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Mancia Giuseppe G aUniversity of Milano-Bicocca, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Istituto Auxologico Italiano IRCCS, Milan, Italy bFoundation Medical Research Institutes, Paris, France cInstituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil dCHU Avicenne, Unité Médecine Interne-Hypertension Artérielle, Bobigny, France eUniversity of Pisa/School of Medicine, Pisa, Italy fInstituto de Corazón de Querétaro, Querétaro, Mexico gMinistry of Health of the Russian Federation, Cardiology Research Complex, Moscow, Russia hServicio de Medicina Interna, Unidad Metabólico-Vascular, Hospital Universitario La Paz, IdiPaz, Madrid, - - 2014
An international double-blind, parallel-group, randomized controlled trial was performed to determine the efficacy and safety of a new first-line strategy in mild to moderate hypertension based on a single-pill combination of perindopril/amlodipine versus a validated stepped-care strategy (initiation with valsartan monotherapy, up-titrating to valsartan/amlodipine after 2 months). At inclusion, patients ...
Henry Thea L TL Bresmed Health Solutions, North Church House, Sheffield, S1 2DW, United - - 2014
Abstract Objectives Safety and efficacy data for catheter-based renal denervation (RDN) in the treatment of resistant hypertension have been used to estimate the cost effectiveness of this approach. However, there are no Dutch-specific analyses. We examined the cost effectiveness of RDN from the perspective of the healthcare payer in The ...
He Zheng Z Dept of Optometry & Vision Sciences, The University of Melbourne, Level 1, Kenneth Myer Building, 30 Royal Parade, Parkville, Melbourne, Victoria, 3010, - - 2014
Purpose: to consider the effect of chronic arterial hypertension on the susceptibility of the retina to acute intraocular (IOP) challenge. Methods: Anesthetized adult Long-Evans rats with normal (n=5, receiving saline subcutaneously), chronic high blood pressure (BP) for 4 weeks (n=15, Angiotensin II subcutaneously) and acute high BP for 1 hour ...
Muntner Paul P Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA; - - 2014
Several ambulatory blood pressure monitoring (ABPM) measures have been associated with increased cardiovascular disease risk independent of clinic blood pressure (BP). African Americans have higher clinic BP compared with Whites but few data are available on racial differences in ABPM measures. We compared ABPM measures between African American (n = ...
Suzuki Hiromichi H Department of Nephrology, Saitama Medical University 38 Morohonngo, Moroyama machi, Iruma gun, Saitama, 350-0495, Japan - - 2014
The guidelines for hypertension require the presence of compelling indications for pharmacological management of hypertension associated with various diseases. Data mainly obtained through randomized controlled trials have provided evidence supporting effectiveness of the combination of losartan (Lo) and hydrochlorothiazide (HCTZ) for management of hypertensive patients. However, there have been few ...
Saladini Francesca F Department of Medicine, University of Padova, Padova, - - 2014
The aim of the present study was to investigate the association of physical activity with small artery elasticity in the early stage of hypertension. We examined 366 young-to-middle-age stage 1 hypertensives (mean blood pressure 145.6±10.3/92.5±5.8 mmHg), divided into two categories of physical activity, sedentary (n=264) and non-sedentary (n=102) subjects. The ...
Zielinska-Krawczyk Monika M Department of Internal Medicine, Pneumonology and Allergology, Medical University of Warsaw, Warsaw, - - 2014
We report intriguing preliminary observations on the effect of cough on pleural pressure changes during therapeutic thoracentesis. We found that cough-related elevation of pleural pressure persisted even when the cough had stopped. Thus, we hypothesize that cough during therapeutic thoracentesis may have a beneficial effect preventing the excessive drop in ...
Ott Christian C Department of Nephrology and Hypertension, University Hospital of the Friedrich-Alexander-University Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, - - 2014
The underlying pathophysiologic concept of diverse invasive devices to treat resistant hypertension (e.g., sympathetic denervation, carotid sinus nerve stimulation) is known for a long time. Since the pioneering work in the 1940s in humans, innovative techniques have been developed resulting in less invasive treatment procedures and, hence, overcoming serious side ...
Li Yan Y Centre for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluations, Shanghai Key Lab of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, - - 2014
Hypertension is a major reversible risk factor for cardiovascular complications. According to recent guidelines, hypertension can be subdivided into isolated diastolic, isolated systolic, and systolic and diastolic mixed hypertension using proposed thresholds of various blood pressure components. In the present article, we reviewed the association of cardiovascular outcomes with diastolic ...
O'Callaghan Erin L EL School of Physiology & Pharmacology, University of Bristol, Bristol, BS8 1TD, - - 2014
Hypertension is a leading risk factor for the development of several cardiovascular diseases. As the global prevalence of hypertension increases, so too has the recognition of resistant hypertension. Whilst figures vary, the proportion of hypertensive patients that are resistant to multiple drug therapies have been reported to be as high ...
Fodor Ljiljana L aDepartment for Nephrology, Hypertension, Dialysis and Transplantation bDepartment for Diagnostic and Interventional Radiology, University Hospital Zagreb, School of Medicine, University of Zagreb, Zagreb, - - 2014
Arterial stiffness is an independent cardiovascular risk factor. Aging, high blood pressure and increased renin-angiotensin system activity contribute to increased arterial stiffness in patients with atherosclerotic renovascular hypertension (aRVH). A literature search failed to identify any study related to this topic. Therefore, our aim was to determine the arterial stiffness ...
Biaggioni Italo I Division of Clinical Pharmacology, Department of Medicine, and the Autonomic Dysfunction Center, 560 RRB, Vanderbilt University, Nashville, TN, 37232, USA, - - 2014
Orthostatic hypotension (OH) is defined as a sustained reduction of ≥20 mmHg systolic blood pressure or ≥10 mmHg diastolic blood pressure upon standing for ≤3 min. Orthostatic hypotension is commonly associated with hypertension, and its prevalence is highest in those with uncontrolled hypertension compared to those with controlled hypertension or normotensive community elderly ...
Aronow Herbert D HD Michigan Heart, 5325 Elliott Dr., Ste. #202, Ypsilanti, MI, 48197, USA, - - 2014
Device therapy for the treatment of uncontrolled and resistant hypertension has evolved significantly over the past several decades. Both renal artery disease and sympathetic hyperactivity have been linked to resistant hypertension. This manuscript will review the current evidence base supporting device therapy (e.g., renal artery revascularization, sympathetic nervous system modulation) ...
Qu En-Ze EZ Departments of Ultrasound (E.-Z.Q.) and Liver Transplantation (Y.-C.Z.), Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Ultrasound, 302 Military Hospital of China, Beijing, China (Z.-Y.L., Y.L.); and Department of Ultrasound, Peking University Third Hospital, Beijing, China - - 2014
The clinical utility of contrast-enhanced sonography in portal hypertension remains unclear. We explored the feasibility of using contrast-enhanced sonography for noninvasive assessment of portal venous pressure. Twenty healthy individuals (control group; 9 men; mean age, 46.4 years) and 18 patients with portal hypertension (15 men; mean age, 46.2 years) were ...
Shimada Taro T Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuou-ku, Chiba, 260-8670, - - 2014
The objective was to examine the effect of splenic circulation using a microbubble agent to assess the severity of portal hypertension. This prospective study consisted of 91 subjects (63.0 ± 12.6 years, 30-86; 60 males, 31 females), 62 cirrhosis and 29 controls, who underwent both Doppler ultrasound and contrast-enhanced ultrasound with a perflubutane ...
Sealy LaToya L LaToya Sealy, RN, FNP-BC, is a Practice Team Supervisor/Nurse Practitioner, ESPRIT Medical Care, Affiliate of the Visiting Nurse Service of New York, New York City, New York. Arthur Oliva, MSN, ANP-BC, is a Practice Team Supervisor/Nurse Practitioner, ESPRIT Medical Care, Affiliate of the Visiting Nurse Service of New York, New York City, New - - 2014
According to the Centers for Disease Control and Prevention (CDC), more than 65 million adults in America have hypertension (HTN) and fewer than half of those 65 million people have their blood pressure (BP) under control. More than 1,000 deaths occur each day related to HTN and Americans are at ...
Bangalore Ramachandra Abhay - - 2014
Vein maladaptation is a serious clinical problem in patients receiving coronary artery bypass grafts, renal dialysis arteriovenous fistulas, and related clinical procedures that subject veins to elevated blood flow and pressure. We propose a computational model of vein adaptation to altered pressure based on a constrained mixture theory of growth ...
Ladner Travis R TR Department of Neurosurgery, Vanderbilt University, Nashville, Tennessee, - - 2014
Aseptic cavernous sinus thrombosis (CST) is rare and may clinically masquerade as a carotid cavernous fistula. Conventional management includes oral anticoagulation, but cases of ocular hypertension affecting vision may require more aggressive intervention. We report a case of a woman with spontaneous bilaterally occluded cavernous sinuses with elevated intraocular pressure ...
Bondonno Catherine P CP School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia; - - 2014
Endothelial nitric oxide (NO) is fundamental to cardiovascular health. Dietary nitrate and nitrate from endothelial derived NO metabolism provides a significant contribution to the circulating NO pool through the nitrate-nitrite-NO pathway. A critical step in this pathway is the reduction of nitrate to nitrite by the oral microbiota. We aimed ...
Abd Elaziz Khaled M KM Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Abbassia 11566, Cairo, - - 2014
Studies have shown alarming levels of hypertension among adults in the Middle East. The aim of our study is to measure the prevalence rate of hypertension among adults in Cairo (Egypt), identify possible risk factors for the development of hypertension and assess the rates of undiagnosed and uncontrolled hypertension. Cluster ...
Bruyne Pauline De - - 2014
Hypertension has been recognized as an important health issue in the pediatric population over the past years. This emphasizes the need for an organized and effective plan for diagnosis and management. This review provides information to guide physicians through a structured approach to (1) screen children for hypertension during routine ...
Wallbach Manuel M Department of Nephrology and Rheumatology, Georg-August-University Goettingen, - - 2014
Background/Aims: Resistant hypertension and chronic kidney disease (CKD) are interlinked via sympathetic overdrive. Baroreflex activation therapy (BAT) has been shown to chronically reduce blood pressure (BP) in patients with resistant hypertension. The effect of BAT on renal function in CKD patients with resistant hypertension has not been reported. The aim ...
Faria Ana Paula Cabral de AP Faculdade de Ciências Médicas, Universidade Estadual de Campinas, São Paulo, SP, - - 2014
Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventricular diastolic dysfunction (LVDD), which ...
Thomas Kevin L KL From the Department of Medicine, Duke University, Durham, NC (K.L.T., B.R.S., R.M., M.A., R.M.C., E.D.P.); Duke Clinical Research Institute, Durham, NC (K.L.T., B.R.S., K.D.T., N.M.A.L., S.C., L.T., R.M., M.A., R.M.C., E.D.P.); Healing with CAARE, Inc, Durham, NC (S. E.-B., K.D.); Duke Translational Medicine Institute, Durham, NC (R.M.C.); Department of Medicine, Ohio State University, Columbus, OH (K.B.). - - 2014
Although home blood pressure (BP) monitoring interventions have shown potential in selected populations, it is unclear whether such strategies can be generalized. We sought to determine whether a multifaceted BP control program that uses a web-based health portal (Heart360), community health coaches, and physician assistant guidance could improve hypertension control ...
Sharma Aman A Department of Internal Medicine, PGIMER, Chandigarh, - - 2014
A common ocular manifestation of sarcoidosis is anterior uveitis. Posterior uveitis is uncommon and optic disc edema is rare. We report one such case in which the initial presentation was mimicking malignant hypertension as the patient had a recent record of high blood pressure. However, the painful progressive vision loss ...
Barochiner Jessica J Hypertension Section, Internal Medicine Department, Hospital Italiano de Buenos Aires , Buenos Aires , - - 2014
Abstract We aimed to determine a possible association between isolated morning hypertension (IMH) and meal-induced blood pressure (BP) fall in adult treated hypertensive patients who underwent home BP measurements. A total of 230 patients were included, median age 73.6, 65.2% women. After adjusting for age, sex, number of antihypertensive drugs, ...
Goessler Karla Fabiana KF Department of Physical Education, Physical Education and Sports Center, State University of Londrina , Londrina-PR , Brazil - - 2014
Abstract Purpose: This study aimed to analyze the hemodynamic and cardiac effects of direct renin inhibitor (DRI) treatment and swimming training in hypertensive rats. Methods: Seventy-seven rats were divide into eight groups: sedentary normotensive (SN), trained normotensive (TN), sedentary normotensive treated with DRI (SN_DRI), trained normotensive treated with DRI (TN_DRI), ...
Volpe Cristina C Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Internal Medicine, Division of Endocrinology, Södersjukhuset, Stockholm, - - 2014
Primary aldosteronism (PA) is the most common cause of secondary hypertension with an estimated prevalence of 4.3% among hypertensive subjects in primary care and 9.5% in referral centres (1). PA is recognized to have specific deleterious effects on the cardiovascular system in addition to the negative effects of hypertension per ...
Zhang Lu L Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2014
The present study aimed to evaluate the accuracy of the Rossmax CF175 upper-arm blood pressure monitor for home blood pressure monitoring according to the International Protocol of the European Society of Hypertension revision 2010. Systolic and diastolic blood pressures were sequentially measured in 33 adult Chinese (17 women, mean age ...
Zhu Jun J Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. - - 2014
Previous studies have demonstrated that a natural product of celery seeds, 3‑n‑butylphthalide (NBP), has significant antihypertensive effects that are widely utilized in Chinese traditional medicine. The present study aimed to investigate the effects of NBP on hypertensive nephropathy, as well as the mechanisms underlying this disease in spontaneously hypertensive rats (SHRs). SHRs ...
Doumas Michael M Michael Doumas, Antonios Lazaridis, 2 Propedeutic Department of Internal Medicine, Aristotle University, 54643 Thessaloniki, - - 2014
Hypertension is one of the most popular fields of research in modern medicine due to its high prevalence and its major impact on cardiovascular risk and consequently on global health. Indeed, about one third of individuals worldwide has hypertension and is under increased long-term risk of myocardial infarction, stroke or ...
Clark Christopher E CE Primary Care Research Group Institute of Health Services Research University of Exeter Medical School Smeall Building St Luke's Campus Magdalen Rd Exeter Devon EX1 2LU.. - - 2014
Differences in blood pressure measurements between arms are commonly encountered in clinical practice. If such differences are not excluded they can delay the diagnosis of hypertension and can lead to poorer control of blood pressure levels. Differences in blood pressure measurements between arms are associated cross sectionally with other signs ...
Hocht Christian - - 2014
Blood pressure variability (BPV) is considered nowadays a novel risk factor for cardiovascular disease. Clinical evidences support that short-term and long-term BPV independently contribute to target organ damage, cardiovascular events and mortality in patients with hypertension or diabetes. Attenuation of excessive fluctuations of systolic and diastolic BPV has been suggested ...
Schillaci Giuseppe - - 2014
Elevated nighttime blood pressure (BP) and a reduced day-night BP fall ("nondipping" condition) are strong predictors of cardiovascular complications, both in hypertension and in the general population. A reduced or inverted nocturnal BP fall might also be theoretically used to define the most appropriate timing for drug administration. In a ...
Kinstry Brian Mc - - 2014
High blood pressure (BP) is an important risk factor for stroke and ischaemic heart disease. Yet, despite the availability of effective drugs, it is generally poorly controlled. Partly this is because some patients do not adhere to treatment regimens and partly because clinicians either measure BP insufficiently frequently or are ...
White L H LH 1] Sleep Research Laboratory, Toronto Rehabilitation Institute, Toronto, Ontario, Canada [2] Centre for Sleep Medicine and Circadian Biology of the University of Toronto, Toronto, Ontario, - - 2014
Obstructive sleep apnoea (OSA) is highly prevalent in hypertensive patients, particularly those with drug resistance. Evidence from animal experiments, epidemiologic studies and clinical trials strongly suggest a causal link. Mechanistic studies argue for increased sympathetic neural activity and endothelial dysfunction. However, disturbances in fluid volume regulation and distribution may also ...
Lotufo Paulo A PA Center for Clinical and Epidemiologic Research, University of Sao Paulo, Sao Paulo, - - 2014
The frequency of resistant hypertension-defined as blood pressure (BP) ≥140/90 mm Hg with proven use of three antihypertensive medications, or as the use of four antihypertensive drug classes regardless of BP-is unknown in low-middle-income countries. Using data from the Brazilian Longitudinal Study of Adult Health, a cohort of 15,105 civil servants aged ...
Newman John H - - 2014
Pulmonary vascular capacitance (PVC) is reduced in pulmonary arterial hypertension (PAH). In normal lung PVC is largely a function of vascular compliance. In PAH, increased resistance (PVR) arises from the arterioles. PVR and PVC share pressure and volume variables. The dependency between the two qualities of the vascular bed is ...
Salazar M R MR 1] Clinica Medica, Hospital San Martín, La Plata, Buenos Aires, Argentina [2] Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, - - 2014
We evaluated the consequences of excluding the first of three blood pressure (BP) readings in different settings: a random population sample (POS, n=1525), a general practice office (GPO, n=942) and a specialized hypertension center (SHC, n=462). Differences between systolic and diastolic BP (SBP and DBP) estimates obtained including and excluding ...
Rinaldi Elisa R - - 2014
Reduction strategies of blood pressure, as a modifiable cardiovascular risk, are currently based on office assessment of brachial artery blood pressure. However, antihypertensive treatment based on brachial BP values reduces cardiovascular risk but cannot completely reverse the hypertension-induced risk of morbidity events. As is well known, BP varies in different ...
Gosmanova Elvira O EO Nephrology Division, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, - - 2014
Significant progress has been made in the management of hypertension (HTN) in the last 60 years. A large number of antihypertensive drugs (AHD) is available for effective control of elevated blood pressure (BP) that were also shown to be beneficial in improving all-cause mortality and cardiovascular morbidity in hypertensive individuals. ...
Al-Karkhi Isam I Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, - - 2014
We aimed to compare blood pressure (BP) levels recorded using the semiautomatic oscillometric Omron i-C10 BP device in patients with or without hypertension in three different settings: (a) when used by a doctor or a nurse at the office (OBP); (b) when used for self-measurement by the patient at the ...
Eugenio Ochoa Juan J Department of Health Sciences, University of Milan-Bicocca, - - 2014
Context: Epidemiological studies have shown a progressive increase in insulin resistance accompanying body weight gain and blood pressure rise. This has led to consider that hemodynamic effects of insulin resistance might depend on its relationship with body mass index and blood pressure levels. Objective: Aim of our study was to ...
Larsen Timothy R TR Department of Internal Medicine, Providence Hospital and Medical Center, Southfield, - - 2014
Masked hypertension (MH), the presence of normal office blood pressure (BP) with elevated ambulatory pressure, has been shown to correlate with organ damage. Population-based studies from Europe and Asia estimate a prevalence of 8.5% to 15.8%. Two small studies in African Americans estimate a prevalence >40%. Therefore, the authors utilized ...
Manios Efstathios E Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, - - 2014
Masked hypertension (MH) is associated with advanced target organ damage. However, patients with MH constitute a group of individuals with heterogeneous characteristics concerning their ambulatory blood pressure (BP) status. The aim of this study was to evaluate the association of isolated systolic MH, isolated diastolic MH, and systolic/diastolic MH with ...
Qin Tingli T Department of Cardiology, China-Japan Friendship Hospital, Beijing, - - 2014
To evaluate the relationship between ambulatory arterial stiffness index (AASI) and other parameters derived from ambulatory blood pressure (BP) monitoring, including dipping status, in patients with grade 1/grade 2 hypertension. This retrospective analysis included baseline data from Chinese outpatients enrolled into a previous study, who had clinic diastolic BP of ...
Ewen Sebastian S From the Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin (S.E., C.U., D.L., I.K., B.C., U.L., M.B., F.M.) and Institut für Medizinische Biometrie, Epidemiologie und Medizinische Informatik (S.W.), Universitätsklinikum des Saarlandes, Homburg/Saar, Germany; and Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen, Erlangen, Germany (R.E.S.). Sebastian.Ewen@uks.eu - - 2014
Renal denervation can reduce blood pressure in certain patients with resistant hypertension. The effect in patients with isolated systolic hypertension (ISH, ≥140/<90 mm Hg) is unknown. This study investigated the effects of renal denervation in 126 patients divided into 63 patients with ISH and 63 patients with combined hypertension (CH, ...
Egan Brent M BM Care Coordination Institute and University of South Carolina School of Medicine-Greenville, Greenville Health System, Greenville, SC - - 2014
-To reduce the cardiovascular disease burden, Healthy People 2020 established U.S. hypertension goals for adults to: (1) decrease prevalence to 26.9%. (2) raise treatment to 69.5% and control to 61.2%, which requires controlling 88.1% on treatment. -To assess current status and progress toward these Healthy People 2020 goals, time trends ...
Dörr Oliver O Department of Cardiology, University of Giessen, Klinikstr. 33, 35392, Giessen, Germany, - - 2014
Renal sympathetic denervation (RSD) represents a potential treatment option for certain patients with resistant arterial hypertension (HT). HT is associated with chronic vascular inflammation and remodeling, contributing to progressive vascular damage, and atherosclerosis. The present study aimed to evaluate the influence of RSD on cardiovascular inflammation and remodeling by determining ...
Leiria Liana F LF Cardiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, - - 2014
The association between hypertensive phenotypes of controlled hypertension (CH), white-coat effect (WCE), masked uncontrolled hypertension (MUH) and sustained hypertension (SH) with target organ damage have not been clearly established in diabetic hypertensive treated patients. The present study aims to evaluate the prevalence of the four phenotypes considering the current cut-off ...
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