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Results 251 - 300 of 2139
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Hanson Josh - - 2013
Adults with severe malaria frequently require intravenous fluid therapy to restore their circulating volume. However, fluid must be delivered judiciously as both under- and over-hydration increase the risk of complications and, potentially, death. As most patients will be cared for in a resource-poor setting, management guidelines necessarily recommend that physical ...
Jaafarpour Molouk M MSc in Midwifery, Department of Midwifery, Nursing & Midwifery Faculty, Ilam University of Medical Science , Ilam, IR-Iran - - 2013
Negative Pressure Pulmonary O/Edema (NPPE) is potentially life-threatening and it is a general anaesthesia side effect. We are mentioning a rare case report of two brothers who were referred to our hospital for elective surgeries (varicocele and septoplasty) in a 3 years period. Both of them were athletes and their ...
Helmi M M Department of Intensive Care Adults, Erasmus MC, Rotterdam, the - - 2013
The last very-successful management of mechanical ventilation was in 2000 when application of low tidal volume and moderate pressure was introduced. It was then followed by the open- and baby-lung concept in order to open up the lung and keep the lung open. However, these strategies are followed with several ...
Kirschbaum Andreas - - 2013
Lung metastases can be non-anatomically resected with a Nd:YAG Laser. It is recommended that the resected lung surface be sealed by slowly resorbable sutures. However, the lung tissue may be restricted by the sutures once it is re-ventilated. Thus, it was analysed whether the lung parenchyma is airtight after laser ...
Lan Chou-Chin - - 2013
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) cause substantial morbidity and mortality despite improvements in the understanding of lung injury and advances in treatment. Recruitment maneuver (RM) with high sustained airway pressures is proposed as an adjunct to mechanical ventilation to maintain alveolar patency. In addition, RM has ...
Kauppert Christoph A - - 2013
Pulmonary hypertension (PH) is considered a clinically important feature of Obesity-Hypoventilation Syndrome (OHS). We aimed to determine prevalence, characteristics and severity of PH including associations with clinical outcomes after established non-invasive positive pressure ventilation (NPPV). In a prospective cross-sectional study, clinically stable OHS-patients (NPPV duration ≥ 3 months) were consecutively assessed using ...
Davenport John - - 2013
Cetaceans are neckless, so the trachea is very short. The upper respiratory tract is separate from the mouth and pharynx. The dorsal blowhole connects, via the vestibular and nasopalatine cavities, directly to the larynx. Toothed cetaceans (Odontoceti) are capable of producing sounds at depth, either for locating prey, or for ...
Rain Silvia - - 2013
The role of right ventricular (RV) diastolic stiffness in pulmonary arterial hypertension (PAH) is not well-established. Therefore, we investigated the presence and possible underlying mechanisms of RV diastolic stiffness in PAH-patients. Single-beat RV pressure-volume analyses were performed in 21 PAH-patients and 7 controls to study RV diastolic stiffness. Data presented ...
Biais Matthieu - - 2013
Infrarenal aortic cross-clamping (ACC) induces hemodynamic disturbances that may affect respiratory-induced variations in stroke volume and, therefore, affect the ability of dynamic parameters such as pulse-pressure variation (PPV) to predict fluid responsiveness. Since this issue has not been investigated yet to authors' knowledge, the hypothesis was tested that ACC may ...
Corley Amanda - - 2013
Airway suctioning in mechanically ventilated patients is required to maintain airway patency. Closed suction catheters (CSC) minimise lung volume loss during suctioning but require cleaning post-suction. Despite their widespread use, there is no published evidence examining lung volumes during CSC cleaning. The study objectives were to quantify lung volume changes ...
Finkelhor Robert S - - 2013
Although the echo Doppler (D) estimation of pulmonary artery systolic pressure (PASP) was initially highly correlated with right heart catheterization (RHC), recent D-RHC studies have questioned its accuracy. The aim of this study was to reevaluate this relationship and to determine possible explanations for disparate D-RHC results. We retrospectively identified ...
Wang Xiaoguang - - 2013
New methods for perfluorocarbon (PFC) application have been proposed which include aerosolization and vaporization. However, the experimental documentation of efficacy of vaporization of PFC in the treatment of acute respiratory distress syndrome (ARDS) is still lacking. This study aims to examine the effects of vaporized PFC on gas exchange and ...
Guihaire Julien - - 2013
The right ventricle (RV) faces major changes in loading conditions associated with cardiovascular and pulmonary vascular disorders. Despite major pharmacological advances since the last decade, pulmonary arterial hypertension remains a deadly disease mainly secondary to the development of right ventricular failure (RVF). Several experimental models of RVF have been developed ...
Yu Lan - - 2013
Abstract The osmotic pressure of xylitol solution at a wide concentration range was calculated according to the UNIFAC model and experimentally determined by our newly reported air humidity osmometry. The measurements from air humidity osmometry were compared with UNIFAC model calculations from dilute to saturated solution. Results indicate that air ...
Main Michael L - - 2013
Ultrasound contrast agent safety has received recent attention based on reports of associated serious adverse events. The US Food and Drug Administration requested this postmarketing study of the effects of Optison on pulmonary hemodynamics. The aim of this study was to compare Optison and a placebo for effects on pulmonary ...
Gattinoni Luciano - - 2013
In patients with acute respiratory distress syndrome (ARDS), in supine position, there is a decrease of inflation along the sternum vertebral axis, up to lung collapse. In 1991 we published a report showing that, in ARDS patients, shifting from supine to prone position led immediately to the inversion of the ...
Emr Bryanna - - 2013
IMPORTANCE Up to 25% of patients with normal lungs develop acute lung injury (ALI) secondary to mechanical ventilation, with 60% to 80% progressing to acute respiratory distress syndrome (ARDS). Once established, ARDS is treated with mechanical ventilation that can paradoxically elevate mortality. A ventilation strategy that reduces the incidence of ...
Hooper Stuart B - - 2013
The transition to newborn life critically depends upon lung aeration and the onset of air-breathing, which triggers major cardiovascular changes required for postnatal life, including increases in pulmonary blood flow. Recent imaging studies indicate that lung aeration and functional residual capacity (FRC) recruitment results from inspiratory efforts, which create transpulmonary ...
Sawatdee Somchai - - 2013
Sildenafil citrate is a selective phosphodiesterase-5 inhibitor used for the treatment of erectile dysfunction and pulmonary hypertension. The delivery of sildenafil directly to the lung could have several advantages over conventional treatments for pulmonary hypertension because of the local delivery, a more rapid onset of response, and reduced side effects. ...
Bermejo Silvia - - 2013
Almitrine enhances hypoxic pulmonary vasoconstriction (HPV) and can improve hypoxemia related to one-lung ventilation (OLV). Studies using almitrine have been conducted without inhaled anesthetics because they could inhibit HPV, counteracting the effect of almitrine. This hypothesis, however, has not been confirmed. This study's aim was to evaluate whether almitrine could ...
Maccari Juçara Gasparetto - - 2013
There have been few reports of factors affecting aerosol delivery during noninvasive ventilation (NIV). Nebulization is a standard practice and our objective was to determine the effect of spontaneous breathing and NIV mode on 99m-Technetium (Tc) lung deposition in subjects with normal lung. Thirteen healthcare volunteers were submitted to a ...
Lampland Andrea L - - 2013
Surfactant therapy may be beneficial in acute lung injury (ALI). In spontaneously breathing newborn pigs with ALI supported with continuous positive airway pressure (CPAP), we evaluated the hypothesis that aerosolized KL4 surfactant (AERO KL4 S) would provide a similar therapeutic effect as intratracheal KL4 surfactant (ETT KL4 S) when compared ...
Linnarsson Dag - - 2013
Lung diffusing capacity for NO (DLNO) was determined in eight subjects at ambient pressures of 505, 1,015, and 4,053 hPa (379, 761 and 3,040mmHg) as they breathed normoxic gases. Mean values were 116.9+- 11.1 (SEM), 113.4+- 11.1 and 99.3+- 10.1 ml min-1 hPa-1 at 505, 1,015, and 4,053 hPa, with ...
Yang Yi - - 2013
Intra-abdominal hypertension (IAH) is common in acute respiratory distress syndrome (ARDS) patients and when resulting in decrease of chest wall compliance will weaken the effect of positive end expiratory pressure (PEEP). We investigated the effect of PEEP titrated by transpulmonary pressure (Ptp) on oxygenation and respiratory mechanics in ARDS patients ...
Stratta C - - 2013
Portopulmonary hypertension has been reported in 2% to 9% of candidates for liver transplantation (OLT). If it is moderate to severe, it represents a contraindication to the procedure until pulmonary vasodilatative therapy has been optimized. We report the case of a 43-year-old man, scheduled for OLT due to alcoholic cirrhosis ...
van Gestel Arnoldus J R - - 2013
Chronic obstructive pulmonary disease (COPD) has been associated with increased risk for cardiovascular disease but mechanisms underlying this association are incompletely understood. The speed of beat-to-beat changes in systolic blood pressure (vSBP) was found to be pronounced in patients with elevated cardiovascular risk. Although increased vSBP may thus be a ...
Buehler Sarah - - 2013
Manual or automated control of mechanical ventilation can be realized as an open or closed-loop system for which the regulation of the ventilation parameters ideally is tuned to the dynamics and equilibration time of the biological system. We investigated the dynamic, transient state and equilibration time (teq) of the CO2 ...
Jin Yanwu - - 2013
This study compared the effects of sevoflurane and propofol on the inflammatory response and pulmonary function of patients with lung cancer during the perioperative period. Forty patients who underwent a selective resection of the inferior lobe of the left lung were randomly divided into two groups, with one group anesthetized ...
Singha Ornuma - - 2013
A one-time oral gavage can be enough to cause of alveologenic edema with higher expression of AQP-1 and -4 than that with repeated-dose oral gavage, which caused both profound perivascular edema and hydrostatic pressure edema, while AQP-5 was similarly expressed. The alteration of AQPs expression was probably related to alveolar ...
Roy Shreyas K SK Department of Surgery, Upstate Medical University, Syracuse, NY 13210, - - 2013
Once established, the acute respiratory distress syndrome (ARDS) is highly resistant to treatment and retains a high mortality. We hypothesized that preemptive application of airway pressure release ventilation (APRV) in a rat model of trauma/hemorrhagic shock (T/HS) would prevent ARDS. Rats were anesthetized, instrumented for hemodynamic monitoring, subjected to T/HS, ...
Kelly Vanessa J - - 2013
Rationale: The mechanisms underlying not well-controlled asthma (NWC) remain poorly understood but accumulating evidence points to peripheral airway dysfunction as a key contributor. The current study tests whether our recently-described respiratory system reactance (Xrs) assessment of peripheral airway dysfunction reveals insight into poor asthma control. Aim: To investigate the contribution ...
Londner Cécile - - 2013
Background: Activity-related dyspnea is the main contributor to the altered quality of life in diffuse parenchymal lung diseases (DPLD). Instruments pertaining to dyspnea are classified as pertaining to domains of sensory-perceptual experience, affective distress or symptom/disease impact; whether these domains are equally related to lung function impairments remains to be ...
Pelosi Paolo - - 2013
The occurrence of moderate to severe acute respiratory distress syndrome due to traumatic brain injury is not uncommon and is associated with an extremely high incidence of morbidity and mortality. Owing to the complex interaction between the lung and brain, protective ventilation for the lung with lower tidal volume and ...
Malte Christian Lind - - 2013
The ventilation pattern of many ectothermic vertebrates, as well as hibernating and diving endotherms, is episodic where breaths are clustered in bouts interspersed among apnoeas of varying duration. Using mechanically ventilated anaesthetized Freshwater turtles (Trachemys scripta), a species that normally exhibit this episodic ventilation pattern, we investigated whether episodic ventilation ...
Trepte Constantin J C - - 2013
The aim of this study was to evaluate the ability of static, volumetric, and dynamic parameters of cardiac preload to predict volume responsiveness during one-lung ventilation (OLV). Prospective experimental study. Laboratory of the animal facility of the University Medical Center Hamburg-Eppendorf. Twenty-three German domestic pigs. Hypovolemia was induced by withdrawing ...
Kim Shin H - - 2013
Peak inspiratory pressures (PIPs) during one-lung ventilation (OLV) have served as a clinical marker that could indirectly verify the proper positioning of double-lumen tubes (DLTs). Patients of short stature are highly susceptible to initial DLT malpositioning. We investigated the usefulness of positioning left-sided DLTs using minimum PIP differences between the ...
Park Hye Yun - - 2013
The aim of our study was to assess whether repeated derecruitments induced by the repetitive withdrawal of high positive end-expiratory pressure could induce lung injury in a swine model. Prospective, randomized, experimental animal study. University laboratory. Specific pathogen-free pigs (Choong-Ang Laboratory Animals, Seoul, Korea) weighing around 30 kg. After lung ...
Henry Nicholas R - - 2013
The apnea test (AT) is used to determine the absence of a respiratory drive when determining brain death. Current guidelines for performing the AT do not specify the size of insufflation catheter (IC) to use with each endotracheal tube (ETT) size despite previous case reports describing procedure-related complications with the ...
Wakabayashi Kenji - - 2013
Ventilator-induced lung injury has substantive impact on mortality of patients with acute respiratory distress syndrome. Although low tidal volume ventilation has been shown to reduce mortality, clinical benefits of open-lung strategy are controversial. In this study, we investigated the impact of two distinct forms of ventilator-induced lung injury, i.e., volutrauma ...
Na J U - - 2013
Different face mask designs can influence bag-valve-mask (BVM) ventilation performance during resuscitation. We compared a single-use, air-cushioned face mask (AM) with a reusable silicone face mask (SM) for quality of BVM ventilation on a manikin simulating cardiac arrest. Thirty-two physicians were recruited, and a prospective, randomized, crossover observational study was ...
Hahn G - - 2013
We studied the influence of three gravity levels (0, 1 and 1.8 g) on unilateral lung aeration in a left lateral position by the application of absolute electrical impedance tomography. The electrical resistivity of the lung tissue was considered to be a meaningful indicator for lung aeration since changes in ...
Solberg Marianne Trygg - - 2013
Ventilator treatment exposes newborns to both hyperoxemia and hyperventilation. It is not known how common hyperoxemia and hyperventilation are in neonatal intensive care units in Norway. The purpose of this study was to assess the quality of current care by studying deviations from the target range of charted oxygenation and ...
Gennai Stéphane - - 2013
Several works highlight the role of Cyclosporine A (CsA) in the prevention of ischemia reperfusion injuries (IRI), but none focus on isolated lungs. Our objective was to evaluate the effects of Cyclosporine A on ischemia reperfusion injuries on ex vivo reperfused pig lungs. Thirty-two pairs of pig lungs were collected and stored for ...
Yoshimura Tatsuya - - 2013
A rare case of a tracheal bronchus coexisting with a left-shifted carina and an acute angle of left main bronchus is presented. A 66 year old man with a history of colon cancer was scheduled for right thoracoscopic pericardial window due to recurrent pericardial effusion. After induction of anesthesia, the ...
de Prost Nicolas - - 2013
Leukocyte infiltration is central to the development of acute lung injury, but it is not known how mechanical ventilation strategy alters the distribution or activation of inflammatory cells. We explored how protective (vs. injurious) ventilation alters the magnitude and distribution of lung leukocyte activation following systemic endotoxin administration. Methods: Anesthetized ...
Mesquita Fabrício O S - - 2013
Acapella® 27 produces high frequency oscillations and positive expiratory pressure (HFOPEP) for use in bronchial hygiene. However, its performance in aerosol delivery has not been described. The aim of this study was to evaluate the effect of nebulizer configuration in relation to the HFOPEP device on deposition of radiotagged aerosols ...
Grossman Alon - - 2013
Pulmonary hypertension (PH) is frequently associated with parenchymal lung disease. To evaluate the association between spirometric values and pulmonary artery systolic pressure (PASP) in young subjects without overt lung disease METHODS:: Applicants to the Israeli air force undergo routine evaluation that includes resting spirometry and echocardiography. Applicants with evidence of ...
Bech-Hanssen Odd - - 2013
The two hemodynamic profiles in left heart disease (LHD) with pulmonary hypertension (PH), passive PH with increased pulmonary venous pressure and reactive PH with increased pulmonary vascular resistance (PVR>3 Wood units, WU), are difficult to distinguish non-invasively. We hypothesized that echocardiographic signs of pressure reflection (PR) in the pulmonary circulation ...
Mellema Matthew S - - 2013
Ventilator waveforms are graphic representations of changes in pressure, flow, and volume within a ventilator circuit. The changes in these parameters over time may be displayed individually (scalars) or plotted one against another (pressure-volume and flow-volume loops). There are 6 basic shapes of scalar waveforms, but only 3 are functionally ...
Levitt Joseph E JE Division of Pulmonary/Critical Care, Stanford University, Stanford, CA, USA. - - 2013
Mortality associated with acute lung injury remains high. Early identification of acute lung injury prior to onset of respiratory failure may provide a therapeutic window to target in future clinical trials. The recently validated Lung Injury Prediction Score identifies patients at risk for acute lung injury but may be limited ...
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