Search Results
Results 251 - 300 of 2112
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Buehler Sarah - - 2013
Manual or automated control of mechanical ventilation can be realized as an open or closed-loop system for which the regulation of the ventilation parameters ideally is tuned to the dynamics and equilibration time of the biological system. We investigated the dynamic, transient state and equilibration time (teq) of the CO2 ...
Jin Yanwu - - 2013
This study compared the effects of sevoflurane and propofol on the inflammatory response and pulmonary function of patients with lung cancer during the perioperative period. Forty patients who underwent a selective resection of the inferior lobe of the left lung were randomly divided into two groups, with one group anesthetized ...
Singha Ornuma - - 2013
A one-time oral gavage can be enough to cause of alveologenic edema with higher expression of AQP-1 and -4 than that with repeated-dose oral gavage, which caused both profound perivascular edema and hydrostatic pressure edema, while AQP-5 was similarly expressed. The alteration of AQPs expression was probably related to alveolar ...
Kelly Vanessa J - - 2013
Rationale: The mechanisms underlying not well-controlled asthma (NWC) remain poorly understood but accumulating evidence points to peripheral airway dysfunction as a key contributor. The current study tests whether our recently-described respiratory system reactance (Xrs) assessment of peripheral airway dysfunction reveals insight into poor asthma control. Aim: To investigate the contribution ...
Londner Cécile - - 2013
Background: Activity-related dyspnea is the main contributor to the altered quality of life in diffuse parenchymal lung diseases (DPLD). Instruments pertaining to dyspnea are classified as pertaining to domains of sensory-perceptual experience, affective distress or symptom/disease impact; whether these domains are equally related to lung function impairments remains to be ...
Pelosi Paolo - - 2013
The occurrence of moderate to severe acute respiratory distress syndrome due to traumatic brain injury is not uncommon and is associated with an extremely high incidence of morbidity and mortality. Owing to the complex interaction between the lung and brain, protective ventilation for the lung with lower tidal volume and ...
Malte Christian Lind - - 2013
The ventilation pattern of many ectothermic vertebrates, as well as hibernating and diving endotherms, is episodic where breaths are clustered in bouts interspersed among apnoeas of varying duration. Using mechanically ventilated anaesthetized Freshwater turtles (Trachemys scripta), a species that normally exhibit this episodic ventilation pattern, we investigated whether episodic ventilation ...
Trepte Constantin J C - - 2013
The aim of this study was to evaluate the ability of static, volumetric, and dynamic parameters of cardiac preload to predict volume responsiveness during one-lung ventilation (OLV). Prospective experimental study. Laboratory of the animal facility of the University Medical Center Hamburg-Eppendorf. Twenty-three German domestic pigs. Hypovolemia was induced by withdrawing ...
Kim Shin H - - 2013
Peak inspiratory pressures (PIPs) during one-lung ventilation (OLV) have served as a clinical marker that could indirectly verify the proper positioning of double-lumen tubes (DLTs). Patients of short stature are highly susceptible to initial DLT malpositioning. We investigated the usefulness of positioning left-sided DLTs using minimum PIP differences between the ...
Park Hye Yun - - 2013
The aim of our study was to assess whether repeated derecruitments induced by the repetitive withdrawal of high positive end-expiratory pressure could induce lung injury in a swine model. Prospective, randomized, experimental animal study. University laboratory. Specific pathogen-free pigs (Choong-Ang Laboratory Animals, Seoul, Korea) weighing around 30 kg. After lung ...
Henry Nicholas R - - 2013
The apnea test (AT) is used to determine the absence of a respiratory drive when determining brain death. Current guidelines for performing the AT do not specify the size of insufflation catheter (IC) to use with each endotracheal tube (ETT) size despite previous case reports describing procedure-related complications with the ...
Wakabayashi Kenji - - 2013
Ventilator-induced lung injury has substantive impact on mortality of patients with acute respiratory distress syndrome. Although low tidal volume ventilation has been shown to reduce mortality, clinical benefits of open-lung strategy are controversial. In this study, we investigated the impact of two distinct forms of ventilator-induced lung injury, i.e., volutrauma ...
Na J U - - 2013
Different face mask designs can influence bag-valve-mask (BVM) ventilation performance during resuscitation. We compared a single-use, air-cushioned face mask (AM) with a reusable silicone face mask (SM) for quality of BVM ventilation on a manikin simulating cardiac arrest. Thirty-two physicians were recruited, and a prospective, randomized, crossover observational study was ...
Hahn G - - 2013
We studied the influence of three gravity levels (0, 1 and 1.8 g) on unilateral lung aeration in a left lateral position by the application of absolute electrical impedance tomography. The electrical resistivity of the lung tissue was considered to be a meaningful indicator for lung aeration since changes in ...
Solberg Marianne Trygg - - 2013
Ventilator treatment exposes newborns to both hyperoxemia and hyperventilation. It is not known how common hyperoxemia and hyperventilation are in neonatal intensive care units in Norway. The purpose of this study was to assess the quality of current care by studying deviations from the target range of charted oxygenation and ...
Gennai Stéphane - - 2013
Several works highlight the role of Cyclosporine A (CsA) in the prevention of ischemia reperfusion injuries (IRI), but none focus on isolated lungs. Our objective was to evaluate the effects of Cyclosporine A on ischemia reperfusion injuries on ex vivo reperfused pig lungs. Thirty-two pairs of pig lungs were collected and stored for ...
Yoshimura Tatsuya - - 2013
A rare case of a tracheal bronchus coexisting with a left-shifted carina and an acute angle of left main bronchus is presented. A 66 year old man with a history of colon cancer was scheduled for right thoracoscopic pericardial window due to recurrent pericardial effusion. After induction of anesthesia, the ...
de Prost Nicolas - - 2013
Leukocyte infiltration is central to the development of acute lung injury, but it is not known how mechanical ventilation strategy alters the distribution or activation of inflammatory cells. We explored how protective (vs. injurious) ventilation alters the magnitude and distribution of lung leukocyte activation following systemic endotoxin administration. Methods: Anesthetized ...
Mesquita Fabrício O S - - 2013
Acapella® 27 produces high frequency oscillations and positive expiratory pressure (HFOPEP) for use in bronchial hygiene. However, its performance in aerosol delivery has not been described. The aim of this study was to evaluate the effect of nebulizer configuration in relation to the HFOPEP device on deposition of radiotagged aerosols ...
Grossman Alon - - 2013
Pulmonary hypertension (PH) is frequently associated with parenchymal lung disease. To evaluate the association between spirometric values and pulmonary artery systolic pressure (PASP) in young subjects without overt lung disease METHODS:: Applicants to the Israeli air force undergo routine evaluation that includes resting spirometry and echocardiography. Applicants with evidence of ...
Bech-Hanssen Odd - - 2013
The two hemodynamic profiles in left heart disease (LHD) with pulmonary hypertension (PH), passive PH with increased pulmonary venous pressure and reactive PH with increased pulmonary vascular resistance (PVR>3 Wood units, WU), are difficult to distinguish non-invasively. We hypothesized that echocardiographic signs of pressure reflection (PR) in the pulmonary circulation ...
Mellema Matthew S - - 2013
Ventilator waveforms are graphic representations of changes in pressure, flow, and volume within a ventilator circuit. The changes in these parameters over time may be displayed individually (scalars) or plotted one against another (pressure-volume and flow-volume loops). There are 6 basic shapes of scalar waveforms, but only 3 are functionally ...
Levitt Joseph E JE Division of Pulmonary/Critical Care, Stanford University, Stanford, CA, USA. - - 2013
Mortality associated with acute lung injury remains high. Early identification of acute lung injury prior to onset of respiratory failure may provide a therapeutic window to target in future clinical trials. The recently validated Lung Injury Prediction Score identifies patients at risk for acute lung injury but may be limited ...
Whayne Thomas F TF - - 2013
Altitude physiology began with Paul Bert in 1878. Chronic mountain sickness (CMS) was defined by Carlos Monge in the 1940s in the Peruvian Andes as consisting of excess polycythemia. Hurtado et al performed studies in the Peruvian Andes in the 1950s to 1960s which defined acclimatization in healthy altitude natives, ...
Silva Pedro L - - 2013
To investigate the effects of the rate of increase in airway pressure and duration of lung recruitment maneuvers in experimental pulmonary and extrapulmonary acute lung injury. Prospective, randomized, controlled experimental study. University research laboratory. Fifty adult male Wistar rats. Acute lung injury was induced by Escherichia coli lipopolysaccharide either intratracheally ...
Curths Christoph - - 2013
Animal models with a high predictive value for human trials are needed to develop novel human-specific therapeutics against respiratory diseases. The aim of the study was to examine lung function parameters in marmoset monkeys (Callithrix jacchus) that can be used to detect pharmacologically or provocation induced airway hyperresponsiveness. Therefore, a ...
Hong Youlian - - 2013
The lunge is the most fundamental skill in badminton competitions. Fifteen university-level male badminton players performed lunge maneuvers in four directions, namely, right-forward, left-forward, right-backward, and left-backward, while wearing two different brands of badminton shoes. The test compared the kinetics of badminton shoes in performing typical lunge maneuvers. A force ...
Amini Reza - - 2013
To determine the impact of ventilation frequency, lung volume, and parenchymal stiffness on ventilation distribution, we developed an anatomically-based computational model of the canine lung. Each lobe of the model consists of an asymmetric branching airway network subtended by terminal, viscoelastic acinar units. The model allows for empiric dependencies of ...
Hu Han-Chung - - 2013
In order to reduce the contamination in the ventilator, bacterial filters were placed on the expiratory limb of a ventilator circuit. Aerosolized mucolytic agents may increase the resistance of the ventilator. The goal of this study is to determine the impact of aerosolized mucolytic agents on the pressure change during ...
Woods D R - - 2013
Our objective was to evaluate the utility of the natriuretic peptides BNP (brain natriuretic peptide) and NT-proBNP as markers of pulmonary artery systolic pressure (PASP) in trekkers ascending to high altitude (HA). 20 participants had BNP and NT-proBNP assayed and simultaneous echocardiographic assessment of PASP performed during a trek to ...
Yehya Nadir - - 2013
Airway pressure release ventilation (APRV) and high frequency oscillatory ventilation (HFOV) are frequently used in acute lung injury (ALI) refractory to conventional ventilation. Our aim was to describe our experience with APRV and HFOV in refractory pediatric ALI, and to identify factors associated with survival. We analyzed 104 patients with ...
García-Fernández Javier - - 2013
Recruitment manoeuvres aim at reversing atelectasis during general anaesthesia but are associated with potential risks such as barotrauma. To explore the range of pressures that can be used safely to fully recruit the lung without causing barotrauma in an ex-vivo healthy lung rabbit model. Prospective, randomised, experimental study. Experimental Unit, ...
Protti Alessandro - - 2013
Healthy piglets ventilated with no positive end-expiratory pressure (PEEP) and with tidal volume (VT) close to inspiratory capacity (IC) develop fatal pulmonary oedema within 36 hours. In contrast, those ventilated with high PEEP and low VT, resulting in the same volume of gas inflated (close to IC), do not. If ...
Rubini Alessandro - - 2013
Interleukin-6 has been shown to be increased in various pathological conditions involving the lungs, both experimentally induced in animals, or spontaneously occurring in humans. Experimental data demonstrating a significant role of interleukin-6 in commonly occurring respiratory system inflammatory diseases are reviewed. These diseases, i.e. asthma and chronic obstructive pulmonary disease, ...
Rubini Alessandro - - 2013
Interleukin-6 has been shown to be increased in various pathological conditions involving the lungs, both experimentally induced in animals, or spontaneously occurring in humans. Experimental data demonstrating a significant role of interleukin-6 in commonly occurring respiratory system inflammatory diseases are reviewed. These diseases, i.e. asthma and chronic obstructive pulmonary disease, ...
Santschi Miriam - - 2013
The aim of this survey was to determine North American and European pediatric intensivists' knowledge and stated practice in the management of children with acute respiratory distress syndrome with regard to mechanical ventilation settings; blood gas and SO2 targets; and use of adjunctive treatments at sites where actual practice had ...
Xie Yu - - 2013
The ratio of tricuspid regurgitation velocity divided by the velocity-time integral of right ventricular outflow tract pulsed-wave Doppler tracing (TRV/VTIRVOT ) has been used to estimate pulmonary vascular resistance (PVR). However, this method has not been validated in chronic thromboembolic pulmonary hypertension (CTEPH). We assessed the utility of TRV/VTIRVOT in ...
Makara Mariano - - 2013
In dogs, a mean broncho-arterial ratio of 1.45 ± 0.21 has been previously defined as normal. These values were obtained in dogs under general inhalational anesthesia using a single breath-hold technique. The purpose of the study was to determine whether ventilation technique and bronchial diameter have an effect on broncho-arterial ...
Oto Jun - - 2013
Ventilators used for non-invasive positive pressure ventilation (NIV) must be able to synchronize in the presence of system leaks. We compared the ability of 7 ICU ventilators and 3 dedicated NIV ventilators to compensate for leaks during pediatric NIV. Using a lung simulator, the Maquet Servo-i, the Dräger V500, the ...
Kubota Satoshi - - 2013
The present study investigates autonomic cardiovascular regulation during postural changes while in Fowler's position. Respiratory sinus arrhythmia (RSA) and sequence baroreflex sensitivity (sBRS) were measured in 12 healthy individuals in three positions (Experiment 1). We also measured RSA, sBRS, tidal volume (TV), lung volume spectrum (LV spectrum), and transfer gain ...
Bikker I G - - 2013
Background: Setting the optimal level of positive end-expiratory pressure (PEEP) in critically ill patients remains a matter of debate. 'Best' PEEP is regarded as minimal lung collapse and overdistention to prevent lung injury. In this study, global and regional variables were evaluated in a porcine model to identify which variables ...
Tyler Laurel - - 2013
Background Functional hemodynamic indicators (systolic pressure variation [SPV and SPV%] and pulse pressure variation [PPV%]) are sensitive and specific indicators of fluid responsiveness. It was unknown if these indicators could be accurately measured directly from the bedside monitor. Objective Determine the accuracy of SPV, SPV%, and PPV% measurements by using ...
Guazzi Marco - - 2013
Recently, it has become increasingly recognized that pulmonary hypertension (PH) is a particularly ominous consequence of left-sided heart failure (HF). The primary aim of this investigation was to assess the ability of key cardiopulmonary exercise testing (CPX) variables to detect elevated pulmonary pressures in a HF cohort. This was a ...
Galanis Dimitris S - - 2013
Healthy male volunteers were investigated for cardiopulmonary adaptations to a head-down posture (HDT). Thirty-three volunteers were enrolled in this study. Their changes in cardiopulmonary parameters at 15° and 30° HDT, for 7.5 minutes in each posture, were studied using echocardiography. Spirometric measurements of pulmonary function were performed during sitting and ...
Seppa Ville-Pekka - - 2013
Diagnosis of asthma in the preschoold children is difficult due to lack of objective lung function tests suitable for this age group. Impedance pneumography (IP) is a mode of measurement that may potentially enable ambulatory 24h recording of tidal breathing indices and respiratory dynamics that are known to relate to ...
Albanese Antonio - - 2013
A method for real-time noninvasive estimation of intrapleural pressure in mechanically ventilated patients is proposed. The method employs a simple first-order lung mechanics model that is fitted in real-time to flow and pressure signals acquired non-invasively at the opening of the patient airways, in order to estimate lung resistance (RL), ...
Albu Gergely G Department of Anesthesiology, Pharmacology and Intensive Care, University of Geneva, Geneva, - - 2013
Effective lung volume (ELV) for gas exchange is a new measure that could be used as a real-time guide during controlled mechanical ventilation. The authors established the relationships of ELV to static end-expiratory lung volume (EELV) with varying levels of positive end-expiratory pressure (PEEP) in healthy and surfactant-depleted rabbit lungs. ...
Lopes Fernanda Maia - - 2013
To assess the oxygenation behavior and ventilatory mechanics after hemodialysis in patients under ventilatory support. The present study was performed in the general intensive care unit of a tertiary public hospital. Patients over 18 years of age under mechanical ventilation and in need of dialysis support were included. Each patient ...
Berger Kenneth I KI André Cournand Pulmonary Physiology Laboratory, the World Trade Center Environmental Health Center, Bellevue Hospital, New York, NY 10016, USA. - - 2013
The present study (1) characterizes a physiologic phenotype of restrictive dysfunction due to airway injury and (2) compares this phenotype to the phenotype of interstitial lung disease (ILD). This is a retrospective study of 54 persistently symptomatic subjects following World Trade Center (WTC) dust exposure. Inclusion criteria were reduced vital ...
Tucci Mauro R MR Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, - - 2013
Lung derecruitment is common during general anesthesia. Mechanical ventilation with physiological tidal volumes could magnify derecruitment, and produce lung dysfunction and inflammation. The authors used positron emission tomography to study the process of derecruitment in normal lungs ventilated for 16 h and the corresponding changes in regional lung perfusion and ...
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