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Mirabella Lucia - - 2014
Experimental work provides insight into potential lung protective strategies. The objective of this study was to evaluate markers of ventilator-induced lung injury after two different ventilation approaches: (1) a "conventional" lung-protective strategy (volume control (VC) with low tidal volume, positive end-expiratory pressure (PEEP) and paralysis), (2) a physiological approach with ...
Borges João Batista JB 1Hedenstierna Laboratory, Department of Surgical Sciences, Section of Anaesthesiology & Critical Care, Uppsala University, Uppsala, Sweden. 2Pulmonary Divison, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. 3Research and Education Institute, Hospital Sírio Libanês, São Paulo, Brazil. 4Centros de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. 5Department of Hospital Physics, Uppsala University Hospital, Uppsala, Sweden. 6Hedenstierna Laboratory, Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, - - 2014
The common denominator in most forms of ventilator-induced lung injury is an intense inflammatory response mediated by neutrophils. PET with [F]fluoro-2-deoxy-D-glucose can be used to image cellular metabolism, which, during lung inflammatory processes, mainly reflects neutrophil activity, allowing the study of regional lung inflammation in vivo. The aim of this ...
Fortis Spyridon S Department of Medicine, Bridgeport Hospital, Yale University, Bridgeport, CT, - - 2014
With increasing realization that sedatives may complicate care of mechanically ventilated patients, greater emphasis might turn to promoting comfort by titration of ventilator settings. Patients with acute on chronic respiratory failure (ACRF) with underlying chronic obstructive pulmonary disease (COPD) demonstrate different levels of comfort in response to varying ventilator settings ...
Al Shehri Abdullah M AM - - 2014
To test the effects of pressure-controlled (PCV) and volume-controlled (VCV) ventilation during one-lung ventilation (OLV) for thoracic surgery on right ventricular (RV) function. A prospective, randomized, double-blind, controlled, crossover study. A single university hospital. Fourteen pairs of consecutive patients scheduled for elective thoracotomy. Patients were assigned randomly to ventilate the ...
Haddad Jorge L JL Division of Cardiology, Department of Internal Medicine, Hospital das Clínicas - Ribeirão Preto Medical School, University of São Paulo, - - 2014
Objective: The objective of the study was to analyse the use of the pressure wire for the acquisition of intravascular pulmonary pressures in the presence of pulmonary atresia and systemic-dependent pulmonary blood flow. Methods: In this study, we included patients with pulmonary atresia and systemic-dependent pulmonary circulation referred for diagnostic ...
Tamplin J J University of Melbourne, Melbourne, Victoria, - - 2014
Study design:Systematic reviewObjectives:To determine the effect of respiratory muscle training (RMT) on pulmonary function in tetraplegia.Methods:A comprehensive search of the research literature included MEDLINE, EMBASE, CINAHL, ISI Web of Science, PubMed, the relevant Cochrane and clinical trials registers and hand-searching the reference lists of appropriate papers. There was no language ...
Paradies P P Department of Emergency and Organs Transplantations, Veterinary Section, Internal Medicine Unit, University of Bari, Strada Provinciale Per Casamassima Km 3, 70010, Valenzano, Bari, Italy, - - 2014
Pulmonary hypertension (PH) decreases resistance to fatigue and life expectancy. The aim of this study was to correlate some indirect Doppler indices of PH with tricuspid and pulmonary regurgitation criteria and to relate PH on different indices with the severity of clinical signs. Furthermore the pathogenetic mechanisms associated to PH ...
Nozoe Masafumi M Department of Rehabilitation, Hyogo College of Medicine Sasayama Medical Center, Kurooka 5, Sasayama, Hyogo, Japan; Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Konan Women's University; Department of Rehabilitation, Konan Kakogawa Hospital; Department of General Medicine and Community Health Science, Hyogo College of Medicine; Department of Functional Regenerative Science, Hyogo College of Medicine; Department of Rehabilitation Medicine, Hyogo College of Medicine. Electronic address: - - 2014
To study the feasibility and the laterality of measurements of chest wall volume variation during tidal breathing in the lateral position in healthy subjects. Eighteen normal subjects were studied. Chest wall volume changes were measured by optoelectronic plethysmography in the supine and right and left lateral positions during quiet breathing. ...
Jurek Samuel C SC Boston Children's Hospital, Medicine, Boston, Massachusetts, United States ; - - 2014
Rationale: The Acute Respiratory Distress Syndrome (ARDS), a devastating lung disease that has no cure, is exacerbated by life-supportive mechanical ventilation that worsens lung edema and inflammation through the syndrome of Ventilator Induced Lung Injury (VILI). Recently, the membrane ion channel TRPV4 on alveolar macrophages was shown to mediate murine ...
Güldner Andreas A From the Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany (A.G., A.B., N.C., A.B., S.Z., C.U., P.M.S., T.K., and M.G.d.A.); Department of Electric Engineering, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (A.B.); Institute of Informatics and Biometry, Dresden, Germany (B.W.); Institute of Nuclear Medicine, University Hospital Dresden, Dresden, Germany (G.W., M.A., and J.K.); and IRCCS San Martino Hospital, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy - - 2014
Spontaneous breathing (SB) in the early phase of the acute respiratory distress syndrome is controversial. Biphasic positive airway pressure/airway pressure release ventilation (BIPAP/APRV) is commonly used, but the level of SB necessary to maximize potential beneficial effects is unknown. Experimental acute respiratory distress syndrome was induced by saline lung lavage ...
Yang Yi Y Department of Critical Care Medicine, Nanjing Zhong-Da Hospital, Southeast University, 87 Dingjiaqiao Rd, Nanjing, 210009, People's Republic of - - 2014
Lung recruitment maneuvers can help open collapsed lung units for sufficient oxygenation, and positive end expiratory pressure (PEEP) is used to keep the lung open after recruitment. However, the application of high PEEP levels may play a significant role in causing regional lung hyperinflation during mechanical ventilation. The authors sought ...
Tusman Gerardo G From the Departments of *Anesthesia and †Surgery, Hospital Privado de Comunidad, Mar del Plata, Buenos Aires; ‡Bioengineering Laboratory, Electronic Department, School of Engineering, Mar del Plata University, Mar del Plata, Argentina; §Swisstom AG, Landquart, Switzerland; ‖Department of Surgical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden; and ¶Instituto de Investigación Santinaria, Fundación Jiménez Díaz, IIS-FJD, CIBERES, Madrid, - - 2014
We conducted this study to determine whether pulse oximetry and volumetric capnography (VCap) can determine the opening and closing pressures of lungs of anesthetized morbidly obese patients. Twenty morbidly obese patients undergoing laparoscopic bariatric surgery with capnoperitoneum were studied. A lung recruitment maneuver was performed in pressure control ventilation as ...
Mariani Alessandro Wasum AW Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, - - 2014
Lung preservation remains a challenging issue for lung transplantation groups. Along with the development of ex vivo lung perfusion, a new preservation method known as topical-ECMO (extracorporal membrane oxygenation) has been proposed. The present study compared topical-ECMO with cold ischemia (CI) for lung preservation in an ex vivo experimental model. ...
Revermann Marc M Department of Anesthesiology and Critical Care Medicine, University Hospital Mannheim, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany ; Institute for Cardiovascular Physiology, Medical Faculty of the Goethe-University Frankfurt, Frankfurt, - - 2014
Right heart failure is a fatal consequence of chronic pulmonary hypertension (PH). The development of PH is characterized by increased proliferation of vascular cells, in particular pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells. In the course of PH, an escalated right ventricular (RV) afterload occurs, which ...
Bitar Abbas A Department of Medicine, Internal Medicine Residency Program, Krannert Institute of Cardiology, Indiana University, Indianapolis, Indiana, United States of - - 2014
Accurate determination of left ventricular filling pressure is essential for differentiation of pre-capillary pulmonary hypertension (PH) from pulmonary venous hypertension (PVH). Previous data suggest only a poor correlation between left ventricular end-diastolic pressure (LVEDP) and its commonly used surrogate, the pulmonary capillary wedge pressure (PCWP). However, no data exist on ...
Oppenheimer Beno W BW André Cournand Pulmonary Physiology Laboratory, Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Bellevue Hospital/New York University School of Medicine, New York, New York, United States of - - 2014
Abnormality in distal lung function may occur in obesity due to reduction in resting lung volume; however, airway inflammation, vascular congestion and/or concomitant intrinsic airway disease may also be present. The goal of this study is to 1) describe the phenotype of lung function in obese subjects utilizing spirometry, plethysmography ...
Fu Qiang Q Department of Anesthesiology, General Hospital of Department of Anesthesiology, General Hospital of - - 2014
The purpose of this study was to investigate the ability of stroke volume variation (SVV) to predict fluid responsiveness in patients undergoing pulmonary lobectomy with one lung ventilation (OLV). Thirty patients intubated with double-lumen tube were scheduled for a pulmonary lobectomy requiring OLV for at least 1 hour under general ...
Kambara Kenta K First Department of Internal medicine, University of Toyama, Toyama, - - 2014
Although airway luminal area (Ai) is affected by lung volume (LV), how is not precisely understood. We hypothesized that the effect of LV on Ai would differ by airway generation, lung lobe, and chronic obstructive pulmonary disease (COPD) severity. Sixty-seven subjects (15 at risk, 18, 20, and 14 for COPD ...
Ohara Daniela G DG Universidade Federal de Sao Carlos, Sao Carlos, SP, - - 2014
Background: Sickle Cell Disease (SCD), which is characterized by a mutation in the gene encoding beta hemoglobin, causes bodily dysfunctions such as impaired pulmonary function and reduced functional capacity. Objective : To assess changes in pulmonary function and functional capacity in patients with SCD and to identify the relationships between ...
Kitchen Marcus J MJ School of Physics, Monash Institute of Medical Research, Clayton, Victoria, - - 2014
Current recommendations suggest the use of positive end-expiratory pressures (PEEP) to assist very preterm infants to develop a functional residual capacity (FRC) and establish gas exchange at birth. However, maintaining a consistent PEEP is difficult and so the lungs are exposed to changing distending pressures after birth, which can affect ...
Sharif-Kashani Babak B Lung Transplantation Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, - - 2014
Pulmonary hypertension (PH) is an important cause of heart failure in chronic obstructive pulmonary disease (COPD). The pro brain natriuretic peptide N-terminal (NT-proBNP) has been suggested as a noninvasive marker to evaluate ventricular function. However, there is no evidence to support the use of NT-proBNP in monitoring the benefits of ...
Jiang Jingyu J 0000-0003-4197-0858 Faculty of Safety Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116, China ; National Engineering Research Center for Coal & Gas Control, China University of Mining & Technology, Xuzhou 221008, China ; Post-Doctoral Research Station, Yima Mining Corporation Limited, Sanmenxia, Henan 472300, - - 2014
This paper describes the effects of igneous intrusions on pore structure and adsorption capacity of the Permian coals in the Huaibei Coalfield, China. Twelve coal samples were obtained at different distances from a ~120 m extremely thick sill. Comparisons were made between unaltered and heat-affected coals using geochemical data, pore-fracture characteristics, ...
Smailys Andrea A Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, - - 2014
Abstract High-frequency oscillatory ventilation (HFOV) may improve gas exchange in patients who are inadequately ventilated by conventional mechanical ventilation (CV); however, the hemodynamic consequences of switching to HFOV remain unclear. We compared the effects of CV and HFOV on pulmonary vascular conductance and left ventricular (LV) preload and performance at ...
Chittawatanarat Kaweesak - - 2014
Cardiopulmonary monitoring (CPM) is rapidly progressing but data regarding CPM in Thai ICUs was unavailable. The objective of this study was to describe the situation, and gaps of CPM in Thai ICUs. Data were retrieved from the ICU-RESOURCE I study database survey CPM was divided into two aspects of device ...
Pu Jun J Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of - - 2014
To explore the effects of ventilatory mode "pressure controlled ventilation-volume guaranteed" (PCV-VG) on the inspiratory pressures, oxygenation parameters and hemodynamics of patients during one lung ventilation (OLV) for thoracic surgery, compared with volume controlled ventilation (VCV). Twenty participants were recruited and equally assigned into two groups in a controlled, randomized, ...
Naue Wagner da Silva WD Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, Physiotherapist. Adult ICU, Hospital de Clínicas de Porto Alegre - HCPA, Porto Alegre Hospital de Clínicas - Porto Alegre, - - 2014
To determine the efficacy of chest compression accompanied by a 10-cmH2O increase in baseline inspiratory pressure on pressure support ventilation, in comparison with that of aspiration alone, in removing secretions, normalizing hemodynamics, and improving respiratory mechanics in patients on mechanical ventilation. This was a randomized crossover clinical trial involving patients ...
D'Souza Crystal Dalia CD Department of Physiology, St. John's Medical College Hospital, Bangalore, - - 2014
To evaluate the effect of yoga on forced vital capacity (FVC), forced expiratory volume in I(st) second (FEV1), peak expiratory flow rate (PEFR), FEVI/FVC ratio, and pulmonary pressures [maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP) at the end of 3 months yoga training and the detraining effect on the ...
Chen Fengshi F Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, - - 2014
Background Living-donor lobar lung transplantation (LDLLT) recipients often have hypercapnia preoperatively, which confers a risk of worsened hypercapnia intraoperatively. We reviewed our experience with continuous carbon dioxide partial pressure (PtcCO2) monitoring in LDLLT to evaluate its accuracy and feasibility. We also assessed preoperative and intraoperative carbon dioxide levels in LDLLT ...
Amrani Amira A Aix-Marseille Université, Université du Sud Toulon-Var, CNRS/INSU, IRD, MIO, UM110, Marseille, France; Aix-Marseille Université, CNRS, LCB-UMR7283, Marseille, - - 2014
RNA-seq was used to study the response of Desulfovibrio hydrothermalis, isolated from a deep-sea hydrothermal chimney on the East-Pacific Rise at a depth of 2,600 m, to various hydrostatic pressure growth conditions. The transcriptomic datasets obtained after growth at 26, 10 and 0.1 MPa identified only 65 differentially expressed genes ...
Zannin Emanuela E Dipartimento di Bioingegneria, Politecnico di Milano University, Milano, - - 2013
Background:The aims of the present study were: 1) to characterise the relationship between mean airway pressure (PAW) and reactance measured at 5 Hz (XRS, forced oscillation technique), 2) to compare optimal PAW (Popt) defined by XRS, oxygenation, lung volume, and tidal volume (VT) in preterm lambs receiving HFOV.Methods:Nine 132d gestation ...
Vachiéry Jean-Luc JL Department of Cardiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: - - 2013
Pulmonary hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms, exercise capacity, and outcome. Although the true prevalence of PH-LHD is unknown, a subset of patients might present significant PH that cannot be explained by a passive increase in left-sided filling pressures. The term "out-of-proportion" PH ...
Hoeper Marius M MM Department of Respiratory Medicine and German Center for Lung Research, Hannover Medical School, Hannover, Germany. Electronic address: - - 2013
Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure ≥25 mm Hg at rest, measured during right heart catheterization. There is still insufficient evidence to add an exercise criterion to this definition. The term pulmonary arterial hypertension (PAH) describes a subpopulation of patients with PH characterized hemodynamically by the presence of ...
Tingay David G DG 1Murdoch Childrens Research - - 2013
The interrelationship between the role of surfactant and a sustained inflation to aid ex-utero transition of the preterm lung is unknown. We compared the effect of surfactant administered before and after an initial sustained inflation on gas exchange, lung mechanics, spatial distribution of ventilation and lung injury in preterm lambs. ...
McCabe Colm C 1Papworth - - 2013
Introduction: Pressure volume loops describe dynamic ventricular performance, relevant to patients with and at risk of pulmonary hypertension. We used conductance catheter-derived pressure volume loops to measure RV mechanics in patients with chronic thromboembolic pulmonary arterial obstruction at different stages of pathological adaptation. Materials and Methods: Resting conductance catheterization was ...
Yu Yung-Huey YH Department of Chest Medicine, En Chu Kong Hospital, - - 2013
Left ventricular (LV) filling impairment is present in patients with chronic obstructive pulmonary disease (COPD). Airflow obstruction is related to reduced LV end-diastolic volume, stroke volume, and cardiac output. The ratio of peak early diastolic filling velocity of the mitral inflow to peak early diastolic velocity of the mitral annulus ...
van Empel Vanessa Pm VP Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: - - 2013
Pulmonary hypertension due to left heart disease is very common. Our aim is to investigate the relationship of the severity of left ventricular diastolic dysfunction with pre-capillary and post-capillary pulmonary hypertension (PH) in an elderly heart failure (HF) population. A post-hoc analysis of the TIME-CHF data was done. Baseline transthoracic ...
João Benedito Barbosa BB Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Hospital Beneficência Portuguesa, São Paulo, SP, Brazil. Electronic address: - - 2014
Evaluate the ability of clonidine to reduce pulmonary arterial pressure in patients with pulmonary hypertension undergoing heart surgery, either by reducing the pressure values from the direct measurement of pulmonary arterial pressure or by reducing or eliminating the need for intraoperative dobutamine and nitroprusside. Randomized, double-blind, placebo-controlled, comparative study conducted ...
Rossier Bernard C BC Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland. Electronic address: - - 2014
The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is regulated by aldosterone and hormones involved in ...
Boussen S - - 2013
Previous studies on ventilators used for air transport showed significant effects of altitude,in particular in regards to the accuracy of the tidal volume (VT) and respiratory rate. The aim of the study was to evaluate transport ventilators under hypobaric conditions. We conducted a bench study of six transport ventilators in ...
Antonelli Andrea A Allergologia e Fisiopatologia Respiratoria, ASO S. Croce e Carle, Cuneo, - - 2013
We hypothesized that dyspnea and its descriptors, that is, chest tightness, inspiratory effort, unrewarded inspiration, and expiratory difficulty in asthma reflect different mechanisms of airflow obstruction and their perception varies with the severity of bronchoconstriction. Eighty-three asthmatics were studied before and after inhalation of methacholine doses decreasing the 1-sec forced ...
Vitarelli Antonio - - 2013
The aim of this study was to assess changes in right ventricular (RV) parameters determined by three-dimensional (3D) echocardiography and speckle-tracking echocardiography in patients with acute pulmonary embolism and RV dysfunction without systemic hypotension (submassive pulmonary embolism). Sixty-six patients were prospectively studied at the onset of the acute episode and ...
D'Andrea Antonello - - 2013
ABSTRACT BACKGROUND. Although transthoracic echocardiography (TTE) is an excellent non-invasive screening test for pulmonary hypertension, the physiologic range of echo-Doppler derived pulmonary pressures remains not completely investigated. The aim of the present study was therefore to explore the full spectrum of pulmonary pressures and RV functional indexes by TTE in ...
Malikiwi Andra - - 2013
Vasopressin is emerging as a therapeutic adjunct option towards treatment of shock states in the pediatric population. Its effects on pulmonary vasculature are less well understood. This report describes a 5-month-old infant with nitric oxide-unresponsive pulmonary hypertension, oxygenation failure, and systemic hypotension. Vasopressin therapy improved oxygenation and blood pressure and ...
Wang Chao-Hong - - 2013
Pulmonary hypertension (PH) is a set of pathophysiological syndromes characterized by increased pulmonary artery pressure and pulmonary vascular resistance, resulting in increased right ventricular afterload. The left and right ventricles interact through hemodynamics. What impact will PH have on synchronization and function of the left ventricle (LV)? The aim of ...
Zhang Ji-Zhuo - - 2013
Pediatric patients are susceptible to lung injury that does not respond to traditional therapies. Partial liquid ventilation (PLV) has been developed as an alternative ventilatory strategy for treating severe lung injury. The aim of this study is to investigate the effect of PLV on lung function in immature piglets. Acute ...
Cereda Maurizio M * Assistant Professor, Department of Anesthesiology and Critical Care, † Research Specialist, ‡ Project Manager, § Student, ‖ Research Assistant Professor, # Technical Director, ‡‡ Professor, Department of Radiology, †† Professor, Department of Anesthesiology and Critical Care and Stavropoulos Sepsis Research Program, University of Pennsylvania, Philadelphia, Pennsylvania. ** Professor, Departments of Critical Care Medicine and Anesthesia, Hospital for Sick Children, University of Toronto, Toronto, Ontario, - - 2013
Although it is recognized that pulmonary hysteresis can influence the effects of positive end-expiratory pressure (PEEP), the extent to which expansion of previously opened (vs. newly opening) peripheral airspaces contribute to increased lung volume is unknown. Following a recruitment maneuver, rats were ventilated with constant tidal volumes and imaged during ...
Maron Bradley A BA Department of Cardiology, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA ; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, - - 2013
In patients with chronic obstructive pulmonary disease (COPD), moderate or severe pulmonary hypertension (COPD-PH) is associated with increased rates of morbidity and mortality. Despite this, approaches to treatment and the efficacy of phosphodiesterase type 5 inhibition (PDE-5i) in COPD-PH are unresolved. We present the clinical rationale and study design to ...
Heresi Gustavo A GA Department of Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, - - 2013
Normal resting mean pulmonary artery pressure (PAP) is 8-20 mmHg. Pulmonary hypertension is defined as mean PAP of ≥25 mmHg. Borderline PAP levels of 21-24 mmHg are of unclear significance. We sought to determine the clinical characteristics and survival of subjects with mean PAP of 21-24 mmHg. We examined 1,491 ...
de Andrade Armèle Dornelas - - 2013
Immersion in water, with the head above the water line, causes acute physiological changes in the pulmonary and cardiovascular systems. The aim of this study was to evaluate the acute physiological responses to immersion on lung volumes and respiratory muscle strength at different depths. A cross-sectional study was conducted in ...
Yang Yi - - 2013
Background: In the acute respiratory distress syndrome (ARDS), lung-protective ventilation strategies combine the delivery of small tidal volumes (VT) with sufficient positive end-expiratory pressure (PEEP). However, an optimal approach guiding the setting of PEEP has not been defined. Monitoring volumetric capnography is useful to detect changes in lung aeration. Objectives: ...
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