Search Results
Results 201 - 250 of 2847
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D'Alto Michele M Department of Cardiology, Monaldi Hospital, Second University of Naples, Naples, - - 2014
The right ventricle (RV) can be described in terms of 3 components: the inlet, the apex, and the infundibulum. In the normal adult, the RV shows an arrangement suited for pumping blood against low resistance, with a mass about one sixth that of left ventricle (LV) mass, and a larger ...
Han Sevtap S Department of Pharmacology, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, - - 2014
Hypertension is a risk factor for the cardiovascular diseases. Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited. Resveratrol decreases blood pressure in animal models of hypertension. This study researched the mechanisms behind the effects of resveratrol on hypertension. Hypertension was induced by ...
Gooding Holly C HC Boston Children's Hospital Division of Adolescent and Young Adult Medicine, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, - - 2014
Adverse childhood experiences are associated with hypertension in older adults. This study assessed whether an association between child maltreatment and blood pressure is detectable in young adults and whether any association differs by sex or is modified by genetic polymorphisms known to be involved in stress sensitivity. We examined these ...
Lardjam-Hetraf S A SA Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, - - 2014
Genome-wide association studies and subsequent replication studies have pinpointed 29 genetic variants associated with blood pressure (BP). None of these studies included North African populations. We therefore looked at whether or not these genetic variants modulated BP and hypertension (HTN) risk in an Algerian population sample. Twenty-nine single-nucleotide polymorphisms (SNPs) ...
Heianza Y Y 1] Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan [2] Health Management Center, Toranomon Hospital, Tokyo, - - 2014
We investigated the effect of elevated concentrations of fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c) on the risk of development of hypertension among apparently healthy Japanese. Studied were 9584 individuals without known diabetes and hypertension. During a 5-year follow-up period, 1098 individuals developed hypertension. Elevated concentrations of FPG, rather ...
Dingemanse J J Actelion Pharmaceuticals Ltd, Department of Clinical Pharmacology, Allschwil, - - 2014
ACT-280778 is an oral, non-dihydropyridine, dual L-/T-type calcium channel blocker. This phase 2a, double-blind, randomized, placebo- and active-controlled study investigated the efficacy and safety of 10 mg ACT-280778. Patients with mild-to-moderate essential hypertension received once-daily placebo (n=53), ACT-280778 10 mg (n=52) or amlodipine 10 mg (n=54) for 4 weeks. The primary end point ...
Schillaci Giuseppe G 1] Dipartimento di Medicina, Università di Perugia, Perugia, Italy [2] Struttura Complessa di Medicina Interna, Azienda Ospedaliero-Universitaria di Terni, Terni, - - 2014
The relationship between arterial stiffness, measured as pulse wave velocity (PWV), and the left ventricle is confounded by the effects of blood pressure. We evaluated the relationship between carotid-femoral PWV and cardio-ankle vascular index (CAVI), a less pressure-dependent measurement of the stiffness constant (β) of the aorta and the iliac, ...
Rohner Andres A Basel Institute for Clinical Epidemiology and Biostatistics, University of Basel, - - 2014
Many patients prefer herbal medications to conventional drugs. Limited trial evidence suggests that garlic preparations reduce high blood pressure (BP). We searched electronic databases through March 2014 to identify all randomized controlled trials that compared a garlic preparation to placebo in hypertensive patients. Trials were required to report BP values ...
Hamnvik Ole-Petter R OP Brigham and Women's Hospital, Division of Endocrinology, Diabetes and Hypertension, Boston, - - 2014
VEGF signaling pathway inhibitor (anti-VEGF) therapy is associated with hypertension, but little is known about predisposing clinical characteristics. This study describes the real-world association between baseline clinical characteristics, blood pressure (BP) response, and survival in patients prescribed anti-VEGF therapies. Clinical data from Partners HealthCare in Massachusetts was obtained from adults ...
Izzo Joseph L JL Jr Department of Medicine, State University of New York at Buffalo, Buffalo, New York, USA. - - 2014
This critique is intended to provide background for the reader to evaluate the relative clinical utilities of brachial cuff systolic blood pressure (SBP) and its derivatives, including pulse pressure, central systolic pressure, central augmentation index (AI), and pulse pressure amplification (PPA). The critical question is whether the newer indicators add ...
Yang Jing J Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology, No. 24 Jinghua Road, Jianxi District, Luoyang, 471003, Henan, - - 2014
The aim of this study was to investigate the dynamic characteristics and changing trends of ambulatory blood pressure in patients with hypertension and coronary heart disease before and after percutaneous coronary intervention (PCI), and to determine the effects of PCI on the ambulatory blood pressure of patients with hypertension and ...
Imai Teppei T Azbil Corporation , Tokyo , Japan - - 2014
Long working hours have been associated with an increased risk of cardiovascular disease, but its relationship with hypertension remains unclear. The objective of this study is to examine the relationship between overtime and presence of hypertension using data from a large-scale multi-company study in Japan. Participants were 52 365 workers of ...
Najafipour Hamid H Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, - - 2014
Hypertension (HTN) is an important cause of cardiovascular related morbidity and mortality. This study aimed at providing the prevalence of pre-HTN, diagnosed and undiagnosed HTN, along with its control and associated factors in an adult population. 5,900 participants aged 15-75 years took part in the study. HTN was verified by examination, ...
Cheng Susan S aFrom the Cardiovascular Division, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts bNovartis, East Hanover, New Jersey cState University of New York at Buffalo, Buffalo, New York dUniversity of Alabama, Birmingham, Alabama eUniversity of Michigan, Ann Arbor, Michigan, - - 2014
Prior studies indicate that hypertension is associated with mechanical systolic dysfunction, even in the presence of a normal ejection fraction, but whether this cardiac dysfunction may be ameliorated by antihypertensive treatment is unknown. To test the hypothesis that mechanical systolic dysfunction in hypertension may respond to blood pressure-lowering therapy, we ...
Pober Jordan S - - 2014
T cells are required for significant blood pressure elevation in mouse models of hypertension. Recent evidence suggests that the treatments that raise blood pressure in these animal models also cause oxidation within DCs, resulting in formation of isoketal adducts of self-proteins, which activate antigen-presenting functions of these cells and serve ...
Peng Jie J Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, - - 2014
This study was designed to explore the appropriate blood pressure (BP) target required to reduce cognitive decline and brain white matter lesions (WMLs) in elderly hypertensive patients. Elderly patients (n = 294, ≥80 years of age) being treated for hypertension were enrolled in a longitudinal study examining cognitive impairment after an initial assessment ...
Kirabo Annet - - 2014
Oxidative damage and inflammation are both implicated in the genesis of hypertension; however, the mechanisms by which these stimuli promote hypertension are not fully understood. Here, we have described a pathway in which hypertensive stimuli promote dendritic cell (DC) activation of T cells, ultimately leading to hypertension. Using multiple murine ...
Gonzalez Maday C MC New York Presbyterian-Weill Cornell Medical Center, New York, New York; - - 2014
A paradoxical pressor systolic response to initial antihypertensive monotherapy has been observed in 8% of hypertensive patients. The long-term consequences of this finding are unknown. We included 945 hypertensive patients with baseline systolic blood pressure (SBP) ≥140mm Hg. A 4-week washout period free of antihypertensive drugs was allowed for those ...
Wallbach M M aDepartment of Nephrology and Rheumatology bDepartment of Cardiology and Pneumology cDepartment of Medical Statistics, University of Göttingen dSt Josefs Hospital, Cloppenburg, - - 2014
High central blood pressure, augmentation index and pulse wave velocity are independent cardiovascular risk factors. Little is known of the effect of baroreflex activation therapy on central hemodynamics. In this prospective clinical trial, radial artery applanation tonometry and pulse wave analysis were used to derive central aortic pressure and hemodynamic ...
Morais Tercio Lemos de TL Universidade Nove de Julho (UNINOVE), São Paulo, - - 2014
The use of combined oral contraceptives is widespread among hypertensive women despite being associated with increased cardiovascular risk. Contraceptives containing drospirenone, which has antimineralocorticoid properties, may have a positive or neutral effect on neurohumoral activation and metabolic homeostasis of hypertensive women at reproductive age. To evaluate the effect of combined ...
Landman Gijs W D GW Diabetes Centre, Isala, Zwolle, the Netherlands2Department of Internal Medicine, Gelre Hospital, Apeldoorn, the - - 2014
Device-guided breathing (DGB) is recommended by the American Heart Association for its blood pressure-lowering effects. Most previous studies that showed beneficial effects on blood pressure had low methodological quality and only investigated short-term blood pressure effects. To assess the efficacy of DGB on blood pressure in a meta-analysis of individual ...
Posadzy-Malaczynska Anna A Department of Family Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland, - - 2014
The aim of the study was to assess the hemodynamic and metabolic actions of estrogen plus progestin therapy (EPT) in hypertensive, postmenopausal women treated with perindopril (ACEI) or hydrochlorothiazide (HCTZ). A group of normotensive postmenopausal women was also studied. 100 hypertensive and 40 normotensive postmenopausal women were recruited for the ...
George Mary G - - 2014
Hypertension and prehypertension have been increasing among children and adolescents since the 1990s. During 2003-2006, among children and adolescents aged 8-17 years, the prevalence of prehypertension was approximately 14% in boys and approximately 6% in girls, and the prevalence of hypertension was estimated to be 3%-4% in various studies. During ...
Páll Dénes D Department of Medicine, Clinical Center, University of Debrecen, Nagyerdei krt 98 Pf 19, 4032, Debrecen, Hungary, - - 2014
The blood pressure (BP) of most patients on antihypertensive monotherapy or bitherapy remains uncontrolled. Our study evaluated the efficacy of triple therapy with perindopril, amlodipine, and indapamide sustained release (SR) in patients with uncontrolled hypertension on previous antihypertensive therapy. This 4-month, multicenter, prospective, observational, open-label study included patients switched from ...
Holló Gábor G Department of Ophthalmology, Semmelweis University, Budapest, Hungary, - - 2014
A new preservative-free fixed-dose combination of 0.0015% tafluprost, a prostaglandin F2α analog, and 0.5% timolol (TAF/TIM; Santen Oy, Tampere, Finland), a beta-adrenergic antagonist has recently been developed. The intraocular pressure (IOP) reduction with TAF/TIM in open-angle glaucoma and ocular hypertension is similar to that of other prostaglandin-timolol fixed-combination products. Patients ...
Austin Christopher - - 2014
Background:Elevated mean right atrial pressure (RAP) measured by cardiac catheterization is an independent risk factor for mortality. Prior studies have demonstrated a modest correlation with invasive and noninvasive echocardiographic right atrial pressure (eRAP), but the prognostic impact of eRAP has not been previously evaluated in pulmonary arterial hypertension (PAH) patients. ...
Hyman D J DJ Section of General Internal Medicine, Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX, - - 2014
Non-adherence has been a major concern in the treatment of hypertension and is particularly important in understanding and intervening in patients who appear to have resistant hypertension. Relatively few studies have examined the role of non-adherence in resistant hypertension. This review will address issues related to measurement of adherence, adherence ...
Vanderpool Rebecca R RR http://orcid.org/0000-0001-6038-0568 Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, - - 2014
Prognosis in pulmonary hypertension (PH) is largely determined by RV function. However, uncertainty remains about what metrics of RV function might be most clinically relevant. The purpose of this study was to assess the clinical relevance of metrics of RV functional adaptation to increased afterload. Patients referred for PH underwent ...
Niehoff Marc O MO Covance Laboratories GmbH, Kesselfeld 29, 48163 Muenster, Germany. Electronic address: - - 2014
The measurement of cardiovascular endpoints in standard toxicology studies remains a challenge as the routinely used non-invasive methods require physical restraint, causing an increase of sympathetic neural activity, leading to excitement and potentially hypertension in the experimental animals. In this study, a miniature telemetry blood pressure transmitter was used to ...
Kim Do Hoon DH Department of Family Medicine, College of Medicine, Korea University, Seoul, South - - 2014
First of all, we would like to thank the authors for an interesting and novel research on primary aldosteronism in hypertensive patients, which unexpectedly is a common problem in resistant hypertension, but is often overlooked. However, there are a few confusing points in statistical descriptions, while surely not intentional, that ...
Meng Guoliang G Key Laboratory of Cardiovascular Disease and Molecular Intervention, State Key Laboratory of Reproductive Medicine, Atherosclerosis Research Centre, Nanjing Medical University, Nanjing, - - 2014
Hydrogen sulfide (H2 S) has traditionally been viewed as a highly toxic gas; however, recent studies have implicated H2 S as a third member of the gasotransmitter family, exhibiting properties similar to nitric oxide (NO) and carbon monoxide (CO). Accumulating evidence has suggested that H2 S influenced a wide range ...
Tsika Evangelia P EP Cardiology Department, Asklepeion Hospital, Athens, - - 2014
It is known that a large proportion of patients with arterial hypertension are undertreated. This may result in an increase of the incidence of cardiovascular events. On the other hand, aggressive reduction of blood pressure may increase cardiovascular events (J-curve phenomenon) in certain populations. This phenomenon may be seen in ...
Chandra Alvin A Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, - - 2014
Obesity has been linked to the development of hypertension, but whether total adiposity or site-specific fat accumulation underpins this relationship is unclear. This study sought to determine the relationship between adipose tissue distribution and incident hypertension. Normotensive participants enrolled in the Dallas Heart Study were followed for a median of ...
Xu Xiaojing X Georgia Prevention Center, Institute of Prevention and Public Health, Georgia Regents University, Augusta, - - 2014
Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and 67% of the ...
Ameloot Koen K Department of Cardiovascular Diseases, Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium - - 2014
Right ventricular (RV) dp/dt is the instantaneous rate of RV pressure rise during early systole and is a surrogate marker of RV contractility. The main objective of this study was to evaluate the ability of echocardiographic Doppler obtained RV dp/dt to predict long-term survival in patients with pulmonary arterial hypertension ...
He Fu-Liang FL Fu-Liang He, Lei Wang, Zhen-Dong Yue, Hong-Wei Zhao, Fu-Quan Liu, Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, - - 2014
To evaluate the feasibility of a second parallel transjugular intrahepatic portosystemic shunt (TIPS) to reduce portal venous pressure and control complications of portal hypertension. From January 2011 to December 2012, 10 cirrhotic patients were treated for complications of portal hypertension. The demographic data, operative data, postoperative recovery data, hemodynamic data, ...
Weltermann Birgitta M BM Institute for General Medicine, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany, - - 2014
Studies showed a positive association between appointment adherence and blood pressure control. In randomized-controlled trials blood pressure therapy was improved by recall systems. We analyze the effectiveness of an active telephone recall on blood pressure control for patients with low appointment adherence in regular primary care. This retrospective cohort study ...
Figueiredo Ricardo Rodrigues RR Federal University of São Paulo, Rua dos Otonis, 700, Vila Clementino, São Paulo, RJ, 04025-002, Brazil, - - 2014
Tinnitus is considered a multi-factorial symptom. Arterial hypertension has been cited as a tinnitus etiological factor. To assess the scientific evidence on the associations between arterial hypertension and tinnitus. A systematic review was performed using PubMed, ISI Web, Lilacs and SciELO scientific databases. This review included articles published in Portuguese, ...
Costello Benedict T BT Royal Hobart Hospital, Hobart - - 2014
Central blood pressure (BP) can be estimated noninvasively by analyzing brachial artery waveforms. In this study, our aim was to assess the validity of a brachial cuff-based (suprasystolic) technique for estimating central BP (CBPestimated) by comparison with invasive aortic BP (CBPinvasive). Eighty-four simultaneous CBPestimated (Pulsecor R7.0) and CBPinvasive measures were ...
Mourato Felipe A FA Círculo do Coração de Pernambuco, Pernambuco, Brazil; Laboratório de Imunopatologia Keizo Asami, Pernambuco, Brazil; and - - 2014
The blood pressure to height ratio (BP:HT) has been proposed as a simple method for identifying children with elevated BP. This procedure shows good accuracy for the screening of hypertension in adolescents but less so in younger children. Our aim in this study was to modify the BP:HT ratio and ...
Solini Anna A aDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa bDivision of Endocrinology and Metabolic Diseases, University of Verona, Verona cDiabetes Unit, Fondazione IRCCS 'Cà Granda-Ospedale Maggiore Policlinico', Milan dDiabetes Unit, University of Siena, Siena eEndocrinology and Diabetes Unit, Ospedali Riuniti, Bergamo fDepartment of Clinical and Experimental Medicine, University of Padua, Padua gDepartment of Clinical and Biological Sciences, University of Turin, Orbassano, Turin hDepartment of Medical Sciences, University of Foggia, Foggia iEndocrinology Unit, San Giuseppe Hospital, Milan jDepartment of Medical Sciences, University of Cagliari, Cagliari kDepartment of Clinical and Molecular Medicine, 'La Sapienza' University, Rome; - - 2014
The phenotype of resistant hypertension in patients with type 2 diabetes has been poorly characterized. This cross-sectional analysis of the large cohort from the Renal Insufficiency and Cardiovascular Events (RIACE) study was aimed at assessing the clinical correlates and association with complications of resistant hypertension in patients with type 2 ...
de Faria Ana Paula AP Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, - - 2014
Resistant hypertension (RH) is a multifactorial disease, frequently associated with obesity and characterized by blood pressure above goal (140/90 mm Hg) despite the concurrent use of ≥3 antihypertensive drugs of different classes. The mechanisms of obesity-related hypertension include, among others, aldosterone excess and inflammatory adipokines, which have demonstrated a significant role ...
Brower Kathryn A KA Department of Pharmacy, Iowa Methodist Medical Center, Des Moines, IA, - - 2014
Hypertension in the hospital setting is common; however, guidelines provide limited guidance specific to the inpatient setting. Acute antihypertensive treatment options can be limited in this setting by monitoring requirements of intravenous medications and patients' inability to take oral medications. A possible treatment choice used to treat acute hypertension is ...
Boonla Orachorn O Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen - - 2014
Oxidative stress plays a role in maintaining high arterial blood pressure and contributes to the vascular changes that lead to hypertension. Consumption of polyphenol-rich foods has demonstrated their beneficial role in the prevention and treatment of hypertension. Curcumin (CUR), a phenolic compound present in the rhizomes of turmeric, possesses cardiovascular ...
Fazeli Nima N Mechanical Engineering, University of Maryland, College Park, - - 2014
This paper demonstrates preliminary in-human validity of a novel subject-specific approach to estimation of central aortic blood pressure (CABP) from peripheral circulatory waveforms. In this "Individualized Transfer Function" (ITF) approach, CABP is estimated in two steps. First, the circulatory dynamics of the cardiovascular system are determined via model-based system identification, ...
Yang Li - - 2014
The prevalence of hypertension in China has risen dramatically in recent decades, but it is not well understood if hypertension is adequately controlled in the elderly population in Southern China. A provincial survey was performed in order to estimate the prevalence of hypertension control and the associated factors in the ...
Im Tae Seong TS Department of Radiology, Seoul National University Bundang Hospital, Gyeonggido, 436-707, - - 2014
Hypertension is known to be a strong risk factor for coronary atherosclerosis. We aimed to investigate the prevalence, severity, and plaque characteristics of coronary atherosclerosis according to grade of blood pressure (BP) using coronary CT angiography (CCTA) in asymptomatic adults. We enrolled 8,238 asymptomatic subjects who underwent coronary artery calcium ...
Sedaghat Sanaz S Departments of Epidemiology (S.S., R.P., A.G.U., A.H., B.H.Ch.S., O.H.F., A.D., M.A.I.), Internal Medicine (A.G.U.), Radiology (M.A.I.), and Neurology (M.A.I.), Erasmus University Medical Center, Rotterdam, The - - 2014
High levels of serum uric acid are associated with hypertension in observational studies. The aim of this study was to investigate the association of uric acid gene variants with blood pressure. We studied 5791 participants aged ≥55 years from the Rotterdam Study. Thirty gene variants identified for serum uric acid ...
Lankhorst Stephanie S From the Division of Pharmacology and Vascular Medicine, Department of Internal Medicine (S.L., M.H.W.K., J.H.M.v.E., A.H.J.D., A.H.v.d.M.) and Department of Medical Oncology, Erasmus MC Cancer Institute (S.S., R.H.J.M.), Erasmus Medical Center, Rotterdam, The Netherlands; Department of Pathology, Reinier de Graaf Groep, Delft, The Netherlands (F.M.M.S.); Department of Internal Medicine, Amphia Hospital, Breda, The Netherlands (M.H.W.K.); and Department of Pathology, Leiden University Medical Center, Leiden - - 2014
Common adverse effects of angiogenesis inhibition are hypertension and renal injury. To determine the most optimal way to prevent these adverse effects and to explore their interdependency, the following drugs were investigated in unrestrained Wistar Kyoto rats exposed to the angiogenesis inhibitor sunitinib: the dual endothelin receptor antagonist macitentan; the ...
Safar Michel E ME Paris Descartes University, AP-HP, Diagnosis and Therapeutic Center, Paris, France; - - 2014
Patho-physiological and pharmacological studies have consistently noticed that, with the exception of subjects with end-stage renal disease, total intravascular blood volume is not increased in patients with chronic hypertension. Because the mean circulatory pressure is enhanced in such subjects, it was postulated that the compliance of the cardiovascular system could ...
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