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Kambara Kenta K First Department of Internal medicine, University of Toyama, Toyama, - - 2014
Although airway luminal area (Ai) is affected by lung volume (LV), how is not precisely understood. We hypothesized that the effect of LV on Ai would differ by airway generation, lung lobe, and chronic obstructive pulmonary disease (COPD) severity. Sixty-seven subjects (15 at risk, 18, 20, and 14 for COPD ...
Ohara Daniela G DG Universidade Federal de Sao Carlos, Sao Carlos, SP, - - 2014
Background: Sickle Cell Disease (SCD), which is characterized by a mutation in the gene encoding beta hemoglobin, causes bodily dysfunctions such as impaired pulmonary function and reduced functional capacity. Objective : To assess changes in pulmonary function and functional capacity in patients with SCD and to identify the relationships between ...
Kitchen Marcus J MJ School of Physics, Monash Institute of Medical Research, Clayton, Victoria, - - 2014
Current recommendations suggest the use of positive end-expiratory pressures (PEEP) to assist very preterm infants to develop a functional residual capacity (FRC) and establish gas exchange at birth. However, maintaining a consistent PEEP is difficult and so the lungs are exposed to changing distending pressures after birth, which can affect ...
Sharif-Kashani Babak B Lung Transplantation Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, - - 2014
Pulmonary hypertension (PH) is an important cause of heart failure in chronic obstructive pulmonary disease (COPD). The pro brain natriuretic peptide N-terminal (NT-proBNP) has been suggested as a noninvasive marker to evaluate ventricular function. However, there is no evidence to support the use of NT-proBNP in monitoring the benefits of ...
Jiang Jingyu J 0000-0003-4197-0858 Faculty of Safety Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116, China ; National Engineering Research Center for Coal & Gas Control, China University of Mining & Technology, Xuzhou 221008, China ; Post-Doctoral Research Station, Yima Mining Corporation Limited, Sanmenxia, Henan 472300, - - 2014
This paper describes the effects of igneous intrusions on pore structure and adsorption capacity of the Permian coals in the Huaibei Coalfield, China. Twelve coal samples were obtained at different distances from a ~120 m extremely thick sill. Comparisons were made between unaltered and heat-affected coals using geochemical data, pore-fracture characteristics, ...
Smailys Andrea A Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, - - 2014
Abstract High-frequency oscillatory ventilation (HFOV) may improve gas exchange in patients who are inadequately ventilated by conventional mechanical ventilation (CV); however, the hemodynamic consequences of switching to HFOV remain unclear. We compared the effects of CV and HFOV on pulmonary vascular conductance and left ventricular (LV) preload and performance at ...
Chittawatanarat Kaweesak - - 2014
Cardiopulmonary monitoring (CPM) is rapidly progressing but data regarding CPM in Thai ICUs was unavailable. The objective of this study was to describe the situation, and gaps of CPM in Thai ICUs. Data were retrieved from the ICU-RESOURCE I study database survey CPM was divided into two aspects of device ...
Pu Jun J Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of - - 2014
To explore the effects of ventilatory mode "pressure controlled ventilation-volume guaranteed" (PCV-VG) on the inspiratory pressures, oxygenation parameters and hemodynamics of patients during one lung ventilation (OLV) for thoracic surgery, compared with volume controlled ventilation (VCV). Twenty participants were recruited and equally assigned into two groups in a controlled, randomized, ...
Naue Wagner da Silva WD Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, Physiotherapist. Adult ICU, Hospital de Clínicas de Porto Alegre - HCPA, Porto Alegre Hospital de Clínicas - Porto Alegre, - - 2014
To determine the efficacy of chest compression accompanied by a 10-cmH2O increase in baseline inspiratory pressure on pressure support ventilation, in comparison with that of aspiration alone, in removing secretions, normalizing hemodynamics, and improving respiratory mechanics in patients on mechanical ventilation. This was a randomized crossover clinical trial involving patients ...
D'Souza Crystal Dalia CD Department of Physiology, St. John's Medical College Hospital, Bangalore, - - 2014
To evaluate the effect of yoga on forced vital capacity (FVC), forced expiratory volume in I(st) second (FEV1), peak expiratory flow rate (PEFR), FEVI/FVC ratio, and pulmonary pressures [maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP) at the end of 3 months yoga training and the detraining effect on the ...
- - 2014
[This corrects the article on p. 481 in vol. 9, PMID: 24868153.].
Zannin Emanuela E Dipartimento di Bioingegneria, Politecnico di Milano University, Milano, - - 2013
Background:The aims of the present study were: 1) to characterise the relationship between mean airway pressure (PAW) and reactance measured at 5 Hz (XRS, forced oscillation technique), 2) to compare optimal PAW (Popt) defined by XRS, oxygenation, lung volume, and tidal volume (VT) in preterm lambs receiving HFOV.Methods:Nine 132d gestation ...
Vachiéry Jean-Luc JL Department of Cardiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: - - 2013
Pulmonary hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms, exercise capacity, and outcome. Although the true prevalence of PH-LHD is unknown, a subset of patients might present significant PH that cannot be explained by a passive increase in left-sided filling pressures. The term "out-of-proportion" PH ...
Hoeper Marius M MM Department of Respiratory Medicine and German Center for Lung Research, Hannover Medical School, Hannover, Germany. Electronic address: - - 2013
Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure ≥25 mm Hg at rest, measured during right heart catheterization. There is still insufficient evidence to add an exercise criterion to this definition. The term pulmonary arterial hypertension (PAH) describes a subpopulation of patients with PH characterized hemodynamically by the presence of ...
Tingay David G DG 1Murdoch Childrens Research - - 2013
The interrelationship between the role of surfactant and a sustained inflation to aid ex-utero transition of the preterm lung is unknown. We compared the effect of surfactant administered before and after an initial sustained inflation on gas exchange, lung mechanics, spatial distribution of ventilation and lung injury in preterm lambs. ...
McCabe Colm C 1Papworth - - 2013
Introduction: Pressure volume loops describe dynamic ventricular performance, relevant to patients with and at risk of pulmonary hypertension. We used conductance catheter-derived pressure volume loops to measure RV mechanics in patients with chronic thromboembolic pulmonary arterial obstruction at different stages of pathological adaptation. Materials and Methods: Resting conductance catheterization was ...
Yu Yung-Huey YH Department of Chest Medicine, En Chu Kong Hospital, - - 2013
Left ventricular (LV) filling impairment is present in patients with chronic obstructive pulmonary disease (COPD). Airflow obstruction is related to reduced LV end-diastolic volume, stroke volume, and cardiac output. The ratio of peak early diastolic filling velocity of the mitral inflow to peak early diastolic velocity of the mitral annulus ...
van Empel Vanessa Pm VP Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: - - 2013
Pulmonary hypertension due to left heart disease is very common. Our aim is to investigate the relationship of the severity of left ventricular diastolic dysfunction with pre-capillary and post-capillary pulmonary hypertension (PH) in an elderly heart failure (HF) population. A post-hoc analysis of the TIME-CHF data was done. Baseline transthoracic ...
João Benedito Barbosa BB Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Hospital Beneficência Portuguesa, São Paulo, SP, Brazil. Electronic address: - - 2014
Evaluate the ability of clonidine to reduce pulmonary arterial pressure in patients with pulmonary hypertension undergoing heart surgery, either by reducing the pressure values from the direct measurement of pulmonary arterial pressure or by reducing or eliminating the need for intraoperative dobutamine and nitroprusside. Randomized, double-blind, placebo-controlled, comparative study conducted ...
Rossier Bernard C BC Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland. Electronic address: - - 2014
The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is regulated by aldosterone and hormones involved in ...
Boussen S - - 2013
Previous studies on ventilators used for air transport showed significant effects of altitude,in particular in regards to the accuracy of the tidal volume (VT) and respiratory rate. The aim of the study was to evaluate transport ventilators under hypobaric conditions. We conducted a bench study of six transport ventilators in ...
Antonelli Andrea A Allergologia e Fisiopatologia Respiratoria, ASO S. Croce e Carle, Cuneo, - - 2013
We hypothesized that dyspnea and its descriptors, that is, chest tightness, inspiratory effort, unrewarded inspiration, and expiratory difficulty in asthma reflect different mechanisms of airflow obstruction and their perception varies with the severity of bronchoconstriction. Eighty-three asthmatics were studied before and after inhalation of methacholine doses decreasing the 1-sec forced ...
Vitarelli Antonio - - 2013
The aim of this study was to assess changes in right ventricular (RV) parameters determined by three-dimensional (3D) echocardiography and speckle-tracking echocardiography in patients with acute pulmonary embolism and RV dysfunction without systemic hypotension (submassive pulmonary embolism). Sixty-six patients were prospectively studied at the onset of the acute episode and ...
D'Andrea Antonello - - 2013
ABSTRACT BACKGROUND. Although transthoracic echocardiography (TTE) is an excellent non-invasive screening test for pulmonary hypertension, the physiologic range of echo-Doppler derived pulmonary pressures remains not completely investigated. The aim of the present study was therefore to explore the full spectrum of pulmonary pressures and RV functional indexes by TTE in ...
Malikiwi Andra - - 2013
Vasopressin is emerging as a therapeutic adjunct option towards treatment of shock states in the pediatric population. Its effects on pulmonary vasculature are less well understood. This report describes a 5-month-old infant with nitric oxide-unresponsive pulmonary hypertension, oxygenation failure, and systemic hypotension. Vasopressin therapy improved oxygenation and blood pressure and ...
Wang Chao-Hong - - 2013
Pulmonary hypertension (PH) is a set of pathophysiological syndromes characterized by increased pulmonary artery pressure and pulmonary vascular resistance, resulting in increased right ventricular afterload. The left and right ventricles interact through hemodynamics. What impact will PH have on synchronization and function of the left ventricle (LV)? The aim of ...
Zhang Ji-Zhuo - - 2013
Pediatric patients are susceptible to lung injury that does not respond to traditional therapies. Partial liquid ventilation (PLV) has been developed as an alternative ventilatory strategy for treating severe lung injury. The aim of this study is to investigate the effect of PLV on lung function in immature piglets. Acute ...
Cereda Maurizio M * Assistant Professor, Department of Anesthesiology and Critical Care, † Research Specialist, ‡ Project Manager, § Student, ‖ Research Assistant Professor, # Technical Director, ‡‡ Professor, Department of Radiology, †† Professor, Department of Anesthesiology and Critical Care and Stavropoulos Sepsis Research Program, University of Pennsylvania, Philadelphia, Pennsylvania. ** Professor, Departments of Critical Care Medicine and Anesthesia, Hospital for Sick Children, University of Toronto, Toronto, Ontario, - - 2013
Although it is recognized that pulmonary hysteresis can influence the effects of positive end-expiratory pressure (PEEP), the extent to which expansion of previously opened (vs. newly opening) peripheral airspaces contribute to increased lung volume is unknown. Following a recruitment maneuver, rats were ventilated with constant tidal volumes and imaged during ...
Maron Bradley A BA Department of Cardiology, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA ; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, - - 2013
In patients with chronic obstructive pulmonary disease (COPD), moderate or severe pulmonary hypertension (COPD-PH) is associated with increased rates of morbidity and mortality. Despite this, approaches to treatment and the efficacy of phosphodiesterase type 5 inhibition (PDE-5i) in COPD-PH are unresolved. We present the clinical rationale and study design to ...
Heresi Gustavo A GA Department of Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, - - 2013
Normal resting mean pulmonary artery pressure (PAP) is 8-20 mmHg. Pulmonary hypertension is defined as mean PAP of ≥25 mmHg. Borderline PAP levels of 21-24 mmHg are of unclear significance. We sought to determine the clinical characteristics and survival of subjects with mean PAP of 21-24 mmHg. We examined 1,491 ...
de Andrade Armèle Dornelas - - 2013
Immersion in water, with the head above the water line, causes acute physiological changes in the pulmonary and cardiovascular systems. The aim of this study was to evaluate the acute physiological responses to immersion on lung volumes and respiratory muscle strength at different depths. A cross-sectional study was conducted in ...
Yang Yi - - 2013
Background: In the acute respiratory distress syndrome (ARDS), lung-protective ventilation strategies combine the delivery of small tidal volumes (VT) with sufficient positive end-expiratory pressure (PEEP). However, an optimal approach guiding the setting of PEEP has not been defined. Monitoring volumetric capnography is useful to detect changes in lung aeration. Objectives: ...
Tedford Ryan J RJ Division of Cardiology, Department of Medicine. Electronic address: - - 2013
Although the transpulmonary gradient (TPG) and pulmonary vascular resistance (PVR) are commonly used to differentiate heart failure patients with pulmonary vascular disease from those with passive pulmonary hypertension (PH), elevations in TPG and PVR may not always reflect pre-capillary PH. Recently, it has been suggested an elevated diastolic pulmonary artery ...
De Lazzari Claudio C C.N.R., Institute of Clinical Physiology, U.O.S. of Rome, Italy; National Institute of Cardiovascular Research, Bologna, Italy. Electronic address: - - 2013
Patients assisted with left ventricular assist device (LVAD) may require prolonged mechanical ventilatory assistance secondary to postoperative respiratory failure. The goal of this work is the study of the interdependent effects LVAD like pulsatile catheter (PUCA) pump and mechanical ventilatory support or thoracic artificial lung (TAL), by the hemodynamic point ...
Aslan Goksen Kuran - - 2013
Objective:To investigate the effects of inspiratory and expiratory muscle training on pulmonary functions in patients with slowly progressive neuromuscular disease.Design:Prospective randomized controlled double-blinded study.Setting:Chest diseases clinic of university hospital.Subjects:Twenty-six patients with slowly progressive neuromuscular disease followed for respiratory problems were included in the study. Patients were randomly divided into two ...
Van De Wauwer Caroline C Laboratory for Experimental Thoracic Surgery, Department of Thoracic Surgery, KU Leuven, Leuven, - - 2013
Formation of microthrombi after circulatory arrest is a concern for the development of reperfusion injury in lung recipients from donation after circulatory death (DCD) donors. In this isolated lung reperfusion study, we compared the effect of postmortem heparinization with preharvest retrograde pulmonary flush or both. Domestic pigs (n = 6/group) were sacrificed ...
Cressoni Massimo - - 2013
Rationale: Pressures and volumes needed to induce ventilator-induced lung injury in healthy lungs are far greater than applied in diseased lungs. A possible explanation may be the presence of local inhomogeneities acting as pressure multipliers (stress raisers). Objectives: quantify lung inhomogeneities in patients with Acute Respiratory Distress Syndrome (ARDS). Methods: ...
Pecchiari Matteo - - 2013
Recent studies in healthy mice and rats have reported that positive pressure ventilation delivered with physiological tidal volumes at normal end-expiratory volume worsens lung mechanics and induces cytokine release, thus suggesting that detrimental effects are due to positive pressure ventilation per se. The aim of this study in healthy animals ...
Tingay David G - - 2013
Background:Sustained inflation (SI) at birth facilitates establishment of functional residual capacity in the preterm lung, but the ideal lung recruitment strategy is unclear. We have compared the effect of SI and a step-wise positive end-expiratory pressure (PEEP; SEP) strategy in a preterm model.Methods:127d gestation lambs received either A) 20-s SI ...
Riffard Guillaume - - 2013
Previous bench studies suggest that dynamic hyperinflation may occur if Intrapulmonary Percussive Ventilation (IPV) is superimposed to mechanical ventilation in volume controlled continuous mandatory ventilation mode (VC-CMV). We tested the hypothesis that pressure controlled continuous mandatory ventilation mode (PC-CMV) can protect against this risk. ICU ventilator was connected to an ...
Minai Omar A - - 2013
We explored the prevalence, clinical and physiologic correlates of pulmonary hypertension (PH), and screening strategies in patients with severe emphysema evaluated for the National Emphysema Treatment Trial (NETT). Patients undergoing Doppler echocardiography (DE) and right heart catheterization were included. Patients with mean pulmonary arterial pressure ≥25 mmHg (PH Group) were compared ...
Masuda Yoshiki - - 2013
Prone ventilation is an effective method for improving oxygenation in patients with acute respiratory failure. However, in extracorporeal circulation, there is a risk of cannula-related complications when changing the position. In this study, we investigated cannula-related complications when changing position for prone ventilation and the effect of prone ventilation on ...
Chen Tongyun - - 2013
To compare the therapeutic efficacy of recombinant human brain natriuretic peptide and prostaglandin E1 in the treatment of pulmonary hypertension after mitral valve replacement. Sixty patients with postoperative pulmonary hypertension were divided randomly into 3 groups that received saline, prostaglandin E1, and natriuretic peptide infusions for 12 hours each. The ...
Ismail M - - 2013
In many biomedical flow problems, reversed flows along with standard treatment of Neumann boundary conditions can cause instabilities. We have developed a method that resolves these instabilities in a consistent way while maintaining correct pressure and flow rate values. We also are able to remove the necessary prescription of both ...
Arvela H - - 2013
Low-energy and passive house construction practices are characterised by increased insulation, high air tightness of the building shell and controlled mechanical ventilation with heat recovery. As a result of the interaction of mechanical ventilation and high air tightness, the pressure difference in a building can be markedly enhanced. This may ...
Frazziano Giovanna G Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, - - 2014
Pulmonary arterial hypertension is a severe progressive disease with marked morbidity and high mortality in which right ventricular (RV) failure is the major cause of death. Thus knowledge of the mechanisms underlying RV failure is an area of active interest. Previous studies suggest a role of NADPH oxidase in cardiomyocyte ...
Yoshida Takeshi - - 2013
Rationale: In normal lungs, local changes in pleural pressure (Ppl) are generalized over the whole pleural surface. However, in a patient with injured lungs, we observed (using electrical impedance tomography, EIT) a Pendelluft phenomenon, i.e. movement of air within the lung from non-dependent to dependent regions without change in tidal ...
Farina Stefania - - 2013
The objective of this study was to evaluate inert gas rebreathing (IGR) reliability in cardiac output (CO) measurement compared with Fick method and thermodilution. IGR is a noninvasive method for CO measurement; CO by IGR is calculated as pulmonary blood flow plus intrapulmonary shunt. IGR may be ideal for follow-up ...
Chiumello Davide - - 2013
Positive end-expiratory pressure exerts its effects keeping open at end-expiration previously collapsed areas of the lung; consequently, higher positive end-expiratory pressure should be limited to patients with high recruitability. We aimed to determine which bedside method would provide positive end-expiratory pressure better related to lung recruitability. Prospective study performed between ...
Koo H-K - - 2013
Factors that influence the annual rate of decline of lung function need to be verified. To determine the effects of metabolic syndrome, especially hypertension, on the annual rate of decline in lung function. A total of 635 healthy participants without known respiratory disease completed baseline and follow-up routine check-ups, including ...
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