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Results 201 - 250 of 2174
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Rossier Bernard C BC Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland. Electronic address: - - 2014
The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is regulated by aldosterone and hormones involved in ...
Boussen S - - 2013
Previous studies on ventilators used for air transport showed significant effects of altitude,in particular in regards to the accuracy of the tidal volume (VT) and respiratory rate. The aim of the study was to evaluate transport ventilators under hypobaric conditions. We conducted a bench study of six transport ventilators in ...
Antonelli Andrea A Allergologia e Fisiopatologia Respiratoria, ASO S. Croce e Carle, Cuneo, - - 2013
We hypothesized that dyspnea and its descriptors, that is, chest tightness, inspiratory effort, unrewarded inspiration, and expiratory difficulty in asthma reflect different mechanisms of airflow obstruction and their perception varies with the severity of bronchoconstriction. Eighty-three asthmatics were studied before and after inhalation of methacholine doses decreasing the 1-sec forced ...
Vitarelli Antonio - - 2013
The aim of this study was to assess changes in right ventricular (RV) parameters determined by three-dimensional (3D) echocardiography and speckle-tracking echocardiography in patients with acute pulmonary embolism and RV dysfunction without systemic hypotension (submassive pulmonary embolism). Sixty-six patients were prospectively studied at the onset of the acute episode and ...
D'Andrea Antonello - - 2013
ABSTRACT BACKGROUND. Although transthoracic echocardiography (TTE) is an excellent non-invasive screening test for pulmonary hypertension, the physiologic range of echo-Doppler derived pulmonary pressures remains not completely investigated. The aim of the present study was therefore to explore the full spectrum of pulmonary pressures and RV functional indexes by TTE in ...
Malikiwi Andra - - 2013
Vasopressin is emerging as a therapeutic adjunct option towards treatment of shock states in the pediatric population. Its effects on pulmonary vasculature are less well understood. This report describes a 5-month-old infant with nitric oxide-unresponsive pulmonary hypertension, oxygenation failure, and systemic hypotension. Vasopressin therapy improved oxygenation and blood pressure and ...
Cereda Maurizio M * Assistant Professor, Department of Anesthesiology and Critical Care, † Research Specialist, ‡ Project Manager, § Student, ‖ Research Assistant Professor, # Technical Director, ‡‡ Professor, Department of Radiology, †† Professor, Department of Anesthesiology and Critical Care and Stavropoulos Sepsis Research Program, University of Pennsylvania, Philadelphia, Pennsylvania. ** Professor, Departments of Critical Care Medicine and Anesthesia, Hospital for Sick Children, University of Toronto, Toronto, Ontario, - - 2013
Although it is recognized that pulmonary hysteresis can influence the effects of positive end-expiratory pressure (PEEP), the extent to which expansion of previously opened (vs. newly opening) peripheral airspaces contribute to increased lung volume is unknown. Following a recruitment maneuver, rats were ventilated with constant tidal volumes and imaged during ...
Heresi Gustavo A GA Department of Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, - - 2013
Normal resting mean pulmonary artery pressure (PAP) is 8-20 mmHg. Pulmonary hypertension is defined as mean PAP of ≥25 mmHg. Borderline PAP levels of 21-24 mmHg are of unclear significance. We sought to determine the clinical characteristics and survival of subjects with mean PAP of 21-24 mmHg. We examined 1,491 ...
Maron Bradley A BA Department of Cardiology, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA ; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, - - 2013
In patients with chronic obstructive pulmonary disease (COPD), moderate or severe pulmonary hypertension (COPD-PH) is associated with increased rates of morbidity and mortality. Despite this, approaches to treatment and the efficacy of phosphodiesterase type 5 inhibition (PDE-5i) in COPD-PH are unresolved. We present the clinical rationale and study design to ...
Zhang Ji-Zhuo - - 2013
Pediatric patients are susceptible to lung injury that does not respond to traditional therapies. Partial liquid ventilation (PLV) has been developed as an alternative ventilatory strategy for treating severe lung injury. The aim of this study is to investigate the effect of PLV on lung function in immature piglets. Acute ...
Wang Chao-Hong - - 2013
Pulmonary hypertension (PH) is a set of pathophysiological syndromes characterized by increased pulmonary artery pressure and pulmonary vascular resistance, resulting in increased right ventricular afterload. The left and right ventricles interact through hemodynamics. What impact will PH have on synchronization and function of the left ventricle (LV)? The aim of ...
de Andrade Armèle Dornelas - - 2013
Immersion in water, with the head above the water line, causes acute physiological changes in the pulmonary and cardiovascular systems. The aim of this study was to evaluate the acute physiological responses to immersion on lung volumes and respiratory muscle strength at different depths. A cross-sectional study was conducted in ...
Yang Yi - - 2013
Background: In the acute respiratory distress syndrome (ARDS), lung-protective ventilation strategies combine the delivery of small tidal volumes (VT) with sufficient positive end-expiratory pressure (PEEP). However, an optimal approach guiding the setting of PEEP has not been defined. Monitoring volumetric capnography is useful to detect changes in lung aeration. Objectives: ...
Tedford Ryan J RJ Division of Cardiology, Department of Medicine. Electronic address: - - 2013
Although the transpulmonary gradient (TPG) and pulmonary vascular resistance (PVR) are commonly used to differentiate heart failure patients with pulmonary vascular disease from those with passive pulmonary hypertension (PH), elevations in TPG and PVR may not always reflect pre-capillary PH. Recently, it has been suggested an elevated diastolic pulmonary artery ...
De Lazzari Claudio C C.N.R., Institute of Clinical Physiology, U.O.S. of Rome, Italy; National Institute of Cardiovascular Research, Bologna, Italy. Electronic address: - - 2013
Patients assisted with left ventricular assist device (LVAD) may require prolonged mechanical ventilatory assistance secondary to postoperative respiratory failure. The goal of this work is the study of the interdependent effects LVAD like pulsatile catheter (PUCA) pump and mechanical ventilatory support or thoracic artificial lung (TAL), by the hemodynamic point ...
Van De Wauwer Caroline C Laboratory for Experimental Thoracic Surgery, Department of Thoracic Surgery, KU Leuven, Leuven, - - 2013
Formation of microthrombi after circulatory arrest is a concern for the development of reperfusion injury in lung recipients from donation after circulatory death (DCD) donors. In this isolated lung reperfusion study, we compared the effect of postmortem heparinization with preharvest retrograde pulmonary flush or both. Domestic pigs (n = 6/group) were sacrificed ...
Aslan Goksen Kuran - - 2013
Objective:To investigate the effects of inspiratory and expiratory muscle training on pulmonary functions in patients with slowly progressive neuromuscular disease.Design:Prospective randomized controlled double-blinded study.Setting:Chest diseases clinic of university hospital.Subjects:Twenty-six patients with slowly progressive neuromuscular disease followed for respiratory problems were included in the study. Patients were randomly divided into two ...
Pecchiari Matteo - - 2013
Recent studies in healthy mice and rats have reported that positive pressure ventilation delivered with physiological tidal volumes at normal end-expiratory volume worsens lung mechanics and induces cytokine release, thus suggesting that detrimental effects are due to positive pressure ventilation per se. The aim of this study in healthy animals ...
Cressoni Massimo - - 2013
Rationale: Pressures and volumes needed to induce ventilator-induced lung injury in healthy lungs are far greater than applied in diseased lungs. A possible explanation may be the presence of local inhomogeneities acting as pressure multipliers (stress raisers). Objectives: quantify lung inhomogeneities in patients with Acute Respiratory Distress Syndrome (ARDS). Methods: ...
Tingay David G - - 2013
Background:Sustained inflation (SI) at birth facilitates establishment of functional residual capacity in the preterm lung, but the ideal lung recruitment strategy is unclear. We have compared the effect of SI and a step-wise positive end-expiratory pressure (PEEP; SEP) strategy in a preterm model.Methods:127d gestation lambs received either A) 20-s SI ...
Riffard Guillaume - - 2013
Previous bench studies suggest that dynamic hyperinflation may occur if Intrapulmonary Percussive Ventilation (IPV) is superimposed to mechanical ventilation in volume controlled continuous mandatory ventilation mode (VC-CMV). We tested the hypothesis that pressure controlled continuous mandatory ventilation mode (PC-CMV) can protect against this risk. ICU ventilator was connected to an ...
Minai Omar A - - 2013
We explored the prevalence, clinical and physiologic correlates of pulmonary hypertension (PH), and screening strategies in patients with severe emphysema evaluated for the National Emphysema Treatment Trial (NETT). Patients undergoing Doppler echocardiography (DE) and right heart catheterization were included. Patients with mean pulmonary arterial pressure ≥25 mmHg (PH Group) were compared ...
Masuda Yoshiki - - 2013
Prone ventilation is an effective method for improving oxygenation in patients with acute respiratory failure. However, in extracorporeal circulation, there is a risk of cannula-related complications when changing the position. In this study, we investigated cannula-related complications when changing position for prone ventilation and the effect of prone ventilation on ...
Chen Tongyun - - 2013
To compare the therapeutic efficacy of recombinant human brain natriuretic peptide and prostaglandin E1 in the treatment of pulmonary hypertension after mitral valve replacement. Sixty patients with postoperative pulmonary hypertension were divided randomly into 3 groups that received saline, prostaglandin E1, and natriuretic peptide infusions for 12 hours each. The ...
Arvela H - - 2013
Low-energy and passive house construction practices are characterised by increased insulation, high air tightness of the building shell and controlled mechanical ventilation with heat recovery. As a result of the interaction of mechanical ventilation and high air tightness, the pressure difference in a building can be markedly enhanced. This may ...
Ismail M - - 2013
In many biomedical flow problems, reversed flows along with standard treatment of Neumann boundary conditions can cause instabilities. We have developed a method that resolves these instabilities in a consistent way while maintaining correct pressure and flow rate values. We also are able to remove the necessary prescription of both ...
Frazziano Giovanna G Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, - - 2014
Pulmonary arterial hypertension is a severe progressive disease with marked morbidity and high mortality in which right ventricular (RV) failure is the major cause of death. Thus knowledge of the mechanisms underlying RV failure is an area of active interest. Previous studies suggest a role of NADPH oxidase in cardiomyocyte ...
Yoshida Takeshi - - 2013
Rationale: In normal lungs, local changes in pleural pressure (Ppl) are generalized over the whole pleural surface. However, in a patient with injured lungs, we observed (using electrical impedance tomography, EIT) a Pendelluft phenomenon, i.e. movement of air within the lung from non-dependent to dependent regions without change in tidal ...
Farina Stefania - - 2013
The objective of this study was to evaluate inert gas rebreathing (IGR) reliability in cardiac output (CO) measurement compared with Fick method and thermodilution. IGR is a noninvasive method for CO measurement; CO by IGR is calculated as pulmonary blood flow plus intrapulmonary shunt. IGR may be ideal for follow-up ...
Chiumello Davide - - 2013
Positive end-expiratory pressure exerts its effects keeping open at end-expiration previously collapsed areas of the lung; consequently, higher positive end-expiratory pressure should be limited to patients with high recruitability. We aimed to determine which bedside method would provide positive end-expiratory pressure better related to lung recruitability. Prospective study performed between ...
Wahab Romina - - 2013
Following the classic 'iron lung' non-invasive negative pressure ventilator, non-invasive positive pressure ventilation (NIPPV), particularly used 'nocturnally' has developed a broad role in both the acute hospital setting and domiciliary long-term use for many cardio-respiratory disorders associated with acute and chronic ventilatory failure. This role is based in part upon ...
Jenab Yaser - - 2013
Objectives- There are few studies evaluating serial changes in tissue Doppler imaging parameters in acute pulmonary thromboembolism. We aimed to compare these changes in male and female patients separately. Methods- Between September 2010 and September 2011, 41 of 64 hemodynamically stable acute patients with pulmonary thromboembolism were included in the ...
Almeida Vívian Pinto de - - 2013
Asthma may cause systemic repercussions due to its severity and the effects of treatment. Our objective was to compare posture, balance, functional capacity, and quality of life (QOL) according to the severity of disease, as assessed by pulmonary function levels. This cross-sectional study evaluated fifty individuals with asthma. We compared ...
Koo H-K - - 2013
Factors that influence the annual rate of decline of lung function need to be verified. To determine the effects of metabolic syndrome, especially hypertension, on the annual rate of decline in lung function. A total of 635 healthy participants without known respiratory disease completed baseline and follow-up routine check-ups, including ...
Suki Béla B Department of Biomedical Engineering, Boston University, Boston, - - 2013
Transpulmonary pressure and the mechanical stresses of breathing modulate many essential cell functions in the lung via mechanotransduction. We review how mechanical factors could influence the pathogenesis of emphysema. Although the progression of emphysema has been linked to mechanical rupture, little is known about how these stresses alter lung remodeling. ...
Kamphuis Vivian P VP Department of Cardiology, Leiden University Medical Center, The - - 2013
Early, preferably noninvasive, detection of pulmonary hypertension improves prognosis. Our study evaluated the diagnostic accuracy of the electrocardiographically derived Butler-Leggett (BL) score and ventricular gradient (VG) to estimate mean pulmonary artery pressure (PAP). In 63 patients with suspected pulmonary hypertension, BL score and VG were calculated. The VG was projected ...
Spieth Peter M - - 2013
This study aims at comparing the very short-term effects of conventional and noisy (variable) pressure support ventilation (PSV) in mechanically ventilated patients with acute hypoxemic respiratory failure. 13 mechanically ventilated patients with acute hypoxemic respiratory failure were enrolled in this monocentric, randomized crossover study. Patients were mechanically ventilated with conventional ...
Schumann S - - 2013
Background: Differences between inspiratory and expiratory lung mechanics result in the hysteresis of the pressure volume-loop. While hysteresis area is a global parameter describing the difference between inspiration and expiration in mechanics under quasi-static conditions, a detailed analysis of this difference under the dynamic conditions of mechanical ventilation is feasible ...
Kiss Thomas - - 2013
In pressure support ventilation (PSV), a non-variable level of pressure support is delivered by the ventilator when triggered by the patient. In contrast, variable PSV delivers a level of pressure support that varies in a random fashion, introducing more physiological variability to the respiratory pattern. Experimental studies show that variable ...
Boerrigter Bart G - - 2013
Respiratory influences are a major confounder when evaluating central hemodynamics during exercise. We studied four different methods to assess mean pulmonary artery pressure (mPAP) and pulmonary capillary wedge pressure (PCWP) in case of respiratory swings.Central hemodynamics were measured simultaneously with esophageal pressure during exercise in 30 COPD-patients. mPAP and PCWP ...
Eising Jacobien B - - 2013
Several studies have shown that raised cardiovascular risk factors are associated with an impaired lung function in adulthood. Whether this association also exists in the young is unknown. Our aim was to study the relation between blood pressure and lung function from neonatal to elderly age. This was a cross-sectional ...
Rose Louise L Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada; Provincial Centre of Weaning Excellence/Prolonged Ventilation Weaning Centre, Toronto East General Hospital, Toronto, Ontario, Canada; Mount Sinai Hospital and the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada. Electronic address: - - 2014
To inform development of educational tools, we sought to identify initial ventilator settings and monitoring targets for 3 scenarios. A survey was e-mailed to Canadian Society of Respiratory Therapists members with 2 reminders in March/April 2011. Total evaluable surveys were 363. More participants selected pressure as opposed to volume ventilation ...
Ju N Y - - 2013
This prospective, double-blind trial was designed to evaluate the effect of inhaled budesonide on lung function and the inflammatory response to one-lung ventilation. One hundred patients scheduled for lobectomy were allocated randomly to pre-operative nebulised budesonide or saline. Bronchoalveolar lavage fluid samples were collected from either the collapsed or the ...
Fornasa E - - 2013
A new device delivering intrapulmonary percussive ventilation (IPV), called Impulsator® (Percussionaire Corporation, Sandpoint, ID, USA), has recently been introduced in an effort to provide effective clearance and to promote homogeneity of ventilation in the lungs of patients with cystic fibrosis. In order to optimize the treatment based on its use, ...
Pomprapa Anake - - 2013
The aim is to provide better understanding of carbon dioxide ([Formula: see text]) elimination during ventilation for both the healthy and atelectatic condition, derived in a pressure-controlled mode. Therefore, we present a theoretical analysis of [Formula: see text] elimination of healthy and diseased lungs. Based on a single-compartment model, [Formula: ...
Nomori Hiroaki - - 2013
Fibrin glue in combination with polyglycolic acid (PGA) mesh is effective in preventing air leakage after segmentectomy, but we frequently experienced air leakage with single-layer application. To investigate improved usage, we compared the sealing effect among single-, double- and triple-layer PGA mesh and fibrin glue in both experimental and clinical ...
Diraimondo Thomas R - - 2013
Previous studies in human patients and animal models have suggested that transglutaminase 2 (TG2) is upregulated in pulmonary hypertension (PH), a phenomenon that appears to be associated with the effects of serotonin (5-hydroxytryptamine; 5-HT) in this disease. Using chemical tools to interrogate and inhibit TG2 activity in vivo, we have ...
Falaize Line - - 2013
Battery life (BL) of portable home ventilators batteries are reported by manufacturers. The aim of the study was to evaluate the effects of ventilatory mode, respiratory frequency, positive end-expiratory pressure (PEEP), and leaks on the BL of 5 commercially available portable ventilators. The effect of the ventilatory mode (volume controlled-continuous ...
Banner Michael J - - 2013
A decision support, rule-based oxygenation advisor that provides guidance for setting positive end expiratory pressure (PEEP) and fractional inhaled oxygen concentration (FIO2) for patients with respiratory failure is described. The target oxygenation goal is to achieve and maintain pulse oximeter oxygen saturation (SpO2) ≥88 and ≤95 %, as posited by the ...
Terzi Nicolas - - 2013
To investigate breathing-swallowing interactions in patients with chronic obstructive pulmonary disease requiring noninvasive mechanical ventilation and, if needed, to develop a technical modification of the ventilator designed to eliminate ventilator insufflations during swallowing. We conducted a prospective, open-label, interventional study. Fifteen consecutive COPD patients with exacerbations requiring ICU admission and ...
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