antihypertensive treatment lowers office blood pressure (BP) in white-coat hypertension (WCH). Data are even more scanty and discrepant on the corresponding effect on ambulatory BP (ABP). In the hypertensive patients of the European Lacidipine Study on Atherosclerosis (ELSA), office ...
Kim Chul-Hee CH Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea. Electronic address: - - 2014
We investigated the association between microalbuminuria and prediabetes in Korean population using data from the KNHANES 2011-2012. Prevalence of microalbuminuria was significantly increased in prediabetes group. However, the odds ratio became insignificant after adjustment for blood pressure, and the prevalence of microalbuminuria was not increased in prediabetic subjects without hypertension.
Bullarbo Maria M Department of Obstetrics and Gynaecology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, - - 2014
A previous study demonstrated that the increase in diastolic blood pressure during pregnancy was reduced by supplementation with magnesium. The present study was undertaken to explore if increases in diastolic blood pressure could be useful for early identification of pre-eclampsia. Hospital records of nulliparous, singleton normal pregnancies (n = 100) and those ...
Kreutz Reinhold R Institute of Clinical Pharmacology and Toxicology, Charité, Universtitätsmedizin -, Berlin, - - 2014
This prespecified subgroup analysis of a phase III study examined the effect of adding hydrochlorothiazide (HCTZ) to olmesartan (OLM)/amlodipine (AML) in patients with moderate to severe hypertension stratified by age, sex, body mass index, and hypertension severity. A total of 2690 patients, aged 18 years and older, with seated blood pressure ...
Gooding Holly C HC Boston Children's Hospital Division of Adolescent and Young Adult Medicine, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, - - 2014
Adverse childhood experiences are associated with hypertension in older adults. This study assessed whether an association between child maltreatment and blood pressure is detectable in young adults and whether any association differs by sex or is modified by genetic polymorphisms known to be involved in stress sensitivity. We examined these ...
Iftikhar Imran H IH aDivision of Pulmonary, Critical Care, and Sleep Medicine, University of South Carolina, Columbia, South Carolina bDivision of Nephrology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA cDisciplina de Medicina e Biologia do Sono, Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil dRenal and Hypertension Division, University of Pennsylvania Perelman School of Medicine eDivision of Sleep Medicine, Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA fFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland gCenter of Sleep Medicine, Charité University Hospital, Berlin, Germany hDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards iWoodcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia jDepartment of Internal Medicine, Taoyuan Chang Gung Memorial Hospital, Taiwan, Republic of China kDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, - - 2014
To systematically analyze the studies that have examined the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with resistant hypertension and obstructive sleep apnea (OSA). Design - meta-analysis of observational studies and randomized controlled trials (RCTs) indexed in PubMed and Ovid (All Journals@Ovid). participants: individuals ...
D'Alto Michele M Department of Cardiology, Monaldi Hospital, Second University of Naples, Naples, - - 2014
The right ventricle (RV) can be described in terms of 3 components: the inlet, the apex, and the infundibulum. In the normal adult, the RV shows an arrangement suited for pumping blood against low resistance, with a mass about one sixth that of left ventricle (LV) mass, and a larger ...
Han Sevtap S Department of Pharmacology, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, - - 2014
Hypertension is a risk factor for the cardiovascular diseases. Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited. Resveratrol decreases blood pressure in animal models of hypertension. This study researched the mechanisms behind the effects of resveratrol on hypertension. Hypertension was induced by ...
Lardjam-Hetraf S A SA Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, - - 2014
Genome-wide association studies and subsequent replication studies have pinpointed 29 genetic variants associated with blood pressure (BP). None of these studies included North African populations. We therefore looked at whether or not these genetic variants modulated BP and hypertension (HTN) risk in an Algerian population sample. Twenty-nine single-nucleotide polymorphisms (SNPs) ...
Heianza Y Y 1] Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan [2] Health Management Center, Toranomon Hospital, Tokyo, - - 2014
We investigated the effect of elevated concentrations of fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c) on the risk of development of hypertension among apparently healthy Japanese. Studied were 9584 individuals without known diabetes and hypertension. During a 5-year follow-up period, 1098 individuals developed hypertension. Elevated concentrations of FPG, rather ...
Dingemanse J J Actelion Pharmaceuticals Ltd, Department of Clinical Pharmacology, Allschwil, - - 2014
ACT-280778 is an oral, non-dihydropyridine, dual L-/T-type calcium channel blocker. This phase 2a, double-blind, randomized, placebo- and active-controlled study investigated the efficacy and safety of 10 mg ACT-280778. Patients with mild-to-moderate essential hypertension received once-daily placebo (n=53), ACT-280778 10 mg (n=52) or amlodipine 10 mg (n=54) for 4 weeks. The primary end point ...
Schillaci Giuseppe G 1] Dipartimento di Medicina, Università di Perugia, Perugia, Italy [2] Struttura Complessa di Medicina Interna, Azienda Ospedaliero-Universitaria di Terni, Terni, - - 2014
The relationship between arterial stiffness, measured as pulse wave velocity (PWV), and the left ventricle is confounded by the effects of blood pressure. We evaluated the relationship between carotid-femoral PWV and cardio-ankle vascular index (CAVI), a less pressure-dependent measurement of the stiffness constant (β) of the aorta and the iliac, ...
Rohner Andres A Basel Institute for Clinical Epidemiology and Biostatistics, University of Basel, - - 2014
Many patients prefer herbal medications to conventional drugs. Limited trial evidence suggests that garlic preparations reduce high blood pressure (BP). We searched electronic databases through March 2014 to identify all randomized controlled trials that compared a garlic preparation to placebo in hypertensive patients. Trials were required to report BP values ...
Hamnvik Ole-Petter R OP Brigham and Women's Hospital, Division of Endocrinology, Diabetes and Hypertension, Boston, - - 2014
VEGF signaling pathway inhibitor (anti-VEGF) therapy is associated with hypertension, but little is known about predisposing clinical characteristics. This study describes the real-world association between baseline clinical characteristics, blood pressure (BP) response, and survival in patients prescribed anti-VEGF therapies. Clinical data from Partners HealthCare in Massachusetts was obtained from adults ...
Izzo Joseph L JL Jr Department of Medicine, State University of New York at Buffalo, Buffalo, New York, USA. - - 2014
This critique is intended to provide background for the reader to evaluate the relative clinical utilities of brachial cuff systolic blood pressure (SBP) and its derivatives, including pulse pressure, central systolic pressure, central augmentation index (AI), and pulse pressure amplification (PPA). The critical question is whether the newer indicators add ...
Shimbo Daichi D Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University Medical Center, New York, NY, USA. Electronic address: - - 2014
The US Centers for Medicaid and Medicare Services reimburses ambulatory blood pressure monitoring (ABPM) for suspected white coat hypertension. We estimated ABPM use between 2007 and 2010 among a 5% random sample of Medicare beneficiaries (≥65 years). In 2007, 2008, 2009, and 2010, the percentage of beneficiaries with ABPM claims was ...
Yang Jing J Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology, No. 24 Jinghua Road, Jianxi District, Luoyang, 471003, Henan, - - 2014
The aim of this study was to investigate the dynamic characteristics and changing trends of ambulatory blood pressure in patients with hypertension and coronary heart disease before and after percutaneous coronary intervention (PCI), and to determine the effects of PCI on the ambulatory blood pressure of patients with hypertension and ...
Imai Teppei T Azbil Corporation , Tokyo , Japan - - 2014
Long working hours have been associated with an increased risk of cardiovascular disease, but its relationship with hypertension remains unclear. The objective of this study is to examine the relationship between overtime and presence of hypertension using data from a large-scale multi-company study in Japan. Participants were 52 365 workers of ...
Najafipour Hamid H Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, - - 2014
Hypertension (HTN) is an important cause of cardiovascular related morbidity and mortality. This study aimed at providing the prevalence of pre-HTN, diagnosed and undiagnosed HTN, along with its control and associated factors in an adult population. 5,900 participants aged 15-75 years took part in the study. HTN was verified by examination, ...
Cheng Susan S aFrom the Cardiovascular Division, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts bNovartis, East Hanover, New Jersey cState University of New York at Buffalo, Buffalo, New York dUniversity of Alabama, Birmingham, Alabama eUniversity of Michigan, Ann Arbor, Michigan, - - 2014
Prior studies indicate that hypertension is associated with mechanical systolic dysfunction, even in the presence of a normal ejection fraction, but whether this cardiac dysfunction may be ameliorated by antihypertensive treatment is unknown. To test the hypothesis that mechanical systolic dysfunction in hypertension may respond to blood pressure-lowering therapy, we ...
Pober Jordan S - - 2014
T cells are required for significant blood pressure elevation in mouse models of hypertension. Recent evidence suggests that the treatments that raise blood pressure in these animal models also cause oxidation within DCs, resulting in formation of isoketal adducts of self-proteins, which activate antigen-presenting functions of these cells and serve ...
Peng Jie J Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, - - 2014
This study was designed to explore the appropriate blood pressure (BP) target required to reduce cognitive decline and brain white matter lesions (WMLs) in elderly hypertensive patients. Elderly patients (n = 294, ≥80 years of age) being treated for hypertension were enrolled in a longitudinal study examining cognitive impairment after an initial assessment ...
Kirabo Annet - - 2014
Oxidative damage and inflammation are both implicated in the genesis of hypertension; however, the mechanisms by which these stimuli promote hypertension are not fully understood. Here, we have described a pathway in which hypertensive stimuli promote dendritic cell (DC) activation of T cells, ultimately leading to hypertension. Using multiple murine ...
Gonzalez Maday C MC New York Presbyterian-Weill Cornell Medical Center, New York, New York; - - 2014
A paradoxical pressor systolic response to initial antihypertensive monotherapy has been observed in 8% of hypertensive patients. The long-term consequences of this finding are unknown. We included 945 hypertensive patients with baseline systolic blood pressure (SBP) ≥140mm Hg. A 4-week washout period free of antihypertensive drugs was allowed for those ...
Wallbach M M aDepartment of Nephrology and Rheumatology bDepartment of Cardiology and Pneumology cDepartment of Medical Statistics, University of Göttingen dSt Josefs Hospital, Cloppenburg, - - 2014
High central blood pressure, augmentation index and pulse wave velocity are independent cardiovascular risk factors. Little is known of the effect of baroreflex activation therapy on central hemodynamics. In this prospective clinical trial, radial artery applanation tonometry and pulse wave analysis were used to derive central aortic pressure and hemodynamic ...
Morais Tercio Lemos de TL Universidade Nove de Julho (UNINOVE), São Paulo, - - 2014
The use of combined oral contraceptives is widespread among hypertensive women despite being associated with increased cardiovascular risk. Contraceptives containing drospirenone, which has antimineralocorticoid properties, may have a positive or neutral effect on neurohumoral activation and metabolic homeostasis of hypertensive women at reproductive age. To evaluate the effect of combined ...
Landman Gijs W D GW Diabetes Centre, Isala, Zwolle, the Netherlands2Department of Internal Medicine, Gelre Hospital, Apeldoorn, the - - 2014
Device-guided breathing (DGB) is recommended by the American Heart Association for its blood pressure-lowering effects. Most previous studies that showed beneficial effects on blood pressure had low methodological quality and only investigated short-term blood pressure effects. To assess the efficacy of DGB on blood pressure in a meta-analysis of individual ...
Posadzy-Malaczynska Anna A Department of Family Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland, - - 2014
The aim of the study was to assess the hemodynamic and metabolic actions of estrogen plus progestin therapy (EPT) in hypertensive, postmenopausal women treated with perindopril (ACEI) or hydrochlorothiazide (HCTZ). A group of normotensive postmenopausal women was also studied. 100 hypertensive and 40 normotensive postmenopausal women were recruited for the ...
George Mary G - - 2014
Hypertension and prehypertension have been increasing among children and adolescents since the 1990s. During 2003-2006, among children and adolescents aged 8-17 years, the prevalence of prehypertension was approximately 14% in boys and approximately 6% in girls, and the prevalence of hypertension was estimated to be 3%-4% in various studies. During ...
Páll Dénes D Department of Medicine, Clinical Center, University of Debrecen, Nagyerdei krt 98 Pf 19, 4032, Debrecen, Hungary, - - 2014
The blood pressure (BP) of most patients on antihypertensive monotherapy or bitherapy remains uncontrolled. Our study evaluated the efficacy of triple therapy with perindopril, amlodipine, and indapamide sustained release (SR) in patients with uncontrolled hypertension on previous antihypertensive therapy. This 4-month, multicenter, prospective, observational, open-label study included patients switched from ...
Holló Gábor G Department of Ophthalmology, Semmelweis University, Budapest, Hungary, - - 2014
A new preservative-free fixed-dose combination of 0.0015% tafluprost, a prostaglandin F2α analog, and 0.5% timolol (TAF/TIM; Santen Oy, Tampere, Finland), a beta-adrenergic antagonist has recently been developed. The intraocular pressure (IOP) reduction with TAF/TIM in open-angle glaucoma and ocular hypertension is similar to that of other prostaglandin-timolol fixed-combination products. Patients ...
Austin Christopher - - 2014
Background:Elevated mean right atrial pressure (RAP) measured by cardiac catheterization is an independent risk factor for mortality. Prior studies have demonstrated a modest correlation with invasive and noninvasive echocardiographic right atrial pressure (eRAP), but the prognostic impact of eRAP has not been previously evaluated in pulmonary arterial hypertension (PAH) patients. ...
Hyman D J DJ Section of General Internal Medicine, Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX, - - 2014
Non-adherence has been a major concern in the treatment of hypertension and is particularly important in understanding and intervening in patients who appear to have resistant hypertension. Relatively few studies have examined the role of non-adherence in resistant hypertension. This review will address issues related to measurement of adherence, adherence ...
Vanderpool Rebecca R RR http://orcid.org/0000-0001-6038-0568 Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, - - 2014
Prognosis in pulmonary hypertension (PH) is largely determined by RV function. However, uncertainty remains about what metrics of RV function might be most clinically relevant. The purpose of this study was to assess the clinical relevance of metrics of RV functional adaptation to increased afterload. Patients referred for PH underwent ...
Niehoff Marc O MO Covance Laboratories GmbH, Kesselfeld 29, 48163 Muenster, Germany. Electronic address: - - 2014
The measurement of cardiovascular endpoints in standard toxicology studies remains a challenge as the routinely used non-invasive methods require physical restraint, causing an increase of sympathetic neural activity, leading to excitement and potentially hypertension in the experimental animals. In this study, a miniature telemetry blood pressure transmitter was used to ...
Kim Do Hoon DH Department of Family Medicine, College of Medicine, Korea University, Seoul, South - - 2014
First of all, we would like to thank the authors for an interesting and novel research on primary aldosteronism in hypertensive patients, which unexpectedly is a common problem in resistant hypertension, but is often overlooked. However, there are a few confusing points in statistical descriptions, while surely not intentional, that ...
Meng Guoliang G Key Laboratory of Cardiovascular Disease and Molecular Intervention, State Key Laboratory of Reproductive Medicine, Atherosclerosis Research Centre, Nanjing Medical University, Nanjing, - - 2014
Hydrogen sulfide (H2 S) has traditionally been viewed as a highly toxic gas; however, recent studies have implicated H2 S as a third member of the gasotransmitter family, exhibiting properties similar to nitric oxide (NO) and carbon monoxide (CO). Accumulating evidence has suggested that H2 S influenced a wide range ...
Tsika Evangelia P EP Cardiology Department, Asklepeion Hospital, Athens, - - 2014
It is known that a large proportion of patients with arterial hypertension are undertreated. This may result in an increase of the incidence of cardiovascular events. On the other hand, aggressive reduction of blood pressure may increase cardiovascular events (J-curve phenomenon) in certain populations. This phenomenon may be seen in ...
Chandra Alvin A Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, - - 2014
Obesity has been linked to the development of hypertension, but whether total adiposity or site-specific fat accumulation underpins this relationship is unclear. This study sought to determine the relationship between adipose tissue distribution and incident hypertension. Normotensive participants enrolled in the Dallas Heart Study were followed for a median of ...
Xu Xiaojing X Georgia Prevention Center, Institute of Prevention and Public Health, Georgia Regents University, Augusta, - - 2014
Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and 67% of the ...
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