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Vemulapalli Sreekanth S Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC; Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC. Electronic address: - - 2014
To identify patients at increased risk of cardiovascular (CV) outcomes, apparent treatment-resistant hypertension (aTRH) is defined as having a blood pressure above goal despite the use of 3 or more antihypertensive therapies of different classes at maximally tolerated doses, ideally including a diuretic. Recent epidemiologic studies in selected populations estimated ...
Pelliccia Francesco F Department 'Attilio Reale', Sapienza University, Rome, Italy. Electronic address: - - 2014
The mineralocorticoid receptor antagonists have been shown to have favourable safety and cost-effectiveness profiles across a broad range of clinical indications, including heart failure, primary aldosteronism and resistant hypertension. The clinical biology of the first aldosterone blocker, i.e. spironolactone, and its effects in several organ systems has been well elucidated ...
White L H LH 1] Sleep Research Laboratory, Toronto Rehabilitation Institute, Toronto, Ontario, Canada [2] Centre for Sleep Medicine and Circadian Biology of the University of Toronto, Toronto, Ontario, - - 2014
Obstructive sleep apnoea (OSA) is highly prevalent in hypertensive patients, particularly those with drug resistance. Evidence from animal experiments, epidemiologic studies and clinical trials strongly suggest a causal link. Mechanistic studies argue for increased sympathetic neural activity and endothelial dysfunction. However, disturbances in fluid volume regulation and distribution may also ...
Lotufo Paulo A PA Center for Clinical and Epidemiologic Research, University of Sao Paulo, Sao Paulo, - - 2014
The frequency of resistant hypertension-defined as blood pressure (BP) ≥140/90 mm Hg with proven use of three antihypertensive medications, or as the use of four antihypertensive drug classes regardless of BP-is unknown in low-middle-income countries. Using data from the Brazilian Longitudinal Study of Adult Health, a cohort of 15,105 civil servants aged ...
Newman John H - - 2014
Pulmonary vascular capacitance (PVC) is reduced in pulmonary arterial hypertension (PAH). In normal lung PVC is largely a function of vascular compliance. In PAH, increased resistance (PVR) arises from the arterioles. PVR and PVC share pressure and volume variables. The dependency between the two qualities of the vascular bed is ...
Salazar M R MR 1] Clinica Medica, Hospital San Martín, La Plata, Buenos Aires, Argentina [2] Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, - - 2014
We evaluated the consequences of excluding the first of three blood pressure (BP) readings in different settings: a random population sample (POS, n=1525), a general practice office (GPO, n=942) and a specialized hypertension center (SHC, n=462). Differences between systolic and diastolic BP (SBP and DBP) estimates obtained including and excluding ...
Rinaldi Elisa R - - 2014
Reduction strategies of blood pressure, as a modifiable cardiovascular risk, are currently based on office assessment of brachial artery blood pressure. However, antihypertensive treatment based on brachial BP values reduces cardiovascular risk but cannot completely reverse the hypertension-induced risk of morbidity events. As is well known, BP varies in different ...
Zheng Meili M Heart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, - - 2014
Recent data indicate that hypertension is not well controlled in many populations throughout the world. The factors that influence individual response to anti-hypertensive treatment need to be clarified. Pulse wave velocity (PWV), as a marker of arterial stiffness, has been demonstrated to have important relationships with BP progression; however, little ...
Gosmanova Elvira O EO Nephrology Division, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, - - 2014
Significant progress has been made in the management of hypertension (HTN) in the last 60 years. A large number of antihypertensive drugs (AHD) is available for effective control of elevated blood pressure (BP) that were also shown to be beneficial in improving all-cause mortality and cardiovascular morbidity in hypertensive individuals. ...
Al-Karkhi Isam I Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, - - 2014
We aimed to compare blood pressure (BP) levels recorded using the semiautomatic oscillometric Omron i-C10 BP device in patients with or without hypertension in three different settings: (a) when used by a doctor or a nurse at the office (OBP); (b) when used for self-measurement by the patient at the ...
Eugenio Ochoa Juan J Department of Health Sciences, University of Milan-Bicocca, - - 2014
Context: Epidemiological studies have shown a progressive increase in insulin resistance accompanying body weight gain and blood pressure rise. This has led to consider that hemodynamic effects of insulin resistance might depend on its relationship with body mass index and blood pressure levels. Objective: Aim of our study was to ...
Larsen Timothy R TR Department of Internal Medicine, Providence Hospital and Medical Center, Southfield, - - 2014
Masked hypertension (MH), the presence of normal office blood pressure (BP) with elevated ambulatory pressure, has been shown to correlate with organ damage. Population-based studies from Europe and Asia estimate a prevalence of 8.5% to 15.8%. Two small studies in African Americans estimate a prevalence >40%. Therefore, the authors utilized ...
Manios Efstathios E Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, - - 2014
Masked hypertension (MH) is associated with advanced target organ damage. However, patients with MH constitute a group of individuals with heterogeneous characteristics concerning their ambulatory blood pressure (BP) status. The aim of this study was to evaluate the association of isolated systolic MH, isolated diastolic MH, and systolic/diastolic MH with ...
Qin Tingli T Department of Cardiology, China-Japan Friendship Hospital, Beijing, - - 2014
To evaluate the relationship between ambulatory arterial stiffness index (AASI) and other parameters derived from ambulatory blood pressure (BP) monitoring, including dipping status, in patients with grade 1/grade 2 hypertension. This retrospective analysis included baseline data from Chinese outpatients enrolled into a previous study, who had clinic diastolic BP of ...
Ewen Sebastian S From the Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin (S.E., C.U., D.L., I.K., B.C., U.L., M.B., F.M.) and Institut für Medizinische Biometrie, Epidemiologie und Medizinische Informatik (S.W.), Universitätsklinikum des Saarlandes, Homburg/Saar, Germany; and Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen, Erlangen, Germany (R.E.S.). Sebastian.Ewen@uks.eu - - 2014
Renal denervation can reduce blood pressure in certain patients with resistant hypertension. The effect in patients with isolated systolic hypertension (ISH, ≥140/<90 mm Hg) is unknown. This study investigated the effects of renal denervation in 126 patients divided into 63 patients with ISH and 63 patients with combined hypertension (CH, ...
Egan Brent M BM Care Coordination Institute and University of South Carolina School of Medicine-Greenville, Greenville Health System, Greenville, SC - - 2014
-To reduce the cardiovascular disease burden, Healthy People 2020 established U.S. hypertension goals for adults to: (1) decrease prevalence to 26.9%. (2) raise treatment to 69.5% and control to 61.2%, which requires controlling 88.1% on treatment. -To assess current status and progress toward these Healthy People 2020 goals, time trends ...
Dörr Oliver O Department of Cardiology, University of Giessen, Klinikstr. 33, 35392, Giessen, Germany, - - 2014
Renal sympathetic denervation (RSD) represents a potential treatment option for certain patients with resistant arterial hypertension (HT). HT is associated with chronic vascular inflammation and remodeling, contributing to progressive vascular damage, and atherosclerosis. The present study aimed to evaluate the influence of RSD on cardiovascular inflammation and remodeling by determining ...
Leiria Liana F LF Cardiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, - - 2014
The association between hypertensive phenotypes of controlled hypertension (CH), white-coat effect (WCE), masked uncontrolled hypertension (MUH) and sustained hypertension (SH) with target organ damage have not been clearly established in diabetic hypertensive treated patients. The present study aims to evaluate the prevalence of the four phenotypes considering the current cut-off ...
Berge Constance C aCardiology Department, European Society of Hypertension Excellence Center, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon bGénomique Fonctionnelle de l'Hypertension artérielle, EA 4173, Université Claude Bernard Lyon1, Villeurbanne cHôpital Nord-Ouest, Villefranche sur saône dCardiology Department, Hôpital Nord-Ouest, Villefranche sur saône eNephrology and Hypertension Department, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France *Constance Berge and Pierre-Yves Courand contributed equally to the writing of this - - 2014
AIM:: Primary aldosteronism could exert a negative feedback on prorenin secretion, of possibly different magnitude, whether it is related to an aldosterone-producing adenoma (APA) or an idiopathic hyperaldosteronism (IHA). The objectives of this study were to evaluate the level of prorenin in three subgroups: APA, IHA, and essential hypertension; and ...
Roush George C GC aUCONN School of Medicine, Farmington, Connecticut, USA bHypertension Unit, U.Z., University of Leuven, Leuven, Belgium cFaculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil dDipartimento di Medicina e Scienze dell'Invecchiamento, Universita Gabriele d'Annunzio, Chieti eDepartment of Internal Medicine, University of Perugia, Perugia fStruttura Complessa di Medicina, Ospedale di Assisi, Assisi, Italy gJichi Medical University School of Medicine, Shimotsuke, Tochigi Prefecture, Japan hFaculdade de Medicine da Universidade do Porto, Porto, Portugal iDepartment of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Terrassa jBioengineering and Chronobiology Laboratories, University of Vigo, Vigo, Spain kCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, - - 2014
Background and method: To determine which SBP measure best predicts cardiovascular events (CVEs) independently, a systematic review was conducted for cohorts with all patients diagnosed with hypertension, 1+ years follow-up, and coronary artery disease and stroke outcomes. Lead investigators provided ad hoc analyses for each cohort. Meta-analyses gave hazard ratios ...
Kwon Beom-June BJ Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of - - 2014
The presence of left ventricular diastolic dyssynchrony is well known to be a frequent and important manifestation in heart failure. We investigated diastolic dyssynchrony in patients with treatment-naive hypertension, compared with normal controls; the determinants of the presence of diastolic dyssynchrony by performing comprehensive studies including laboratory, arterial stiffness, central ...
Grassi Guido G Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano-Bicocca, Monza, Italy; IRCCS Multimedica, Sesto San Giovanni, Milano, Italy. Electronic address: - - 2014
An increase in sympathetic drive to the heart and the peripheral circulation characterizes mild and severe essential hypertension. However, it remains unsettled whether sympathetic cardiovascular influences are potentiated in true resistant hypertension (RHT). In 32 RHT patients treated with 4.6±0.3 drugs (mean±SEM) and aged 58.6±2.1years, 35 non-resistant treated hypertensives (HT) ...
Mendelson Monique M Univ Grenoble Alpes, HP2 laboratory, Grenoble, France; Inserm U1042, HP2, Grenoble, France; and CHU Grenoble, HP2, Grenoble, - - 2014
Obstructive sleep apnea (OSA) has been associated with hypertension, which is one of the intermediary mechanisms leading to increased cardiovascular morbidity. This study aimed at evaluating the effects of a combination of continuous positive airway pressure (CPAP) and telemedicine support on blood pressure (BP) reduction in high cardiovascular risk OSA ...
Verloop Willemien L WL Department of Cardiology, University Medical Center, Utrecht, the - - 2014
Renal denervation (RDN) is believed to reduce sympathetic nerve activity and is a potential treatment for resistant hypertension. The present study investigated the effects of RDN on end organ damage (EOD). The present study was a prospective cohort study (registered as NCT01427049). Uncontrolled hypertensive patients underwent a work-up prior to ...
Laflamme Maxime M Department of Cardiac - - 2014
To retrospectively evaluate the effects of combined inhaled prostacyclin and milrinone to reduce the severity of pulmonary hypertension when administered prior to cardiopulmonary bypass. Retrospective case control analysis of high-risk patients undergoing cardiac surgery. Single cardiac center. Sixty one adult cardiac surgical patients with pulmonary hypertension, 40 of whom received ...
Gorostidi Manuel M Department of Nephrology, Hospital Universitario Central de Asturias, Oviedo, Asturias, Red de Investigación Renal REDinREN, - - 2014
In the past two decades, techniques for the measurement of blood pressure outside the medical setting have unmasked highly prevalent situations. A significant proportion of patients with office blood pressure levels above the thresholds for diagnosing hypertension or above the limits where those being treated are considered to be adequately ...
Asayama Kei K 1] Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium [2] Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, - - 2014
This review addresses methodological issues in the assessment of blood pressure variability and the predictive value of blood pressure variability derived from blood pressure readings obtained in the relaxed home environment. Preference should be given to indexes of blood pressure variability that are independent of the mean because we should ...
Courand Pierre-Yves PY Cardiology Department, European Society of Hypertension Excellence Centre, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France; Génomique Fonctionnelle de l'Hypertension Artérielle, EA 4173, Université Claude-Bernard Lyon 1, Villeurbanne, France; Hôpital Nord-Ouest, Villefranche-sur-Saône, France. Electronic address: - - 2014
Despite a wide choice of effective antihypertensive treatments, blood pressure (BP) in roughly half of hypertensive subjects is not controlled. Resistant hypertension is defined as an uncontrolled BP despite optimal doses of three antihypertensive treatments, including a diuretic. After confirmation of resistant BP using home BP measurement or 24-hour ambulatory ...
Hedrick Michael S MS Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA. Electronic address: - - 2014
Anurans from terrestrial environments have an enhanced ability to maintain mean arterial blood pressure (Pm) through lymph mobilization in response to desiccation or hemorrhage compared with semiaquatic or aquatic species. Because short term blood pressure homeostasis is regulated by arterial baroreceptors, we compared baroreflex function in three species of anurans ...
Kjeldsen Sverre S Department of Cardiology, Faculty of Medicine, Oslo University Hospital Ullevaal, University of Oslo, 0450, Oslo, - - 2014
Despite the availability of effective pharmacological treatments to aid the control of blood pressure, the global rate of uncontrolled blood pressure remains high. As such, further measures are required to improve blood pressure control. Recently, several national and international guidelines for the management of hypertension have been published. These aim ...
Kostrzewska M M Department of Pulmonology, Allergology and Respiratory Oncology, University of Medical Sciences, 84. Szamarzewskiego St., PoznaƄ, 60-569, Poland, - - 2014
In this study we determined the relationship between the severity of obstructive sleep apnea (OSA) and body mass index (BMI), systolic and diastolic blood pressure (SBP, DBP), and carotid intima-media thickness (cIMT) in 30 hypertensive male patients, aged 30-70, with newly diagnosed OSA (15 with moderate OSA - Group A, ...
Takeshita Junko J Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia2Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, - - 2014
Hypertension is prevalent among patients with psoriasis. The effect of psoriasis and its severity on hypertension control is unknown. To determine the association between uncontrolled blood pressure and psoriasis, both overall and according to objectively measured psoriasis severity, among patients with diagnosed hypertension. Population-based cross-sectional study nested in a prospective ...
Lee Chung-Jen CJ Department of Nursing, Tzu Chi College of - - 2014
Aim: Arterial stiffness is recognized to be an independent risk factor for cardiovascular morbidity and mortality. Recent studies have found that osteoprotegerin (OPG) is associated with increased pulse wave velocity and may reflect endothelial dysfunction. The aim of this study was to evaluate the relationship between the serum OPG level ...
Wu S-X SX Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, 5# Haiyuncang, Dongcheng District, Beijing, 100700, China. - - 2014
Objective: There are more than 300 million patients with hypertension in China, and at least 1 in 5 is using or has ever used Chinese Medicine (CM) treatment. Scope: This article reviews the efficacy and safety of CM as monotherapy and in combination with western medicine (WM) to explore its ...
Aronow Wilbert S WS Cardiology Division, Department of Medicine, Westchester Medical Center/New York Medical College, Valhalla, NY, USA. Electronic address: - - 2014
Prehypertension should be treated with lifestyle measures and not with antihypertensive drug therapy in older adults. Lifestyle measures should be encouraged both to retard development of hypertension and as adjunctive therapy in those with hypertension. A meta-analysis of 11 randomized controlled trials of 40,325 older persons showed that antihypertensive drug ...
Almeida Daniel D Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, - - 2014
Monitoring blood pressure under general anesthesia in animals is important to prevent hypotension and poor tissue perfusion. Thirteen sheep were enrolled to evaluate the accuracy of the petMAP, a portable non-invasive blood pressure (NIBP) monitor. Animals were anesthetized with midazolam, fentanyl, ketamine, propofol and maintained with isoflurane in oxygen for ...
Han Wei W Department of Internal Medicine, Hebei Medical University, No. 361 Zhongshan East Road, Shijiazhuang, 050017, Hebei, People's Republic of - - 2014
To investigate whether inhibition of miR-29a functioning prevents the hypertension-induced ventricular hypertrophy and fibrosis. Patients diagnosed with hypertension and left ventricular hypertrophy were recruited for the study. Serum levels of miR-29a were determined by RT-PCR. Levels of serum matrix metalloproteinase-9 (MMP-9), collagen type I and III (PINP and PIIINP) were ...
Xu Tianyuan T Department of Urology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197, 2nd Ruijin Road, Shanghai, 200025, - - 2014
To evaluate the effect of adrenal surgery on blood pressure (BP) in patients with both nonfunctional adrenal adenoma (NFA) and hypertension and to assess factors affecting hypertension outcomes after surgery. Nonfunctional adrenal adenoma patients with hypertension who were treated with or without adrenal surgery at our center during 2005-2011 were ...
Nascimento Regina A RA Department of Pharmacology, Biosciences Institute of Botucatu, Sao Paulo State University - UNESP, Botucatu, Sao Paulo, - - 2014
Intoxication with Pb (lead) results in increased blood pressure by mechanisms involving matrix metalloproteinases (MMPs). Recent findings have revealed that MMP type two (MMP-2) seems to cleave vasoactive peptides. This study examined whether MMP-2 and MMP-9 levels/activity increase after acute intoxication with low lead concentrations and if these changes were ...
Rubio-Ruiz María Esther ME Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", México, - - 2014
Aging impairs blood vessel function and leads to cardiovascular disease. The mechanisms underlying the age-related endothelial, smooth muscle and extracellular matrix vascular dysfunction are discussed. Vascular dysfunction is caused by: 1) Oxidative stress enhancement. 2) Reduction of nitric oxide (NO) bioavailability, by diminished NO synthesis and/or augmented NO scavenging. 3) ...
Bento André Moreira - - 2014
Background: The hemodynamic effects of noninvasive ventilation with positive pressure in patients with pulmonary hypertension without left ventricular dysfunction are not clearly established. Objectives: Analyze the impact of increasing airway pressure with continuous positive airway pressure on hemodynamic parameters and, in particular, on cardiac output in patients with variable degrees ...
Tremblay-Gravel Maxime M Montreal Heart Institute and Université de Montréal, Montreal, Quebec, - - 2014
To investigate the association between baseline systolic blood pressure levels and mortality in patients with AF with or without LV dysfunction. Hypertension leads to cardiovascular disease but, in specific groups, low blood pressure has been associated with a paradoxical increase in mortality. In patients with AF and heart failure, the ...
Muskalla Anne M AM Division of Internal Medicine, University Hospital of Zurich, Zurich, - - 2014
G-protein receptor kinase 4 polymorphism influences blood pressure regulation via modulation of dopamine receptor D1 in renal proximal tubular cells. We investigated the role of G-protein receptor kinase 4 polymorphism in the response to hypertensive therapy in patients with essential hypertension. In a prospective study, we assessed the G-protein receptor ...
Zhu Jiaquan J 1Division of Cardiovascular Surgery, The Labatt Family Heart Centre, The Hospital for Sick Children, 2Division of Cardiovascular Surgery, Toronto General Hospital Department of Surgery, University of Toronto, Toronto, Canada 3Cardiothoracic Surgery Department of Xinhua Hospital, Shanghai Jiaotong University, Shanghai, - - 2014
The number of patients with the failing Fontan physiology is increasing. We tested a novel in-situ micro-axial pump (Impella) to support the failing atrio-pulmonary Fontan circulation in an acute pig model. A Fontan model was established in 8 juvenile pigs by connecting the right atrium to the main pulmonary artery ...
Kollias Anastasios A Hypertension Center, STRIDE Hellas-7, Third University Department of Medicine, Sotiria Hospital, University of Athens, Athens, - - 2014
In children, out-of-office blood pressure (BP) assessment (especially ambulatory monitoring) is regarded as indispensable for accurate hypertension diagnosis. This article reviewed the evidence on the association between out-of-office BP measurements and preclinical organ damage indices in children. A systematic review and meta-analysis of 93 relevant articles (1974-2012) was performed. Analysis ...
Park Hye Y HY aDepartment of Preventive Medicine, Seoul National University College of Medicine bDepartment of Environmental Health, Graduate School of Public Health, Seoul National University cEnvironmental Health Center, Seoul National University College of Medicine, Seoul dDepartment of Biochemistry eDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu fInstitute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of - - 2014
Hypertension and vitamin D deficiency are prevalent worldwide, especially in the elderly. Considering the possibility of gene-environment contributions to disease development, we evaluated the influence of certain cytochrome P450 polymorphisms and vitamin D levels on blood pressure (BP). We measured serum 25-hydroxyvitamin D levels [25(OH)D] and BP in 535 individuals ...
Smith W W Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South - - 2014
Severe underweight may be a risk factor for hypertension in developing countries, although the manner whereby this occurs is unknown. Leptin is known to exert both beneficial and detrimental vascular effects, and is predictive of poor cardiovascular outcome at high levels, but also at low levels. We explored the relationship ...
Bebawy John F JF From the Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, - - 2014
Emergence hypertension after craniotomy is a well-documented phenomenon for which natural history is poorly understood. Most clinicians attribute this phenomenon to an acute and transient increase in catecholamine release, but other mechanisms such as neurogenic hypertension or activation of the renin-angiotensin-aldosterone system have also been proposed. In this open-label study, ...
Zullig Leah L LL Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC; Division of General Internal Medicine, Department of Medicine, Duke University, Durham, - - 2014
Hypertension is a common and costly disease among US veterans. The Veterans Affairs (VA) healthcare system is the largest integrated healthcare provider in the United States and reviewing hypertension interventions developed in the VA may inform interventions delivered in other integrated healthcare systems. This review describes behavioral interventions to improve ...
Poortvliet Rosalinde K E RK Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands; - - 2014
Visit-to-visit variability in blood pressure is an independent predictor of cardiovascular disease. This study investigates biological correlates of intra-individual variability in blood pressure in older persons. Nested observational study within the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) among 3,794 male and female participants (range 70-82 years) ...
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